JoVE Visualize What is visualize?
Stop Reading. Start Watching.
Advanced Search
Stop Reading. Start Watching.
Regular Search
Find video protocols related to scientific articles indexed in Pubmed.
Associations Between Genetic Obesity Susceptibility and Early Postnatal Fat and Lean Mass: An Individual Participant Meta-analysis.
JAMA Pediatr
PUBLISHED: 10-21-2014
Show Abstract
Hide Abstract
Patterns of body size and body composition associated with genetic obesity susceptibility inform the mechanisms that increase obesity risk.
Related JoVE Video
Prenatal exposure to phenols and growth in boys.
Epidemiology
PUBLISHED: 07-26-2014
Show Abstract
Hide Abstract
Phenols interact with nuclear receptors implicated in growth and adipogenesis regulation. Only a few studies have explored their effects on growth in humans.
Related JoVE Video
Predicting changes in language skills between 2 and 3 years in the EDEN mother-child cohort.
PeerJ
PUBLISHED: 01-01-2014
Show Abstract
Hide Abstract
Objective. To examine the factors predicting changes in language skills between 2 and 3 years. Methods. By using longitudinal data concerning 1002 children from the EDEN study, linear regression was used to predict 3-year language performance from 2-year language performance and the risk factors associated with language delays. Logistic regressions were performed to examine two change trajectories: children who fall below the 10th percentile of language skills between 2 and 3 years (declining trajectory), and those who rose above the 10th percentile (resilient trajectory). Results. The final linear model accounted for 43% of the variance in 3-year language scores, with 2-year language scores accounting for 22%. Exposure to alcohol during pregnancy, earlier birth term, lower level of parental education and lower frequency of maternal stimulation were associated with the declining trajectory. Breastfeeding was associated with the resilient trajectory. Conclusions. This study provides a better understanding of the natural history of early language delays by identifying biological and social factors that predict changes in language skills between the ages of 2 and 3 years.
Related JoVE Video
Validity of electronically administered Recent Physical Activity Questionnaire (RPAQ) in ten European countries.
PLoS ONE
PUBLISHED: 01-01-2014
Show Abstract
Hide Abstract
To examine the validity of the Recent Physical Activity Questionnaire (RPAQ) which assesses physical activity (PA) in 4 domains (leisure, work, commuting, home) during past month.
Related JoVE Video
Breastfeeding duration, social and occupational characteristics of mothers in the French EDEN mother-child cohort.
Matern Child Health J
PUBLISHED: 12-24-2013
Show Abstract
Hide Abstract
Socio-demographic characteristics of mothers have been associated with exclusive breastfeeding duration, but little is known about the association with maternal full- and part-time employment and return to work in European countries. To study the associations between breastfeeding, any and almost exclusive (infants receiving breast milk as their only milk) breastfeeding, at 4 months of infants age and the socio-demographic and occupational characteristics of mothers. We used the EDEN mother-child cohort, a prospective study of 2002 singleton pregnant women in two French university hospitals. We selected all mothers (n = 1,339) who were breastfeeding at discharge from the maternity unit. Data on feeding practices were collected at the maternity unit and by postal questionnaires at 4, 8 and 12 months after the birth. Among infants breastfed at discharge, 93% were still receiving any breastfeeding (83% almost exclusive breastfeeding) at the 3rd completed week of life, 78% (63%) at the 1st completed month, and 42% (20%) at the 4th completed month. Time of return to work was a major predictor for stopping breastfeeding: the sooner the mothers returned to work, the less they breastfed their babies at 4 months of infants age, independently of full-time or part-time employment. The association was stronger for almost exclusive breastfeeding mothers than for any breastfeeding ones. In a society where breastfeeding is not the norm, women may have difficulties combining work and breastfeeding. Specific actions need to be developed and assessed among mothers who return to work and among employers.
Related JoVE Video
Degree of methylation of ZAC1 (PLAGL1) is associated with prenatal and post-natal growth in healthy infants of the EDEN mother child cohort.
Epigenetics
PUBLISHED: 12-06-2013
Show Abstract
Hide Abstract
The ZAC1 gene, mapped to the 6q24 region, is part of a network of co-regulated imprinted genes involved in the control of embryonic growth. Loss of methylation at the ZAC1 differentially methylated region (DMR) is associated with transient neonatal diabetes mellitus, a developmental disorder involving growth retardation and diabetes in the first weeks of post-natal life. We assessed whether the degree of methylation of the ZAC1 DMR in leukocytes DNA extracted from cord blood is associated with fetal, birth and post-natal anthropometric measures or with C-peptide concentrations in cord serum. We also searched for an influence of dietary intake and maternal parameters on ZAC1 DMR methylation. We found positive correlations between the ZAC1 DMR methylation index (MI) and estimated fetal weight (EFW) at 32 weeks of gestation, weight at birth and weight at one year of age (respectively, r = 0.15, 0.09, 0.14; P values = 0.01, 0.15, 0.03). However, there were no significant correlations between the ZAC1 DMR MI and cord blood C-peptide levels. Maternal intakes of alcohol and of vitamins B2 were positively correlated with ZAC1 DMR methylation (respectively, r = 0.2 and 0.14; P = 0.004 and 0.04). The influence of ZAC1 seems to start in the second half of pregnancy and continue at least until the first year of life. The maternal environment also appears to contribute to the regulation of DNA methylation.
Related JoVE Video
The effect of fall prevention exercise programmes on fall induced injuries in community dwelling older adults: systematic review and meta-analysis of randomised controlled trials.
BMJ
PUBLISHED: 10-31-2013
Show Abstract
Hide Abstract
To determine whether, and to what extent, fall prevention exercise interventions for older community dwelling people are effective in preventing different types of fall related injuries.
Related JoVE Video
The dietary n6:n3 fatty acid ratio during pregnancy is inversely associated with child neurodevelopment in the EDEN mother-child cohort.
J. Nutr.
PUBLISHED: 07-31-2013
Show Abstract
Hide Abstract
Long-chain polyunsaturated fatty acids (LC-PUFAs) of the n6 (?6) and n3 series are essential for the development of a childs brain. Fetal LC-PUFA exposure as well as infant exposure via breast milk depend on the maternal intake of these LC-PUFAs and of their respective dietary precursors (PUFAs). We aimed to investigate the associations between maternal LC-PUFA and PUFA [(LC)PUFA] dietary intake during pregnancy and child neurodevelopment at ages 2 and 3 y. In 1335 mother-child pairs from the EDEN cohort, we evaluated associations between daily maternal (LC)PUFA intake during the last 3 months of pregnancy with the childs language at age 2 y and with different assessments of development at age 3 y. Associations were investigated separately in breastfed and never-breastfed children. We examined interactions between the ratios of n6 and n3 (LC)PUFA intakes (n6:n3 fatty acid ratio) and duration of breastfeeding. Breastfeeding mothers had a lower n6:n3 fatty acid ratio (8.4 vs. 8.8; P = 0.02). Among never-breastfed children (n = 338), we found negative associations between maternal dietary n6:n3 fatty acid ratios and neurodevelopment, as reflected by the childs language at age 2 y (? ± SE = -2.1 ± 0.7; P = 0.001) and development assessed with the Ages and Stages Questionnaire at age 3 y (-1.5 ± 0.8; P = 0.05). Among mothers with a high n6:n3 fatty acid ratio only, breastfeeding duration was positively associated with language at age 2 y (P-interaction < 0.05). This suggests that the ratio between maternal dietary n6 and n3 (LC)PUFA intake possibly influences the childs brain development during fetal life but not during or by breastfeeding. However, breastfeeding might compensate for prenatal imbalance in maternal dietary n6:n3 fatty acid ratio.
Related JoVE Video
The influence of early feeding practices on fruit and vegetable intake among preschool children in 4 European birth cohorts.
Am. J. Clin. Nutr.
PUBLISHED: 07-17-2013
Show Abstract
Hide Abstract
Fruit and vegetable intake in children remains below recommendations in many countries. The long-term effects of early parental feeding practices on fruit and vegetable intake are not clearly established.
Related JoVE Video
Does consideration of larger study areas yield more accurate estimates of air pollution health effects? An illustration of the bias-variance trade-off in air pollution epidemiology.
Environ Int
PUBLISHED: 06-22-2013
Show Abstract
Hide Abstract
Spatially-resolved air pollution models can be developed in large areas. The resulting increased exposure contrasts and population size offer opportunities to better characterize the effect of atmospheric pollutants on respiratory health. However the heterogeneity of these areas may also enhance the potential for confounding. We aimed to discuss some analytical approaches to handle this trade-off.
Related JoVE Video
Pregnancy and birth cohort resources in europe: a large opportunity for aetiological child health research.
Paediatr Perinat Epidemiol
PUBLISHED: 06-19-2013
Show Abstract
Hide Abstract
During the past 25 years, many pregnancy and birth cohorts have been established. Each cohort provides unique opportunities for examining associations of early-life exposures with child development and health. However, to fully exploit the large amount of available resources and to facilitate cross-cohort collaboration, it is necessary to have accessible information on each cohort and its individual characteristics. The aim of this work was to provide an overview of European pregnancy and birth cohorts registered in a freely accessible database located at http://www.birthcohorts.net.
Related JoVE Video
Exposure to food contaminants during pregnancy.
Sci. Total Environ.
PUBLISHED: 03-29-2013
Show Abstract
Hide Abstract
During pregnancy, the fetus is exposed to contaminants from its mothers diet. This work provides an assessment of the dietary exposure of pregnant women to inorganic contaminants (aluminum, mercury, lead, inorganic arsenic, cobalt), polychlorodibenzodioxins, polychlorodibenzofurans, dioxin-like and non-dioxin-like polychlorobiphenyls (DL-PCBs, NDL-PCBs), polybromodiphenyl ethers (PBDEs), perfluoroalkyl acids, mycotoxins (zearalenone, patulin, trichothecenes), and heat-generated compounds (acrylamide and polycyclic aromatic hydrocarbons). Consumption data of 2002 pregnant women aged 18 to 45 from the EDEN cohort study were combined with contamination data from the second French total diet study to assess the exposure before pregnancy (n=1861) and during the third trimester of pregnancy (n=1775). Exposure was also assessed considering the season during which the third trimester of pregnancy occurred. Significant changes in consumptions during pregnancy and between seasons were associated with differences in exposures for some substances. Some contaminant exposures appeared to be of health concern. Margins of exposure to acrylamide (635 to 1094 for mean), inorganic arsenic, lead, and BDE-99 (?100) were too low to exclude all risks. For NDL-PCBs, T-2 and HT-2 toxins, and deoxynivalenol, significant exceedings of toxicological reference values were found before pregnancy, but there was no significant exceeding in the third trimester.
Related JoVE Video
Blood microbiota dysbiosis is associated with the onset of cardiovascular events in a large general population: the D.E.S.I.R. study.
PLoS ONE
PUBLISHED: 01-25-2013
Show Abstract
Hide Abstract
We recently described a human blood microbiome and a connection between this microbiome and the onset of diabetes. The aim of the current study was to assess the association between blood microbiota and incident cardiovascular disease.
Related JoVE Video
Breastfeeding duration and cognitive development at 2 and 3 years of age in the EDEN mother-child cohort.
J. Pediatr.
PUBLISHED: 01-11-2013
Show Abstract
Hide Abstract
To investigate the dose-response relationship between breastfeeding duration and cognitive development in French preschool children.
Related JoVE Video
A Pilot Study of the ELFE Longitudinal Cohort: Feasibility and Preliminary Evaluation of Biological Collection.
Biopreserv Biobank
PUBLISHED: 10-07-2011
Show Abstract
Hide Abstract
Etude Longitudinale Française depuis lEnfance (ELFE) will be a national French cohort of 20,000 children followed from birth to adulthood. Biological samples will be taken at birth to evaluate the fetal exposition to several substances. A pilot study was carried out in October 2007 to test the preanalytical factors that affected sample quality. A variety of fractions were collected by the midwife after delivery from different blood collection tubes. Options in the collection process were 2 daily transports of samples, centralized and standardized processing methodology, and storage of multiple aliquots in liquid nitrogen or at -80°C. We analyzed preanalytical factors that could have affected coagulation and then soluble CD40 Ligand (sCD40L) as a quality control tool for serum quality. Cord blood and urine were collected from 82% and 84% of women, respectively, who agreed to be followed up in the ELFE project. The use of syringe was the main factor correlated with coagulation (relative risk: 2.79 [1.47; 5.31], P<0.01). Maternity unit status was also associated with coagulation (RR: 1.48 [1.03; 2.13] in a private maternity unit vs. a public maternity) as well as time between collection and centrifugation (RR 1.03 [1; 1.07] when time between collection and centrifugation increases from 1?h). There were no extremely low sCD40L values indicating extreme exposures to room temperatures. This first evaluation study allowed us to stress the importance of carefully recording all potentially critical preanalytical variables that might be used at a large-scale level.
Related JoVE Video
Parent-offspring correlations in pedometer-assessed physical activity.
PLoS ONE
PUBLISHED: 09-28-2011
Show Abstract
Hide Abstract
Physical activity is a major component of a healthy lifestyle in youth and adults. To identify determinants of this complex behavior is an important research objective in the process of designing interventions to promote physical activity at population level. In addition to individual determinants, there is evidence documenting familial influences on physical activity. However, the few studies that have addressed this issue with objective measures did not provide data on parent-offspring physical activity relationships throughout childhood and adolescence. The purpose of this study was to assess familial correlations in pedometer-assessed physical activity.
Related JoVE Video
Association of the Pro12Ala and C1431T variants of PPARgamma and their haplotypes with susceptibility to gestational diabetes.
J. Clin. Endocrinol. Metab.
PUBLISHED: 07-27-2011
Show Abstract
Hide Abstract
The protective role of the Ala allele in the Pro12Ala polymorphism of PPAR? on type 2 diabetes has been well established but not confirmed in the context of pregnancy, for gestational diabetes, a known predictor of later type 2 diabetes onset. Another PPAR? polymorphism, the C1431T, is in strong linkage disequilibrium with Pro12Ala and has been shown to be associated with body weight, but its association with diabetes is controversial.
Related JoVE Video
Short-term impact of ambient air pollution and air temperature on blood pressure among pregnant women.
Epidemiology
PUBLISHED: 07-07-2011
Show Abstract
Hide Abstract
Epidemiologic studies have reported inconsistent findings for the association between air pollution levels and blood pressure (BP), which has been studied mainly in elderly subjects. Short-term air pollution effects on BP have not been investigated in pregnant women, who may constitute a vulnerable population.
Related JoVE Video
Higher cord C-peptide concentrations are associated with slower growth rate in the 1st year of life in girls but not in boys.
Diabetes
PUBLISHED: 06-23-2011
Show Abstract
Hide Abstract
To understand the relationships between maternal glycemia during pregnancy and prenatal and early postnatal growth by evaluating cord C-peptide and IGF-I as mediating biomarkers in boys and girls separately.
Related JoVE Video
Maternal exposure to air pollution before and during pregnancy related to changes in newborns cord blood lymphocyte subpopulations. The EDEN study cohort.
BMC Pregnancy Childbirth
PUBLISHED: 06-15-2011
Show Abstract
Hide Abstract
Toxicants can cross the placenta and expose the developing fetus to chemical contamination leading to possible adverse health effects, by potentially inducing alterations in immune competence. Our aim was to investigate the impacts of maternal exposure to air pollution before and during pregnancy on newborns immune system.
Related JoVE Video
Maternal weight change before pregnancy in relation to birthweight and risks of adverse pregnancy outcomes.
Eur. J. Epidemiol.
PUBLISHED: 03-14-2011
Show Abstract
Hide Abstract
Maternal weight change before pregnancy can be considered as an indicator of maternal energy balance and nutritional status before conception, and may be involved in early life programming. We aimed to investigate the association of maternal Weight Change Before Pregnancy (WCBP) with fetal growth and adverse pregnancy outcomes. Data are from the French EDEN mother-child cohort where 1,756 mother-child pairs had information on mothers weight at 20 years, weight just before pregnancy, fetal anthropometry at second and third trimesters, infants birthweight and pregnancy complications. The average annual WCBP between 20 years and start of pregnancy (in kg/year) was categorized as: "Weight Loss" (n = 320), "Moderate weight gain" (n = 721) and "High weight gain" (n = 715). The associations of WCBP with fetal and newborn characteristics and with adverse pregnancy outcomes were analyzed, adjusting for maternal and pregnancy characteristics, including the mothers prepregnancy BMI. Interactions between WCBP and prepregnancy BMI were tested. Birthweight and estimated fetal weight in the third trimester increased significantly with increasing WCBP in mothers with BMI <25 kg/m(2). In these mothers, weight loss before pregnancy was associated with a higher risk of newborns small for gestational age (SGA). Whatever the prepregnancy BMI, WCBP was positively associated with a maternal risk of gestational diabetes and hypertension. The ponderal history of mothers before pregnancy can impact on fetal growth and on pregnancy outcomes such as gestational diabetes or hypertension. Our analysis is the first to report that in non-overweight women, those who lost weight before pregnancy are at higher risk of having SGA newborns.
Related JoVE Video
Discordant time trends in maternal body size and offspring birthweight of term deliveries in France between 1972 and 2003: data from the French National Perinatal Surveys.
Paediatr Perinat Epidemiol
PUBLISHED: 03-07-2011
Show Abstract
Hide Abstract
We investigated time trends in maternal weight before and during pregnancy and in infant birthweight in France, from 1972 to 2003, using data on singleton live term births from the representative National Perinatal Surveys of 1972, 1981, 1995, 1998 and 2003 (n=8,664, 4,494, 11,445, 12,006, 12,692, respectively). Mothers were interviewed a few days after delivery and data on delivery and the newborn were extracted from hospital records. Maternal prepregnancy weight, height, body mass index and pregnancy weight gain all increased from 1972 to 2003; however, birthweight did not show a parallel trend. After taking gestational age, maternal age, parity, country of origin, newborn gender and maternal smoking during pregnancy into account, mean birthweight increased between 1972 and 1995 but decreased thereafter and, consistently, there was an increase in small-for-gestational age (SGA) and a decrease in large-for-gestational age newborns. Further adjustment for induced delivery, an indicator of obstetric practice, did not change the results. A similar variation has been observed very recently in the US and in Germany. Further research is needed to identify the factors responsible for these discordant changes and especially the factors responsible for the recent increase in SGA since this has been shown to be associated with poorer health in later life.
Related JoVE Video
Exposure to phthalates and phenols during pregnancy and offspring size at birth.
Environ. Health Perspect.
PUBLISHED: 03-04-2011
Show Abstract
Hide Abstract
Data concerning the effects of prenatal exposures to phthalates and phenols on fetal growth are limited in humans. Previous findings suggest possible effects of some phenols on male birth weight.
Related JoVE Video
Clinical outcomes after insulin initiation in patients with type 2 diabetes: 6-month data from the INSTIGATE observational study in five European countries.
Curr Med Res Opin
PUBLISHED: 02-22-2011
Show Abstract
Hide Abstract
To examine insulin regimens and factors that affect glycaemic control at 6 months after initiation of insulin therapy in patients with type 2 diabetes mellitus.
Related JoVE Video
Determinants of neonatal weight loss in term-infants: specific association with pre-pregnancy maternal body mass index and infant feeding mode.
Arch. Dis. Child. Fetal Neonatal Ed.
PUBLISHED: 01-17-2011
Show Abstract
Hide Abstract
We aimed to study the determinants of neonatal weight loss measured on the third day of life in term-infants.
Related JoVE Video
Determinants of early ponderal and statural growth in full-term infants in the EDEN mother-child cohort study.
Am. J. Clin. Nutr.
PUBLISHED: 06-30-2010
Show Abstract
Hide Abstract
Growth velocity in the first months of postnatal life has been associated with later overweight and obesity.
Related JoVE Video
Prenatal mercury contamination: relationship with maternal seafood consumption during pregnancy and fetal growth in the EDEN mother-child cohort.
Br. J. Nutr.
PUBLISHED: 05-21-2010
Show Abstract
Hide Abstract
Maternal seafood intake is of great health interest since it constitutes an important source of n-3 fatty acids, but provides also an important pathway for fetal exposure to Hg. The objective of the present study was to determine associations between Hg contamination and both maternal seafood consumption and fetal growth in French pregnant women. Pregnant women included in the EDEN mother-child cohort study answered FFQ on their usual diet in the year before and during the last 3 months of pregnancy, from which frequencies of seafood intake were evaluated. Total hair-Hg level was determined for the first 691 included women. Associations between Hg level, seafood intake and several neonatal measurements were studied using linear regressions adjusted for confounding variables. The median Hg level for mothers was 0.52 ?g/g. Maternal seafood intake was associated with Hg level (r 0.33; P < 0.0001). There was no association between Hg level and fetal growth in the whole sample of women, except for an early negative relationship with biparietal diameter. A positive association was found between seafood intake and fetal growth in overweight women only which remained unchanged after adjustment for Hg level (birth weight: +101 g for a difference of 1 sd in seafood consumption; P = 0.008). Although seafood intake was associated with Hg contamination in French pregnant women, the contamination level was low. There was no consistent association between Hg level and fetal growth. Taking into account Hg level did not modify associations between seafood intake and fetal growth.
Related JoVE Video
Maternal exposure to nitrogen dioxide during pregnancy and offspring birth weight: comparison of two exposure models.
Environ. Health Perspect.
PUBLISHED: 05-14-2010
Show Abstract
Hide Abstract
Studies of the effects of air pollutants on birth weight often assess exposure with networks of permanent air quality monitoring stations (AQMSs), which have a poor spatial resolution.
Related JoVE Video
Quality control and single nucleotide resolution analysis of methylated DNA immunoprecipitation products.
Anal. Biochem.
PUBLISHED: 05-06-2010
Show Abstract
Hide Abstract
DNA methylation patterns are altered in many diseases, and their analysis has become of great interest. Methylated DNA immunoprecipitation (MeDIP) is a simple method to enrich the methylated fraction of the genome. However, it has been difficult to assess the quality and the detailed methylation patterns of the immunoprecipitated DNA. Here we present a simple method for the analysis of the immunoprecipitated DNA at single nucleotide resolution by bisulfite treatment and pyrosequencing of genomic regions. The presented method can be used as an initial quality measure prior to genome-wide read-out technologies such as microarrays and second-generation sequencing.
Related JoVE Video
Latent variables and structural equation models for longitudinal relationships: an illustration in nutritional epidemiology.
BMC Med Res Methodol
PUBLISHED: 04-30-2010
Show Abstract
Hide Abstract
The use of structural equation modeling and latent variables remains uncommon in epidemiology despite its potential usefulness. The latter was illustrated by studying cross-sectional and longitudinal relationships between eating behavior and adiposity, using four different indicators of fat mass.
Related JoVE Video
Evolution of obesity prevalence in France: an age-period-cohort analysis.
Epidemiology
PUBLISHED: 04-09-2010
Show Abstract
Hide Abstract
A rapid increase in the prevalence of obesity has been reported in France since 1990. We investigated the impact of birth cohort on the changes in obesity prevalence after taking into account age and survey period.
Related JoVE Video
Parental body size and early weight and height growth velocities in their offspring.
Early Hum. Dev.
PUBLISHED: 02-05-2010
Show Abstract
Hide Abstract
Whereas weight or height at a given age are the results of the cumulative growth experience, growth velocities allows the study of factors affecting growth at given ages.
Related JoVE Video
Downward trends in the prevalence of childhood overweight in the setting of 12-year school- and community-based programmes.
Public Health Nutr
PUBLISHED: 12-16-2009
Show Abstract
Hide Abstract
A school-based nutrition information programme was initiated in 1992 in two towns in northern France (Fleurbaix and Laventie, FL) and was followed by a number of community-based interventions. We took the opportunity to measure the outcomes in terms of childhood obesity and overweight over the next 12 years.
Related JoVE Video
Birth weight, body silhouette over the life course, and incident diabetes in 91,453 middle-aged women from the French Etude Epidemiologique de Femmes de la Mutuelle Generale de lEducation Nationale (E3N) Cohort.
Diabetes Care
PUBLISHED: 11-16-2009
Show Abstract
Hide Abstract
Obesity and increases in body weight in adults are considered to be among the most important risk factors for type 2 diabetes. Low birth weight is also associated with a higher diabetes incidence. We aimed to examine to what extent the evolution of body shape, from childhood to adulthood, is related to incident diabetes in late adulthood.
Related JoVE Video
Maternal fatty acid intake and fetal growth: evidence for an association in overweight women. The EDEN mother-child cohort (study of pre- and early postnatal determinants of the childs development and health).
Br. J. Nutr.
PUBLISHED: 09-18-2009
Show Abstract
Hide Abstract
Recent studies suggest a benefit of seafood and n-3 fatty acid intake on fetal growth and infant development. The objective was to study the association between fatty acid intake and fetal growth in pregnant French women. Pregnant women included in the EDEN mother-child cohort study completed FFQ on their usual diet: (1) in the year before pregnancy and (2) during the last 3 months of pregnancy (n 1439). Conversion into nutrient intakes was performed using data on portion size and a French food composition table. Associations between maternal fatty acid intakes and several neonatal anthropometric measurements were studied using linear regressions adjusted for centre, mothers age, smoking habits, height, parity, gestational age and newborns sex. Due to significant interaction, analyses were stratified according to maternal pre-pregnancy overweight status. Neither total lipid nor SFA, MUFA or PUFA intake was significantly associated with newborn size. In overweight women only (n 366), a high pre-pregnancy n-3 fatty acid intake (% PUFA) was positively associated with the newborns birth weight (P=0.01), head, arm and wrist circumferences and sum of skinfolds (P<0.04). A substitution of 1% of n-3 fatty acids per d before pregnancy by other PUFA was related to an average decrease in birth weight of 60 g (P=0.01). Relationships with n-3 fatty acid intake at the end of pregnancy were weaker and not significant. We concluded that a high pre-pregnancy n-3 fatty acid:PUFA ratio may sustain fetal growth in overweight women. Follow-up of the children may help determine whether this has beneficial consequences for the childs health and development.
Related JoVE Video
Monoamine oxidase activity in placenta in relation to manganese, cadmium, lead, and mercury at delivery.
Neurotoxicol Teratol
PUBLISHED: 08-23-2009
Show Abstract
Hide Abstract
Environmental prenatal exposure to potentially neurotoxic metals poses a particular challenge with regard to the study of early toxic effects. Monoamine oxidase activity, shown to be influenced by metals in experimental studies, could be a useful biomarker in humans.
Related JoVE Video
Obesity and cholesterol in Japanese, French, and U.S. children.
J Pediatr Nurs
PUBLISHED: 07-28-2009
Show Abstract
Hide Abstract
The number of children at risk for overweight/obesity has increased dramatically in the last decade worldwide. This study compares measures of obesity (body mass index [BMI] and body fat percentage) and total cholesterol in 4,013 fourth-grade students from three countries, France, Japan, and the United States. Data were analyzed using t test, chi-square, and analysis of variance to determine differences between groups and by multiple linear regression. All variables differed significantly by group. BMI was highest in U.S. children. Body fat percentage was also highest in U.S. children and lowest in French children. Total cholesterol was highest in French children and lowest in U.S. White children. There were modest but significant associations between BMI and cholesterol in all groups except French children; associations varied by gender. Results indicate there was great variation in measures of obesity and cholesterol by country. The association between obesity and cholesterol may vary by culture, ethnicity, and gender.
Related JoVE Video
Maternal blood lead levels and the risk of pregnancy-induced hypertension: the EDEN cohort study.
Environ. Health Perspect.
PUBLISHED: 06-26-2009
Show Abstract
Hide Abstract
Prior studies revealed associations of environmental lead exposure with risks of hypertension and elevated blood pressure.
Related JoVE Video
Parental feeding practices in the United States and in France: relationships with childs characteristics and parents eating behavior.
J Am Diet Assoc
PUBLISHED: 05-26-2009
Show Abstract
Hide Abstract
Given the role of parental feeding practices in establishing childrens eating habits, understanding sources of individual differences in feeding practices is important. This study examined the role of several psychological variables (ie, parental perceived responsibility for childs eating, parental perceptions of the childs weight, and parents own eating patterns) in individual differences in a variety of feeding practices. Parents of preschool-aged children completed surveys in a cross-sectional study. Two cultural contexts (ie, United States, n=97 parents; and France, n=122 parents) were included to assess the cross-cultural generalizability of the findings. Monitoring was associated with parental perceived responsibility for childs eating, parental restrained eating, and parents desire for their child to be thinner, especially in France. Restriction for weight reasons was more prevalent in France and was associated with parents perceived responsibility for childs eating, perception of childs body weight, and parental restrained eating. Parental use of foods for nonnutritive purposes was more prevalent in the United States and was associated with parental uncontrolled or emotional eating. Finally, parents perceived responsibility for childs eating was strongly related to child control over feeding, teaching about nutrition, encouragement of balance, and variety and modeling. These associations between psychological variables and parental feeding practices shed light on the sources of individual differences in feeding practices and suggest possible opportunities for intervention when feeding practices are suboptimal.
Related JoVE Video
Ethnic differences in gestational oral glucose screening in a large US population.
Ethn Dis
PUBLISHED: 04-02-2009
Show Abstract
Hide Abstract
To estimate gestational diabetes mellitus (GDM) prevalence and hyperglycemia in a large multi-ethnic population and evaluate the differences in glucose measures by age and ethnicity.
Related JoVE Video
Maternal personal exposure to airborne benzene and intrauterine growth.
Environ. Health Perspect.
PUBLISHED: 04-01-2009
Show Abstract
Hide Abstract
Studies relying on outdoor pollutants measures have reported associations between air pollutants and birth weight.
Related JoVE Video
Cognitive restraint, uncontrolled eating and emotional eating: correlations between parent and adolescent.
Matern Child Nutr
PUBLISHED: 03-19-2009
Show Abstract
Hide Abstract
The purpose of this study was to examine, in a general population, the resemblance in eating behaviour between adolescents and their parents. This study was based on the first examination of a community-based epidemiological study in Northern France. Subjects were offspring aged 14-22 years (135 boys and 125 girls) and their parents (174 fathers and 205 mothers). The Three-Factor Eating Questionnaire Revised 18-item version (TFEQ-R18) identified three aspects of eating behaviour: cognitive restraint of eating, uncontrolled eating and emotional eating. Familial resemblance in eating behaviour was measured by partial Spearmans correlations, adjusted for age and body mass index. Sons uncontrolled eating was positively related to fathers cognitive restraint of eating (r = 0.36), but not to fathers uncontrolled eating (r = 0.07), nor to mothers eating behaviour. Sons cognitive restraint of eating was related to no parental eating behaviour scores. In daughters, cognitive restraint of eating was positively related to mothers uncontrolled eating (r = 0.26), but not to mothers cognitive restraint of eating (r = 0.13). Daughters uncontrolled eating and emotional eating were positively associated with the same scores in mothers. Finally, daughters eating behaviour was not related to fathers eating behaviour. In conclusion, correlations in eating behaviour were higher with the parent of the same gender, and eating behaviours in adolescents seem to reflect opposition to parents behaviour more than familial resemblance.
Related JoVE Video
Relationships of self-reported physical activity domains with accelerometry recordings in French adults.
Eur. J. Epidemiol.
PUBLISHED: 03-04-2009
Show Abstract
Hide Abstract
The objective was to examine the relationships of self-reported physical activity (PA) by domain (leisure, occupational, other) with PA and sedentary time as measured objectively by accelerometry. Subjects were adults with low habitual PA levels from a community in northern France. Among subjects in the lowest tertile of a PA score from a screening questionnaire, 160 (37% males, age: 41.0 +/- 10.8 years, BMI: 25.1 +/- 4.1 kg/m(2), mean +/- SD) completed a detailed instrument (Modifiable Activity Questionnaire), and wore an accelerometer (Actigraph) for seven consecutive days. Relationships between questionnaire domains (occupational, leisure, and "non-occupational non-leisure") and accelerometry measures (total activity and sedentary time) were assessed using Spearman correlation coefficients. In this population, the highest contributor to total reported PA (h/week) was occupational PA. Time spent in non-occupational non-leisure PA ranked second in women and third in men. The most frequent non-occupational non-leisure PA were shopping and household chores. In women, non-occupational non-leisure PA contributed more than occupational or leisure-time PA to total PA energy expenditure (median: 18.0, 9.1, and 4.9 MET-h/week, respectively). Total PA by accelerometry (count/day) was correlated to leisure-time PA in women (r = 0.22, P < 0.05) and to occupational (r = 0.43, P < 0.01) and total reported PA (r = 0.39, P < 0.01) in men (all in MET-h/week). There was an inverse relationship between accelerometry sedentary time (h/day) and non-occupational non-leisure PA (MET-h/week, r = -0.30, P < 0.001). These findings indicate the importance of assessing non-occupational non-leisure PA for a better understanding of how individuals partition their time between active or sedentary occupations.
Related JoVE Video
Child and parent characteristics related to parental feeding practices. A cross-cultural examination in the US and France.
Appetite
PUBLISHED: 02-24-2009
Show Abstract
Hide Abstract
Although cross-cultural research between France and the United States has contributed to our understanding of adult eating habits, no research to date has considered differences in the way that French and American parents feed their children. American mothers (n=59) and fathers (n=38) and French mothers (n=72) and fathers (n=50) provided information about the feeding practices that they use with their children. U.S. parents reported higher levels of non-nutritive feeding practices and child control over feeding, whereas French parents reported greater monitoring and restriction of their childs food intake for weight reasons. Feeding practices were linked to child Body Mass Index (BMI) in both socio-cultural contexts.
Related JoVE Video
Association between maternal seafood consumption before pregnancy and fetal growth: evidence for an association in overweight women. The EDEN mother-child cohort.
Paediatr Perinat Epidemiol
PUBLISHED: 02-21-2009
Show Abstract
Hide Abstract
Studies in countries with high seafood consumption have shown a benefit on fetal growth and child development. The objective of our study was to determine the association between seafood consumption in French pregnant women and fetal growth. Pregnant women included in the EDEN mother-child cohort study completed two food frequency questionnaires on their usual diet in the year before and during the last 3 months of pregnancy (n = 1805). Fetal circumferences were measured by ultrasound and anthropometry at birth. Variables were compared across tertiles of the mothers seafood consumption using multiple linear regression to adjust for confounding variables. Analyses were stratified by maternal overweight status because of an interaction between maternal seafood consumption and her body mass index (P < 0.01). There was no association between seafood intake and fetal growth in the whole sample of women. For overweight women (n = 464), higher consumption of seafood before pregnancy was associated with higher fetal biparietal and abdominal circumferences and anthropometric measures. From the lowest to the highest tertiles, mean birthweight was 167 g higher (P = 0.002). No significant association was found with consumption at the end of pregnancy. In conclusion, high seafood consumption before pregnancy is positively associated with fetal growth in overweight women.
Related JoVE Video
Association between maternal blood cadmium during pregnancy and birth weight and the risk of fetal growth restriction: the EDEN mother-child cohort study.
Reprod. Toxicol.
Show Abstract
Hide Abstract
The objective of this study is to investigate the potential effect of maternal environmental cadmium (Cd) exposure on birth weight and fetal growth restriction (FGR). A total of 901 pregnant women from the EDEN cohort study were enrolled from two maternity units. Blood Cd was measured at mid-pregnancy and associations with birth weight and FGR were analyzed. Maternal Cd levels were associated with reduced birth weight in the offspring of women who smoked during pregnancy (b=-113.7; p=0.001). Smoking during pregnancy and maternal blood Cd concentrations had comparable effects on FGR incidence (OR 1.89; 95% CI: 1.00-3.58 and OR=1.41; 95% CI: 1.00-1.99, respectively). This study highlights the effect of Cd toxicity on fetal growth through the probable accumulation and transmission of this metal through the placenta. The close relationship between blood Cd levels and smoking habits indicates that Cd may be a relevant biomarker for smoking toxicity on fetal development.
Related JoVE Video
Pregnancy exposure to atmospheric pollutants and placental weight: an approach relying on a dispersion model.
Environ Int
Show Abstract
Hide Abstract
Epidemiologic studies suggest an association between air pollution exposure and foetal growth. The possible underlying biological mechanisms have little been studied in humans, but animal studies suggest an impact of atmospheric pollutants on placental function.
Related JoVE Video
Specific role of maternal weight change in the first trimester of pregnancy on birth size.
Matern Child Nutr
Show Abstract
Hide Abstract
The specific role of weight change in the first weeks of gestation in fetal growth has not been fully explored in humans. Our aims were to investigate: (1) the specific association between weight change in the first trimester of pregnancy (WCT1) and size at birth in term pregnancies; and (2) the role of placental weight in this relationship. From 2002 women included in the French EDEN study, 1744 mother-child pairs reached term, had pre-pregnancy weight available and at least five measures of weight in pregnancy. We extrapolated womens weight at each week of gestation with a three-degree polynomial model and estimated weight change during each trimester of gestation. We used a multivariate linear model to investigate the associations between WCT1 and birth size after taking into account potential confounders (age, parity, BMI, tobacco use, educational level, length of gestation, newborn gender, weight change after the first trimester and centre of study). Then, we performed path analysis to investigate whether the relation between WCT1 and birth size could be mediated by placental weight. After taking into account weight gain in later gestation, WCT1 was positively associated with birthweight. Results of path analysis showed that there was no direct association between WCT1 and birth size, but that this association was mediated by placental weight. Weight change during the first weeks of pregnancy may impact on fetal growth independently of weight change later in pregnancy through its effects on placental growth and function.
Related JoVE Video
Determinants of infant formula use and relation with growth in the first 4 months.
Matern Child Nutr
Show Abstract
Hide Abstract
The wide variety of infant formula available on the market can be confusing for parents and physicians. We aimed to determine associations between predominant type of formula used from birth to 4 months and parental and child characteristics and type of physician consulted, and then to describe relations between type of formula used and growth. Our analyses included 1349 infants from the EDEN mother-child cohort. Infants feeding mode and type of formula used were assessed at 4 months by maternal self-report. Infants weight and height from birth to 4 months, measured in routine follow-up, were documented by health professionals in the infants personal health record. Anthropometric z-scores were calculated by using World Health Organization growth standards. Multinomial logistic regression was used to identify factors associated with the type of formula predominantly used; relations with growth were analysed by linear regressions. Partially hydrolysed formulas were more likely to be used by primiparous women (P??0.20). Infants breastfed shorter showed higher weight-for-age (P?
Related JoVE Video
Correcting for the influence of sampling conditions on biomarkers of exposure to phenols and phthalates: a 2-step standardization method based on regression residuals.
Environ Health
Show Abstract
Hide Abstract
Environmental epidemiology and biomonitoring studies typically rely on biological samples to assay the concentration of non-persistent exposure biomarkers. Between-participant variations in sampling conditions of these biological samples constitute a potential source of exposure misclassification. Few studies attempted to correct biomarker levels for this error. We aimed to assess the influence of sampling conditions on concentrations of urinary biomarkers of select phenols and phthalates, two widely-produced families of chemicals, and to standardize biomarker concentrations on sampling conditions.
Related JoVE Video
?(15)N and ?(13)C in hair from newborn infants and their mothers: a cohort study.
Pediatr. Res.
Show Abstract
Hide Abstract
Protein intake in fetal life or infancy may play a key role in determining early growth rate, a determinant of later health and disease. Previous work has indicated that hair isotopic composition is influenced by diet and protein intake.
Related JoVE Video
Depression and anxiety in women during pregnancy and neonatal outcome: data from the EDEN mother-child cohort.
Early Hum. Dev.
Show Abstract
Hide Abstract
According to the World Health Organization, mental health disorders are the leading causes of disease burden in women from 15 to 44 years. These conditions in pregnant women may affect the offspring.
Related JoVE Video

What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.