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Find video protocols related to scientific articles indexed in Pubmed.
Indistinguishability and distinguishability between amide and ester moieties in the construction and properties of M6L8 octahedral nanocages.
Dalton Trans
PUBLISHED: 11-20-2014
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A series of 25 × 25 × 25 Å(3) octahedral coordination cages [Pd6(L)8](NO3)12 (L = L(1), ; L = L(2), ; L(1) = tris(6-quinolyl)trimesic ester; L(2) = N,N',N''-tris(6-quinolyl)-1,3,5-benzenetricarboxamide) is reported. L(1) and L(2) are indistinguishable for construction of octahedral nanocages, and thus the desirable mixed ligand nanocage comprising a statistical ligand distribution ([Pd6(L(1))n(L(2))8-n](NO3)12, ) can be efficiently constructed. However, the nanocages are distinguishable for functions such as photoluminescence (PL) and catalysis. The PL intensity is in the order ? > , wherein shows a blue emission. The nanocages show excellent catalytic activity for the C-C coupling reaction under mild conditions in the order > > , presumably owing to the spacer-functional groups.
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Improvement in skin wrinkles using a preparation containing human growth factors and hyaluronic acid serum.
J Cosmet Laser Ther
PUBLISHED: 09-27-2014
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Background: Skin aging is accompanied by wrinkle formation. At some sites, such as the periorbital skin, this is a relatively early phenomenon. Objective: We evaluated the anti-wrinkle effect of a preparation containing human growth factor and hyaluronic acid serum on periorbital wrinkles (crow's feet). Materials and methods: In total, 23 Korean women (age range: 39-59 years), who were not pregnant, nursing, or undergoing any concurrent therapy, were enrolled in this study. All the patients completed an 8-week trial of twice-daily application of human growth factor and hyaluronic acid serum on the entire face. Efficacy was based on a global photodamage score, photographs, and image analysis using replicas and visiometer analysis every 4 weeks. The standard wrinkle and roughness parameters used in assessing skin by visiometer were calculated and statistically analyzed. Results: Periorbital wrinkles were significantly improved after treatment, with improvements noted both by physician's assessment and visiometer analysis. Conclusion: Topical application of human growth factor and hyaluronic acid was beneficial in reducing periorbital wrinkles.
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One-step isolation of sappanol and brazilin from Caesalpinia sappan and their effects on oxidative stress-induced retinal death.
BMB Rep
PUBLISHED: 09-25-2014
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Caesalpinia sappan is a well-distributed plant that is cultivated in Southeast Asia, Africa, and the Americas. C. sappan has been used in Asian folk medicine and its extract has been shown to have pharmacological effects. Two homoisoflavonoids, sappanol and brazilin, were isolated from C. sappan by using centrifugal partition chromatography (CPC), and tested for protective effects against retinal death. The isolated homoisoflavonoids produced approximately 20-fold inhibition of N-retinylidene-N-retinyl-ethanolamine (A2E) photooxidation in a dose-dependent manner. Of the 2 compounds, brazilin showed better inhibition (197.93 ± 1.59 ?M of IC50). Cell viability tests and PI/Hoechst 33342 double staining method indicated that compared to the negative control, sappanol significantly attenuated H2O2-induced retinal death. The compounds significantly blunted the up-regulation of intracellular reactive oxygen species (ROS), and sappanol inhibited lipid peroxidation in a concentration-dependent manner. Thus, both compounds represent potential antioxidant treatments for retinal diseases.
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Bioequivalence Comparison of Two Formulations of Fixed-Dose Combination Glimepiride/Metformin (2/500 mg)Tablets in Healthy Volunteers.
Iran J Pharm Res
PUBLISHED: 09-20-2014
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Glimepiride/metformin (2/500 mg) is an oral antihyperglycemic agent for the treatment of type 2 diabetes. A generic glimepiride/metformin (2/500 mg) fixed-dose combination (FDC) tablet was developed recently. This study was designed to collect data for submission to Korean regulatory authorities to allow the marketing of the test formulation. We evaluated the comparative bioavailability and tolerability of the test and reference formulations in healthy male adult volunteers. This single-dose, randomized, double-blind, two-way crossover trial was conducted at Bestian Medical Center in Bucheon, Korea. In total, 40 male Korean volunteers were enrolled. The subjects were randomized to receive an FDC tablet containing the glimepiride/metformin (2/500 mg) test or reference formulation, and pharmacokinetic(PK) parameters were measured. After a 1-week washout period, the other formulation was administered and the PK parameters were measured again. The Cmax and AUCt were determined from blood samples obtained at 0, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 5, 6, 8, 12, and 24 h after drug administration. Bioequivalence was considered established if the 90% CIs of the geometric mean ratios(GMRs) of the test-to-reference formulations for Cmax and AUCt were within the predetermined regulatory range of 80-125%. In total, 40 healthy male subjects were enrolled and completed the study (mean [SD] age, 23.2[2.26]years[range, 19-30years];weight, 68.95[8.30]Kg[range, 52.0-87.0 Kg]; and height, 175.4[5.34] cm[range, 164-189 cm]). The GMRs(90% CI) of the glimepiride Cmax and AUCt were 1.006(0.947-1.069) and 1.010(0.953-1.071), respectively. For metformin, the values were 1.019(0.959-1.083) and 1.035(0.989-1.084), respectively. The test and reference formulations had similar PK parameters. The test formulation of glimepiride/metformin (2/500 mg) FDC tablets met the Korean regulatory criteria for bioequivalence.
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Effects of Acupuncture at GB20 on CO2 Reactivity in the Basilar and Middle Cerebral Arteries During Hypocapnia in Healthy Participants.
J Altern Complement Med
PUBLISHED: 09-16-2014
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Abstract Objectives: The acupoint GB20 is known to affect vertebrobasilar blood flow regulation. However, no previous study has used transcranial Doppler imaging to examine whether acupuncture at GB20 has a selective effect on blood flow in various cerebral arteries, such as the basilar artery (BA) and the middle cerebral arteries (MCAs). Therefore, this study sought to determine the specific effects of GB20 acupuncture on cerebral blood flow (CBF).
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Clinicopathologic characteristics and surgical outcomes of elderly patients with thyroid cancer.
Jpn. J. Clin. Oncol.
PUBLISHED: 09-08-2014
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Age is one of the important prognostic factors in thyroid cancer, and old age is generally related to higher rate of post-operative morbidity and mortality. The study analyzed the characteristics of thyroid cancer in elderly patients compared with those in younger patients.
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Comparison of abdominal ultrasonographic findings with endoscopic ultrasonographic findings of solid pseudopapillary neoplasms of the pancreas.
Ultrasound Q
PUBLISHED: 08-23-2014
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To compare abdominal ultrasonographic (AU) findings with endoscopic ultrasonographic (EUS) findings of solid pseudopapillary neoplasm (SPN) of the pancreas, 13 patients (male-to-female ratio, 3:10; mean age, 36 years) with surgically proven SPN who underwent both preoperative AU and EUS were included in the study. Ultrasonographic findings of the 2 modalities were compared according to internal echogenicity, calcification, demarcation, internal septum, and main pancreatic duct dilatation. Nine cases showed hypoechogenicity on both AU and EUS. The remaining 4 cases showed different echogenicity on both modalities as follows: hypoechogenicity (n = 2) and isoechogenicity (n = 2) on AU; and hyperechogenicity (n = 1), poor visualization of internal architecture due to dense rim calcification (n = 2), and isoechogenicity (n = 1) on EUS. In 2 cases with dense rim calcification, evaluation of the internal contents was more difficult on EUS compared with AU. In addition, central punctate calcifications of 2 cases were well visualized on both AU and EUS, but the 1 case of peripheral calcification was only seen on EUS. All cases showed good demarcation without main pancreatic ductal dilatation or internal septa. Endoscopic ultrasonography was superior to AU for the evaluation of internal echogenicity of pancreatic SPN; however, AU was superior at evaluating larger tumors and tumors with dense rim calcification.
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The effect of baicalin in a mouse model of retinopathy of prematurity.
BMB Rep
PUBLISHED: 08-20-2014
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Baicalin is a flavonoid derived from the dried root of Scutellaria baicalensis. In this study, oxygen-induced retinopathy was used to characterize the anti-angiogenic properties of baicalin in mice. Pups were exposed to a hyperbaric oxygen environment to induce retinal angiogenesis and were subjected to intraperitoneal injection of baicalin. Avascular area, neovascular tufts, and neovascular lumens were quantified from digital images. Compared to the vehicle, baicalin clearly reduced the central avascular zone and the number of neovascular tufts and lumens. High-dose baicalin (10 mg/kg) significantly reduced the expression of matrix metalloproteinase-2 (MMP-2), MMP-9, angiotensin II, and vascular endothelial growth factor (VEGF). These results show that baicalin is a powerful antiangiogenic compound that attenuates new vessel formation in the retina after systemic administration, and is a candidate substance for therapeutic inhibition of retinal angiogenesis.
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Expression of microRNA miR-126 and miR-200c is associated with prognosis in patients with non-small cell lung cancer.
Virchows Arch.
PUBLISHED: 08-16-2014
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MicroRNAs (miRNAs) are short non-coding RNAs that exert a critical influence on tumorigenesis through post-transcriptional modification and are considered to be potential biomarkers for the diagnosis or prognosis of various cancers. Although several miRNAs have been proposed as relevant biomarkers for non-small cell lung cancer (NSCLC), detailed working mechanisms and validated prognostic significance of these miRNAs remain controversial. In this study, we evaluated expression levels of miRNA-126 (miR-126) and miR-200c in 72 NSCLCs and 30 benign lung tissues by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and analyzed the correlation of miRNA expression with a variety of clinicopathological factors and patient survival. Compared with the benign control group, miR-126 expression was significantly downregulated in NSCLCs (p?3 cm (p?=?0.026). There were no other significant associations between miRNA expression and clinicopathological features. In univariate survival analysis for all NSCLC patients, high miR-200c expression (p?=?0.037), large tumor size (p?=?0.026), and lymphovascular invasion (p?=?0.012) were significantly correlated with worse overall survival. High miR-126 expression was significantly associated with favorable prognosis only in patients with adenocarcinoma (p?=?0.033). In multivariate analysis, miR-200c and tumor size remained as independent prognostic factors. Our results suggest that miR-126 might play tumor-suppressive and miR-200c an oncogenic role, and these miR's are potential prognostic biomarkers for NSCLC.
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Expression of receptor activator of nuclear factor kappa-B as a poor prognostic marker in breast cancer.
J Surg Oncol
PUBLISHED: 08-11-2014
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Receptor activator of nuclear factor kappa-B and its ligand (RANK/RANKL) and Osteoprotegerin (OPG) are key molecules for regulating osteoclastic activity in bone. However, little is known about the role of RANK-related molecules in breast cancer prognosis. We aimed to evaluate RANK, RANKL, and OPG expression and the associated clinical impact in breast cancer.
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Expression of the brother of the regulator of imprinted sites gene in the sputum of patients with lung cancer.
Korean J Thorac Cardiovasc Surg
PUBLISHED: 08-05-2014
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Brother of the regulator of imprinted sites (BORIS) is a putative new oncogene that is classified as a cancer germline gene; however, its role in the development of cancer is unclear. This study investigated the expression of BORIS in lung cancer and its clinical implications.
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Pyrolysis and co-pyrolysis of Laminaria japonica and polypropylene over mesoporous Al-SBA-15 catalyst.
Nanoscale Res Lett
PUBLISHED: 08-01-2014
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The catalytic co-pyrolysis of a seaweed biomass, Laminaria japonica, and a typical polymer material, polypropylene, was studied for the first time. A mesoporous material Al-SBA-15 was used as a catalyst. Pyrolysis experiments were conducted using a fixed-bed reactor and pyrolysis gas chromatography/mass spectrometry (Py-GC/MS). BET surface area, N2 adsorption-desorption isotherms, and NH3 temperature programmed desorption were measured to examine the catalyst characteristics. When only L. japonica was pyrolyzed, catalytic reforming slightly increased the gas yield and decreased the oil yield. The H2O content in bio-oil was increased by catalytic reforming from 42.03 to 50.32 wt% due to the dehydration reaction occurring on the acid sites inside the large pores of Al-SBA-15. Acids, oxygenates, mono-aromatics, poly aromatic hydrocarbons, and phenolics were the main components of the bio-oil obtained from the pyrolysis of L. japonica. Upon catalytic reforming over Al-SBA-15, the main oxygenate species 1,4-anhydro-d-galactitol and 1,5-anhydro-d-manitol were completely removed. When L. japonica was co-pyrolyzed with polypropylene, the H2O content in bio-oil was decreased dramatically (8.93 wt% in the case of catalytic co-pyrolysis), contributing to the improvement of the oil quality. A huge increase in the content of gasoline-range and diesel-range hydrocarbons in bio-oil was the most remarkable change that resulted from the co-pyrolysis with polypropylene, suggesting its potential as a transport fuel. The content of mono-aromatics with high economic value was also increased significantly by catalytic co-pyrolysis.
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Development of a population pharmacokinetic model to describe olmesartan medoxomil/ hydrochlorothiazide (20/12.5 mg) FDC tablet in male healthy South Korean subjects.
Int J Clin Pharmacol Ther
PUBLISHED: 07-31-2014
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The objective of the present study was to develop population pharmacokinetic models for olmesartan medoxomil and hydrochlorothiazide and to investigate the influence of demographic factors on these population pharmacokinetics.
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Dysregulated microRNA expression in adenocarcinoma of the uterine cervix: Clinical impact of miR-363-3p.
Gynecol. Oncol.
PUBLISHED: 07-14-2014
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Adenocarcinoma (ACA) of the uterine cervix is increasing in incidence and currently accounts for approximately 20% of all cervical malignancies. MicroRNAs (miRNAs) have been investigated as potential biomarkers of cervical cancer; however, their role in ACA remains unknown. Here, we characterized miRNA expression profiles and investigated miRNAs as diagnostic and prognostic factors in ACA.
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Effect of ST36 Acupuncture on Hyperventilation-Induced CO 2 Reactivity of the Basilar and Middle Cerebral Arteries and Heart Rate Variability in Normal Subjects.
Evid Based Complement Alternat Med
PUBLISHED: 07-14-2014
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This study was conducted to verify the effect of acupuncture on cerebral haemodynamics to provide evidence for the use of acupuncture treatment as a complementary therapy for the high-risk stroke population. The effect of ST36 acupuncture treatment on the hyperventilation-induced CO2 reactivity of the basilar and middle cerebral arteries was studied in 10 healthy male volunteers (mean age, 25.2 ± 1.5 years) using a transcranial Doppler sonography with an interval of 1 week between measurements, and a portable ECG monitoring system was used to obtain ECG data simultaneously. The CO2 reactivity of the basilar and middle cerebral arteries increased significantly after ST36 acupuncture treatment, whereas the mean arterial blood pressure and pulse rate did not change significantly. The high-frequency power significantly increased after ST36 acupuncture treatment, and the percentage increase of high-frequency power correlated significantly with the percentage increase in the CO2 reactivity of the contralateral middle cerebral artery. These data suggest that ST36 acupuncture treatment increases CO2 reactivity, indicating improvement of vasodilatory potential of the cerebral vasculature to compensate for fluctuations caused by changes in external conditions. The increase in parasympathetic tone by ST36 acupuncture treatment is responsible for this therapeutic effect.
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Risk factors associated with germinal matrix-intraventricular hemorrhage in preterm neonates.
J Korean Neurosurg Soc
PUBLISHED: 06-26-2014
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The purpose of this study is to identify the risk factors associated with the development of germinal matrix-intraventricular hemorrhage (GM-IVH) and the relationship of the severity of disease and prematurity.
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Tetramethylpyrazine, a natural alkaloid, attenuates pro-inflammatory mediators induced by amyloid ? and interferon-? in rat brain microglia.
Eur. J. Pharmacol.
PUBLISHED: 06-19-2014
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Neuroinflammation has been consistently reported as a pathological hallmark of Alzheimer?s disease and other neurodegenerative diseases. Microglial cells are activated by diverse pathological stimuli and play key roles in development of neuroinflammation. Amyloid ? peptide (A?), the major constituent of amyloid plaques in Alzheimer?s brain, is known to activate cultured microglial cells to produce increased amounts of proinflammatory and neurotoxic factors. Tetramethylpyrazine (TMP) is the main bioactive alkaloid isolated from Ligusticum chuanxiong. TMP has multiple pharmacological activities, including anti-oxidant, anti-inflammatory, and anti-cancer effects. Neuroprotective potential of TMP has been demonstrated in animal models of neuropathologies. However, the efficacy of this compound for controlling A?-related neuropathology has not been explored yet. We examined the efficacy of TMP in the repression of inflammatory response in cultured microglial cells stimulated with A?25-35 in the presence of interferon (IFN)-?. TMP significantly inhibited the A?25-35 and IFN-?-stimulated productions of nitric oxide, tumor necrosis factor (TNF)-?, interleukin (IL)-1?, monocyte chemoattractant protein-1, and intracellular reactive oxygen species from primary microglial cells. TMP also effectively reduced A?25-35 and IFN-?-elicited NF-?B activation. In organotypic hippocampal slice cultures (OHSCs), TMP significantly blocked A?25-35-induced reactive oxygen species generation and phosphorylation of Akt. Furthermore, TMP also inhibited A?1-42-induced TNF-? and IL-1? production in primary microglial cells and neuronal death in OHSCs. These results suggest that TMP provide a possible therapeutic approach for alleviating the inflammatory progression of Alzheimer?s disease.
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Does papillary thyroid carcinoma have a better prognosis with or without Hashimoto thyroiditis?
Int. J. Clin. Oncol.
PUBLISHED: 06-17-2014
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It has been reported that the BRAF (V600E) mutation is related to a low frequency of background Hashimoto thyroiditis (HT); however, there are not many factors known to be related to the development of HT. The aim of this study was to determine whether patients with both papillary thyroid carcinoma (PTC) and HT show aggressive features, by investigating the clinicopathological features of HT in patients with PTC.
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Truncated trigonal prismatic tubular crystals consisting of a zeolite L-mimic metal-organic framework.
Chem. Commun. (Camb.)
PUBLISHED: 05-31-2014
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Research on the construction, crystal morphology, and functions of a novel zeolite L-mimic metal-organic framework (ZLMOF) was carried out. Treatment of the tubular crystals with AgBF4 in acetone at 40 °C smoothly coated the surface of the ZLMOF crystals with silver(0) nanoparticles.
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Fertility preservation by photodynamic therapy combined with conization in young patients with early stage cervical cancer: a pilot study.
Photodiagnosis Photodyn Ther
PUBLISHED: 05-30-2014
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Vaginal radical trachelectomy (VRT) is the standard fertility preserving procedure for early stage cervical cancer patients. There have been reports in the literature, however, that VRT to be too radical procedure for early stage cervical cancer, as its post-operative obstetric morbidity was high. In this study, PDT with Loop electrosurgical excision procedure (LEEP) or conization was investigated as a less radical fertility preserving treatment alternative to VRT for early stage cervical cancer patients.
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Characteristics of BRCA1/2 Mutation-Positive Breast Cancers in Korea: A Comparison Study Based on Multicenter Data and the Korean Breast Cancer Registry.
J Breast Cancer
PUBLISHED: 05-14-2014
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Mutations in BRCA genes are the main cause of hereditary breast cancer in Korea. The aim of this study was to investigate the characteristics of breast cancers involving BRCA1 (BRCA1 group) and BRCA2 (BRCA2 group) mutations.
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Electrochemical properties of chemically processed SiO x as coating material in lithium-ion batteries with Si anode.
ScientificWorldJournal
PUBLISHED: 04-07-2014
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A SiO x coating material for Si anode in lithium-ion battery was processed by using SiCl4 and ethylene glycol. The produced SiO x particles after heat treatment at 725°C for 1 h were porous and irregularly shaped with amorphous structure. Pitch carbon added to SiO x was found to strongly affect solid electrolyte interphase stabilization and cyclic stability. When mixed with an optimal amount of 30 wt% pitch carbon, the SiO x showed a high charge/discharge cyclic stability of about 97% for the 2nd to the 50th cycle. The initial specific capacity of the SiO x was measured to be 1401?mAh/g. On the basis of the evaluation of the SiO x coating material, the process utilized in this study is considered an efficient method to produce SiO x with high performance in an economical way.
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Secretome profiling reveals the signaling molecules of apoptotic HCT116 cells induced by the dietary polyacetylene gymnasterkoreayne B.
J. Agric. Food Chem.
PUBLISHED: 03-07-2014
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Dietary polyacetylenes from various foods have been receiving attention as promising cancer chemopreventive agents. However, until now, the detailed molecular mechanism and the regulatory proteins underlying these effects have not been elucidated. We investigated the effects of gymnasterkoreayne B (GKB), a model dietary polyacetylene from wild vegetables, on the programmed cell death of HCT116 human colorectal cancer cells. GKB inhibited HCT116 cell proliferation by inducing apoptotic cell death. GKB treatment resulted in ROS accumulation, leading to the activation of both intrinsic and extrinsic apoptotic pathway. We also found that FN1, TGFB1, APP, SERPINE1, HSPD1, SOD1, TXN, and ACTN4 may act as secretory signaling molecules during GKB-induced apoptotic cell death using LC-MS/MS identification followed by spectrum counting, statistical calculation, and gene ontology analysis. The secretory proteins suggested in this study may be promising candidates involved in apoptotic cell death of cancer cells induced by GKB that warrant further functional study.
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The role of diffusion-weighted magnetic resonance imaging in the treatment response evaluation of hepatocellular carcinoma patients treated with radiation therapy.
Int. J. Radiat. Oncol. Biol. Phys.
PUBLISHED: 02-09-2014
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We investigated the role of diffusion-weighted magnetic resonance imaging (DW MRI) as a response evaluation indicator for hepatocellular carcinoma (HCC) treated with radiation therapy (RT).
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Baicalin attenuates laser-induced choroidal neovascularization.
Curr. Eye Res.
PUBLISHED: 02-06-2014
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To determine whether intravitreally-injected baicalin inhibits the growth of choroidal neovascularization (CNV) experimentally induced via laser photocoagulation through analysis of angiogenic factors.
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Comparing the Effects of Kamikihito in Japan and Kami-Guibi-Tang in Korea on Memory Enhancement: Working Towards the Development of a Global Study.
Phytother Res
PUBLISHED: 02-05-2014
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Traditional medicine is widely used in East Asia, and studies that demonstrate its usefulness have recently become more common. However, formulation-based studies are not globally understood because these studies are country-specific. There are many types of formulations that have been introduced to Japan and Korea from China. Establishing whether a same-origin formulation has equivalent effects in other countries is important for the development of studies that span multiple countries. The present study compared the effects of same-origin traditional medicine used in Japan and Korea in an in vivo experiment. We prepared drugs that had the same origin and the same components. The drugs are called kamikihito (KKT) in Japan and kami-guibi-tang (KGT) in Korea. KKT (500?mg extract/kg/day) and KGT (500?mg extract/kg/day) were administered to ddY mice, and object recognition and location memory tests were performed. KKT and KGT administration yielded equivalent normal memory enhancement effects. 3D-HPLC showed similar, but not identical, patterns of the detected compounds between KKT and KGT. This comparative research approach enables future global clinical studies of traditional medicine to be conducted through the use of the formulations prescribed in each country. Copyright © 2014 John Wiley & Sons, Ltd.
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Aglycosylated full-length IgG antibodies: steps toward next-generation immunotherapeutics.
Curr. Opin. Biotechnol.
PUBLISHED: 02-05-2014
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Albeit the removal of Asn297 glycans of IgG perturbs the overall conformation and flexibility of the IgG CH2 domain, resulting in the loss of Fc-ligand interactions and therapeutically critical immune effector functions, aglycosylated full-length IgG antibodies are nearly identical to the glycosylated counterparts in terms of antigen binding, stability at physiological or low temperature conditions, pharmacokinetics, and biodistribution. To bypass the drawbacks of glycosylated antibodies that include glycan heterogeneity and requirement of high capital investment for biomanufacturing, aglycosylated antibodies have been developed and several are under clinical trials. Comprehensive cellular and bioprocess engineering has enabled to produce highly complex aglycosylated IgGs in a simple bacterial cultivation with comparable production level as that of mammalian cells. Moreover, extensive engineering of aglycosylated Fc has converted the aglycosylated IgG antibodies into a new class of effector functional human immunotherapeutics.
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Hydroxycinnamic acids in Crepidiastrum denticulatum protect oxidative stress-induced retinal damage.
J. Agric. Food Chem.
PUBLISHED: 01-30-2014
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We investigated the effects of an ethanol extract of C. denticulatum (EECD) in a mouse model of glaucoma established by optic nerve crush (ONC), and found that EECD significantly protected against retinal ganglion cell (RGC) death caused by ONC. Furthermore, EECD effectively protected against N-methyl-d-aspartate-induced damage to the rat retinas. In vitro, EECD attenuated transformed retinal ganglion cell (RGC-5) death and significantly blunted the up-regulation of apoptotic proteins and mRNA level induced by 1-buthionine-(S,R)-sulfoximine combined with glutamate, reduced reactive oxygen species production by radical species, and inhibited lipid peroxidation. The major EECD components were found to be chicoric acid and 3,5-dicaffeoylquinic acid (3,5-DCQA) that have shown beneficial effects on retinal degeneration both in vitro and in vivo studies. Thus, EECD could be used as a natural neuroprotective agent for glaucoma, and chicoric acid and 3,5-DCQA as mark compounds for the development of functional food.
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8-hydrocalamenene, derived from Reynoutria elliptica, suppresses constitutive STAT3 activation, inhibiting proliferation and enhancing chemosensitization of human multiple myeloma cells.
J Med Food
PUBLISHED: 01-29-2014
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The identification of the active compounds of herbal medicines and the molecular targets of those compounds is an attractive therapeutic objective. Reynoutria elliptica has been used for the treatment of various inflammatory diseases as a Korean folk remedy. Based on the evidence that anti-inflammatory agents frequently exert antiproliferative activity, we tested two sesquiterpene derivatives, 8-hydrocalamenene (HC) and 8,14-dihydrocalamenene (DHC), for their ability to induce apoptosis and suppress signal transducer and activator of transcription 3 (STAT3) activation in multiple myeloma (MM) U266 cells. We found that HC inhibited cell viability in U266, but not in peripheral blood mononuclear cells. HC exerted significant cytotoxicity and induced substantial subG1-phase arrest and apoptosis as compared with DHC. HC inhibited the expression of gene products involved in antiapoptosis (Bcl-2 and Bcl-xL), proliferation (cyclin D1), and invasion (MMP-9), all of which are known to be regulated by STAT3. Furthermore, HC up-regulated cyclin-dependent kinase inhibitor p21 and induced apoptosis through the activation of caspase-8, -9, and -3 in U266 cells. Interestingly, HC blocked constitutive STAT3 activation through the inhibition of activation of upstream kinases Janus-like kinase 1 (JAK1), JAK2, and c-Src and up-regulated PIAS3. Deletion of STAT3 reversed cytotoxic effects and the down-regulation of cyclin D1 and c-myc by HC in MM cells. Finally, this sesquiterpene significantly synergized the cytotoxic and apoptotic effects of bortezomib in U266 cells. Taken together, these results suggest that HC is a novel blocker of STAT3 activation which may have a potential in the prevention and treatment of MM.
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Red cell distribution width as a predictor of mortality in organophosphate insecticide poisoning.
Am J Emerg Med
PUBLISHED: 01-23-2014
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Suicide by organophosphate insecticide (OPI) poisoning is a major clinical concern (predominantly in developing countries), and 200000 deaths occur annually worldwide. Red cell distribution width (RDW) has been used to predict outcome in several clinical conditions. Here, we aimed to investigate the relationship between the RDW and 30-day mortality during OPI poisoning.
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Halogen effects on photoluminescence and catalytic properties: a series of spatially arranged trimetallic zinc(II) complexes.
Dalton Trans
PUBLISHED: 01-21-2014
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Self-assembly of ZnX2 (X = Cl, Br, and I) with N,N',N''-tris(2-pyridinylethyl)-1,3,5-benzenetricarboxamide (L) as a tridentate N-donor ligand yields discrete C3-symmetric trimetallic zinc(II) complexes, [Zn3X6L(MeOH)3]. These form, via ????? interactions and NH????O=C hydrogen-bonds, an ensemble constituting a unique columnar stacking structure in an abab staggered fashion. For this series of complexes, the halogen effects on the photoluminescence, catalysis, and thermal properties were investigated. For [Zn3Cl6L(MeOH)3], a blue luminescence was observed at 462 nm (?ex = 369 nm). The transesterification catalysis showed significant halogen effects in the order [Zn3I6L(MeOH)3] > [Zn3Cl6L(MeOH)3] > [Zn3Br6L(MeOH)3] in methanol, whereas in a mixture of methanol and acetonitrile, the order was [Zn3I6L(MeOH)3] > [Zn3Br6L(MeOH)3] > [Zn3Cl6L(MeOH)3]. Such notable different effects among the three complexes might be explained by the halogens' electronic effects and dissociation properties.
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Cytokine levels of the aqueous humour in central serous chorioretinopathy.
Clin Exp Optom
PUBLISHED: 01-14-2014
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This study aimed to investigate the levels of aqueous humour cytokines in the eyes of patients with central serous chorioretinopathy (CSC), who received an intravitreal injection of bevacizumab, and to evaluate the differences in cytokine levels between bevacizumab responders and non-responders.
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Association of aqueous humor cytokines with the development of retinal ischemia and recurrent macular edema in retinal vein occlusion.
Invest. Ophthalmol. Vis. Sci.
PUBLISHED: 01-09-2014
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We evaluated the association of angiogenic and inflammatory cytokine levels in the aqueous humor with development of retinal ischemia and recurrent macular edema in retinal vein occlusion (RVO) patients.
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Sulodexide inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy.
BMB Rep
PUBLISHED: 01-08-2014
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Sulodexide is a mixed glycosaminoglycan composed of heparin and dermatan sulfate. In this study, the anti-angiogenic effect of sulodexide was investigated using an oxygen-induced retinopathy (OIR) mouse model. The retinas of sham-injected OIR mice (P17) had a distinctive central area of nonperfusion, and this area was significantly decreased in sulodexide-injected mice. The number of neovascular tufts measured by SWIFT_NV and mean neovascular lumen number were significantly decreased in sulodexide-injected mice. Hyperbaric oxygen exposure resulted in increased levels of VEGF, MMP-2 and MMP-9, and when mice were treated with sulodexide, a dose-dependent reduction in VEGF, MMP-2 and MMP-9 levels was observed. Our results clearly demonstrate the anti-angiogenic effect of sulodexide and highlight sulodexide as a candidate supplementary substance to be used for the treatment of ocular pathologies that involve neovascularization.
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Chlorogenic Acid and Coffee Prevent Hypoxia-Induced Retinal Degeneration.
J. Agric. Food Chem.
PUBLISHED: 12-20-2013
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This study explored whether chlorogenic acid (CGA) and coffee have protective effects against retinal degeneration. Under hypoxic conditions, the viability of transformed retinal ganglion (RGC-5) cells was significantly reduced by treatment with the nitric oxide (NO) donor S-nitroso-N-acetylpenicillamine (SNAP). However, pretreatment with CGA attenuated cell death in a concentration-dependent manner. In addition, CGA prevented the up-regulation of apoptotic proteins such as Bad and cleaved caspase-3. Similar beneficial effects of both CGA and coffee extracts were observed in mice that had undergone an optic nerve crush (ONC) procedure. CGA and coffee extract reduced cell death by preventing the down-regulation of Thy-1. Our in vitro and in vivo studies demonstrated that coffee and its major component, CGA, significantly reduce apoptosis of retinal cells induced by hypoxia and NO, and that coffee consumption may help in preventing retinal degeneration.
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Effect of Axillary Lymph Node Dissection after Sentinel Lymph Node Biopsy on Overall Survival in Patients with T1 or T2 Node-positive Breast Cancer: Report from the Korean Breast Cancer Society.
Ann. Surg. Oncol.
PUBLISHED: 12-07-2013
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The effect of axillary lymph node dissection (ALND) after sentinel lymph node biopsy (SLNB) in patients with clinically node-negative patients in preoperative evaluations on overall survival (OS) is uncertain. The study aimed to evaluate the difference of survival between node-positive patients who underwent SLNB alone and those who received ALND after SLNB using the Korean Breast Cancer Society registry.
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Neuroprotective effect of Chunghyuldan (Qing Xue Dan) on hypoxia-reoxygenation induced damage of neuroblastoma 2a cell lines.
Chin J Integr Med
PUBLISHED: 12-05-2013
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Chunghyuldan (CHD), a combinatorial drug that has anti-hyperlipidemic and antiinflammatory activities, has been shown to reduce infarct volume in a focal ischemia-reperfusion rat model. To explore the molecular basis of CHDs neuroprotective effect, we examined whether CHD shows a cell-protective activity and has a regulatory effect on Bax and/or B-cell leukemia/lymphoma 2 (Bcl-2) expression in mouse neuroblastoma 2a (N2a) cells subjected to hypoxia-reoxygenation (H/R).
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Preparation of carbon blacks by liquid phase plasma (LPP) process.
J Nanosci Nanotechnol
PUBLISHED: 11-20-2013
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In this study, carbon black nanoparticles were synthesized by Liquid Phase Plasma (LPP) technique; plasma generated in the organic solvent of benzene at 4.9 kV with the pulse frequency of 15 kHz and width of 5 micros transformed the carbon atoms in the solvent into carbon blacks by oxidation and reduction reactions. Graphite phase was found to be introduced into the carbon blacks without any additional processes due to the characteristics of LPP process, resulting in a higher G/D ratio of 0.92, compared to 0.83 of commercial Ketjen carbon blacks. For the performance improvement, heat treatment was employed and its parameters such as temperature and duration time were optimized in relation to the crystallinity and specific surface area of the carbon blacks. Carbon blacks heat treated at 450 degrees C in the air for 20 min were measured to have the discharge capacity of 1750 mAh/g and irreversible charging and discharging capacity ratio of 52.6%.
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Synthesis of manganese nanoparticles in the liquid phase plasma.
J Nanosci Nanotechnol
PUBLISHED: 11-12-2013
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The liquid phase plasma reduction method was applied to prepare the polycrystalline manganese nanoparticles from the solution of manganese chloride tetrahydrate. A bipolar pulsed power supply was used to generate discharge in the aqueous solutions. While large size of dendrite-shaped manganese nanoparticles were mostly observed in the initial stage and particle size decreased with discharge time. The particles were dispersed with less and less small particles by the addition of CTAB and anisotropic shapes nanoparticles were mostly observed at long time plasma-treated. Many spots could be seen in the ED pattern for polycrystalline particles.
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Gymnaster koraiensis and its major components, 3,5-di-O-caffeoylquinic acid and gymnasterkoreayne B, reduce oxidative damage induced by tert-butyl hydroperoxide or acetaminophen in HepG2 cells.
BMB Rep
PUBLISHED: 10-24-2013
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We investigated the protective effects of Gymnaster koraiensis against oxidative stress-induced hepatic cell damage. We used two different cytotoxicity models, i.e., the administration of tert-butyl hydroperoxide (t-BHP) and acetaminophen, in HepG2 cells to evaluate the protective effects of G. koraiensis. The ethyl acetate (EA) fraction of G. koraiensis and its major compound, 3,5-di-O-caffeoylquinic acid (DCQA), exerted protective effects in the t-BHP-induced liver cytotoxicity model. The EA fraction and DCQA ameliorated t-BHP-induced reductions in GSH levels and exhibited free radical scavenging activity. The EA fraction and DCQA also significantly reduced t-BHP-induced DNA damage in HepG2 cells. Furthermore, the hexane fraction of G. koraiensis and its major compound, gymnasterkoreayne B (GKB), exerted strong hepatoprotection in the acetaminophen-induced cytotoxicity model. CYP 3A4 enzyme activity was strongly inhibited by the extract, hexane fraction, and GKB. The hexane fraction and GKB ameliorated acetaminophen-induced reductions in GSH levels and protected against cell death.
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Comparison of surgical outcomes between papillary thyroid cancer patients treated with the Harmonic ACE scalpel and LigaSure Precise instrument during conventional thyroidectomy: a single-blind prospective randomized controlled trial.
J. Surg. Res.
PUBLISHED: 09-25-2013
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The aim of this study was to evaluate the safety and efficacy of thyroidectomy using the Harmonic ACE scalpel (HS) or the LigaSure Precise (LS) instrument in conventional thyroidectomy.
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Photodynamic therapy for management of cervical intraepithelial neoplasia II and III in young patients and obstetric outcomes.
Lasers Surg Med
PUBLISHED: 09-12-2013
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To evaluate the response and efficacy of photodynamic therapy (PDT) with or without loop electrosurgical excision procedure (LEEP)/conization (Cone) to preserve fertility in young patients with cervical intraepithelial neoplasia (CIN) II and III.
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Electrochemical properties of the TiO2(B) powders ball mill treated for lithium-ion battery application.
Chem Cent J
PUBLISHED: 08-31-2013
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Belt or wire shaped TiO2(B) particles were synthesized for lithium ion battery application by a hydrothermal and heat treatment process. In order to facilitate TiO2(B)/C composites fabrication, the synthesized TiO2(B) particles were crushed into smaller sizes by ball milling.
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Reversible supra-channel effects: 3D kagome structure and catalysis via a molecular array of 1D coordination polymers.
Chem. Commun. (Camb.)
PUBLISHED: 08-29-2013
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Self-assembly of CuX2 (X(-) = ClO4(-) and BF4(-)) with 2,3-bis(nicotinoyloxy)naphthalene yields a 1D loop-chain skeleton. The loop-chains form an ensemble constituting a unique 3D kagome-type structure with both hexagonal and trigonal supra-channels. The unprecedented supra-channel effects on the catalytic oxidation of 3,5-di-tert-butylcatechol to 3,5-di-tert-butylbenzoquinone were investigated.
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Bifunctional chemopreventive effects of Adenocaulon himalaicum through induction of detoxification enzymes and apoptosis.
J Med Food
PUBLISHED: 08-21-2013
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Phase II detoxification enzymes are known to play essential roles in the detoxification and elimination of activated carcinogens during tumor initiation, while apoptosis is one of the most important chemopreventive targets for inhibiting tumor promotion in cancer. In this study, we investigated the cancer chemopreventive activity of two plant extracts, the ethanolic extract of Adenocaulon himalaicum (AHE) and the butanolic fraction of AHE (AHB). Both, the AHE and AHB induced NQO1 activity and had relatively high chemoprevention indices (CI=12.4). The AHE and AHB were associated with increased NQO1 and HO-1 mRNA levels via Nrf2-ARE pathway activation. In addition, the AHB increased CYP1A1 activity through AhR-XRE pathway activation. We also found that the AHE and AHB induced apoptosis, as evidenced by phosphatidylserine externalization, an increase in the sub-G0/G1 content, chromatin condensation, poly(ADP-ribose) polymerase cleavage, and p53 induction. These data suggest that AHE and AHB act as bifunctional inducers and that their chemopreventive effects result from the biphasic induction of phase II detoxification enzymes and apoptosis. Therefore, these results suggest that A. himalaicum plant extracts have potential for use as chemopreventive agents for the prevention and/or treatment of human cancers.
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Triple-meso helices as alcohol reservoirs and discriminators: structural properties and thermal behaviors of silver(I) coordination molecular braids containing diethylbis(4-pyridyl)silanes.
Dalton Trans
PUBLISHED: 08-08-2013
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Self-assembly of silver triflate with L in alcohol solvent produces characteristic triple-meso helices [Ag3(L)3(ROH)](CF3SO3)3 (L = diethylbis(4-pyridyl)silane; R = Me, Et, n-Pr, and n-Bu) with six units in each turn. Their unit cell volumes are sensitive to the size of the coordinated alcohol molecules. An unusual "alcohol molecules at triple-meso helices" system is a characteristic reversible alcohol container and discriminator via appropriate association/dissociation. The meso helical solids are favored in the order MeOH > EtOH > n-PrOH > n-BuOH via an interaction between the silver(I) ion and the alcohol molecule. The crystals evaporate the coordinated alcohol molecules at low temperatures, and finally calcination at 600 °C produces micro-sized chaotic surface materials consisting of silver(0) without silicon(IV) oxide.
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8?-hydroxy-3-oxopimar-15-ene exerts anti-inflammatory effects by inhibiting ROS-mediated activation of the TRAF6-ASK1-p38 signaling pathway.
Immunopharmacol Immunotoxicol
PUBLISHED: 08-05-2013
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The flying squirrels droppings (Pteropus pselaphon) have been used for improving the blood circulation, arresting bleeding to treat hematological disorders, and reducing pain. Here, 8?-hydroxy-3-oxopimar-15-ene (OXO), one of main constituents of P. pselaphon, was examined for its anti-inflammatory activity in murine macrophages. We found that OXO significantly suppressed LPS-induced nitric oxide (NO) without exerting cytotoxic effects on RAW 264.7 cells. OXO inhibited the expression of LPS-induced iNOS and COX-2 protein and their mRNA in a dose-dependent manner. Also, TNF-?, IL-6, and PGE2 secretion was decreased by OXO in LPS-stimulated macrophages. These inflammatory biomarkers were attributed to the suppression of LPS-induced activation of p38 MAPK and subsequent activation of two components of AP-1 (c-Jun and c-Fos), but not of ERK, JNK, NF-?B. Moreover, OXO inhibited LPS-induced intracellular reactive oxygen species (ROS) production and co-incubation of OXO and hydrogen peroxide (H2O2) suppressed the phosphorylation of p38 in a concentration-dependent manner. In addition, OXO completely disrupted the formation of TRAF6-ASK complex in the cells. Therefore, we demonstrate here that OXO can potentially inhibit several biomarkers related to inflammation through inhibition of ROS-mediated activation of TRAF6-ASK1-p38 pathway.
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A Ball-Joint-Type Host-Guest System that Consists of Conglomerate Helical Metallacyclophanes.
Angew. Chem. Int. Ed. Engl.
PUBLISHED: 07-31-2013
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Flexible joint: The synthesis and characterization of a nanoscale ball-joint-type host-guest system are described. The system consists of unprecedented conglomerates of two distinct helical metallacyclophanes. Its structure features one ????? interaction and three NH???O?C hydrogen bonds.
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Photocatalytic degradation of methylene blue over nanosized TiO2 particles prepared using the self-propagating high-temperature synthesis method.
J Nanosci Nanotechnol
PUBLISHED: 07-26-2013
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In order to reutilize the spent metallic titanium chips, TiO2 photocatalysts were prepared using the self-propagating high-temperature synthesis (SHS) method, and were characterized by N2 gas adsorption, X-ray diffraction, and scanning electron microscope, particle size distribution. Also, their photocatalytic activities were evaluated using methylene blue as a model organic compound. It was confirmed that the crystal structure of TiO2 prepared by SHS method was relatively homogeneous powder of rutile type. Optimum conditions for photocatalytic degradation of methylene blue under UV-C irradiation were methylene blue 9.5 ppm in solution and at amount of TiO2 added of 0.02 g/L. In addition, it was found that the photocatalytic activity for methylene blue degradation over the prepared TiO2 particles was positively related with BET specific surface area.
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Nanosized CuO and ZnO catalyst supported on titanium chip for conversion of carbon dioxide to methyl alcohol.
J Nanosci Nanotechnol
PUBLISHED: 07-26-2013
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In order to reutilize spent metallic titanium chips (TC) as catalyst support or photocatalytic materials, the surface of the TC was modified by thermal treatment under air atmosphere. TC-supported nanosized CuO and ZnO catalysts were prepared by impregnation (IMP) and co-precipitation (CP) method, respectively. The catalytic activity for CO2 hydrogenation to CH3OH was investigated using a flow-typed reactor under various reaction pressures. The crystals of CuO and ZnO was well formed on TC. CO2 conversion, CH3OH selectivity, and CH3OH yield were obtained as a function of time on stream over CuO-ZnO/TC catalysts. Conversion of CO2 to CH3OH over CuO-ZnO/TC catalyst by CP method and CuO/ZnO/TC catalyst by IMP method were ca. 16% and ca. 12%, respectively. Conversion of CO2 over CuO-ZnO/TC catalyst by CP method was increased with increasing reaction temperature in the range of 15-30 atm. Maximum selectivity and yield to CH3OH over CuO-ZnO/TC at 250 degrees C were ca. 90% at 20 atm and ca. 18.2% at 30 atm, respectively.
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Synthesis and characterization of platinum(II) complexes containing spiro system.
J Nanosci Nanotechnol
PUBLISHED: 07-19-2013
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Platinum complexes [Pt(bpy)Cl2](bpy: 2,2-bipyridine) and [Pt(PT)Cl2](PT: 1,10-phenantroline) were reacted with 5,5"-(9,9-dioctyl-9H-fluorene-2,7-diyl)bis(2,2-bipyrine), bpy-spiro-bpy, to afford mono and diplatinium complexes: [(bpy)Pt(bpy-spiro-bpy)][PF6]2, [(bpy)Pt(bpy-spiro-bpy)Pt(bpy)])[PF6]4, and [(PT)Pt(bpy-spiro-bpy)])][PF6]2, which were characterized by NMR, UV/VIS, mass spectrum, and PL spectroscopy. They showed very high internal quantum yields (0.35-0.67) and emitted light in the blue region (473-520 nm). Herein, we describe the synthesis, characterization of the mono- and di-platinum complexes in detail.
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Reduction in facial hyperpigmentation after treatment with a combination of topical niacinamide and tranexamic acid: a randomized, double-blind, vehicle-controlled trial.
Skin Res Technol
PUBLISHED: 07-18-2013
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Facial hyperpigmentation occurs in multiple conditions. In addition, many Asian women desire a lighter skin color. Thus, there is a need for the development of skin lightening agents, and niacinamide and tranexamic acid (TXA) are promising candidates.
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Direct anion effects on coordination polymerizations: construction and physicochemical properties of 1D, 2D, and 3D copper(II) coordination polymers containing 1,3,5-tris(isonicotinoyloxyethyl)cyanurate.
Dalton Trans
PUBLISHED: 06-27-2013
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Investigations into the anion effects on the molecular construction of a series of CuX? (X? = BF??, ClO??, and NO??) complexes with 1,3,5-tris(isonicotinoyloxyethyl)cyanurate (L) were carried out. Suitable combinations of tridentate N-donor ligands and a variety of coordination geometries of copper(II) ions produce unique 1D, 2D, and 3D coordination polymers containing open cavities suitable for small chemical species, according to the nature of the polyatomic anions. Indeed, the anion exchangeability and catalytic effects of these polymers are strongly dependent on subtle anion differences, including solubility. Calcination of [Cu(ClO?)(L)(Me?SO)?](ClO?)·2CH?Cl? crystals preserves its crystallinity at 200 °C, and at 600 °C finally produces stick-shaped microcrystalline copper(ii) oxide.
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Development of a moment model for condensational obliteration of nanoparticle aggregates.
J Nanosci Nanotechnol
PUBLISHED: 06-13-2013
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A new method of simulating condensational obliteration in the framework of the moment method is presented. The nanoparticle size distribution was assumed to be represented by a time-evolving log-normal function during the particle growth. The rate of change in the primary particle size due to obliteration was expressed as a function of the surface growth rate and three size distribution moments. Model validation was carried out by comparing with sectional model simulations. Compared to the sectional model, the new moment model was shown to provide similar results for primary and aggregate particle growth with much less computing time.
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The synthesis of nickel nanoparticles by liquid phase plasma processing.
J Nanosci Nanotechnol
PUBLISHED: 06-13-2013
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In this work, the liquid phase plasma reduction method was applied to prepare the spherical nickel nanoparticles from the solution of nickel chloride. A bipolar pulsed power supply was used to generate discharges in the aqueous solutions. Nickel nanoparticle peaks produced by surface plasmon absorption were observed around 381 nm with electrical discharge. Spherical nickel nanoparticles were mostly observed in this study, pentagonal nanoparticles were also observed occasionally. The TEM image showed that the average particle size varied from 10 to 200 nm in diameter as discharge time was increased. Many spots could be seen in the ED pattern for polycrystalline particles.
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Bipolar pulsed electrical discharge for decomposition of methylene blue in aqueous TiO2 nanoparticle dispersions.
J Nanosci Nanotechnol
PUBLISHED: 06-13-2013
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The objective of this paper is to investigate the decomposition process of organic pollutants by liquid phase plasma. A bipolar pulsed power supply was used to generate discharges in the aqueous TiO2 nanoparticle dispersions. The applied voltage, pulse width, and frequency were 250 V, 5 micros, and 30 kHz, respectively. Properties of generated plasma were investigated by electrical and optical emission spectroscopy methods. The comparison of properties of the discharge operated with and without oxygen gas bubbling is shown. The results of electrical-discharge degradation of methylene blue showed that the decomposition rate increased with the TiO2 particle dosages. Addition of oxygen gas bubbles also increased the degradation rate of methylene blue.
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Annealing effect on the microstructure and electrochemical properties of Fe2O3/H-TiNT/FTO thin film.
J Nanosci Nanotechnol
PUBLISHED: 06-13-2013
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A layer of titanate nanotubular (H-TiNT) particles between Fe2O3 film and FTO substrate was inserted and heat-treated to improve electrochemical property of Fe2O3 for water splitting. Heat-treatment of the synthesized F2O3/H-TiNT/FTO thin film was found to significantly affect photoelectrochemical properties of the film through electrochemical impedance analysis. The film showed larger oxidation-reduction peaks of I-V characteristics and capacitive properties under UV-Vis light illumination with heat treatment temperatures during transformation of H-TiNT into anatase TiO2 phase. The overall results showed an appropriate heat treatment was a promising way to improve the electrochemical property of the photoanode film.
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Rapid destruction of the rhodamine B using TiO2 photocatalyst in the liquid phase plasma.
Chem Cent J
PUBLISHED: 06-08-2013
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Rhodamine B (RhB) is widely used as a colorant in textiles and food stuffs, and is also a well-known water tracer fluorescent. It is harmful to human beings and animals, and causes irritation of the skin, eyes and respiratory tract. The carcinogenicity, reproductive and developmental toxicity, neurotoxicity and chronic toxicity toward humans and animals have been experimentally proven. RhB cannot be effectively removed by biological treatment due to the slow kinetics. Therefore, RhB is chosen as a model pollutant for liquid phase plasma (LPP) treatment in the present investigation.
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The effect of ouhyul herbal acupuncture point injections on shoulder pain after stroke.
Evid Based Complement Alternat Med
PUBLISHED: 05-20-2013
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An effective and safe remedy for shoulder pain is needed as shoulder pain is a common complication of stroke and restricts recovery of patients. This study was carried out to evaluate the effect of Ouhyul herbal acupuncture point injection (O-API) on shoulder pain in patients with stroke. Twenty-four participants with shoulder pain after stroke were recruited and randomized to the O-API and control groups. Treatment was conducted for 2 weeks three times per week. We evaluated the effects of treatment with a numerical rating scale (NRS), painless passive range of motion (PROM) of external shoulder rotation, and the Fugl-Meyer Motor Assessment (FMMA) at baseline, each week, and 1 week after the final treatment. All measures were similar between the O-API and control groups at baseline. The O-API group showed significant improvement on the NRS compared with that in the control group after 2 weeks of treatment, and the treatment effect was maintained until the follow-up period. PROM decreased significantly in both groups, but the reduction was maintained only in the O-API group. No significant difference was observed on the FMMA between the two groups. O-API resulted in significant improvement in shoulder pain after stroke, and its effect was maintained after termination of treatment without any severe side effects.
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Feasibility of sentinel lymph node biopsy in breast cancer patients clinically suspected of axillary lymph node metastasis on preoperative imaging.
World J Surg Oncol
PUBLISHED: 05-12-2013
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Generally, sentinel lymph node biopsy (SLNB) is performed in patients with clinically negative axillary lymph node (LN). This study was to assess imaging techniques in axillary LN staging and to evaluate the feasibility of SLNB in patients clinically suspected of axillary LN metastasis on preoperative imaging techniques (SI).
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Effect of Mg ion bioactivity on the TiO2 nano-network surface.
J Nanosci Nanotechnol
PUBLISHED: 05-08-2013
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Magnesium (Mg) ion is well known for improving the Ca-P nucleation and growth. TiO2 nano-network (NT) surface was prepared by alkali-treatment. To introduce the Mg ion to TiO2 NT surface, acrylic acid plasma polymerization was used. Bioactivity of the Mg ions coated samples was evaluated by immersed in simulated body fluid (SBF). Surface morphology and chemical composition of all samples were characterized by SEM, XRD and XPS. Mg ion promotes hydroxyapatite (HA) nucleation and growth on TiO2 NT in SBF and improves crystallinity of HA deposited layer.
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Heat shock protein 70 (HSP70) expression is associated with poor prognosis in intestinal type gastric cancer.
Virchows Arch.
PUBLISHED: 04-29-2013
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Heat shock protein 70 (HSP70) is a molecular chaperone which plays an important role in cellular protection against various stressful stimuli and in the regulation of cellular growth and apoptosis. This study was conducted in gastric carcinoma (GC) to assess correlations of HSP70 expression with clinicopathological parameters and overall survival (OS). Tissue microarray blocks were constructed from 172 GCs and immunohistochemically stained for HSP70. Low HSP70 expression was found in 122 GCs (71 %), whereas 50 (29 %) had high expression. HSP70 expression was higher in tumours in the cardia (p?=?0.008), with non-signet ring cell histology (p?
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Expression of MAGE A1-6 and the clinical characteristics of papillary thyroid carcinoma.
Anticancer Res.
PUBLISHED: 04-09-2013
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The expression of melanoma-associated antigen (MAGE) gene has been studied in many types of cancer. In the present study we evaluated the correlation between MAGE expression and the clinical features and oncologic outcomes of patients with papillary thyroid cancer (PTC).
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Construction of right-handed-, left-handed-, and racemic helical coordination polymers. Enantioselective recognition using chiral helical crystals.
Chem. Commun. (Camb.)
PUBLISHED: 04-05-2013
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Infinite square-tubular helices, [CuCl2(L)(S)] (L = bis(4-pyridyl)methylvinylsilane; S = Me2SO, HCONMe2), were constructed. This helical system affords three kinds of P, M crystals in Me2SO, and racemic crystals in HCONMe2. The cyclic voltammogram (CV) technique using the M-crystals is an effective tool for discerning the chirality of proline.
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A comparison of brain activity between healthy subjects and stroke patients on fMRI by acupuncture stimulation.
Chin J Integr Med
PUBLISHED: 04-02-2013
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To investigate brain activity patterns during acupuncture in stroke patients, and to compare the result with normal subjects using functional magnetic resonance imaging (fMRI).
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Fertility preservation via photodynamic therapy in young patients with early-stage uterine endometrial cancer: a long-term follow-up study.
Int. J. Gynecol. Cancer
PUBLISHED: 03-13-2013
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We evaluated the effectiveness of photodynamic therapy (PDT) as a conservative fertility-sparing treatment in young women with early-stage endometrial cancer.
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Protective effects of the compounds isolated from the seed of Psoralea corylifolia on oxidative stress-induced retinal damage.
Toxicol. Appl. Pharmacol.
PUBLISHED: 03-06-2013
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The mechanism underlying glaucoma remains controversial, but apoptosis caused by increased levels of reactive oxygen species (ROS) is thought to play a role in its pathogenesis. We investigated the effects of compounds isolated from Psoralea corylifolia on oxidative stress-induced cell death in vitro and in vivo. Transformed retinal ganglion cells (RGC-5) were treated with l-buthione-(S,R)-sulfoximine (BSO) and glutamate in the presence or with pre-treatment with compound 6, bakuchiol isolated from P. corylifolia. We observed reduced cell death in cells pre-treated with bakuchiol. Moreover, bakuchiol inhibited the oxidative stress-induced decrease of mitochondrial membrane potential (MMP, ??m). Furthermore, while intracellular Ca(2+) was high in RGC-5 cells after exposure to oxidative stress, bakuchiol reduced these levels. In an in vivo study, in which rat retinal damage was induced by intravitreal injection of N-methyl-d-aspartate (NMDA), bakuchiol markedly reduced translocation of AIF and release of cytochrome c, and inhibited up-regulation of cleaved caspase-3, cleaved caspase-9, and cleaved PARP. The survival rate of retinal ganglion cells (RGCs) 7days after optic nerve crush (ONC) in mice was significantly decreased; however, bakuchiol attenuated the loss of RGCs. Moreover, bakuchiol attenuated ONC-induced up-regulation of apoptotic proteins, including cleaved PARP, cleaved caspase-3, and cleaved caspase-9. Bakuchiol also significantly inhibited translocation of mitochondrial AIF into the nuclear fraction and release of mitochondrial cytochrome c into the cytosol. These results demonstrate that bakuchiol isolated from P. corylifolia has protective effects against oxidative stress-induced retinal damage, and may be considered as an agent for treating or preventing retinal degeneration.
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Computed tomography findings for predicting severe acute hepatitis with prolonged cholestasis.
World J. Gastroenterol.
PUBLISHED: 02-19-2013
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To evaluate the significance of computed tomography (CT) findings in relation to liver chemistry and the clinical course of acute hepatitis.
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Bee venom acupuncture point injection for central post stroke pain: a preliminary single-blind randomized controlled trial.
Complement Ther Med
PUBLISHED: 02-07-2013
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We investigated apipuncture, or acupuncture point injection with diluted bee venom, as a promising new treatment for central post stroke pain (CPSP).
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