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Find video protocols related to scientific articles indexed in Pubmed.
Altered profile of circulating microparticles in Rheumatoid Arthritis patients.
Clin. Sci.
PUBLISHED: 10-23-2014
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Microparticles (MPs) could be considered biomarkers of cell damage and activation as well as novel signaling structures. Since Rheumatoid Arthritis (RA) is characterized by immune and endothelial activation, the main aim of this study was to analyze MP counts in RA patients. Citrated-blood samples were obtained from 114 RA patients, 33 healthy controls (HC) and 72 individuals with marked cardiovascular (CV) risk without autoimmune manifestations (CVR). MPs were analyzed in platelet-poor plasma and different subsets were identified by their surface markers: platelet- (CD41+), endothelial- (CD146+), granulocyte- (CD66+), monocyte- (CD14+) and Tang-derived (CD3+CD31+). Disease activity (DAS28), clinical and immunological parameters as well as traditional CV risk factors (diabetes, hypertension, dyslipidemia, and obesity) were registered from clinical records and all data were integrated using Principal Component Analysis. Absolute MP number was increased in RA patients compared to HC and positively correlated with traditional CV risk factors, similar to that of CVR subjects. In addition, frequency of the different MP subsets was different in RA patients and significantly associated to disease features. Moreover, in vitro assays revealed that MPs isolated from RA patients were able to promote endothelial activation and exhibited detrimental effects on HMEC-I endothelial cell functionality. Circulating MPs from RA patients displayed quantitative and qualitative alterations that are the result of both disease-specific and traditional CV risk factors. Accordingly, this MP pool exhibited in vitro detrimental effects on endothelial cells, thus supporting their role as biomarkers of vascular damage.
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T2238C ANP gene variant and risk of recurrent acute coronary syndromes in an Italian cohort of ischemic heart disease patients.
J Cardiovasc Med (Hagerstown)
PUBLISHED: 09-25-2014
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The role of C2238/atrial natriuretic peptide (ANP) minor allele, at the T2238C ANP gene variant, as a predisposing risk factor for acute cardiovascular events, has been previously reported. We aimed at evaluating, by a retrospective approach, the long-term impact of C2238/ANP-minor allele carrier status toward the risk of recurrent acute coronary syndromes (re-ACS) in an Italian cohort of ischemic heart disease patients.
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Red cell distribution width is associated with cardiovascular risk and disease parameters in rheumatoid arthritis.
Rheumatology (Oxford)
PUBLISHED: 09-21-2014
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Since red cell distribution width (RDW) has been associated with cardiovascular (CV) disease and inflammation in several conditions, the main aim of this study was to evaluate its prognostic value in RA patients and its potential associations with clinical features.
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Promoting social-emotional learning in adolescent latino ells: A study of the culturally adapted strong teens program.
Sch Psychol Q
PUBLISHED: 04-09-2014
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The current study evaluated the effects of the culturally adapted Jóvenes Fuertes (Strong Teens) Social-Emotional Learning (SEL) program on the social-emotional outcomes of Latino English language learners (ELLs). A quasi-experimental design with random assignment by classrooms was used to assess the intervention's effects on students' knowledge of SEL and resiliency. A sample of 102 Spanish-dominant Latino ELLs enrolled in middle or high school participated in this study. The results indicated significant intervention effects on SEL knowledge and social-emotional resiliency. The findings are discussed in terms of their implications for preventive, culturally responsive SEL programs in school settings. (PsycINFO Database Record (c) 2014 APA, all rights reserved).
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Posterior reversible encephalopathy syndrome due to malignant hypercalcemia: physiopathological considerations.
J. Clin. Endocrinol. Metab.
PUBLISHED: 01-29-2014
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Posterior reversible encephalopathy syndrome (PRES) is a neurological entity characterized by seizures, headache, and reversible subcortical vasogenic edema. It is associated with many etiologies, most often hypertension, chronic renal failure, and chemotherapy. Hypercalcemia is rarely associated with PRES.
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Human vaginal histology in long-term users of the injectable contraceptive depot-medroxyprogesterone acetate.
Contraception
PUBLISHED: 01-28-2014
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Apparently, depot-medroxyprogesterone acetate (DMPA) increases a woman's risk of acquiring HIV. The objective of this study was to test whether the vaginal mucosal thickness and Langerhans cell counts were significantly different in long-term DMPA users compared with women users of an intrauterine device (IUD) who had never used DMPA.
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Angiogenic T cells are decreased in rheumatoid arthritis patients.
Ann. Rheum. Dis.
PUBLISHED: 01-09-2014
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The mechanisms underlying the increased cardiovascular risk (CVR) of rheumatoid arthritis (RA) patients remain unclear. Since the recently discovered angiogenic T cells (Tang) could have a role in endothelial repair through cooperating with endothelial progenitor cells (EPC), the main aim of this study was to analyse the Tang and EPC populations in relation to disease-specific features and traditional CVR factors.
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The C2238/?ANP Variant Is a Negative Modulator of Both Viability and Function of Coronary Artery Smooth Muscle Cells.
PLoS ONE
PUBLISHED: 01-01-2014
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Abnormalities of vascular smooth muscle cells (VSMCs) contribute to development of vascular disease. Atrial natriuretic peptide (ANP) exerts important effects on VSMCs. A common ANP molecular variant (T2238C/?ANP) has recently emerged as a novel vascular risk factor.
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"Communicate to vaccinate": the development of a taxonomy of communication interventions to improve routine childhood vaccination.
BMC Int Health Hum Rights
PUBLISHED: 05-05-2013
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Vaccination is a cost-effective public health measure and is central to the Millennium Development Goal of reducing child mortality. However, childhood vaccination coverage remains sub-optimal in many settings. While communication is a key feature of vaccination programmes, we are not aware of any comprehensive approach to organising the broad range of communication interventions that can be delivered to parents and communities to improve vaccination coverage. Developing a classification system (taxonomy) organised into conceptually similar categories will aid in: understanding the relationships between different types of communication interventions; facilitating conceptual mapping of these interventions; clarifying the key purposes and features of interventions to aid implementation and evaluation; and identifying areas where evidence is strong and where there are gaps. This paper reports on the development of the Communicate to vaccinate taxonomy.
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Tele-care and tele-alarms for the elderly: preliminary experiences in Mexico.
Rev Saude Publica
PUBLISHED: 04-21-2013
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To analyze the effect of a pilot program of tele-assistance and tele-alarms on the elderlys self-perception of health status and to identify the satisfaction with and acceptance of the program.
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Differential modulation of uncoupling protein 2 in kidneys of stroke-prone spontaneously hypertensive rats under high-salt/low-potassium diet.
Hypertension
PUBLISHED: 01-07-2013
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The stroke-prone spontaneously hypertensive rat (SHRsp) represents an animal model of increased susceptibility to high-salt diet-induced cerebral and renal vascular injuries. High blood pressure and genetic factors are viewed as major contributing factors. In high-salt-loaded SHRsp and stroke-resistant SHR animals, we determined blood pressure levels, degree of kidney lesions, renal uncoupling protein 2 (UCP2) gene and protein expression levels along with rattus norvegicus (rno)-microRNA (miR) 24 and 34a gene expression, nuclear factor-?B protein levels, and oxidative stress. In vitro, UCP2 gene silencing was performed in renal mesangial cells. We found more severe degree of renal damage in SHRsp at the end of 4-week high-salt dietary treatment as compared with stroke-resistant SHR, despite comparable blood pressure levels, along with increased rate of inflammation and oxidative stress. Kidney UCP2 gene and protein expression levels were significantly downregulated under high-salt diet in SHRsp, but not in stroke-resistant SHR. Differential UCP2 regulation was paralleled by differential expression of kidney rno-miR 24 and 34a, known to target UCP2 gene, in the 2 strains. UCP2 gene silencing in renal mesangial cells led to increased rate of reactive oxygen species generation, increased inflammation and apoptosis, reduced cell vitality, and increased necrosis. In conclusion, high-salt diet downregulates the antioxidant UCP2-dependent mechanism in kidneys of SHRsp, but not of stroke-resistant SHR. A parallel differential kidney miR regulation under high-salt diet in the 2 strains may contribute to the differential UCP2 modulation. UCP2 is a critical protein to prevent oxidative stress damage in renal mesangial cells in vitro.
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Communicate to vaccinate (COMMVAC). building evidence for improving communication about childhood vaccinations in low- and middle-income countries: protocol for a programme of research.
Implement Sci
PUBLISHED: 09-06-2011
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Effective provider-parent communication can improve childhood vaccination uptake and strengthen immunisation services in low- and middle-income countries (LMICs). Building capacity to improve communication strategies has been neglected. Rigorous research exists but is not readily found or applicable to LMICs, making it difficult for policy makers to use it to inform vaccination policies and practice.The aim of this project is to build research knowledge and capacity to use evidence-based strategies for improving communication about childhood vaccinations with parents and communities in LMICs.
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A cross-sectional study of the forearm bone mineral density in long-term current users of the injectable contraceptive depot medroxyprogesterone acetate.
Contraception
PUBLISHED: 05-24-2011
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One of the well-established effects of the use of depot medroxyprogesterone acetate (DMPA) contraception is on bone mineral density (BMD). However, little evidence assesses the skeletal impact of long-term DMPA use. The objective of this study was to assess BMD on a cohort of women who used DMPA uninterruptedly between 1 and 15 years.
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Long-term assessment of forearm bone mineral density in postmenopausal former users of depot medroxyprogesterone acetate.
Contraception
PUBLISHED: 11-01-2010
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There are many controversies on the association between depot medroxyprogesterone acetate (DMPA) and bone mineral density (BMD). This study reevaluated BMD in postmenopausal women who had used DMPA as a contraceptive until they reached menopause and compared them with non-users. BMD had previously been measured in these women either at 1 year or 2-3 years after menopause and was reassessed in these women 2 years later. Therefore, comparisons were made between the first and third years and between the second to third and fourth to fifth years after menopause.
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Identification of a novel MYBPC3 gene variant in a patient with hypertrophic cardiomyopathy.
Ann. Clin. Lab. Sci.
PUBLISHED: 08-07-2010
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Hypertrophic cardiomyopathy (HCM) is a genetic disorder characterized by cardiac hypertrophy caused by mutations in sarcomere protein genes. MYBPC3 mutations are reported as a frequent cause of HCM. We aimed to identify the gene mutation underlying HCM in an Italian patient and his family composed of 13 relatives. Mutation screening of 658 known mutations was performed using a rapid and efficient mutation detection system based on semiautomated MALDI-TOF mass spectrometry using the Sequenom MassArray System and iPLEX Gold genotyping chemistry. Subsequently, direct sequencing of the coding exons and flanking intronic regions was performed for the most suitable HCM genes (MYBPC3, MYH7, TNNT2, TNNI3, and TPM1) in the index patient. We found a novel MYBPC3 gene mutation: G13999T (Gln689His). No other sarcomere gene mutation was found in this family. This genetic variant, which changes the last amino acid of MYBPC3 exon 21, affects a highly conserved residue. Furthermore, the Gln689His does not appear in public databases and has never been described as a polymorphism. The potential pathogenic role of this novel mutation was underlined by its absence in a sample of healthy subjects (n = 122) from the general Italian population. In summary, a novel MYBPC3 gene mutation has been identified in a patient affected by HCM, whereas it was absent in 244 reference alleles.
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[Validation of the Quality of Life in Alzheimers Disease (QOL-AD) scale in Mexican patients with Alzheimer, vascular and mixed-type dementia].
Rev Neurol
PUBLISHED: 07-06-2010
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To adapt the Quality of Life in Alzheimers Disease (QOL-AD) scale to Spanish, as well as to evaluate its reliability and validity in Mexico.
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Determinants of N-terminal proatrial natriuretic peptide plasma levels in a survey of adult male population from Southern Italy.
J. Hypertens.
PUBLISHED: 05-11-2010
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Natriuretic peptides control cardiovascular functions through diuretic, natriuretic, and vasodilatory properties. Several anthropometric, cardiac and renal variables were found to be independently correlated to their levels. Few studies, however, systematically investigated the independent determinants of natriuretic peptide levels in large populations.
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Prospective study of the forearm bone mineral density of long-term users of the levonorgestrel-releasing intrauterine system.
Hum. Reprod.
PUBLISHED: 02-25-2010
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The levonorgestrel-releasing intrauterine system (LNG-IUS) induces amenorrhoea, and its effect on bone mineral density (BMD) may constitute a concern. This study evaluated BMD in long-term users of the LNG-IUS or intrauterine device (IUD).
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[Biologic therapies different from the anti-TNF? therapy in psoriasis and psoriatic arthritis].
Reumatol Clin
PUBLISHED: 02-12-2010
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Psoriasis and psoriatic arthritis (PsA) are common conditions in the clinical practice of both dermatologists and rheumatologists. Both entities may cause an important loss in quality of life, and in the case of PsA, joint structural damage may arise over time. For these reasons, clinicians may be faced with the need for treating these cases with highly effective therapies, such as TNF? blocking agents, although these drugs may be paradoxically related with de novo onset (or exacerbation of previous lesions) of psoriasis or psoriasiform lesions. In spite of the clinical efficacy of these therapies, recent registry studies show that up to 25% of PsA cases exposed to anti-TNF therapies are withdrawn from these drugs within the first year of therapy. Therefore, there is a need for the use of alternative biologic therapies in this context. The present review deals with this subject.
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Effectiveness of two rehabilitation strategies provided by nurses for stroke patients in Mexico.
J Clin Nurs
PUBLISHED: 10-14-2009
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Rehabilitation strategies have been developed to improve functional state in stroke patients. The main objective of this study was to evaluate the effectiveness of the early rehabilitation at hospital and its continuity at home provided by nurses, on the functional recovery of basic and social activities in stroke patients compared with conventional care.
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Reactive oxygen species-mediated effects on vascular remodeling induced by human atrial natriuretic peptide T2238C molecular variant in endothelial cells in vitro.
J. Hypertens.
PUBLISHED: 08-25-2009
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T2238C ANP (atrial natriuretic peptide) gene variant has been associated with increased cardiovascular risk in humans and with a significant pharmacogenomic effect on cardiovascular disease outcome in hypertensive patients. We investigated the impact of T2238C ANP gene variant on oxidative stress production, cell proliferation and migration, angiogenesis and vascular remodeling in human umbilical vein endothelial cells in vitro.
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IUHPE and social determinants of health: setting an action agenda.
Glob Health Promot
PUBLISHED: 05-30-2009
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This commentary introduces the recently created IUHPE Global Working Group (GWG) on Social Determinants of Health, which provides a unique opportunity to bring a global health promotion response to the social inequalities that result from the unequal distribution of the social determinants of health.The two launch meetings of the GWG, which were held in the context of the conference ;Closing the gap in a generation, enabled direct discussion and reaction with respect to the implementation of the WHO Commission on Social Determinants of Healths (CSDH) recommendations. Over the course of these meetings the group identified five main areas of work to specifically focus on over the next 18 months, leading to the 20th IUHPE World Conference on ;Health, equity and sustainable development. The discussions also facilitated the revision of the GWGs terms of reference, as presented in this commentary.
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Phosphodiesterase 4D and 5-lipoxygenase activating protein genes and risk of ischemic stroke in Sardinians.
Eur. J. Hum. Genet.
PUBLISHED: 05-06-2009
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Genetic factors contribute to the risk of ischemic stroke (IS). The phosphodiesterase-4D (PDE4D) and the 5-lipoxygenase activating protein (ALOX5AP) genes were identified as contributors to stroke in an Icelandic population. In an attempt to better define the contributory role of PDE4D and ALOX5AP genes to the risk of IS in humans, we carried out the present association study in a well-characterized, earlier published, genetically homogenous population from the island of Sardinia, Italy. In this cohort, including 294 cases and 235 controls, age, hypertension, hypercholesterolemia, and atrial fibrillation represent risk factors for IS. The PDE4D gene was evaluated by four single nucleotide polymorphisms (SNP32, SNP45, SNP83, SNP87) and by the microsatellite AC008818-1; the ALOX5AP gene was characterized by three SNPs (SG13S32, SG13S89, ALO2A). The results of our study provide no evidence of association between any single PDE4D and ALOX5AP gene variant with the risk of IS in the Sardinian cohort. Haplotype analysis, including that constructed with allele 0 of microsatellite AC008818-1 and SNP45 of the PDE4D gene, was also negative. In conclusion, we found no evidence of association between PDE4D and ALOX5AP genes and the risk of IS in a genetically homogenous population from Sardinia.
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Association of a single nucleotide polymorphism of the NPR3 gene promoter with early onset ischemic stroke in an Italian cohort.
Eur. J. Intern. Med.
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NPR3, located on human chromosome 5 (5p14-p13), encodes the natriuretic peptide receptor type C (NPR-C) that is mainly known as the natriuretic peptide clearance receptor. Involvement of NPR3 in susceptibility to cardiovascular diseases, i.e. hypertension, has been previously shown. With regard to stroke predisposition, evidence for a potential role of genetic variation within or nearby NPR3 has been suggested by a previous genome wide association study.
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Influence of rs5065 atrial natriuretic peptide gene variant on coronary artery disease.
J. Am. Coll. Cardiol.
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The aim of this study was to investigate the impact of rs5065 atrial natriuretic peptide (ANP) gene variant on coronary artery disease (CAD) and its outcomes and to gain potential mechanistic insights on the association with CAD.
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Patients with psoriatic arthritis may show differences in their clinical and genetic profiles depending on their age at psoriasis onset.
Clin. Exp. Rheumatol.
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The age of psoriasis onset has an important impact on the clinical expression and heritability of psoriasis. Psoriasis characteristics according to the age at disease onset have been extensively studied. However, the impact of the age of psoriasis onset on psoriatic arthritis (PsA) features has not been analysed in depth. The aim of the present paper is to analyse whether the age of psoriasis onset may have an impact on the clinical and genetic characteristics in a cohort of PsA patients.
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Management of missing strings in users of intrauterine contraceptives.
Contraception
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A common question among health care professionals is how to manage nonvisible strings in users of intrauterine contraceptives (IUCs) at repeat follow-up visits. This study assessed the position of the IUCs in women who consulted repeatedly with nonvisible IUC strings.
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JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

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We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

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In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.