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Find video protocols related to scientific articles indexed in Pubmed.
Rituximab-including combined modality treatment for primary thyroid lymphoma: an effective regimen for elderly patients.
Thyroid
PUBLISHED: 05-15-2014
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Primary thyroid lymphoma (PTL) develops mostly in middle-aged and older females. However, the optimal treatment for elderly patients with diffuse large B-cell lymphoma (DLBCL), which accounts for most PTL cases, is unclear. Rituximab is a promising drug that, in combination with traditional combination therapy, has demonstrated an increased antitumor effect without a substantial increase in toxicity. In this study, treatment outcomes of elderly patients with thyroid DLBCL who underwent rituximab-including combination therapy were analyzed.
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Development of a national agreement on human papillomavirus vaccination in Japan: an infodemiology study.
J. Med. Internet Res.
PUBLISHED: 04-09-2014
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A national agreement on human papillomavirus (HPV) vaccination was achieved relatively quickly in Japan as compared to the United States and India.
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Concerns about unapproved meningococcal vaccination for eculizumab therapy in Japan.
Orphanet J Rare Dis
PUBLISHED: 04-07-2014
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An orphan medicinal product, eculizumab is approved in Japan and globally for treating paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. Eculizumab therapy can cause late complement pathway deficiencies that predispose patients to meningococcal infections. Although meningococcal vaccinations are typically considered mandatory for eculizumab therapy, no approved vaccine is available in Japan as of March, 2014. Advertising unapproved, privately imported pharmaceuticals is prohibited under Japanese pharmaceutical law; detailed information concerning the unapproved meningococcal vaccines is therefore not widely available. The situation jeopardizes the safety of patients receiving eculizumab therapy, and Japanese clinicians are advised caution when prescribing this therapy.
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Assessment of the risk of medium-term internal contamination in Minamisoma City, Fukushima, Japan, after the Fukushima Dai-ichi nuclear accident.
Environ. Health Perspect.
PUBLISHED: 03-11-2014
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The Fukushima Dai-ichi nuclear disaster, the first level-7 major nuclear disaster since Chernobyl, raised concerns about the future health consequences of exposure to and intake of radionuclides. Factors determining the risk and level of internal radiation contamination after a nuclear accident, which are a key to understanding and improving current nuclear disaster management, are not well studied.
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The immediate physical and mental health crisis in residents proximal to the evacuation zone after Japan's nuclear disaster: an observational pilot study.
Disaster Med Public Health Prep
PUBLISHED: 02-13-2014
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The 2011 earthquake and Fukushima nuclear disaster in Japan have had devastating effects on residents near the damaged nuclear power plant, but quantifying its effect on their health has been difficult.
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Detection of 131I in a patient with thyroid cancer by internal radiation exposure screening using a whole-body counter in Fukushima.
Clin Nucl Med
PUBLISHED: 01-08-2014
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We have been performing a systematic screening using a whole-body counter of internal radiation exposure in the affected areas by the Fukushima Daiichi nuclear incident. This case suggests 2 important points regarding the thyroid internal exposure screening immediately after a nuclear disaster. First, clinicians should recognize the possibility of overestimation of I exposure during the initial checkups of thyroid internal exposure if a detailed history of treatment by radioisotopes is not obtained. Second, in vivo measurements should be taken immediately after the disaster because all of the radioactive iodine generated after the disaster disappears within a few months.
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Reduction of high levels of internal radio-contamination by dietary intervention in residents of areas affected by the Fukushima Daiichi nuclear plant disaster: a case series.
PLoS ONE
PUBLISHED: 01-01-2014
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Maintaining low levels of chronic internal contamination among residents in radiation-contaminated areas after a nuclear disaster is a great public health concern. However, the efficacy of reduction measures for individual internal contamination remains unknown. To reduce high levels of internal radiation exposure in a group of individuals exposed through environmental sources, we performed careful dietary intervention with identification of suspected contaminated foods, as part of mass voluntary radiation contamination screenings and counseling program in Minamisoma Municipal General Hospital and Hirata Central Hospital. From a total of 30,622 study participants, only 9 residents displayed internal cesium-137 (Cs-137) levels of more than 50 Bq/kg. The median level of internal Cs-137 contamination in these residents at the initial screening was 4,830 Bq/body (range: 2,130-15,918 Bq/body) and 69.6 Bq/kg (range: 50.7-216.3 Bq/kg). All these residents with high levels of internal contamination consumed homegrown produce without radiation inspection, and often collected mushrooms in the wild or cultivated them on bed-logs in their homes. They were advised to consume distributed food mainly and to refrain from consuming potentially contaminated foods without radiation inspection and local produces under shipment restrictions such as mushrooms, mountain vegetables, and meat of wild life. A few months after the intervention, re-examination of Cs levels revealed remarkable reduction of internal contamination in all residents. Although the levels of internal radiation exposure appear to be minimal amongst most residents in Fukushima, a subset of the population, who unknowingly consumed highly contaminated foodstuffs, experienced high levels of internal contamination. There seem to be similarities in dietary preferences amongst residents with high internal contamination levels, and intervention based on pre- and post-test counseling and dietary advice from medical care providers about risky food intake appears to be a feasible option for changing residents' dietary practices, subsequently resulting in a reduction in Cs internal contamination levels.
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Measurement of internal radiation exposure among decontamination workers in villages near the crippled Fukushima Daiichi Nuclear Power Plant.
Health Phys
PUBLISHED: 08-29-2013
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Decontamination workers may face a high risk of exposure to internal irradiation through inhalation during decontamination activities; there is, however, little previous research on the levels of internal contamination during decontamination procedures. The authors reviewed the medical records, including whole body counter measurements, of decontamination workers in villages near the crippled Fukushima Daiichi Nuclear Power Plant to assess their levels of internal radiation exposure. In total, 83 decontamination workers were enrolled in this study. They were regularly engaged in decontamination activities in highly contaminated areas where surface 137Cs deposition density was over 100 kBq m-2. The present study showed low levels of internal exposure among the decontamination workers near the Fukushima Daiichi nuclear plant. The cesium burdens of all the decontamination workers were below detection limits. They had reported no acute health problems. The resuspension of radioactive materials may cause minimal internal contamination during decontamination activities.
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Extension and verification of the SEIR model on the 2009 influenza A (H1N1) pandemic in Japan.
Math Biosci
PUBLISHED: 08-20-2013
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In order to understand the evolution of the 2009 influenza A (H1N1) pandemic within local regions of Japan, we studied the significance of regional migration between these regions. For this purpose, we have employed an extended SEIR model to describe the immigration of infected people and the stochastic variation of the infectious efficiency. We then applied a data assimilation technique in order to study how the agreement of the simulation results with the observed data depends on the presence/absence of immigration and the degree of variation of the infectious efficiency. Reproducibility is evaluated by log-likelihood values. The log-likelihood does not indicate the significance of immigration. Although there are multiple waves in the time course of the number of reported infected individuals, these waves could be explained by the stochastic nature of infectious events.
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Changes in metabolic profiles after the Great East Japan Earthquake: a retrospective observational study.
BMC Public Health
PUBLISHED: 03-19-2013
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A magnitude 9.0 earthquake struck off eastern Japan in March 2011. Many survivors have been living in temporary houses provided by the local government since they lost their houses as a result of the great tsunami (tsunami group) or the expected high-dose radiation resulting from the nuclear accident at the Fukushima Daiichi Nuclear Power Plant (radiation group). The tsunami was more than 9 m high in Soma, Fukushima, which is located 30 km north of the Fukushima Daiichi Nuclear Power Plant and adjacent to the mandatory evacuation area. A health screening program was held for the evacuees in Soma in September 2011. The aim of this study was to compare the metabolic profiles of the evacuees before and after the disaster. We hypothesized that the evacuees would experience deteriorated metabolic status based on previous reports of natural disasters.
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Mid-career changes in the occupation or specialty among general surgeons, from youth to middle age, have accelerated the shortage of general surgeons in Japan.
Surg. Today
PUBLISHED: 03-04-2013
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PURPOSES: Concerns have been raised regarding an apparent shortage of general surgeons in Japan, but the actual situation is actually not altogether clear. To clarify the trends in the number of general surgeons in Japan, we studied the number of doctors by specialty over time. METHODS: This study investigated the covered trends in the number of doctors over time, a comparison of work formats (employment in hospitals versus clinics), and the trends in the ratio of female doctors. We used data from the Survey of Doctors, Dentists and Pharmacists from 1996, 1998, 2000, 2002, 2004, and 2006. RESULTS: Between 1994 and 2006, the number of general surgeons fell by 12.7 %, from 24,718 to 21,574. More than 20 % of the general surgeons, aged 25 to 54 years old, either changed jobs or changed specialties between 1996 and 2006. Among the general surgeons, aged 25 to 54 years old, the number of those working in hospitals fell by 2,567 (16.2 %) between 2000 and 2006, while the number working in health clinics rose by 348 (19.8 %). The ratio of female general surgeons rose from 2.4 % in 1996 to 4.5 % in 2006. CONCLUSIONS: The decrease in general surgeons in Japan is largely often due to mid-career job separation.
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Mortality risk amongst nursing home residents evacuated after the Fukushima nuclear accident: a retrospective cohort study.
PLoS ONE
PUBLISHED: 02-22-2013
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Safety of evacuation is of paramount importance in disaster planning for elderly people; however, little effort has been made to investigate evacuation-related mortality risks. After the Fukushima Daiichi Nuclear Plant accident we conducted a retrospective cohort survival survey of elderly evacuees.
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Increased incidence of dog-bite injuries after the Fukushima nuclear accident.
Prev Med
PUBLISHED: 02-11-2013
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The objective of this study is to assess the localized incidence of dog bites following the nuclear accident related to the Great East Japan Earthquake in March 2011.
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Does Twitter trigger bursts in signature collections?
PLoS ONE
PUBLISHED: 02-05-2013
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The quantification of social media impacts on societal and political events is a difficult undertaking. The Japanese Society of Oriental Medicine started a signature-collecting campaign to oppose a medical policy of the Government Revitalization Unit to exclude a traditional Japanese medicine, "Kampo," from the public insurance system. The signature count showed a series of aberrant bursts from November 26 to 29, 2009. In the same interval, the number of messages on Twitter including the keywords "Signature" and "Kampo," increased abruptly. Moreover, the number of messages on an Internet forum that discussed the policy and called for signatures showed a train of spikes.
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Cancer articles in weekly magazines: useful media to deliver cancer information to the public?
Jpn. J. Clin. Oncol.
PUBLISHED: 01-30-2013
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Japanese weekly magazines, which have a circulation of over 2 700 000, play important roles in communicating with the public. They offer a wide range of information, entertainment, gossip, politics and economics, and often include articles on cancer. However, cancer articles in magazines have not been systematically analyzed.
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A patient with heatstroke associated with consciousness disturbance secondary to hyponatremia: a case report.
J Med Case Rep
PUBLISHED: 01-28-2013
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Little information is available on the pathogenesis of heatstroke without strenuous exercise in younger patients. Here, we report the case of a 31-year-old man who developed heatstroke secondary to hyponatremia. His condition was initially misdiagnosed as classic heatstroke. We hope the detailed description of our patients case will provide valuable information for medical professionals faced with similar cases in the future.
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Limited internal radiation exposure associated with resettlements to a radiation-contaminated homeland after the fukushima daiichi nuclear disaster.
PLoS ONE
PUBLISHED: 01-01-2013
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Resettlement to their radiation-contaminated hometown could be an option for people displaced at the time of a nuclear disaster; however, little information is available on the safety implications of these resettlement programs. Kawauchi village, located 12-30 km southwest of the Fukushima Daiichi nuclear power plant, was one of the 11 municipalities where mandatory evacuation was ordered by the central government. This village was also the first municipality to organize the return of the villagers. To assess the validity of the Kawauchi villagers resettlement program, the levels of internal Cesium (Cs) exposures were comparatively measured in returnees, commuters, and non-returnees among the Kawauchi villagers using a whole body counter. Of 149 individuals, 5 villagers had traceable levels of Cs exposure; the median detected level was 333 Bq/body (range, 309-1050 Bq/kg), and 5.3 Bq/kg (range, 5.1-18.2 Bq/kg). Median annual effective doses of villagers with traceable Cs were 1.1 x 10(-2) mSv/y (range, 1.0 x 10(-2)-4.1 x 10(-2) mSv/y). Although returnees had higher chances of consuming locally produced vegetables, Cochran-Mantel-Haenszel test showed that their level of internal radiation exposure was not significantly higher than that in the other 2 groups (p=0.643). The present findings in Kawauchi village imply that it is possible to maintain internal radiation exposure at very low levels even in a highly radiation-contaminated region at the time of a nuclear disaster. Moreover, the risks for internal radiation exposure could be limited with a strict food control intervention after resettlement to the radiation-contaminated village. It is crucial to establish an adequate number of radio-contaminated testing sites within the village, to provide immediate test result feedback to the villagers, and to provide education regarding the importance of re-testing in reducing the risk of high internal radiation exposure.
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Enhancement of collective immunity in Tokyo metropolitan area by selective vaccination against an emerging influenza pandemic.
PLoS ONE
PUBLISHED: 01-01-2013
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Vaccination is a preventive measure against influenza that does not require placing restrictions on social activities. However, since the stockpile of vaccine that can be prepared before the arrival of an emerging pandemic strain is generally quite limited, one has to select priority target groups to which the first stockpile is distributed. In this paper, we study a simulation-based priority target selection method with the goal of enhancing the collective immunity of the whole population. To model the region in which the disease spreads, we consider an urban area composed of suburbs and central areas connected by a single commuter train line. Human activity is modelled following an agent-based approach. The degree to which collective immunity is enhanced is judged by the attack rate in unvaccinated people. The simulation results show that if students and office workers are given exclusive priority in the first three months, the attack rate can be reduced from [Formula: see text] in the baseline case down to 1-2%. In contrast, random vaccination only slightly reduces the attack rate. It should be noted that giving preference to active social groups does not mean sacrificing those at high risk, which corresponds to the elderly in our simulation model. Compared with the random administration of vaccine to all social groups, this design successfully reduces the attack rate across all age groups.
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Antithyroid drug-induced hematopoietic damage: a retrospective cohort study of agranulocytosis and pancytopenia involving 50,385 patients with Graves disease.
J. Clin. Endocrinol. Metab.
PUBLISHED: 11-02-2011
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Although antithyroid drug (ATD)-induced hematopoietic damage is a significant concern, it has not been comprehensively investigated.
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Internet-based survey on medical manga in Japan.
Health Commun
PUBLISHED: 06-09-2011
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The more manga (Japanese graphic novels) communicate medical information, the more people are likely to be influenced by manga. We investigated through an Internet search using Google the characteristics of medical manga published in Japan, defined as those in which the main character is a medical professional and that occur in a medical setting. As of December 2008, 173 medical manga had been published. For a period of time after the first medical manga by Osamu Tezuka in 1970, the number of publications maintained a steady level, but increased rapidly in the mid 1980s. The professions of the protagonist were 134 doctors, 19 nurses, 3 dentists, 3 medical students, and 1 nursing student. Although the main character was mostly a doctor, manga featuring paramedical professionals have increased since 1990s. Medical manga may be a powerful tool for increasing the awareness of the public regarding medicine.
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Data mining of mental health issues of non-bone marrow donor siblings.
J Clin Bioinforma
PUBLISHED: 06-08-2011
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Allogenic hematopoietic stem cell transplantation is a curative treatment for patients with advanced hematologic malignancies. However, the long-term mental health issues of siblings who were not selected as donors (non-donor siblings, NDS) in the transplantation have not been well assessed. Data mining is useful in discovering new findings from a large, multidisciplinary data set and the Scenario Map analysis is a novel approach which allows extracting keywords linking different conditions/events from text data of interviews even when the keywords appeared infrequently. The aim of this study is to assess mental health issues on NDSs and to find helpful keywords for the clinical follow-up using a Scenario Map analysis.
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Clinicopathological features of 171 cases of primary thyroid lymphoma: a long-term study involving 24553 patients with Hashimotos disease.
Br. J. Haematol.
PUBLISHED: 03-04-2011
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There are few large-scale reports of primary thyroid lymphoma (PTL). This study clinically and pathologically reviewed 171 patients with PTL and 24,553 patients with Hashimotos disease at Ito Hospital between January 1990 and December 2004, to investigate the clinical features and the treatment outcomes of PTL. The median age of the patients with PTL was 67?years (range, 27-90?years). The pathological diagnosis of PTL patients included diffuse large B-cell lymphoma (DLBCL) (n=74), DLBCL with mucosa-associated lymphoid tissue (MALT) lymphoma (n=13), MALT lymphoma (n=80) and others (n=4). Of the 167 patients with B-cell lymphoma, treatment included combined modality therapy (CMT) (n=95), radiation therapy (RT) alone (n=60) and chemotherapy alone (n=6). Information on treatment was not available in six patients. Information on treatment response was available in 154 patients; 149 patients (97%) responded to treatment. According to the institutional treatment strategy of Ito Hospital, 45 of 54 patients with stage IE disease received RT alone, and 87 of 113 stage IIE patients received CMT. The 5-year overall survival rate was 85% (95% confidence interval, 79-91%). This study demonstrated that PTL showed good response to radiotherapy and chemotherapy and had a favourable prognosis.
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H1N1 influenza A outbreak among young medical staff members who received single dose of non-adjuvanted split-virion 2009 H1N1 vaccine.
Hum Vaccin
PUBLISHED: 01-01-2011
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We experienced an H1N1 influenza A outbreak among medical staff members who had received a vaccination. To investigate the preventive effects of the H1N1 influenza vaccine on the H1N1 influenza A infection, we examined the data on the medical staff members and patients with confirmed H1N1 influenza A or influenza-like illness retrospectively. Approximately half of the young individuals under 30 years of age developed H1N1 influenza A, while the diagnosis was established in 3% of medical staff over the age of 30 and 0.9% of patients with a median age of 67. The mechanism for association between age and the risk of H1N1 infection is unclear; however, it might have been associated with an age-related increase in the prevalence of neutralizing antibody titers against the 2009 H1N1 influenza A as indicated by previous reports. This study showed that current Japanese H1N1 influenza A vaccine program using one dose of non-adjuvant split-virion 2009 H1N1 vaccine with 7.5 ?g hemagglutinin had a limited preventive effect on H1N1 influenza A infection in adults under 30 years of age.
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Why do Japans advanced medical treatments never get ahead?
Keio J Med
PUBLISHED: 07-06-2010
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Islet cell transplantation is a minimally invasive procedure which effectively controls blood glucose level for diabetic patients but is considered as experimental. After islet transplantation, type 1 diabetic patients could become insulin free with stable glycemic control. But for long term effects, only stable glycemic control was maintained and not insulin free status. In 2004 Kyoto University performed the first Japanese islet cell transplant using non-heart beating donor. Of note, due to the lack of cadaveric donors in Japan, the same group performed the worlds first successful case of living donor islet transplantation in 2005. Both patients achieved transit insulin-independence; however excellent glycemic control was able to be maintained for a prolonged period. Even though the series of islet transplants at Kyoto University showed promising results, the leading scientist did not continue his research in Japan. This was because it is extremely difficult to implement newly developed treatment as a standard therapy in Japan.
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Endoscopic diagnosis of cytomegalovirus gastritis after allogeneic hematopoietic stem cell transplantation.
World J. Gastroenterol.
PUBLISHED: 06-18-2010
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To clarify the endoscopic and clinical findings of cytomegalovirus (CMV) gastritis after allogeneic hematopoietic stem cell transplantation (allo-SCT).
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The impact of H1N1 influenza A virus pandemic on the blood donations in Hyogo Prefecture, Japan.
Transfusion
PUBLISHED: 05-12-2010
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BACKGROUND: The impact of the H1N1 influenza on blood donation is unknown. STUDY DESIGN AND METHODS: We examined number of blood donors presenting to blood donation centers or bloodmobiles using a blood donation database of Red Cross Hyogo Prefectural Blood Center between 4 weeks before and after May 16, 2009, respectively, when the first case of H1N1 influenza was confirmed in Kobe. The numbers of blood donors per donation site (i.e., blood donation centers and bloodmobiles) and per blood products (i.e., red blood cells [RBCs], platelet [PLT]-poor plasma, and PLTs) were also examined. RESULTS: The number of blood donors decreased by 21% and whole blood donations declined by 1329 units within 1 week of the first case of H1N1 influenza. While number of blood donors showed a rapid decrease, blood donations returned to the normal level within 1 week. This quick recovery was attributed to the diligent efforts made by Red Cross Centers, including the use of e-mail to encourage blood donation, on-the-street campaigns, and requesting new bloodmobile drives in workplaces and universities. RBCs that were donated in bloodmobiles was predominantly affected; the number of blood donors in bloodmobiles decreased by 39%. CONCLUSION: H1N1 influenza pandemic had a great but transient impact on blood donation.
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[Economic burden for patients with chronic myelogenous leukemia--healthcare economics and medical governance of cancer].
Gan To Kagaku Ryoho
PUBLISHED: 04-24-2010
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Due to the recent economic downturn, the economic burden of cancer patients has been further worsened. Specifically for chronic myelogenous leukemia patients, their annual income has decreased by 1, 500, 000 yen from 2000 to 2008, while the cost of their medications has increased from 1,000,000 yen to 1,200,000 yen due the advent of the new drug, Glivec, which was approved in 2001. The scores for psychological burden have increased 30% over the past 8 years before Glivec became available. The economic crisis among cancer patients is a consequence of structural problems with many anticancer drugs and cancer treatment. Especially, problems involving the cost of medical care and the system of drug pricing should be resolved by thorough discussion not only with cancer patients but also with the entire population. Discussion on the medical expense burden for CML patients has flourished through patients spontaneous activities and information disclosure to a wider population through the internet. This methodology will be significant in establishing medical governance in cancer treatment in Japan.
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Interests in beta-cell replacement therapies among Japanese patients with type 1 diabetes.
Diabetes Res. Clin. Pract.
PUBLISHED: 04-12-2010
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The purpose of this study is to evaluate patients perspective about beta-cell replacement therapies. 105 Japanese type 1 diabetic patients answered questionnaire on current treatments, transplantation and necessity of psychosomatic therapy. The motivation of receiving transplantation seems to become insulin-free. Providing adequate information is necessary for wide-spread beta-cell replacement therapies.
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Structural problems of medical news reports in newspapers: a verification of news reports on an incident of mass nosocomial Serratia infection.
J. Infect. Chemother.
PUBLISHED: 01-27-2010
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It is unclear how changes in the content and number of news reports over time affect the impressions made in the minds of newspaper readers. This study targeted news reports in major newspapers regarding an incident of mass nosocomial Serratia infection that occurred at one clinic. The trends in the total number of articles and total number of characters contained in the articles were congruent, with a peak on the day after the incident was disclosed and a rapid decrease thereafter. The numbers of articles and characters that appeared during the first 3 days corresponded to 45 and 51% of those that appeared during the entire study period. On day 9, it was published that Serratia liquefaciens propagated on medical instruments, and both the number of articles and the number of characters increased by approximately 40% in comparison to those published on the day after the initial report of the incident. The individual articles were deemed to be medically accurate; however, the main problem was that only part of the specific medical issue had been emphasized because of a poor balance in the number of news reports on this topic.
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Regional social system for specialized medical care in hematologic malignancies: a pilot study.
Rural Remote Health
PUBLISHED: 07-28-2009
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The uneven distribution of physicians in Japan disadvantages rural and remote patients with hematological malignancies to the extent that they may not receive standard treatments. There are 7 core regional medical centers in Tokushima Prefecture. A Tokushima rural medical centers clinical hematology division experienced difficulty in treating patients due to a lack of physicians despite an increasing number of patients with hematological malignancies. The aim of this pilot study was to investigate the regional medical supply and demand associated with newly diagnosed hematological malignancies in Tokushima Prefecture, Japan.
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Retrospective study on home care for patients with hematologic malignancies.
Jpn. J. Clin. Oncol.
PUBLISHED: 06-17-2009
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There is a lack of sufficient information on the employment of home care for the treatment of hematologic malignancies.
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Healthcare safety committee in Japan: mandatory accountability reporting system and punishment.
Curr Opin Anaesthesiol
PUBLISHED: 04-25-2009
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The publication of To Err is Human by the Institute of Medicine highlighted the increased international concern about patient safety. Each country has developed its own medical adverse event reporting system. In 2007, the Japanese government attempted to establish a new accountability system in medicine, after an obstetrician was arrested for manslaughter. This paper reviews how this accountability system affected Japanese physicians behavior, and describes different types of medical adverse event reporting systems.
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Successful delivery after planned discontinuation of imatinib in a patient with chronic myeloid leukemia.
Intern. Med.
PUBLISHED: 03-02-2009
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A 24-year-old woman with chronic myeloid leukemia (CML) chronic phase was started on imatinib in August 2004 and complete hematologic response (CHR) was achieved. In May 2006, controlled ovarian hyperstimulation was started after stopping imatinib. Her pregnancy test was positive in October 2006. At 32 weeks, she had 29% metaphases positive for the Ph chromosome; CHR was sustained. She had a normal delivery at 38 weeks without any complications. Five weeks after delivery, imatinib was resumed. Complete molecular response was sustained 5 months after re-administration of imatinib. A CML patient may give a birth after intentionally stopping imatinib before conception.
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Forecasting Japans physician shortage in 2035 as the first full-fledged aged society.
PLoS ONE
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Japan is rapidly becoming a full-fledged aged society, and physician shortage is a significant concern. The Japanese government has increased the number of medical school enrollments since 2008, but some researchers warn that this increase could lead to physician surplus in the future. It is unknown how many physicians will be required to accommodate future healthcare needs.
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Differences in drug approval processes of 3 regulatory agencies: a case study of gemtuzumab ozogamicin.
Invest New Drugs
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Major discrepancies concerning risk-benefit assessments and regulatory actions are frequent among regulatory agencies. We explored the differences by scrutinizing a case of gemtuzumab ozogamicin (GO) in patients with acute myeloid leukaemia (AML). Assessment reports of GO were retrieved form the websites of the US Food and Drug Administration (FDA), the European Medicines Agency (EMA) and Japanese regulatory agency, and we also reviewed published clinical trials. While GO was approved by the US FDA under the accelerated approval program in 2000, it was withdrawn from the market in 2010, based on the required post-marketing commitment failure. The EMA refused granting marketing authorization for GO in 2008 on the grounds that there were no randomised controlled trials (RCTs). GO was approved as an orphan drug in Japan in 2005, and the Japanese regulatory authority decided to continue with the approval in 2010 on the condition that post-marketing surveillance is strengthened. Under these situations, promising new results of RCTs appeared in 2011, and the role of GO in AML treatment was refocused worldwide. The stringent regulation may not be suitable in case of an orphan drug of targeted therapy, and more room should be kept to facilitate effective developments of new anti-neoplastic agents.
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Increased financial burden among patients with chronic myelogenous leukaemia receiving imatinib in Japan: a retrospective survey.
BMC Cancer
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The financial burden of medical expenses has been increasing for cancer patients. We investigated the relationship between household income and financial burden among patients with chronic myelogenous leukaemia (CML) who have been treated with imatinib.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.