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Find video protocols related to scientific articles indexed in Pubmed.
Six-year incidence of ocular hypertension in a South Indian population: the Chennai eye disease incidence study.
Br J Ophthalmol
PUBLISHED: 11-13-2014
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To report the 6-year incidence and risk factors for ocular hypertension (OHT) in a population-based study in southern India.
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Prevalence and causes of low vision and blindness in an urban population: The Chennai Glaucoma Study.
Indian J Ophthalmol
PUBLISHED: 09-30-2014
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To evaluate the prevalence and causes of low vision and blindness in an urban south Indian population.
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Ahmed glaucoma valve in eyes with preexisting episcleral encircling element.
Indian J Ophthalmol
PUBLISHED: 06-03-2014
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To describe the use of Ahmed glaucoma valve (AGV) in the management of intractable glaucoma in eyes with a preexisting episcleral encircling element.
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Safety and Efficacy of Single-site Phacotrabeculectomy With Mitomicin C Using Nylon and Polyglactin Suture for Scleral Tunnel Closure.
J. Glaucoma
PUBLISHED: 05-27-2014
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To evaluate the efficacy of polyglactin use along with nylon suture in scleral tunnel closure after single-site phacotrabeculectomy.
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Intra-bleb hematoma and hyphema following digital ocular compression.
Oman J Ophthalmol
PUBLISHED: 05-07-2014
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We report successful outcome of a huge post- trabeculectomy intra-bleb hematoma and hyphema that occurred following digital ocular compression. The patient was a 64-year-old lady suffering from bilateral primary angle closure glaucoma and cataract. She was on anti-platelet therapy. She underwent single-site phacoemulsification, intra-ocular lens implantation and trabeculectomy with mitomycin C in the right eye. The trabeculectomy was under-filtering. She was asked to perform digital ocular compression thrice daily. On 15(th) post-operative day, she presented with a huge intra-bleb hematoma and hyphema. The hematoma did not respond to conservative measures and was drained to prevent bleb failure. We recommend caution in the consideration of digital ocular compression in patients on prophylactic anti-coagulation.
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The use of Ahmed glaucoma valve in the management of pediatric glaucoma.
J AAPOS
PUBLISHED: 03-02-2014
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To assess the intraocular pressure control (IOP), changes in visual acuity, complications, reoperation rates and risk factors for failure following Ahmed glaucoma valve implantation in pediatric eyes with glaucoma.
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ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma.
PLoS Genet.
PUBLISHED: 03-01-2014
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Anterior chamber depth (ACD) is a key anatomical risk factor for primary angle closure glaucoma (PACG). We conducted a genome-wide association study (GWAS) on ACD to discover novel genes for PACG on a total of 5,308 population-based individuals of Asian descent. Genome-wide significant association was observed at a sequence variant within ABCC5 (rs1401999; per-allele effect size =? -0.045 mm, P = 8.17 × 10(-9)). This locus was associated with an increase in risk of PACG in a separate case-control study of 4,276 PACG cases and 18,801 controls (per-allele OR = 1.13 [95% CI: 1.06-1.22], P = 0.00046). The association was strengthened when a sub-group of controls with open angles were included in the analysis (per-allele OR = 1.30, P = 7.45 × 10(-9); 3,458 cases vs. 3,831 controls). Our findings suggest that the increase in PACG risk could in part be mediated by genetic sequence variants influencing anterior chamber dimensions.
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Prospective evaluation of early visual loss following glaucoma-filtering surgery in eyes with split fixation.
J. Glaucoma
PUBLISHED: 02-14-2014
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The aim of this study was to evaluate the incidence and etiology of loss of vision in the early postoperative period after glaucoma-filtration surgery in eyes with split fixation.
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Prevalence and causes of vision loss in Central and South Asia: 1990-2010.
Br J Ophthalmol
PUBLISHED: 01-23-2014
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To examine the prevalence, patterns and trends of vision impairment and its causes from 1990 to 2010 in Central and South Asia.
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Long-term change in central corneal thickness from a glaucoma perspective.
Indian J Ophthalmol
PUBLISHED: 10-23-2013
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Aim: To investigate the longitudinal change in central corneal thickness (CCT) over 3 years in patients with glaucoma. Materials and Methods: The Chennai Glaucoma Follow-up Study, an offshoot of the Chennai Glaucoma Study, was designed to evaluate the progression of glaucoma. A cohort of participants in the Chennai Glaucoma Study that were suffering from glaucoma or were at a higher risk for glaucoma underwent comprehensive ophthalmic evaluation at the base hospital at 6-month intervals during the years 2004 to 2007. The CCT (average of 10 readings) was measured between 11 am and 1 pm on any given day using an ultrasonic pachymeter. Patients with a history of ocular surgery, corneal disease and usage of topical carbonic anhydrase inhibitor were excluded. No patient was a contact lens wearer. Results: One hundred and ninety-six patients (84 male, 112 female) met the inclusion criteria. We analyzed data from the right eye. The mean age of the patients was 59.97 ± 9.06 years. Fifty-nine (30.1%) of the patients were diabetic. The mean change in CCT (CCT at first patient visit - CCT at last patient visit) was 3.46 ± 7.63 ?m. The mean change in CCT was 0.75 ?m per year (R 2 = 0.00). Age, gender, intraocular pressure at the first patient visit and diabetic status had no significant influence on the magnitude of change in CCT. Conclusion: A carefully obtained CCT reading by a trained examiner need not be repeated for at least 3 years as long as the ocular and systemic factors known to affect the measurement of CCT are constant.
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Seven new loci associated with age-related macular degeneration.
Lars G Fritsche, Wei Chen, Matthew Schu, Brian L Yaspan, Yi Yu, Gudmar Thorleifsson, Donald J Zack, Satoshi Arakawa, Valentina Cipriani, Stephan Ripke, Robert P Igo, Gabriëlle H S Buitendijk, Xueling Sim, Daniel E Weeks, Robyn H Guymer, Joanna E Merriam, Peter J Francis, Gregory Hannum, Anita Agarwal, Ana Maria Armbrecht, Isabelle Audo, Tin Aung, Gaetano R Barile, Mustapha Benchaboune, Alan C Bird, Paul N Bishop, Kari E Branham, Matthew Brooks, Alexander J Brucker, William H Cade, Melinda S Cain, Peter A Campochiaro, Chi-Chao Chan, Ching-Yu Cheng, Emily Y Chew, Kimberly A Chin, Itay Chowers, David G Clayton, Radu Cojocaru, Yvette P Conley, Belinda K Cornes, Mark J Daly, Baljean Dhillon, Albert O Edwards, Evangelos Evangelou, Jesen Fagerness, Henry A Ferreyra, James S Friedman, Asbjorg Geirsdottir, Ronnie J George, Christian Gieger, Neel Gupta, Stephanie A Hagstrom, Simon P Harding, Christos Haritoglou, John R Heckenlively, Frank G Holz, Guy Hughes, John P A Ioannidis, Tatsuro Ishibashi, Peronne Joseph, Gyungah Jun, Yoichiro Kamatani, Nicholas Katsanis, Claudia N Keilhauer, Jane C Khan, Ivana K Kim, Yutaka Kiyohara, Barbara E K Klein, Ronald Klein, Jaclyn L Kovach, Igor Kozak, Clara J Lee, Kristine E Lee, Peter Lichtner, Andrew J Lotery, Thomas Meitinger, Paul Mitchell, Saddek Mohand-Saïd, Anthony T Moore, Denise J Morgan, Margaux A Morrison, Chelsea E Myers, Adam C Naj, Yusuke Nakamura, Yukinori Okada, Anton Orlin, M Carolina Ortube, Mohammad I Othman, Chris Pappas, Kyu Hyung Park, Gayle J T Pauer, Neal S Peachey, Olivier Poch, Rinki Ratna Priya, Robyn Reynolds, Andrea J Richardson, Raymond Ripp, Guenther Rudolph, Euijung Ryu, José-Alain Sahel, Debra A Schaumberg, Hendrik P N Scholl, Stephen G Schwartz, William K Scott, Humma Shahid, Haraldur Sigurdsson, Giuliana Silvestri, Theru A Sivakumaran, R Theodore Smith, Lucia Sobrin, Eric H Souied, Dwight E Stambolian, Hreinn Stefansson, Gwen M Sturgill-Short, Atsushi Takahashi, Nirubol Tosakulwong, Barbara J Truitt, Evangelia E Tsironi, André G Uitterlinden, Cornelia M van Duijn, Lingam Vijaya, Johannes R Vingerling, Eranga N Vithana, Andrew R Webster, H-Erich Wichmann, Thomas W Winkler, Tien Y Wong, Alan F Wright, Diana Zelenika, Ming Zhang, Ling Zhao, Kang Zhang, Michael L Klein, Gregory S Hageman, G Mark Lathrop, Kari Stefansson, Rando Allikmets, Paul N Baird, Michael B Gorin, Jie Jin Wang, Caroline C W Klaver, Johanna M Seddon, Margaret A Pericak-Vance, Sudha K Iyengar, John R W Yates, Anand Swaroop, Bernhard H F Weber, Michiaki Kubo, Margaret M DeAngelis, Thierry Léveillard, Unnur Thorsteinsdottir, Jonathan L Haines, Lindsay A Farrer, Iris M Heid, Gonçalo R Abecasis, .
Nat. Genet.
PUBLISHED: 03-03-2013
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Age-related macular degeneration (AMD) is a common cause of blindness in older individuals. To accelerate the understanding of AMD biology and help design new therapies, we executed a collaborative genome-wide association study, including >17,100 advanced AMD cases and >60,000 controls of European and Asian ancestry. We identified 19 loci associated at P < 5 × 10(-8). These loci show enrichment for genes involved in the regulation of complement activity, lipid metabolism, extracellular matrix remodeling and angiogenesis. Our results include seven loci with associations reaching P < 5 × 10(-8) for the first time, near the genes COL8A1-FILIP1L, IER3-DDR1, SLC16A8, TGFBR1, RAD51B, ADAMTS9 and B3GALTL. A genetic risk score combining SNP genotypes from all loci showed similar ability to distinguish cases and controls in all samples examined. Our findings provide new directions for biological, genetic and therapeutic studies of AMD.
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Six-year incidence of angle-closure disease in a South Indian population: the Chennai Eye Disease Incidence Study.
Am. J. Ophthalmol.
PUBLISHED: 02-28-2013
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To estimate the 6-year incidence of primary angle-closure (PAC) disease among adult population aged 40 years and older from rural and urban south India.
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Prevalence and associated factors for pterygium and pinguecula in a South Indian population.
Ophthalmic Physiol Opt
PUBLISHED: 11-24-2011
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To describe the prevalence and factors associated with pterygium and pinguecula in a south Indian population.
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Variability in the calibration error of the goldmann applanation tonometer.
J. Glaucoma
PUBLISHED: 11-05-2011
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To investigate the variability in the measured calibration error with continued usage of Goldmann applanation tonometers (GATs) having unacceptable calibration error.
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Optic disc dimensions and cup-disc ratios among healthy South Indians: The Chennai Glaucoma Study.
Ophthalmic Epidemiol
PUBLISHED: 10-04-2011
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To present optic disc and cup dimensions, cup-disc ratios (CDRs) and asymmetry among healthy South Indians, and their associations with ocular and systemic variables.
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A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration.
PLoS ONE
PUBLISHED: 05-24-2011
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Complement factor H shows very strong association with Age-related Macular Degeneration (AMD), and recent data suggest that multiple causal variants are associated with disease. To refine the location of the disease associated variants, we characterized in detail the structural variation at CFH and its paralogs, including two copy number polymorphisms (CNP), CNP147 and CNP148, and several rare deletions and duplications. Examination of 34 AMD-enriched extended families (N?=?293) and AMD cases (White N?=?4210 Indian?=?134; Malay?=?140) and controls (White N?=?3229; Indian?=?117; Malay?=?2390) demonstrated that deletion CNP148 was protective against AMD, independent of SNPs at CFH. Regression analysis of seven common haplotypes showed three haplotypes, H1, H6 and H7, as conferring risk for AMD development. Being the most common haplotype H1 confers the greatest risk by increasing the odds of AMD by 2.75-fold (95% CI?=?[2.51, 3.01]; p?=?8.31×10(-109)); Caucasian (H6) and Indian-specific (H7) recombinant haplotypes increase the odds of AMD by 1.85-fold (p?=?3.52×10(-9)) and by 15.57-fold (P?=?0.007), respectively. We identified a 32-kb region downstream of Y402H (rs1061170), shared by all three risk haplotypes, suggesting that this region may be critical for AMD development. Further analysis showed that two SNPs within the 32 kb block, rs1329428 and rs203687, optimally explain disease association. rs1329428 resides in 20 kb unique sequence block, but rs203687 resides in a 12 kb block that is 89% similar to a noncoding region contained in ?CNP148. We conclude that causal variation in this region potentially encompasses both regulatory effects at single markers and copy number.
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Management of complications in glaucoma surgery.
Indian J Ophthalmol
PUBLISHED: 04-01-2011
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Surgical option for glaucoma is considered when other modalities are not working out to keep the intraocular pressure under control. Since the surgical procedures for glaucoma disrupt the integrity of the globe, they are known to produce various complications. Some of those complications can be vision-threatening. To minimize the morbidity, it is very important that one should know how to prevent them, recognize them and treat them. The objective of this article is to provide insight into some of those complications that will help the ophthalmologists in treating glaucoma patients in their clinical practice.
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Importance of population-based studies in clinical practice.
Indian J Ophthalmol
PUBLISHED: 04-01-2011
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In the last decade, there have been reports on the prevalence of glaucoma from the Vellore Eye Survey, Andhra Pradesh Eye Diseases Survey, Aravind Comprehensive Eye Survey, Chennai Glaucoma Study and West Bengal Glaucoma Study. Population-based studies provide important information regarding the prevalence and risk factors for glaucoma. They also highlight regional differences in the prevalence of various types of glaucoma. It is possible to gather important insights regarding the number of persons affected with glaucoma and the proportion with undiagnosed disease. We reviewed the different population-based studies from India and compare their findings. The lacunae in ophthalmic care that can be inferred from these studies are identified and possible reasons and solutions are discussed. We also discuss the clinical relevance of the various findings, and how it reflects on clinical practice in the country. Since India has a significantly high disease burden, we examine the possibility of population-based screening for disease in the Indian context.
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Epoxyeicosatrienoic acid agonist regulates human mesenchymal stem cell-derived adipocytes through activation of HO-1-pAKT signaling and a decrease in PPAR?.
Stem Cells Dev.
PUBLISHED: 10-09-2010
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Human mesenchymal stem cells (MSCs) expressed substantial levels of CYP2J2, a major CYP450 involved in epoxyeicosatrienoic acid (EET) formation. MSCs synthesized significant levels of EETs (65.8?±?5.8?pg/mg protein) and dihydroxyeicosatrienoic acids (DHETs) (15.83?±?1.62?pg/mg protein), suggesting the presence of soluble epoxide hydrolase (sEH). The addition of an sEH inhibitor to MSC culture decreased adipogenesis. EETs decreased MSC-derived adipocytes in a concentration-dependent manner, 8,9- and 14,15-EET having the maximum reductive effect on adipogenesis. We examined the effect of 12-(3-hexylureido)dodec-8(Z)-enoic acid, an EET agonist, on MSC-derived adipocytes and demonstrated an increased number of healthy small adipocytes, attenuated fatty acid synthase (FAS) levels (P?
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Glaucoma in India: estimated burden of disease.
J. Glaucoma
PUBLISHED: 08-17-2010
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Over the last decade the prevalence of glaucoma has been reported by the Vellore Eye Survey, Andhra Pradesh Eye Disease Study, Aravind Comprehensive Eye Survey, Chennai Glaucoma Study, and West Bengal Glaucoma Study. There have been some differences largely because of methodologic variations. We use the reported age and gender stratified prevalence estimates from these studies and the Indian population census estimates to calculate the number of persons with glaucoma or at risk of the disease in the country. On the basis of the available data, we estimate that there are approximately 11.2 million persons aged 40 years and older with glaucoma in India. Primary open angle glaucoma is estimated to affect 6.48 million persons. The estimated number with primary angle-closure glaucoma is 2.54 million. Those with any form of primary angle-closure disease could comprise 27.6 million persons. Most of those with disease are undetected and there exist major challenges in detecting and treating those with disease. In the light of the existing manpower and resource constraints, we evaluate options for improving case detection rates in the country.
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Perimetric severity in hospital-based and population-based glaucoma patients.
Clin Exp Optom
PUBLISHED: 07-12-2010
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The aim was to compare the severity of glaucoma among newly diagnosed patients presenting to a hospital-based glaucoma care centre (HBGS: Sankara Nethralaya, Medical Research Foundation) with that of age matched subjects from the population-based Chennai Glaucoma Follow-up Study (CGFS).
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The Chennai glaucoma study: prevalence and risk factors for glaucoma in cataract operated eyes in urban Chennai.
Indian J Ophthalmol
PUBLISHED: 04-24-2010
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We report the prevalence and risk factors for glaucoma among aphakes and pseudophakes in 3850 subjects who participated in a population-based study in urban south India. The subjects underwent an ophthalmic examination including applanation tonometry, gonioscopy, optic disc evaluation and frequency doubling perimetry. Glaucoma was diagnosed using the International Society of Geographical and Epidemiological Ophthalmology (ISGEO) criteria. Thirty eight, 15 aphakes and 23 pseudophakes (0.99% of 3850 subjects) of the 406 persons who had undergone cataract surgery were diagnosed with glaucoma. Aphakes/pseudophakes were at higher risk of glaucoma as compared to the phakic population (Odds Ratio: 2.71, 95% CI: 1. 94, 3.38, p=0.001). On multivariate analysis, older age and higher intra ocular pressure were risk factors for glaucoma. Blindness attributable to glaucoma was detected in 20% of aphakic and 4.3% of pseudophakic eyes. Glaucoma was a significant cause of morbidity in those who had undergone cataract surgery in this urban population.
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Outcomes of cataract surgery in a rural and urban south Indian population.
Indian J Ophthalmol
PUBLISHED: 04-24-2010
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To assess the visual outcome after cataract surgery in a south Indian population.
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Plateau Iris Configuration and Dark-Light Changes in Anterior Segment Optical Coherence Tomography.
Ophthalmic Surg Lasers Imaging
PUBLISHED: 03-27-2010
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The angle opening distance (AOD) was analyzed using anterior segment optical coherence tomography (ASOCT) in dark-light conditions in 14 convex iris configuration (CIC) and 12 plateau iris configuration (PIC) patients. AOD500 measured in dark and bright conditions in nasal quadrants were 0.156 +/- 0.072 mum; 0.186 +/- 0.084 mum for CIC (P = .025) and 0.177 +/- 0.121 mum; 0.186 +/- 0.116 mum for PIC (P = .38). AOD750 in dark and bright conditions in nasal quadrants were 0.235 +/- 0.082 mum; 0.280 +/- 0.097 mum for CIC (P = .000) and 0.294 +/- 0.181 mum; 0.306 +/- 0.172 mum for PIC. PIC showed no significant difference in the dynamic changes, whereas the nasal quadrant in CIC showed significant changes. The AOD parameters from ASOCT can be used to analyze the dark-light changes of the anterior chamber angle to differentiate between CIC and PICs.
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Peribulbar anesthesia for cataract surgery: effect of lidocaine warming and alkalinization on injection pain, motor and sensory nerve blockade.
Indian J Ophthalmol
PUBLISHED: 03-03-2010
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To compare self-reported pain and efficacy of warmed, alkalinized, and warmed alkalinized lidocaine with plain 2% lidocaine at room temperature for peribulbar anesthesia in cataract surgery.
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Central corneal thickness in adult South Indians: the Chennai Glaucoma Study.
Ophthalmology
PUBLISHED: 01-15-2010
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To evaluate the characteristics of central corneal thickness (CCT) and its association with age, gender, and intraocular pressure in rural and urban South Indian populations.
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Follow-up of primary angle closure suspects after laser peripheral iridotomy using ultrasound biomicroscopy and A-scan biometry for a period of 2 years.
J. Glaucoma
PUBLISHED: 09-12-2009
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To determine the morphologic changes in the anterior segment of primary angle closure suspects (PACS) who underwent laser peripheral iridotomy (LPI) for a period of 2 years.
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Determinants of glaucoma awareness and knowledge in urban Chennai.
Indian J Ophthalmol
PUBLISHED: 08-25-2009
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To assess the awareness and knowledge levels about glaucoma and its determinants in an urban population of Chennai in south India.
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Comparison of Humphrey MATRIX and Swedish interactive threshold algorithm standard strategy in detecting early glaucomatous visual field loss.
Indian J Ophthalmol
PUBLISHED: 04-23-2009
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The aim of this study was to compare the Humphrey MATRIX visual field (frequency doubling technology threshold) and Swedish interactive threshold algorithm (SITA) standard strategy white on white perimetry in detecting glaucomatous visual field loss.
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Betaxolol hydrochloride ophthalmic suspension 0.25% and timolol gel-forming solution 0.25% and 0.5% in pediatric glaucoma: a randomized clinical trial.
J AAPOS
PUBLISHED: 01-16-2009
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To describe the safety profile and clinical response on elevated intraocular pressure (IOP) of betaxolol hydrochloride ophthalmic suspension 0.25% (betaxolol) and timolol maleate ophthalmic gel-forming solution (TGFS) (0.25% and 0.5%), in subjects under 6 years of age.
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Measurement of Goldmann applanation tonometer calibration error.
Ophthalmology
PUBLISHED: 01-16-2009
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To determine the frequency and possible origins of calibration errors of the Goldmann applanation tonometer and to investigate intraobserver and interobserver agreement in the measurement of such calibration errors.
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Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma.
Nat. Genet.
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Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant associations at three new loci: rs11024102 in PLEKHA7 (per-allele odds ratio (OR)=1.22; P=5.33×10(-12)), rs3753841 in COL11A1 (per-allele OR=1.20; P=9.22×10(-10)) and rs1015213 located between PCMTD1 and ST18 on chromosome 8q (per-allele OR=1.50; P=3.29×10(-9)). Our findings, accumulated across these independent worldwide collections, suggest possible mechanisms explaining the pathogenesis of PACG.
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Change in iris parameters with physiological mydriasis.
Optom Vis Sci
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A pilot study to analyze the association of change in iris parameters with physiological mydriasis in angle closure eyes compared with normal control eyes among south Indian participants.
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JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

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