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Find video protocols related to scientific articles indexed in Pubmed.
Pasteurization of bone for tumour eradication prior to reimplantation - an in vitro & pre-clinical efficacy study.
Indian J. Med. Res.
PUBLISHED: 06-14-2014
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In current era of limb-salvage therapy, pasteurization of bone sarcomas is receiving growing attention as a potential extracorporeal treatment and cost-effective alternative to allografts and radiation before surgical reimplantation. Detailed in vitro and in vivo pre-clinical study to evaluate efficacy of pasteurization to eradicate malignant cells has not been reported yet. The present study was carried out to assess the efficacy of pasteurization to kill tumour cells both in vitro and in vivo.
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Thermodynamic, diffusional, and structural anomalies in rigid-body water models.
J Phys Chem B
PUBLISHED: 05-10-2011
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Structural, density, entropy, and diffusivity anomalies of the TIP4P/2005 model of water are mapped out over a wide range of densities and temperatures. The locus of temperatures of maximum density (TMD) for this model is very close to the experimental TMD locus for temperatures between 250 and 275 K. Four different water models (mTIP3P, TIP4P, TIP5P, and SPC/E) are compared with the TIP4P/2005 model in terms of their anomalous behavior. For all the water models, the density regimes for anomalous behavior are bounded by a low-density limit at around 0.85-0.90 g cm(-3) and a high-density limit at about 1.10-1.15 g cm(-3). The onset temperatures of the density anomaly in the various models show a much greater variation, ranging from 202 K for mTIP3P to 289 K for TIP5P. The order maps for the various water models are qualitatively very similar with the structurally anomalous regions almost superimposable in the q(tet)-? plane. Comparison of the phase diagrams of water models with the region of liquid-state anomalies shows that the crystalline phases are much more sensitive to the choice of water models than the liquid state anomalies; for example, SPC/E and TIP4P/2005 show qualitatively similar liquid state anomalies but very different phase diagrams. The anomalies in the liquid in all the models occur at much lower pressures than those at which the melting line changes from negative to positive slope. The results in this study demonstrate several aspects of structure-entropy-diffusivity relationships of water models that can be compared with experiment and used to develop better atomistic and coarse-grained models for water.
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Phosphaturic mesenchymal tumor with chondromyxoid fibroma-like feature: an unusual morphological appearance.
Skeletal Radiol.
PUBLISHED: 01-19-2011
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Phosphaturic mesenchymal tumor (PMT) is a rare and distinctive tumor almost always associated with oncogenic osteomalacia. This tumor is often misdiagnosed due to its widely varied histomorphological spectrum. More recently the term PMT or its variants has been used whatever the histomorphological features. Herein, we present a case of a 32-year-old woman who presented with a 2-year history of oncogenic osteomalacia. The clinical examination failed to detect any tumor. The F-18 FDG PET scan and subsequent MRI revealed a tumor in the soft tissues of the right popliteal fossa. The histological features resembled a chondromyxoid fibroma (CMF), a feature documented only in two cases so far.
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Excess entropy scaling of transport properties in network-forming ionic melts (SiO(2) and BeF(2)).
J Chem Phys
PUBLISHED: 01-12-2011
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The regime of validity of Rosenfeld excess entropy scaling of diffusivity and viscosity is examined for two tetrahedral, network-forming ionic melts (BeF(2) and SiO(2)) using molecular dynamics simulations. With decrease in temperature, onset of local caging behavior in the diffusional dynamics is shown to be accompanied by a significant increase in the effect of three-body and higher-order particle correlations on the excess entropy, diffusivity, ionic conductivity, and entropy-transport relationships. The signature of caging effects on the Rosenfeld entropy scaling of transport properties is a distinctly steeper dependence of the logarithm of the diffusivity on the excess entropy in ionic melts. This is shown to be true also for a binary Lennard-Jones glassformer, based on available results in the literature. Our results suggest that the onset of a landscape-influenced regime in the dynamics is correlated with this characteristic departure from Rosenfeld scaling. The breakdown of the Nernst-Einstein relation in the ionic melts can also be correlated with the emerging cooperative dynamics.
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Joint-sparing or physeal-sparing diaphyseal resections: the challenge of holding small fragments.
Clin. Orthop. Relat. Res.
PUBLISHED: 07-08-2010
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Joint-sparing or physeal-sparing diaphyseal resections are technically challenging when only a small length of bone is available for implant purchase.
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Tetrahedral order, pair correlation entropy, and waterlike liquid state anomalies: comparison of GeO2 with BeF2, SiO2, and H2O.
J Chem Phys
PUBLISHED: 06-25-2010
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Molecular dynamics simulations of the Oeffner-Elliot model of germania (GeO(2)) are performed to identify nested regions of anomalous behavior in structural order, diffusivity, and pair entropy in the density-temperature plane, analogous to that seen in BeF(2), SiO(2), and H(2)O. The decreasing constraint of local tetrahedrality in GeO(2), compared to SiO(2) and BeF(2), substantially lowers the onset temperatures for anomalous behavior relative to the experimental melting temperatures (T(m)). Germania resembles water, more strongly than the ionic melts, in terms of temperatures for onset of anomalous behavior as well as in the order maps; for example, the structural anomaly sets in at 3.42T(m) in BeF(2), 3.09T(m) in SiO(2), 1.43T(m) in GeO(2), and 1.21T(m) in H(2)O. The detailed shapes of the anomalous regimes vary for different systems but the relative temperatures of onset for different anomalies are very similar in the different systems. The pair correlation entropy is shown to be a crucial and experimentally accessible quantity for relating structure, entropy, and diffusivity that could be potentially useful for a large class of inorganic ionic liquids.
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Revision of broken knee megaprostheses: new solution to old problems.
Clin. Orthop. Relat. Res.
PUBLISHED: 06-15-2010
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Low-cost indigenous megaprostheses used in the developing world are prone to mechanical failure but the frequency and causes are not well established.
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Bone metastasis of glandular cardiac myxoma mimicking a metastatic carcinoma.
Skeletal Radiol.
PUBLISHED: 05-11-2010
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Skeletal metastasis from a cardiac myxoma is rare. We describe an extremely unusual case of a cardiac myxoma metastasing to the femur in a 46-year-old female presenting with pain in the right hip. Radiographs showed an expansile lytic lesion with pathological fracture involving the neck and proximal shaft of the right femur. Histology revealed features of cardiac myxoma with heterologous glandular elements, which was initially mistaken for a metastatic mucin-secreting adenocarcinoma.
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Relationship between structure, entropy, and diffusivity in water and water-like liquids.
J Phys Chem B
PUBLISHED: 05-05-2010
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Anomalous behavior of the excess entropy (S(e)) and the associated scaling relationship with diffusivity are compared in liquids with very different underlying interactions but similar water-like anomalies: water (SPC/E and TIP3P models), tetrahedral ionic melts (SiO(2) and BeF(2)), and a fluid with core-softened, two-scale ramp (2SRP) interactions. We demonstrate the presence of an excess entropy anomaly in the two water models. Using length and energy scales appropriate for onset of anomalous behavior, we show the density range of the excess entropy anomaly to be much narrower in water than in ionic melts or the 2SRP fluid. While the reduced diffusivities (D*) conform to the excess-entropy-scaling relation, D* = A exp(alphaS(e)) for all the systems (Rosenfeld, Y. Phys. Rev. A 1977, 15, 2545), the exponential scaling parameter, alpha, shows a small isochore dependence in the case of water. Replacing S(e) by pair correlation-based approximants accentuates the isochore dependence of the diffusivity scaling. Isochores with similar diffusivity-scaling parameters are shown to have the temperature dependence of the corresponding entropic contribution. The relationship between diffusivity, excess entropy, and pair correlation approximants to the excess entropy are very similar in all the tetrahedral liquids.
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Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers.
J. Agric. Food Chem.
PUBLISHED: 01-23-2010
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Curcumin is the lipid-soluble antioxidant compound obtained from the rhizome of Curcuma longa Linn, also known as turmeric. Curcumin targets multiple chemotherapeutic and inflammatory pathways and has demonstrated safety and tolerability in humans, supporting its potential as a therapeutic agent; however, the clinical literature lacks conclusive evidence supporting its use as a therapeutic agent due to its low bioavailability in humans. The purpose of this study was to quantify plasma levels of free curcumin after dosing of a solid lipid curcumin particle (SLCP) formulation versus unformulated curcumin in healthy volunteers and to determine its tolerability and dose-plasma concentration relationship in late-stage osteosarcoma patients. Doses of 2, 3, and 4 g of SLCP were evaluated in 11 patients with osteosarcoma. Plasma curcumin levels were measured using a validated high-performance liquid chromatography method. The limit of detection of the assay was 1 ng/mL of curcumin. In healthy subjects, the mean peak concentration of curcumin achieved from dosing 650 mg of SLCP was 22.43 ng/mL, whereas plasma curcumin from dosing an equal quantity of unformulated 95% curcuminoids extract was not detected. In both healthy individuals and osteosarcoma patients, high interindividual variability in pharmacokinetics and nonlinear dose dependency was observed, suggesting potentially complex absorption kinetics. Overall, good tolerability was noted in both healthy and osteosarcoma groups.
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Total hip arthroplasty in slipped capital femoral epiphysis: a novel technique to remove embedded knowles pins.
Am J. Orthop.
PUBLISHED: 12-17-2009
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The Knowles pin has been well recognized in fixing slipped capital femoral epiphysis. When these pins are left in place for a long period, it is very difficult to remove them during total hip arthroplasty, because the pins have fluted threads, which are oversized in the end and allow bone growth in the previously threaded slots. We present a simple and novel technique to remove Knowles pins so that both unnecessary trauma to the lateral femoral cortex and operating time is reduced significantly.
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Transport properties of tetrahedral, network-forming ionic melts.
J Phys Chem B
PUBLISHED: 10-29-2009
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Molecular dynamics simulations of liquid silica and beryllium fluoride are performed using the van Beest-Kramer-van Santen and transferable rigid ion model potentials, respectively, in order to compare transport properties. The ionic conductivity (sigma), shear viscosity (eta) and ionic self-diffusivities (D(+/-)) are computed over a fairly wide range of temperatures and densities and deviations from Arrhenius behavior along different isochores is studied. The Stokes-Einstein relation is shown to hold over the entire range of state points, though the effective hydrodynamic radius shows small variations due to thermal fluctuations, compression, and local tetrahedral order. Several alternative tests of the Nernst-Einstein relation are implemented which show that significant network-formation in the anomalous regime leads to a breakdown of this relationship. The relaxation times, tau(sigma) and tau(M), associated with the decay of the charge-flux and pressure ACFs respectively, are computed. In the anomalous regime, as the tetrahedral network formation progresses, tau(M) increases rapidly while tau(sigma) shows very little variation, indicating a decoupling of charge and momentum transport processes.
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Decision making in primary sacral tumors.
Spine J
PUBLISHED: 06-24-2009
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Primary tumors of the sacrum are extremely rare lesions. Their management is governed by an interplay of complex factors. Appropriate decision making is crucial to obtain the best possible outcome in terms of maximizing disease control while attempting to minimize neurological dysfunction.
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Integrated PET/CT in evaluating sarcomatous transformation in osteochondromas.
Clin Nucl Med
PUBLISHED: 06-03-2009
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To study the role of PET-CT in evaluating sarcomatous transformation in osteochondromas.
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The validity, reliability, responsiveness, and bias of the Manchester-Modified Disability of the Arm, Shoulder, and Hand score in hand injuries.
Hand (N Y)
PUBLISHED: 03-19-2009
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The Manchester-Modified Disability of Arm, Shoulder and Hand questionnaire (M(2) DASH) was developed by the authors as a modification to the original DASH questionnaire. In this study, we assessed the validity, reliability, responsiveness, and bias of the M(2) DASH questionnaire for hand injuries using completed M(2) DASH, Patient Evaluation Measure, and Michigan Hand Outcome questionnaires from 40 patients. The M(2) DASH scores showed significant positive correlations with the Patient Evaluation Measure and Michigan Hand Outcome scores suggesting validity. There was also no evidence of a statistical difference in the M(2) DASH scores when the condition had stabilized suggesting good test-retest reproducibility and reliability. The effect size and the standardized response mean for the M(2) DASH score were greater than those for the Patient Evaluation Measure and Michigan Hand Outcome scores establishing that the M(2) DASH is highly responsive. There was no gender, hand dominance, or dominant side injured bias for the M(2) DASH score. There was, however, a relatively weak association between age and the M(2) DASH score at presentation. We conclude that the M(2) DASH questionnaire is a robust region-specific outcome measure. It is a valid and responsive questionnaire with test-retest reliability proven for hand injuries in this study. Gender, handedness, and side injured did not cause bias in the responses.
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Chondrosarcoma of bone: does the size of the tumor, the presence of a pathologic fracture, or prior intervention have an impact on local control and survival?
J Cancer Res Ther
PUBLISHED: 03-19-2009
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We studied 45 patients with chondrosarcoma, without metastasis at diagnosis, who were surgically treated between January 2000 and December 2004 to evaluate the risk factors associated with local recurrence and metastasis.
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Computer-aided methods for assessing lower limb deformities in orthopaedic surgery planning.
Comput Med Imaging Graph
PUBLISHED: 03-13-2009
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Accurate, simple, and quick measurement of anatomical deformities at preoperative stage is clinically important for decision making in surgery planning. The deformities include excessive torsional, angular, and curvature deformation. This paper presents computer-aided methods for automatically measuring anatomical deformities of long bones of the lower limb. A three-dimensional bone model reconstructed from CT scan data of the patient is used as input. Anatomical landmarks on femur and tibia bone models are automatically identified using geometric algorithms. Medial axes of femur and tibia bones, and anatomical landmarks are used to generate functional and reference axes. These methods have been implemented in a software program and tested on a set of CT scan data. Overall, the performance of the computerized methodology was better or similar to the manual method and its results were reproducible.
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Relationship between structure, entropy, and mobility in network-forming ionic melts.
Phys Rev E Stat Nonlin Soft Matter Phys
PUBLISHED: 02-23-2009
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Diffusivity, ionic conductivity, and viscosity of network-forming ionic melts are examined using molecular dynamics simulations of BeF2 and SiO2 melts. These tetrahedral, network-forming ionic melts are shown to possess a conductivity anomaly, in addition to waterlike viscosity and diffusivity anomalies, corresponding to a striking breakdown of the Nernst-Einstein relation. The contrasting scaling behavior of the different mobility measures with different structural contributions to the excess entropy is demonstrated.
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Automated identification of anatomical landmarks on 3D bone models reconstructed from CT scan images.
Comput Med Imaging Graph
PUBLISHED: 02-05-2009
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Identification of anatomical landmarks on skeletal tissue reconstructed from CT/MR images is indispensable in patient-specific preoperative planning (tumour referencing, deformity evaluation, resection planning, and implant alignment and anchoring) as well as intra-operative navigation (bone registration and instruments referencing). Interactive localisation of landmarks on patient-specific anatomical models is time-consuming and may lack in repeatability and accuracy. We present a computer graphics-based method for automatic localisation and identification (labelling) of anatomical landmarks on a 3D model of bone reconstructed from CT images of a patient. The model surface is segmented into different landmark regions (peak, ridge, pit and ravine) based on surface curvature. These regions are labelled automatically by an iterative process using a spatial adjacency relationship matrix between the landmarks. The methodology has been implemented in a software program and its results (automatically identified landmarks) are compared with those manually palpated by three experienced orthopaedic surgeons, on three 3D reconstructed bone models. The variability in location of landmarks was found to be in the range of 2.15-5.98 mm by manual method (inter surgeon) and 1.92-4.88 mm by our program. Both methods performed well in identifying sharp features. Overall, the performance of the automated methodology was better or similar to the manual method and its results were reproducible. It is expected to have a variety of applications in surgery planning and intra-operative navigation.
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Supraglottic airway devices during neonatal resuscitation: an historical perspective, systematic review and meta-analysis of available clinical trials.
Resuscitation
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Various supraglottic airway devices are routinely used to maintain airway patency in children and adults. However, oropharyngeal airways or laryngeal masks (LM) are not routinely used during neonatal resuscitation.
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Extramedullary versus intramedullary tibial cutting guides in megaprosthetic total knee replacement.
J Orthop Surg Res
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In a standard total knee replacement, tibial component alignment is a key factor for the long term success of the surgery. The purpose of this study is to compare the accuracy of extramedullary and intramedullary tibial cutting guides used in indigenous and imported implants respectively, in positioning of the tibial components in megaprosthetic knee replacements.
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Structural correlations and cooperative dynamics in supercooled liquids.
J Chem Phys
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The relationships between diffusivity and the excess, pair and residual multiparticle contributions to the entropy are examined for Lennard-Jones liquids and binary glassformers, in the context of approximate inverse power law mappings of simple liquids. In the dense liquid where diffusivities are controlled by collisions and cage relaxations, Rosenfeld-type excess entropy scaling of diffusivities is found to hold for both crystallizing as well as vitrifying liquids. The crucial differences between the two categories of liquids emerge only when local cooperative effects in the dynamics result in significant caging effects in the time-dependent behaviour of the single-particle mean square displacement. In the case of glassformers, onset of such local cooperativity coincides with onset of deviations from Rosenfeld-type excess entropy scaling of diffusivities and increasing spatiotemporal heterogeneity. In contrast, for two- and three-dimensional liquids with a propensity to crystallise, the onset of local cooperative dynamics is sufficient to trigger crystallization provided that the liquid is sufficiently supercooled that the free energy barrier to nucleation of the solid phase is negligible. The state points corresponding to onset of transient caging effects can be associated with typical values, within reasonable bounds, of the excess, pair, and residual multiparticle entropy as a consequence of the isomorph-invariant character of the excess entropy, diffusivity and related static and dynamic correlation functions.
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Osteosarcoma of the femur mimicking Ewing sarcoma/primitive neuroectodermal tumour on biopsy and metastatic carcinoma on resection.
Skeletal Radiol.
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Osteosarcoma (OS) is known to have several morphological appearances, small cell osteosarcoma and epithelioid osteosarcoma being two well recognized patterns. The former can be mistaken for a Ewing sarcoma/primitive neuroectodermal tumour (ES/PNET), whereas the latter mimics metastatic carcinoma. Herein we present an osteosarcoma in a 17-year-old girl that was diagnosed as an ES/PNET on biopsy; however, the resected specimen revealed a very unusual morphology mimicking a metastatic carcinoma with a sex cord stromal tumour-like pattern.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

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We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

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In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.