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Find video protocols related to scientific articles indexed in Pubmed.
Association of single nucleotide polymorphisms in the prostaglandin-endoperoxide synthase 2 (PTGS2) and phospholipase A? group IIA (PLA2G2A) genes with susceptibility to esophageal squamous cell carcinoma.
Asian Pac. J. Cancer Prev.
PUBLISHED: 03-20-2014
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The prostaglandin-endoperoxide synthase 2 (PTGS2) and phospholipase A2 group IIA (PLA2G2A) genes encode enzymes that are involved in arachidonic acid and prostaglandin biosynthesis. Dysregulation of both genes is associated with inflammation and carcinogenesis, including esophageal squamous cell carcinoma (ESCC). We therefore hypothesized that there is an association between single nucleotide polymorphisms (SNPs) in these genes and susceptibility to ESCC.
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Serum peptide mapping in gastric precancerous lesion and cancer.
J Dig Dis
PUBLISHED: 01-21-2014
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To construct and verify a diagnostic model using proteomic analysis of serum samples for identifying gastric precancerous lesions and gastric cancer (GC).
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[Measurements of stable isotopes in atmospheric CO2 and H2O by open-path Fourier transform infrared spectrometry].
Guang Pu Xue Yu Guang Pu Fen Xi
PUBLISHED: 10-29-2013
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The development of spectroscopic techniques has offered continuous measurement of stable isotopes in the ambient air. The method of measuring environmental stable isotopes based on Fourier transform infrared spectrometry (FTIR) is described. In order to verify the feasibility of the method for continuous measurement of the stable isotopes, an open-path FTIR system was used to measure stable isotopes of CO2 and H2O in ambient air directly in a seven-day field experiment, including 12CO2, 3CO2, H2 16O and HD16 O. Also, the time course of carbon isotopic ratio delta13 C and deuterium isotope composition deltaD was calculated. The measurement precision is about 1.08 per thousand for delta13 C and 1.32 per thousand for deltaD. The measured stable isotopes of CO2 and H2O were analyzed on different time scales by Keeling plot methods, and the deuterium isotopic ratios of evapotranspiration were determined. The results of the field experiment demonstrate the potential of the open-path FTIR system for continuous measurement of stable isotopes in the air.
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Effect of enteral nutrition on dextran sulfate sodium-induced colitis in rats.
J Dig Dis
PUBLISHED: 11-29-2011
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To study the effect of enteral nutrition (EN) on dextran sulfate sodium (DSS)-induced colitis in rats.
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[Ozone concentration inversion based on multi-reflected cell FTIR spectra and correlation analysis].
Guang Pu Xue Yu Guang Pu Fen Xi
PUBLISHED: 08-02-2011
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The stratosphere ozone plays the protective action role for human and the ground-level ozone is harmful to human health. Monitoring ozone with different ways and methods took an active part in understanding distribution and transformation of ozone, which was useful to controlling pollution emission. Spectra were got by multi-reflected white cell Fourier transform infrared (FTIR) spectrometer, inversed with nonlinear least squares (NLLSQ) method and then the concentrations of ozone were got exactly. The correlations of measured ozone concentration time series by Fourier transform infrared spectrometer, open path UV differential optical absorption spectrometer and ozone analyzer of the Thermo Corporation were significant. The results showed that the measured ozone absolute concentrations with different monitoring methods and instruments had some differences, but the concentration diurnal variations were coincident and the correlations were good. Therefore, ozone concentration inversion method, based on multi-reflected cell Fourier transform infrared spectrum and not reported in domestic articles, could be used as an effective technique to measure ozone concentration.
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Effects of DNA methyltransferase 1 inhibition on esophageal squamous cell carcinoma.
Dis. Esophagus
PUBLISHED: 05-03-2011
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To explore the role of DNA methyltransferase 1 (DNMT1) in esophageal squamous cell carcinoma (ESCC) and the potential of DNMT1-targeted small interfering RNA as ESCC therapy, we examined expression changes of DNMT1 in ESCC and investigated the effect of DNMT1 knockdown by RNA interference in a human ESCC cell line, KYSE30. DNMT1 messenger RNA was over-expressed in seven out of 12 ESCC samples, and the percentage of cells expressing DNMT1 was significantly higher in ESCC tissues compared with paired non-cancerous tissues. DNMT1 protein levels correlated with lymph node metastasis, but exhibited no correlation with sex, age, tumor site, or tumor differentiation. Knockdown of DNMT1 in KYSE30 cells using RNA interference resulted in a reduction of promoter methylation and re-expression of methyl-guanine methyl-transferase and retinoic acid receptors beta, inhibition of cell proliferation/viability and induction of cell apoptosis. These results indicate that DNMT1 over-expression is involved in ESCC and correlated with lymph node metastasis. Knockdown of DNMT1 led to promoter demethylation and re-expression of several tumor suppressor genes thereby inhibiting cell proliferation/viability and inducing cell apoptosis.
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Effects of cyclooxygenase-2 on human esophageal squamous cell carcinoma.
World J. Gastroenterol.
PUBLISHED: 04-19-2011
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To study the relationship between the cyclooxygenase (COX)-2 gene and the proliferation and apoptosis of esophageal squamous carcinoma EC109 cells.
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[Concentration inversion of high temperature air from FTIR spectra and analyzing residual error structure].
Guang Pu Xue Yu Guang Pu Fen Xi
PUBLISHED: 03-25-2011
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The spectral line widths of theory and experiment are analyzed with different temperatures; the line strengths under room temperature in HITRAN database are corrected to measured temperature, and then synthetic spectra are calculated. With the nonlinear least squares fit between measured spectra and calibration spectra, standard gas concentrations of CO at different temperatures are obtained. The inversion concentration error of this algorithm at room temperature is less than 5% with high precision. But with the temperature increasing, the concentration error will increase gradually. At the same time, there is the same apparent structure to component CO in the residual spectrum. Also, with higher temperature, the structure is more obvious and can not be removed by increasing the number of fitting. Comparing experimental results and theoretical analysis, the temperature correction methods of calibration spectra, which are not suitable for high temperature gas, are the main reason for inversion error at higher temperature. These results have important significance for further research on accurately correcting parameters and how to inverse the high temperature gas concentrations more accurately.
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Aberrant methylation of the 3q25 tumor suppressor gene PTX3 in human esophageal squamous cell carcinoma.
World J. Gastroenterol.
PUBLISHED: 03-24-2011
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To identify the novel methylation-silenced gene pentraxin 3 (PTX3) in esophageal squamous cell carcinoma (ESCC).
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Dual inhibition of 5-LOX and COX-2 suppresses esophageal squamous cell carcinoma.
Cancer Lett.
PUBLISHED: 02-07-2011
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COX-2 and 5-LOX are up-regulated in ESCC. This study aims to determine the efficacy of COX-2 inhibitor, 5-LOX inhibitor and their combination on ESCC. Nimesulide can suppress cell growth and promote apoptosis, accompanied with a decrease of PGE(2) production. AA861 has the similar effect with a down-regulation of LTB(4). In animal experiment, the tumor volumes in drug-treated groups were significantly smaller with the lowest rates of Ki-67 positive cells. In conclusion, either COX-2 inhibitor or 5-LOX inhibitor can suppress ESCC. Dual inhibition of COX-2 and 5-LOX pathway may present a superior anticancer efficacy to either inhibition of COX-2 or 5-LOX alone.
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Epigenetic inactivation of the SFRP1 gene in esophageal squamous cell carcinoma.
Dig. Dis. Sci.
PUBLISHED: 02-04-2011
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The secreted frizzled-related protein 1 (SFRP1) gene, as a Wnt signaling modulator, is frequently inactivated by promoter methylation in many tumors including gastric cancer, breast cancer, oral squamous cell carcinoma, and esophageal adenocarcinoma. However, the role of SFRP1 in esophageal squamous cell carcinoma (ESCC) is not clear. In this study, we investigated the epigenetic inactivation of the SFRP1 gene in ESCC.
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[Application of SOF-FTIR method to measuring ammonia emission flux of chemical plant].
Guang Pu Xue Yu Guang Pu Fen Xi
PUBLISHED: 08-17-2010
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In the present paper, a new method is introduced for real-time monitoring polluted gas emission flux of chemical plant, which is called FTIR based on the solar occultation flux technique (SOF-FTIR). The model to obtain background spectrum, measured spectrum and atmospheric penetration rate surrounding polluted gas under complicated conditions is also proposed. Continuous measurements were preformed at a closed loop surrounding the contaminated areas that need to be mornitored to obtain measured spectrum, and finally column concentration of polluted gas was retrieved by using the nonlinear least squares fitting algorithm (NLLS). Then the flux information combined with the meteorological data and GPS information of the time was obtained when the experiments were done. Using this method, remote sensing experiment of ammonia emission around a chemical plant was done, and the concentration distribution and its emission flux was quantitatively analyzed. Compared with traditional FTIR methods of monitoring, this method is featured by convenient operation and high maneuverability, so it has a good application prospect in pollution monitoring and other applications in regional air pollution contingency monitoring.
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[Evaluation of the effect of ilaprazole on intragastric pH in patients with duodenal ulcer].
Zhonghua Nei Ke Za Zhi
PUBLISHED: 07-15-2010
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To evaluate the effect of ilaprazole enteric tablets on intragastric pH in duodenal ulcer patients.
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Upper gastrointestinal hemorrhage caused by superwarfarin poisoning.
World J. Gastroenterol.
PUBLISHED: 04-01-2010
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Superwarfarins are a class of rodenticides. Gastrointestinal hemorrhage is a fatal complication of superwarfarin poisoning, requiring immediate treatment. Here, we report a 55-year-old woman with tardive upper gastrointestinal hemorrhage caused by superwarfarin poisoning after endoscopic cold mucosal biopsy.
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Aortoesophageal fistula: a case misdiagnosed as esophageal polyp.
World J. Gastroenterol.
PUBLISHED: 12-17-2009
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Aortoesophageal fistula (AEF) is a rare and fatal disorder. It is also a life-threatening cause of massive upper gastrointestinal hemorrhage. Thoracic aortic aneurysm is the most common cause of AEF. Management of a patient with this disorder requires rapid diagnosis and immediate intervention, which is considered the best way to save the patients life. We report a case of AEF misdiagnosed as esophageal polyp.
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[The diagnostic value of intraductal ultrasonography for complex biliary and pancreatic diseases].
Zhonghua Nei Ke Za Zhi
PUBLISHED: 12-04-2009
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To assess the diagnostic value of intraductal ultrasonography (IDUS)when the findings of endoscopic retrograde cholangiopancreatography (ERCP) were not clearly demonstrated.
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Successful endoscopic removal of a giant upper esophageal inflammatory fibrous polyp.
World J. Gastroenterol.
PUBLISHED: 11-06-2009
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Giant esophageal inflammatory fibrous polyp (especially > 17 cm in size) is seen rarely. Endoscopic removal has been reported rarely because the procedure is technically demanding and the hemostasis is difficult to ascertain. Here, we describe a case of a giant upper esophageal inflammatory fibrous polyp that was resected successfully by endoscopy.
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[Analyzing NH3 volatilization of different fertilizers by FTIR spectra measurement].
Guang Pu Xue Yu Guang Pu Fen Xi
PUBLISHED: 10-06-2009
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In the present paper, the authors used FTIR spectra measurement to analyze the volatilization of NH3 of different fertilizers. With the help of HITRAN database, using NLLS arithmetic, the authors retrieved the concentrations of NH3. The authors compared the concentrations and simply analyzed the reason why the concentrations are different. This experiment indicated that the FTIR spectra measurement used to analyze the volatilization of NH3 has many advantages, such as simple operation, high efficiency, measuring in real time and continuity, so this measurement can completely satisfy the demand of analysis in field.
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Chloroform extract of cigarette smoke induces proliferation of human esophageal squamous-cell carcinoma cells: modulation by beta-adrenoceptors.
Drug Chem Toxicol
PUBLISHED: 06-23-2009
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The present study aimed to delineate the actions of cigarette smoke extracts on esophageal squamous-cell carcinoma cell growth in vitro. Both chloroform- and ethanol-extracts from cigarette smoke stimulated human esophageal squamous carcinoma EC109 cell proliferation. Chloroform- and ethanol-extracts also upregulated beta-adrenoceptors expression in EC109 cells. Cyclo-oxygenase-2 (COX-2) expression was increased by chloroform-extract. The stimulatory actions of chloroform-extract on cell proliferation and COX-2 expression were abolished by beta(1)- and beta(2)-adrenoceptor selective antagonists, implicating that COX-2 was downstream to the beta-adrenoceptors. Collectively, the promoting action of chloroform-extract from cigarette smoke on esophageal squamous-cell carcinoma cell proliferation is beta-adrenoceptor- and COX-2-dependent.
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A rare case of bile duct cyst.
World J. Gastroenterol.
PUBLISHED: 05-27-2009
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Choledochal cyst is an uncommon disease usually seen in young women and can be divided into five types. We report a 66-year-old woman who was diagnosed with types I and III bile duct cyst simultaneously after surgery, which is a rare type of bile duct cyst.
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Nicotine enhances migration and invasion of human esophageal squamous carcinoma cells which is inhibited by nimesulide.
World J. Gastroenterol.
PUBLISHED: 05-27-2009
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To study the effect of nicotine on the migration and invasion of human esophageal squamous carcinoma cells and to investigate whether nimesulide can inhibit the effect of nicotine.
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Effects of the inhibition of cyclooxygenase-2 on human esophageal cancer cells: inhibition of cell proliferation and induction of apoptosis.
Pathol. Oncol. Res.
PUBLISHED: 04-22-2009
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Cyclooxygenase-2 (COX-2) has been shown to be upregulated in a variety of tumors so that COX-2 may be a potential target in the treatment of cancer. In order to further explore the mechanism, we used RNA interference to study effects of the inhibition of COX-2 on esophageal squamous cell carcinoma (ESCC) lines. Western blot analysis demonstrated that COX-2 expression was significantly reduced in ESCC cells treated with the COX-2-specific siRNA. Furthermore, the COX-2 siRNA treatment inhibited cell proliferation and induced apoptosis in ESCC cells. In addition, the combination treatment of COX-2 siRNA and acidum acetil salicylicum (aspirin) has a synergistic effect. Therefore, this combination has potential as an anticancer therapy for the treatment of ESCC.
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How safe and successful are live demonstrations of therapeutic ERCP? A large multicenter study.
Am. J. Gastroenterol.
PUBLISHED: 02-25-2009
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Live demonstrations of endoscopic retrograde cholangiopancreatography (ERCP) have a high educational value and contribute significantly to endoscopy development and training. However, the success and safety of live demonstration have been questioned. The aim of this study was to evaluate the success rate and complications of therapeutic ERCP among patients who participated in live demonstrations.
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[A new retrieval method for ozone concentration at the troposphere based on differential absorption lidar].
Guang Pu Xue Yu Guang Pu Fen Xi
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Aerosols interfere with differential absorption lidar ozone concentration measurement and can introduce significant errors. A new retrieval method was introduced, and ozone concentration and aerosol extinction coefficient were gained simultaneously based on the retrieval method. The variables were analyzed by experiment including aerosol lidar ratio, aerosol wavelength exponent, and aerosol-molecular ratio at the reference point. The results show that these parameters introduce error less than 8% below 1 km. The measurement error derives chiefly from signal noise and the parameters introduce error less than 3% above 1 km. Finally the vertical profile of tropospheric ozone concentration and aerosol extinction coefficient were derived by using this algorithm. The retrieval results of the algorithm and traditional dual-wavelength difference algorithm are compared and analyzed. Experimental results indicate that the algorithm is feasible, and the algorithm can reduce differential absorption lidar measurement error introduced by aerosol.
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Non-Alcoholic Fatty Liver Disease Is not Related to the Incidence of Diabetic Nephropathy in Type 2 Diabetes.
Int J Mol Sci
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To analyze the association between non-alcoholic fatty liver disease (NAFLD) and the incidence of diabetic nephropathy in patients with type 2 diabetes, the incidence of diabetic nephropathy was assessed in 413 type 2 diabetic patients, by testing the 24 h urinary albumin excretion rate (UAER). The NAFLD was diagnosed based on patients medical history and liver ultrasound. The difference in diabetic nephropathy incidence between patients with and without NAFLD was tested by X². Multivariate logistic regression analysis was used to assess the factors associated with diabetic nephropathy among type 2 diabetic patients. Total 363 out of 413 type 2 diabetic patients were enrolled in this study. The incidences of NAFLD and diabetic nephropathy in participants were approximately 56% (202/363) and 38% (137/363) respectively, and there was no significant difference in the prevalence of diabetic nephropathy between patients with and without NAFLD (37.1% vs. 38.5%, p = 0.787). The duration of diabetes (odds ratio [OR] 1.065, 95% confidence interval [CI] 1.014--1.120, p = 0.012), waist circumference (OR 1.077, 95% CI 1.040--1.116, p = 0.000), and fasting blood glucose (FBG; OR 1.136, 95% CI 1.023--1.1262, p = 0.017) were significantly associated with diabetic nephropathy, whereas sex, high blood pressure, total cholesterol (TC), triglyceride (TG), and ankle brachial pressure index (ABI) were not significantly associated with the disorder. The present results suggest that NAFLD is not related to the incidence of diabetic nephropathy in type 2 diabetes, but the duration of diabetes, waist circumference, and FBG are important factors for diabetic nephropathy in type 2 diabetes.
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Identification of Nedd4 as a novel regulator in Hedgehog signaling.
Chin. Med. J.
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Hedgehog (Hh) signaling plays an important role in both embryonic development and postnatal tissue homeostasis. Aberrant Hh activation results in a large variety of cancers. This study was designed to discover novel modulators in Hh signaling pathway.
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SULF1 inhibits proliferation and invasion of esophageal squamous cell carcinoma cells by decreasing heparin-binding growth factor signaling.
Dig. Dis. Sci.
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Heparin-binding growth factor signaling is involved in the pathogenesis and development of human cancers. It can be regulated by sulfation of cell-surface heparan sulfate proteoglycans (HSPG). SULF1 is a heparin-degrading endosulfatase which can modulate the sulfation of HSPGs.
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Promoter methylation regulates cigarette smoke-stimulated cyclooxygenase-2 expression in esophageal squamous cell carcinoma.
J Dig Dis
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Cigarette smoke extracts (CSE) could promote esophageal squamous cell carcinoma (ESCC) through upregulation of cyclooxygenase-2 (COX-2) expression. Promoter methylation mediates the transcriptional modulation of the COX-2 gene. The aim of the study was to explore whether COX-2 promoter methylation regulated COX-2 expression and functional activity in ESCC exposed to CSE.
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Epigenetic inactivation of secreted frizzled-related protein 2 in esophageal squamous cell carcinoma.
World J. Gastroenterol.
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To investigate the expression and methylation status of the secreted frizzled-related protein 2 (SFRP2) in esophageal squamous cell carcinoma (ESCC) and explore its role in ESCC carcinogenesis.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

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We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

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In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.