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Find video protocols related to scientific articles indexed in Pubmed.
Health-related quality of life over time in children with eosinophilic esophagitis and their families.
J. Pediatr. Gastroenterol. Nutr.
PUBLISHED: 06-05-2014
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Existing treatments for pediatric eosinophilic esophagitis (EoE) effectively reduce inflammation. The impact of treatment on health-related quality of life (HRQoL) over time for pediatric patients with EoE and their families, however, has not been systematically assessed. We hypothesized that individualized multidisciplinary treatment would improve both child and family HRQoL over time, with improvements associated with decreased symptom severity.
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Cystatin C: a potential biomarker for pulmonary arterial hypertension.
Respirology
PUBLISHED: 01-13-2014
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Cystatin C (CysC), a novel marker of renal function, predicts left heart failure and cardiovascular mortality. The hypothesis that serum CysC levels correlate with right ventricular (RV) morphology, function and pressure in pulmonary arterial hypertension (PAH) was tested.
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Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis.
JAMA
PUBLISHED: 05-23-2013
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Current prediction models of mortality in idiopathic pulmonary fibrosis (IPF), which are based on clinical and physiological parameters, have modest value in predicting which patients will progress. In addition to the potential for improving prognostic models, identifying genetic and molecular features that are associated with IPF mortality may provide insight into the underlying mechanisms of disease and inform clinical trials.
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Cytosolic phospholipase A(2)? and eicosanoids regulate expression of genes in macrophages involved in host defense and inflammation.
PLoS ONE
PUBLISHED: 01-01-2013
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The role of Group IVA cytosolic phospholipase A2 (cPLA2?) activation in regulating macrophage transcriptional responses to Candida albicans infection was investigated. cPLA2? releases arachidonic acid for the production of eicosanoids. In mouse resident peritoneal macrophages, prostacyclin, prostaglandin E2 and leukotriene C4 were produced within minutes of C. albicans addition before cyclooxygenase 2 expression. The production of TNF? was lower in C. albicans-stimulated cPLA2?(+/+) than cPLA2?(-/-) macrophages due to an autocrine effect of prostaglandins that increased cAMP to a greater extent in cPLA2?(+/+) than cPLA2?(-/-) macrophages. For global insight, differential gene expression in C. albicans-stimulated cPLA2?(+/+) and cPLA2?(-/-) macrophages (3 h) was compared by microarray. cPLA2?(+/+) macrophages expressed 86 genes at lower levels and 181 genes at higher levels than cPLA2?(-/-) macrophages (?2-fold, p<0.05). Several pro-inflammatory genes were expressed at lower levels (Tnf?, Cx3cl1, Cd40, Ccl5, Csf1, Edn1, CxCr7, Irf1, Irf4, Akna, Ifn?, several IFN?-inducible GTPases). Genes that dampen inflammation (Socs3, Il10, Crem, Stat3, Thbd, Thbs1, Abca1) and genes involved in host defense (Gja1, Csf3, Trem1, Hdc) were expressed at higher levels in cPLA2?(+/+) macrophages. Representative genes expressed lower in cPLA2?(+/+) macrophages (Tnf?, Csf1) were increased by treatment with a prostacyclin receptor antagonist and protein kinase A inhibitor, whereas genes expressed at higher levels (Crem, Nr4a2, Il10, Csf3) were suppressed. The results suggest that C. albicans stimulates an autocrine loop in macrophages involving cPLA2?, cyclooxygenase 1-derived prostaglandins and increased cAMP that globally effects expression of genes involved in host defense and inflammation.
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The response of children with asthma to ambient particulate is modified by tobacco smoke exposure.
Am. J. Respir. Crit. Care Med.
PUBLISHED: 08-25-2011
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Ambient particulate matter concentrations have been positively associated with urinary leukotriene E(4) (LTE(4)) levels and albuterol usage in children with asthma but interactions with environmental tobacco smoke (ETS) exposure have not been demonstrated despite obvious exposure to both pollutants in an urban setting.
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Urinary leukotriene E? levels identify children with tobacco smoke exposure at risk for asthma exacerbation.
J. Allergy Clin. Immunol.
PUBLISHED: 04-14-2011
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Children with asthma exposed to secondhand smoke (SHS) might be at higher risk for severe exacerbations, but biomarkers of susceptibility to SHS exposure have not been previously reported.
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Exposure and genetics increase risk of beryllium sensitisation and chronic beryllium disease in the nuclear weapons industry.
Occup Environ Med
PUBLISHED: 04-02-2011
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Beryllium sensitisation (BeS) and chronic beryllium disease (CBD) are caused by exposure to beryllium with susceptibility affected by at least one well-studied genetic host factor, a glutamic acid residue at position 69 (E69) of the HLA-DP? chain (DP?E69). However, the nature of the relationship between exposure and carriage of the DP?E69 genotype has not been well studied. The goal of this study was to determine the relationship between DP?E69 and exposure in BeS and CBD.
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Risk of chronic beryllium disease by HLA-DPB1 E69 genotype and beryllium exposure in nuclear workers.
Am. J. Respir. Crit. Care Med.
PUBLISHED: 03-11-2011
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Beryllium sensitization (BeS) and chronic beryllium disease (CBD) are determined by at least one genetic factor, a glutamic acid at position 69 (E69) of the HLA-DPB1 gene, and by exposure to beryllium. The relationship between exposure and the E69 genotype has not been well characterized.
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Safety of investigative bronchoscopy in the Severe Asthma Research Program.
J. Allergy Clin. Immunol.
PUBLISHED: 02-15-2011
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Investigative bronchoscopy was performed in a subset of participants in the Severe Asthma Research Program to gain insights into the pathobiology of severe disease. We evaluated the safety aspects of this procedure in this cohort with specific focus on patients with severe asthma.
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Racial differences in biologic predictors of severe asthma: Data from the Severe Asthma Research Program.
J. Allergy Clin. Immunol.
PUBLISHED: 07-20-2010
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Biologic factors are known to contribute to asthma severity. It is unknown whether these factors differentially contribute to asthma severity in black compared with white subjects.
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Smoking reduces surfactant protein D and phospholipids in patients with and without chronic obstructive pulmonary disease.
BMC Pulm Med
PUBLISHED: 06-23-2010
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Pulmonary surfactant D (SP-D) has important regulatory functions for innate immunity and has been implicated as a biomarker for chronic obstructive pulmonary disease (COPD). We hypothesized that COPD patients would have reduced bronchoalveolar lavage (BAL) fluid SP-D levels compared to healthy smoking and non-smoking controls.
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Gene-environment interactions influence airways function in laboratory animal workers.
J. Allergy Clin. Immunol.
PUBLISHED: 01-07-2010
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Most diseases, including asthma, result from the interaction between environmental exposures and genetic variants. Functional variants of CD14 negatively affect lung function in farm workers and children exposed to animal allergens and endotoxin.
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Response to sublingual immunotherapy with grass pollen extract: monotherapy versus combination in a multiallergen extract.
J. Allergy Clin. Immunol.
PUBLISHED: 04-24-2009
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To date, there have been no randomized, double-blind studies showing the effectiveness of sublingual immunotherapy with multiple allergens.
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Risk analysis of early childhood eczema.
J. Allergy Clin. Immunol.
PUBLISHED: 03-11-2009
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The increasing prevalence of eczema suggests the role of environmental factors triggering a genetic predisposition.
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Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality.
Am. J. Respir. Crit. Care Med.
PUBLISHED: 01-24-2009
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Extracellular superoxide dismutase (EC-SOD) is a potent antioxidant that plays an important role in controlling oxidant-mediated stress and inflammation. High levels of EC-SOD are found in the lung. Acute lung injury (ALI) frequently occurs in patients with infection, and levels of EC-SOD have been shown to modulate severity of lung injury in transgenic animal models of endotoxemia-induced ALI. An R213G single nucleotide polymorphism (SNP) has been shown to alter levels of EC-SOD and patient outcomes in chronic obstructive pulmonary disease (COPD) and ischemic heart disease.
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Chronic beryllium disease, HLA-DPB1, and the DP peptide binding groove.
J. Immunol.
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Multiple epidemiologic studies demonstrate associations between chronic beryllium disease (CBD), beryllium sensitization (BeS), and HLA-DPB1 alleles with a glutamic acid residue at position 69 (E69). Results suggest that the less-frequent E69 variants (non-*0201/*0202 alleles) might be associated with greater risk of CBD. In this study, we sought to define specific E69-carrying alleles and their amino acid sequences in the DP peptide binding groove, as well as their relationship to CBD and BeS risk, using the largest case control study to date. We enrolled 502 BeS/CBD subjects and 653 beryllium-exposed controls from three beryllium industries who gave informed consent for participation. Non-Hispanic white cases and controls were frequency-matched by industry. HLA-DPB1 genotypes were determined using sequence-specific primer PCR. The E69 alleles were tested for association with disease individually and grouped by amino acid structure using logistic regression. The results show that CBD cases were more likely than controls to carry a non-*02 E69 allele than an *02 E69, with odds ratios (95% confidence interval) ranging from 3.1 (2.1-4.5) to 3.9 (2.6-5.9) (p < 0.0001). Polymorphic amino acids at positions 84 and 11 were associated with CBD: DD versus GG, 2.8 (1.8-4.6), p < 0.0001; GD versus GG, 2.1 (1.5-2.8), p < 0.0001; LL versus GG, 3.2 (1.8-5.6), p < 0.0001; GL versus GG, 2.8 (2.1-3.8), p < 0.0001. Similar results were found within the BeS group and CBD/BeS combined group. We conclude that the less frequent E69 alleles confer more risk for CBD than does *0201. Recent studies examining how the composition and structure of the binding pockets influence peptide binding in MHC genes, as well of studies showing the topology of the TCR to likely bind DPB1 preferentially, give plausible biological rationale for these findings.
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Bronchoalveolar lavage neuregulin-1 is elevated in acute lung injury and correlates with inflammation.
Eur. Respir. J.
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Shedding of neuregulin (NRG)-1 from the pulmonary epithelium leads to activation of the epithelial human epidermal growth factor receptor (HER)2 receptor, increased pulmonary epithelial permeability and acute lung injury (ALI). We sought to determine whether NRG-1 was detectable and elevated in bronchoalveolar lavage (BAL) and plasma from patients with ALI compared with controls and to determine whether a correlation exists between NRG-1 and inflammation and outcome in ALI. Matched BAL and plasma samples were obtained from 23 ALI patients requiring intubation and mechanical ventilation. Control patients (n=5) included healthy volunteers. NRG-1 and indices of inflammation were measured in BAL and plasma via ELISA. The mean±sd BAL NRG-1 concentration in ALI patients was 187.0±21.35 pg·mL(-1) compared with 85.50±9.2 pg·mL(-1) in controls (p=0.001). Increased BAL NRG-1 was associated with markers of inflammation, and inversely correlated with ventilator-free days (VFDs; r= -0.51, p=0.015). Plasma NRG-1 was elevated in ALI patients compared with controls (611.7±354.2 versus 25.17±19.33 pg·mL(-1), p<0.001) and inversely correlated with VFDs (r= -0.51, p=0.04). These results confirm shedding of NRG-1 in ALI and suggest that the NRG-1-HER2 pathway is active in patients with ALI.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.