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Find video protocols related to scientific articles indexed in Pubmed.
Associations between primary open angle glaucoma, Alzheimer's disease and vascular dementia: record linkage study.
Br J Ophthalmol
PUBLISHED: 11-06-2014
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The potential association between primary open angle glaucoma (POAG) and Alzheimer's disease (AD) is uncertain and has implications for understanding disease pathogenesis, referral and treatments. The aim was to determine whether individuals diagnosed with POAG are at higher risk of subsequently developing AD or vascular dementia.
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Career progression of men and women doctors in the UK NHS: a questionnaire study of the UK medical qualifiers of 1993 in 2010/2011.
JRSM Open
PUBLISHED: 11-01-2014
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To report the career progression of a cohort of UK medical graduates in mid-career, comparing men and women.
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Views of senior UK doctors about working in medicine: questionnaire survey.
JRSM Open
PUBLISHED: 11-01-2014
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We surveyed the UK medical qualifiers of 1993. We asked closed questions about their careers; and invited them to give us comments, if they wished, about any aspect of their work. Our aim in this paper is to report on the topics that this senior cohort of UK-trained doctors who work in UK medicine raised with us.
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Associations between Klinefelter's syndrome and autoimmune diseases: English national record linkage studies.
Autoimmunity
PUBLISHED: 10-09-2014
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Abstract There are reports suggesting that people with Klinefelter's syndrome (KS) may be at increased risk of some autoimmune diseases, but the evidence is not substantial. We wanted to add to the evidence by systematically assessing the risk of autoimmune diseases in a national cohort of people with KS. We selected records of all people with KS in a record-linked dataset of all hospital day cases and inpatient admissions in England, 1999-2011; and we followed them up by electronic record linkage to identify the occurrence of autoimmune diseases. We compared their occurrence in the KS cohort with a control cohort, studied in the same way, and expressed the results as rate ratios (RR). Of 30 autoimmune diseases studied in people with KS, there were significantly increased risks of seven-Addison's disease (RR 11.7, 95% confidence interval 2.4-34.4), diabetes mellitus type 1 (6.1, 4.4-8.3), multiple sclerosis (4.3, 1.2-11.0), acquired hypothyroidism (2.7, 1.8-4.0), rheumatoid arthritis (3.3, 2.0-5.2), Sjogren's syndrome (19.3, 4.0-57.0) and systemic lupus erythematosus (18.1, 2.2-65.6). We concluded that people with KS have increased risk of some autoimmune diseases, particularly those that are female-predominant. The increased risk of autoimmune diseases associated with the XXY karyotype may hold clues to the pathogenesis of some aspects of autoimmunity.
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UK doctors and equal opportunities in the NHS: national questionnaire surveys of views on gender, ethnicity and disability.
J R Soc Med
PUBLISHED: 10-02-2014
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To seek doctors' views about the NHS as an employer, our surveys about doctors' career intentions and progression, undertaken between 1999 and 2013, also asked whether the NHS was, in their view, a good 'equal opportunities' employer for women doctors, doctors from ethnic minority groups and doctors with disabilities.
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Testicular hypofunction and multiple sclerosis risk: A record-linkage study.
Ann. Neurol.
PUBLISHED: 08-30-2014
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The influence of gonadal hormones on multiple sclerosis (MS) is not well characterized and has thus far been investigated primarily in animal models or as a proposed therapeutic approach. We investigated a potential association between testicular hypofunction, as a proxy for low testosterone levels, and MS risk through analysis of linked English national Hospital Episode Statistics from 1999 to 2011. We report a strong positive association between testicular hypofunction and subsequent MS (rate ratio = 4.62, 95% confidence interval = 2.3-8.24, p < 0.0001). Future work should aim more directly to elucidate the relationship between testosterone levels and MS in both males and females. Ann Neurol 2014;76:625-628.
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Age at obesity and association with subsequent dementia: record linkage study.
Postgrad Med J
PUBLISHED: 08-20-2014
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Obesity in mid-life may increase the risk of subsequent dementia. Our objective was to study this risk, focusing on differences by age at the time of recording of obesity, in a large defined population.
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Demographic characteristics of doctors who intend to follow clinical academic careers: UK national questionnaire surveys.
Postgrad Med J
PUBLISHED: 08-18-2014
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It is well recognised that women are underrepresented in clinical academic posts. Our aim was to determine which of a number of characteristics-notably gender, but also ethnicity, possession of an intercalated degree, medical school attended, choice of specialty-were predictive of doctors' intentions to follow clinical academic careers.
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HIV and lower risk of multiple sclerosis: beginning to unravel a mystery using a record-linked database study.
J. Neurol. Neurosurg. Psychiatr.
PUBLISHED: 08-06-2014
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Even though multiple sclerosis (MS) and HIV infection are well-documented conditions in clinical medicine, there is only a single case report of a patient with MS and HIV treated with HIV antiretroviral therapies. In this report, the patient's MS symptoms resolved completely after starting combination antiretroviral therapy and remain subsided for more than 12?years. Authors hypothesised that because the pathogenesis of MS has been linked to human endogenous retroviruses, antiretroviral therapy for HIV may be coincidentally treating or preventing progression of MS. This led researchers from Denmark to conduct an epidemiological study on the incidence of MS in a newly diagnosed HIV population (5018 HIV cases compared with 50?149 controls followed for 31?875 and 393?871 person-years, respectively). The incidence rate ratio for an HIV patient acquiring MS was low at 0.3 (95% CI 0.04 to 2.20) but did not reach statistical significance possibly due to the relatively small numbers in both groups. Our study was designed to further investigate the possible association between HIV and MS.
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Differential risks of cancer types in people with Parkinson's disease: a national record-linkage study.
Eur. J. Cancer
PUBLISHED: 04-10-2014
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There is evidence that people with Parkinson's disease (PD) have a decreased risk of developing cancer. PD has also variably been shown to be associated with an increased risk of cancers like melanoma and breast. We investigated this relationship in a very large cohort of PD patients.
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Hospital admission rates for meningitis and septicaemia caused by Haemophilus influenzae, Neisseria meningitidis, and Streptococcus pneumoniae in children in England over five decades: a population-based observational study.
Lancet Infect Dis
PUBLISHED: 03-14-2014
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Infection with Haemophilus influenzae, Neisseria meningitidis, and Streptococcus pneumoniae causes substantial mortality and long-term morbidity in children. We know of no study to assess the long-term trends in hospital admission rates for meningitis and septicaemia caused by these pathogens in children in England. We aimed to do such a study using routinely reported data in England.
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Subsequent primary malignancies in patients with nonmelanoma skin cancer in England: a national record-linkage study.
Cancer Epidemiol. Biomarkers Prev.
PUBLISHED: 03-11-2014
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Conflicting evidence exists about whether people with a history of nonmelanoma skin cancer (NMSC) are at higher risk of subsequent primary malignant cancers than those without.
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Mortality following hospital discharge with a diagnosis of eating disorder: national record linkage study, England, 2001-2009.
Int J Eat Disord
PUBLISHED: 03-05-2014
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To calculate mortality of people with eating disorders (ED) in England, relative to that of people of the same age and sex, between 2001 and 2009. We were specifically interested in mortality amongst adolescents and young adults (15-24 years), and older adults (25-44 years).
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Record-linkage studies of the coexistence of epilepsy and bipolar disorder.
Soc Psychiatry Psychiatr Epidemiol
PUBLISHED: 02-27-2014
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Interest is growing in a possible link between epilepsy and bipolar disorder (BPD). We used two large datasets of hospital admission data to determine whether epilepsy and BPD occur together in the same individuals more commonly than expected.
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Risk of self-harm and suicide in people with specific psychiatric and physical disorders: comparisons between disorders using English national record linkage.
J R Soc Med
PUBLISHED: 02-13-2014
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Psychiatric illnesses are known risk factors for self-harm but associations between self-harm and physical illnesses are less well established. We aimed to stratify selected chronic physical and psychiatric illnesses according to their relative risk of self-harm.
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Trends in hospital admission rates for whooping cough in England across five decades: database studies.
J R Soc Med
PUBLISHED: 02-13-2014
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Our aim was to report on trends in hospitalisation rates for pertussis in England from the 1960s to 2011; and to provide context for the recent unexpected activity of Bordetella pertussis in the UK.
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UK doctors' views on the implementation of the European Working Time Directive as applied to medical practice: a quantitative analysis.
BMJ Open
PUBLISHED: 02-08-2014
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To report on doctors' views, from all specialty backgrounds, about the European Working Time Directive (EWTD) and its impact on the National Health Service (NHS), senior doctors and junior doctors.
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UK doctors' views on the implementation of the European Working Time Directive as applied to medical practice: a qualitative analysis.
BMJ Open
PUBLISHED: 02-08-2014
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To report on what doctors at very different levels of seniority wrote, in their own words, about their concerns about the European Working Time Directive (EWTD) and its implementation in the National Health Service (NHS).
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A comparison of American and English hospital discharge rates for pediatric bipolar disorder, 2000 to 2010.
J Am Acad Child Adolesc Psychiatry
PUBLISHED: 01-31-2014
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Controversy exists over the diagnosis and prevalence of pediatric bipolar disorder (PBD). Although several small surveys suggest that the rate of the PBD diagnosis in clinical settings is higher in the United States than in other countries, no comprehensive cross-national comparisons of clinical practice have been performed. Here, we used longitudinal national datasets from 2000 to 2010 to compare US and English hospital discharge rates for PBD in patients aged 1 to 19 years.
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Career choices for geriatric medicine: national surveys of graduates of 1974-2009 from all UK medical schools.
Age Ageing
PUBLISHED: 01-14-2014
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numbers of elderly people are increasing worldwide. This increases the importance of the specialty of geriatric medicine. Recruitment to the specialty may not be keeping pace with need.
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Atrial fibrillation as a cause of death increased steeply in England between 1995 and 2010.
Europace
PUBLISHED: 12-30-2013
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To report trends in mortality rates for atrial fibrillation/flutter (AF), using all the certified causes of death mentioned on death certificates (conventionally known as mentions) as well as the underlying cause of death, in the national population of England (1995-2010) and in a regional population with longer coverage of all-mentions mortality (1979-2010).METHODS AND RESULTS: Analysis of death registration data in England and in the Oxford record linkage study. In England between 1995 and 2010, AF was mentioned as a cause of death (either as an underlying cause or as a contributory cause) in 192 770 registered deaths in people aged 45 years of age and over (representing 0.254% of all registered deaths in this age group). Atrial fibrillation was given as the underlying cause of death in 21.4% of all deaths in which it was mentioned (41 298 of 192 770). In England, age-standardized death rates for mentions of AF increased almost three-fold between 1995 and 2010, from 202.5 deaths per million (1995) to 554.1 deaths per million (2010), with an average annual percentage change of 6.6% (95% confidence interval: 6.3, 7.0). Mortality rates for AF did not increase substantially until the mid-1990s: rates in Oxford were 145.4 deaths per million in 1979, 178.1 in 1995, and 505.1 in 2010.CONCLUSION: Atrial fibrillation has become much more common as a certified cause of death. The reasons for this are likely to be multifactorial, with changes in demographics, lifestyle, advances in therapeutics, and altered perception of the importance of the condition by certifying doctors all likely to be contributing factors.
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Orbital Decompression for Thyroid-Associated Orbitopathy in England: Trends over Time and Geographical Variation.
Orbit
PUBLISHED: 12-02-2013
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Abstract Aims: The aims of this study were to examine trends over time and geographical variation in the annual incidence of surgical orbital decompression for thyroid-associated ophthalmopathy (TAO) in England. Methods: Data on hospital admissions for orbital decompression surgery in patients with thyroid disease were analysed using English national Hospital Episode Statistics for admissions from 1991-2011. Results: Annual rates of orbital decompression surgery performed for patients with thyroid disease increased from 0.06 (95% confidence interval, 0.04--0.09) per 100,000 population in 1991, to 0.62 (0.54--0.67) in 2008, and then fell to 0.56 (0.48--0.60) in 2011. The surgical rate was highest in women aged 45--64 years. Geographical analysis showed significant variation across strategic health authority areas in surgical rates, from 0.22 (0.14-0.35) to 1.04 (0.79-1.34) people per 100,000 population per year in 2007-2011. Conclusion: The incidence of orbital decompression surgery performed annually in England has increased substantially over the past two decades, but peaked in 2008 and decreased since then. Significant geographical variation exists in surgical rates. Potential reasons for the decline include improved management of thyroid disease itself, but altered threshold in medical versus surgical management of TAO may also have played a role. The Amsterdam Declaration and EUGOGO treatment guidelines may also have influenced decisions about whether to operate on these patients.
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GPs job satisfaction: doctors who chose general practice early or late.
Br J Gen Pract
PUBLISHED: 11-26-2013
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In the UK many practising GPs did not choose general practice as their first choice of career when they originally graduated as doctors.
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Risk of subarachnoid haemorrhage in people admitted to hospital with selected immune-mediated diseases: record-linkage studies.
BMC Neurol
PUBLISHED: 11-09-2013
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Subarachnoid hemorrhage (SAH) is a devastating cause of stroke, occurring in relatively young people. It has been suggested that some immune-mediated diseases may be associated with an increased ris k of SAH.
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Gender, ethnicity and graduate status, and junior doctors self-reported preparedness for clinical practice: national questionnaire surveys.
J R Soc Med
PUBLISHED: 10-09-2013
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ObjectivesMedical schools need to ensure that graduates feel well prepared for their first medical job. Our objective was to report on differences in junior doctors self-reported preparedness for work according to gender, ethnicity and graduate status.DesignPostal and electronic questionnaires.SettingUK.ParticipantsMedical graduates of 2008 and 2009, from all UK medical schools, one year after graduation.Main outcome measuresThe main outcome measure was the doctors level of agreement with the statement that My experience at medical school prepared me well for the jobs I have undertaken so far, to which respondents were asked to reply on a scale from strongly agree to strongly disagree.ResultsWomen were slightly less likely than men to agree that they felt well prepared for work (50% of women agreed or strongly agreed vs. 54% of men), independently of medical school, ethnicity, graduate entry status and intercalated degree status, although they were no more likely than men to regard lack of preparedness as having been a problem for them. Adjusting for the other subgroup differences, non-white respondents were less likely to report feeling well prepared than white (44% vs. 54%), and were more likely to indicate that lack of preparedness was a problem (30% non-white vs. 24% white). There were also some gender and ethnic differences in preparedness for specific areas of work.ConclusionsThe identified gender and ethnic differences need to be further explored to determine whether they are due to differences in self-confidence or in actual preparedness.
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Turner syndrome and autoimmune diseases: record-linkage study.
Arch. Dis. Child.
PUBLISHED: 09-24-2013
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There is increasing evidence that Turner syndrome is associated with an elevated risk of a range of autoimmune disorders. We aimed to document this in a national study.
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Gout as a risk factor for myocardial infarction and stroke in England: evidence from record linkage studies.
Rheumatology (Oxford)
PUBLISHED: 09-17-2013
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Some studies suggest that gout is a risk factor for cardiovascular disease. There is more evidence about the association between gout and acute myocardial infarction (MI) than about gout and stroke, and only limited information about risks by age group and sex. We aimed to study MI and stroke following gout, including types of stroke, by age group and comparing men and women.
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Association between multiple sclerosis and epilepsy: large population-based record-linkage studies.
BMC Neurol
PUBLISHED: 08-28-2013
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Multiple sclerosis (MS) and epilepsy are both fairly common and it follows that they may sometimes occur together in the same people by chance. We sought to determine whether hospitalisation for MS and hospitalisation for epilepsy occur together more often than expected by chance alone.
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Autoimmune disease preceding amyotrophic lateral sclerosis: an epidemiologic study.
Neurology
PUBLISHED: 08-14-2013
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To study whether the risk of amyotrophic lateral sclerosis (ALS) is increased in people with prior autoimmune disease.
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Trends in junior doctors certainty about their career choice of eventual clinical specialty: UK surveys.
Postgrad Med J
PUBLISHED: 07-09-2013
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The paper explores whether UK qualified junior doctors certainty about their choice of eventual clinical specialty has changed in recent years following structural changes to postgraduate training.
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Breast cancer mortality trends in England and the assessment of the effectiveness of mammography screening: population-based study.
J R Soc Med
PUBLISHED: 06-14-2013
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To investigate whether mortality statistics show an effect of mammographic screening on population-based breast cancer mortality in England.
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Epidemiology of hospitalised osteochondritis dissecans in young people: Incidence, geographical variation and trends over time in England from 2002 to 2010.
Knee
PUBLISHED: 05-29-2013
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Osteochondritis dissecans (OCD) is an important cause of knee pain in physically active adolescents, but its aetiology remains controversial. Modern data on its epidemiology are lacking. The aim of this study was to analyse the hospitalised incidence, age and sex distribution, trends over time and geographical variation in OCD in the whole of England.
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Hospital admissions for vitamin D related conditions and subsequent immune-mediated disease: record-linkage studies.
BMC Med
PUBLISHED: 05-13-2013
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Previous studies have suggested that there may be an association between vitamin D deficiency and the risk of developing immune-mediated diseases.
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Career choices for emergency medicine: national surveys of graduates of 1993-2009 from all UK medical schools.
Emerg Med J
PUBLISHED: 04-12-2013
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BACKGROUND: In the UK, recruitment of adequate numbers of doctors to emergency medicine (EM) has been problematic. With this as background, we analysed data about career choice for, and progression in, EM in a large multi-purpose study of doctors careers. METHODS: Questionnaire surveys of medical graduates of 1993, 1996, 1999, 2000, 2002, 2005, 2008 and 2009 from all UK medical schools. RESULTS: EM was specified as a first choice of career by 4.2% of graduates in postgraduate year 1, 4.8% in year 3, and 3.8% in year 5. Graduates who chose EM were much less likely to be certain about their choice than those who chose other specialties. Of those who specified EM as their first choice of career in year 1, only 26% still had it as their first choice in year 5. Of those who gave EM as their first career choice in year 5, only 27% had given EM as their first choice in year 1. Switches to EM were made, notably, by doctors who previously favoured surgical specialties, hospital physician-led specialties and anaesthetics. CONCLUSIONS: Early career choices for EM are less predictive of career destinations than choices for other specialties, and, compared with many other specialties, doctors who pursue it may turn to it relatively late. Training policies on transferable competencies should enable clinical trainees in other related specialties to bank some of their skills if they transfer to EM, rather than necessarily having to start core training in year 1 of EM specialty training.
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Time trends over five decades, and recent geographical variation, in rates of childhood squint surgery in England.
Br J Ophthalmol
PUBLISHED: 04-10-2013
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To study trends in rates of childhood squint surgery in England over five decades, and to study recent geographical variation in England.
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Participation in medicine by graduates of medical schools in the United Kingdom up to 25 years post graduation: national cohort surveys.
Acad Med
PUBLISHED: 03-26-2013
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To determine--as a guide to assess outcomes of medical education, and for medical workforce planning--whether the great majority of graduates from UK medical schools eventually practice medicine.
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Geographical movement of doctors from education to training and eventual career post: UK cohort studies.
J R Soc Med
PUBLISHED: 03-14-2013
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To investigate the geographical mobility of UK-trained doctors.
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Associations between bullous pemphigoid and primary malignant cancers: an English national record linkage study, 1999-2011.
Arch. Dermatol. Res.
PUBLISHED: 02-22-2013
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We conducted a nationwide record-linked study using all English NHS hospital admission data and mortality statistics from 1999 to 2011 to evaluate the risk of concurrent or subsequent bullous pemphigoid (BP) in a cohort of 2,873,720 individuals with malignant cancers, when compared with a reference cohort. We calculated standardised rate ratios (RRs) based on person-years at risk, comparing the observed and expected numbers of BP cases in the cancer cohort with those in the reference cohort. Overall, the cohort of people with a record of a malignant cancer was not found to be at greater risk of concurrent or subsequent BP than the cohort of people without a record of a malignant cancer (RR 0.96, 95 % CI 0.88-1.04), although elevated risks of BP were found in sub-cohorts of people with either kidney cancer, laryngeal cancer or lymphoid leukaemia. We also similarly analysed the risk of concurrent and subsequent malignant cancers in a cohort of people with a principal diagnosis of BP, and again found no increased risk as compared with the reference cohort (RR 1.00, 95 % CI 0.92-1.09).
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Increase in emergency admissions to hospital for children aged under 15 in England, 1999-2010: national database analysis.
Arch. Dis. Child.
PUBLISHED: 02-11-2013
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To investigate a reported rise in the emergency hospital admission of children in England for conditions usually managed in the community.
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Associations between selected immune-mediated diseases and tuberculosis: record-linkage studies.
BMC Med
PUBLISHED: 02-04-2013
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Previous studies have suggested that there may be an association between some immune-mediated diseases and risk of tuberculosis (TB).
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Mortality from meningococcal disease by day of the week: English national linked database study.
J Public Health (Oxf)
PUBLISHED: 02-01-2013
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There are concerns that quality of medical care may be poorer on weekends than weekdays. Invasive meningococcal disease, comprising septicaemia and meningitis, is often life threatening unless it is immediately and effectively treated regardless of day of the week. We test the hypothesis that numbers of deaths from meningococcal disease outside hospital without admission, and case fatality rates (CFRs) following admission, did not differ between weekends and weekdays.
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Career choices of the United Kingdom medical graduates of 2005, 2008 and 2009: questionnaire surveys.
Med Teach
PUBLISHED: 01-29-2013
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To compare specialty choices of the UK medical graduates of 2005, 2008 and 2009, one year after graduation, with those of graduates from previous years and with the distribution of senior medical practitioners working in England.
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Career choices for cardiology: cohort studies of UK medical graduates.
BMC Med Educ
PUBLISHED: 01-21-2013
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Cardiology is one of the most popular of the hospital medical specialties in the UK. It is also a highly competitive specialty in respect of the availability of higher specialty training posts. Our aims are to describe doctors early intentions about seeking careers in cardiology, to report on when decisions about seeking a career in cardiology are made, to compare differences between men and women doctors in the choice of cardiology, and to compare early career choices with later specialty destinations.
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Views of UK-trained medical graduates of 1999-2009 about their first postgraduate year of training: national surveys.
BMJ Open
PUBLISHED: 01-01-2013
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In the UK, doctors first year of medical work is also their first year of postgraduate training. It is very important that their experience of work and training is good.
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Cardiovascular fitness as a risk factor for amyotrophic lateral sclerosis: indirect evidence from record linkage study.
J. Neurol. Neurosurg. Psychiatr.
PUBLISHED: 11-09-2011
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Amyotrophic lateral sclerosis (ALS) appears to be a sporadic disorder in 95% of cases. Although few personal characteristics associated with developing ALS are known, identification of those at risk is essential to any vision of early intervention. There is persistent anecdotal observation that those with ALS are premorbidly physically fitter, although such observations are susceptible to bias. Hospital admission for coronary heart disease (CHD) might serve as an objective marker of reduced cardiovascular fitness.
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Career plans and views of trainees in the Academic Clinical Fellowship Programme in England.
Med Teach
PUBLISHED: 10-26-2011
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The Academic Clinical Fellowship (ACF) programme in England was introduced in 2007 to support the training of clinical academics.
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Mortality after hospital discharge for people with schizophrenia or bipolar disorder: retrospective study of linked English hospital episode statistics, 1999-2006.
BMJ
PUBLISHED: 09-15-2011
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To investigate whether the mortality gap has reduced in recent years between people with schizophrenia or bipolar disorder and the general population.
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Career choices for public health: cohort studies of graduates from UK medical schools.
J Public Health (Oxf)
PUBLISHED: 09-12-2011
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The aim of this paper is to describe UK-trained doctors early intentions about seeking careers in public health and their eventual speciality destinations.
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Trends over time and geographical variation in rates of intravitreal injections in England.
Br J Ophthalmol
PUBLISHED: 08-28-2011
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The recent emergence of antivascular endothelial growth factor (anti-VEGF) drugs has led to increased numbers of patients undergoing intravitreal injection for age-related macular degeneration (AMD). The aims of this study were to report on trends over time and geographical variation in intravitreal injection rates in England, and consider the implications for publicly funded health services of introducing new and expensive treatments.
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Trends in doctors early career choices for general practice in the UK: longitudinal questionnaire surveys.
Br J Gen Pract
PUBLISHED: 07-05-2011
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The percentage of newly qualified doctors in the UK who want a career in general practice declined substantially in the 1990s. The English Department of Health expects that half of all doctors will become GPs.
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Quantifying urbanization as a risk factor for noncommunicable disease.
J Urban Health
PUBLISHED: 06-04-2011
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The aim of this study was to investigate the poorly understood relationship between the process of urbanization and noncommunicable diseases (NCDs) in Sri Lanka using a multicomponent, quantitative measure of urbanicity. NCD prevalence data were taken from the Sri Lankan Diabetes and Cardiovascular Study, comprising a representative sample of people from seven of the nine provinces in Sri Lanka (n?=?4,485/5,000; response rate?=?89.7%). We constructed a measure of the urban environment for seven areas using a 7-item scale based on data from study clusters to develop an "urbanicity" scale. The items were population size, population density, and access to markets, transportation, communications/media, economic factors, environment/sanitation, health, education, and housing quality. Linear and logistic regression models were constructed to examine the relationship between urbanicity and chronic disease risk factors. Among men, urbanicity was positively associated with physical inactivity (odds ratio [OR]?=?3.22; 2.27-4.57), high body mass index (OR?=?2.45; 95% CI, 1.88-3.20) and diabetes mellitus (OR?=?2.44; 95% CI, 1.66-3.57). Among women, too, urbanicity was positively associated with physical inactivity (OR?=?2.29; 95% CI, 1.64-3.21), high body mass index (OR?=?2.92; 95% CI, 2.41-3.55), and diabetes mellitus (OR?=?2.10; 95% CI, 1.58 - 2.80). There is a clear relationship between urbanicity and common modifiable risk factors for chronic disease in a representative sample of Sri Lankan adults.
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Epilepsy and the subsequent risk of cerebral tumour: record linkage retrospective cohort study.
J. Neurol. Neurosurg. Psychiatr.
PUBLISHED: 03-28-2011
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Studies suggest that seizures may precede the detection of cerebral tumour by several years. Aim To quantify the risk of cerebral tumour after new onset seizures, with particular interest in long term risk.
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Perinatal and early life risk factors for inflammatory bowel disease.
World J. Gastroenterol.
PUBLISHED: 03-11-2011
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To investigate associations between perinatal risk factors and subsequent inflammatory bowel disease (IBD) in children and young adults.
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Maternal and perinatal factors associated with hospitalised infectious mononucleosis in children, adolescents and young adults: record linkage study.
BMC Infect. Dis.
PUBLISHED: 02-28-2011
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There is current interest in the role of perinatal factors in the aetiology of diseases that occur later in life. Infectious mononucleosis (IM) can follow late primary infection with Epstein-Barr virus (EBV), and has been shown to increase the risk of multiple sclerosis and Hodgkins disease. Little is known about maternal or perinatal factors associated with IM or its sequelae.
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Trends in mortality from appendicitis and from gallstone disease in English populations, 1979-2006: study of multiple-cause coding of deaths.
Postgrad Med J
PUBLISHED: 02-10-2011
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To report on trends in mortality from appendicitis and from gallstone disease.
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Risk of venous thromboembolism in people admitted to hospital with selected immune-mediated diseases: record-linkage study.
BMC Med
PUBLISHED: 01-10-2011
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Venous thromboembolism (VTE) is a common complication during and after a hospital admission. Although it is mainly considered a complication of surgery, it often occurs in people who have not undergone surgery, with recent evidence suggesting that immune-mediated diseases may play a role in VTE risk. We, therefore, decided to study the risk of deep vein thrombosis (DVT) and pulmonary embolism (PE) in people admitted to hospital with a range of immune-mediated diseases.
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Geography of hospital admissions for multiple sclerosis in England and comparison with the geography of hospital admissions for infectious mononucleosis: a descriptive study.
J. Neurol. Neurosurg. Psychiatr.
PUBLISHED: 01-06-2011
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It is well recognised that variation in the geographical distribution of multiple sclerosis (MS) exists. Early studies in England have shown the disease to have been more common in the North than the South. However, this could be an artefact of inaccurate diagnosis and ascertainment, and recent data on MS prevalence are lacking. In the present study, data were analysed to provide a more contemporary map of the distribution of MS in England and, as infectious mononucleosis (IM) has been shown to be associated with the risk of MS, the geographical distribution of IM with that of MS was compared.
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Birth order and childhood type 1 diabetes risk: a pooled analysis of 31 observational studies.
Int J Epidemiol
PUBLISHED: 12-10-2010
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The incidence rates of childhood onset type 1 diabetes are almost universally increasing across the globe but the aetiology of the disease remains largely unknown. We investigated whether birth order is associated with the risk of childhood diabetes by performing a pooled analysis of previous studies.
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Adolescent inpatient psychiatric admission rates and subsequent one-year mortality in England: 1998-2004.
J Child Psychol Psychiatry
PUBLISHED: 08-27-2010
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Adolescence is a time of very rapid change not only in physical but also psychological development. During the teenage years there is a reported rise in the prevalence of psychiatric disorders. The aim of this study was to investigate age- and sex-specific National Health Service (NHS) hospital inpatient admission rates for psychiatric conditions in adolescents in England, and to examine their mortality within one year of discharge.
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Medical graduates early career choices of specialty and their eventual specialty destinations: UK prospective cohort studies.
BMJ
PUBLISHED: 07-08-2010
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To report on doctors early choices of specialty at selected intervals after qualification, and eventual career destinations.
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Trends in corneal graft surgery in the UK.
Br J Ophthalmol
PUBLISHED: 06-27-2010
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The aims of this study were to examine trends over time and regional variation in rates of corneal graft surgery in the UK.
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Views of junior doctors about whether their medical school prepared them well for work: questionnaire surveys.
BMC Med Educ
PUBLISHED: 06-25-2010
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The transition from medical student to junior doctor in postgraduate training is a critical stage in career progression. We report junior doctors views about the extent to which their medical school prepared them for their work in clinical practice.
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Early career choices and successful career progression in surgery in the UK: prospective cohort studies.
BMC Surg
PUBLISHED: 05-27-2010
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Changes to the structure of medical training worldwide require doctors to decide on their career specialty at an increasingly early stage after graduation. We studied trends in career choices for surgery, and the eventual career destinations, of UK graduates who declared an early preference for surgery.
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Influence of maternal and perinatal factors on subsequent hospitalisation for asthma in children: evidence from the Oxford record linkage study.
BMC Pulm Med
PUBLISHED: 03-16-2010
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There is much interest in the possibility that perinatal factors may influence the risk of disease in later life. We investigated the influence of maternal and perinatal factors on subsequent hospital admission for asthma in children.
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Certification of obesity as a cause of death in England 1979-2006.
Eur J Public Health
PUBLISHED: 02-02-2010
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There is increasing recognition of the importance of obesity as a cause of death but it is uncommon for obesity to be certified on death certificates. We considered it useful to study what doctors actually do in respect of certification of obesity and to study trends, if any, in certification practice.
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Hospitalized prevalence and 5-year mortality for IBD: record linkage study.
World J. Gastroenterol.
PUBLISHED: 01-27-2010
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To establish the hospitalized prevalence of severe Crohns disease (CD) and ulcerative colitis (UC) in Wales from 1999 to 2007; and to investigate long-term mortality after hospitalization and associations with social deprivation and other socio-demographic factors.
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Career destinations, views and future plans of the UK medical qualifiers of 1988.
J R Soc Med
PUBLISHED: 01-09-2010
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To report the career destinations, views and future plans of a cohort of senior doctors who qualified in the 1980s.
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Head and other physical trauma requiring hospitalisation is not a significant risk factor in the development of ALS.
J. Neurol. Sci.
PUBLISHED: 09-19-2009
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The pathogenesis of ALS is not fully understood but, as an overwhelmingly sporadic disorder, it is likely to result from a complex mixture of polygenic and environmental risk factors operating in the context of an ageing nervous system. Physical trauma, in particular head injury, has been variably associated with both Alzheimers and Parkinsons disease, and largely discounted in relation to multiple sclerosis. Several case-control studies in ALS have reported an association with physical trauma or head injury, but such studies are greatly limited by recall bias. The Oxford Record Linkage Study (ORLS) includes brief statistical abstracts of records of all hospital admissions, including day cases, and all deaths for a defined region of UK National Health Service hospitals. We used ORLS spanning a 36year period to study the relationship between recorded head, upper and lower limb trauma both before and after a diagnosis of ALS. Overall the adjusted rate ratio for ALS after head injury, compared with a control group, was 1.5 (95% confidence interval 1.1-2.1); but this elevation of risk was only found within the first year after injury, and we speculate that this is most likely to be a consequence of incipient ALS causing a tendency to fall. We conclude that there is no association between antecedent injury requiring hospitalisation, and the later development of ALS. The high risk of head injury observed in the immediate post-diagnosis period may be amenable to primary prevention.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.