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Find video protocols related to scientific articles indexed in Pubmed.
Primary thyroid diffuse large B-cell lymphoma coexistent with papillary thyroid carcinoma: A case report.
Head Neck
PUBLISHED: 07-16-2014
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Background: Primary thyroid lymphoma (PTL) is uncommon, accounting for 2%-5% of all thyroid malignancies. Papillary thyroid carcinoma (PTC) is the most frequent thyroid cancer. The coexistence of PTL and PTC is very rare, and the pre-operative diagnosis is rather difficult. Methods: A 41 year-old male patient complaining of fast painless thyroid enlargement for 2 months and a cervical mass for half a month was presented. Imaging demonstrated an enlarged thyroid and a mass in the thyroid. Results: A surgery was conducted, and the final diagnosis of coexistence of PTL and PTC was confirmed by histopathological and immunohistochemical examination. The patient was then treated with CHOP chemotherapy and radiotherapy. With 2 months of follow-up, no recurrence or metastasis was noted. Conclusions: This rare case highlights the importance for physicians to keep PTL in mind for differential diagnosis in patients with sudden thyroid enlargement and who have clinical history of Hashimoto's thyroiditis. Head Neck, 2014.
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Factors Behind Negative Attitudes Toward Cadaveric Organ Donation: A Comparison Between Medical and Non-Medical Students in China.
Transplantation
PUBLISHED: 05-20-2014
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The purposes of this study were to identify knowledge and attitudes held by Chinese university students regarding cadaveric organ donation and to understand the factors that drive negative attitudes.
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Validation of EORTC QLQ-LC43 for Chinese patients with lung cancer.
Lung Cancer
PUBLISHED: 01-28-2014
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To test the validity, reliability and acceptability of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Lung Cancer 43 (EORTC QLQ-LC43) for Chinese patients with lung cancer.
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Preferences for treatment of lobectomy in Chinese lung cancer patients: video-assisted thoracoscopic surgery or open thoracotomy?
Patient Prefer Adherence
PUBLISHED: 01-01-2014
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This study was designed to investigate the preferences for treatment of lobectomy in Chinese lung cancer patients and differences in the psychological and social factors that influence treatment decision-making.
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Validation of EORTC IN-PATSAT32 for Chinese patients with gastrointestinal cancer.
Patient Prefer Adherence
PUBLISHED: 01-01-2014
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To test the psychometric properties and applicability of the European Organization for Research and Treatment of Cancer In-patient Satisfaction with Care Questionnaire 32 (EORTC IN-PATSAT32) for Chinese patients with gastrointestinal cancer.
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Investigation and analysis of oncologists' knowledge of morphine usage in cancer pain treatment.
Onco Targets Ther
PUBLISHED: 01-01-2014
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To examine oncologists' knowledge of cancer pain and morphine's clinical application in the People's Republic of China. In addition, this study analyzes and discusses the negative factors that currently affect the clinical application of morphine.
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Activation of the IL-6/JAK/STAT3 signaling pathway in human middle ear cholesteatoma epithelium.
Int J Clin Exp Pathol
PUBLISHED: 01-01-2014
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Interleukin-6 (IL-6) is one of the most important cytokines which has been shown to play a critical role in the pathogenesis of cholesteatoma. In this study, we aimed to investigate the expression of interleukin-6 (IL-6) and phosphorylated signal transducer and activator of transcription 3 (p-STAT3) in middle ear cholesteatoma epithelium in an effort to determine the role of IL-6/JAK/STAT3 signaling pathway in the pathogenesis of cholesteatoma. Immunohistochemistry was used to examine the expression of IL-6 and p-STAT3 in 25 human middle ear cholesteatoma samples and 15 normal external auditory canal (EAC) epithelium specimens. We also analyzed the relation of IL-6 and p-STAT3 expression levels to the degree of bone destruction in cholesteatoma. We found that the expression of IL-6 and p-STAT3 were significantly higher in cholesteatoma epithelium than in normal EAC epithelium (p<0.05). In cholesteatoma epithelium, a significant positive association was observed between IL-6 and p-STAT3 expression (p<0.05). However, no significant relationships were observed between the degree of bone destruction and the levels of IL-6 and p-STAT3 expression (p>0.05). To conclude, our results support the concept that IL-6/JAK/STAT3 signaling pathway is active and may play an important role in the mechanisms of epithelial hyper-proliferation responsible for cholesteatoma.
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Strategies for changing negative public attitudes toward organ donation in the Peoples Republic of China.
Patient Prefer Adherence
PUBLISHED: 12-16-2013
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In recent decades, the demand for organ transplantation has risen rapidly worldwide, due to an increased incidence of vital organ failure. However, the scarcity of organs appropriate for transplantation has led to an organ shortage crisis. This article retrospectively reviews strategies to change negative public attitudes toward organ donation in the Peoples Republic of China. We strongly believe that efforts to publicize knowledge of organ donation, promote family discussions, train medical staff and students, establish incentive systems, and implement regulatory oversight may combat unfavorable Chinese public opinion toward organ donation and transplantation, thus potentially increasing the organ donation rate in the Peoples Republic of China.
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The Role of EGFR/PI3K/Akt/cyclinD1 Signaling Pathway in Acquired Middle Ear Cholesteatoma.
Mediators Inflamm.
PUBLISHED: 07-12-2013
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Cholesteatoma is a benign keratinizing and hyper proliferative squamous epithelial lesion of the temporal bone. Epidermal growth factor (EGF) is one of the most important cytokines which has been shown to play a critical role in cholesteatoma. In this investigation, we studied the effects of EGF on the proliferation of keratinocytes and EGF-mediated signaling pathways underlying the pathogenesis of cholesteatoma. We examined the expressions of phosphorylated EGF receptor (p-EGFR), phosphorylated Akt (p-Akt), cyclinD1, and proliferating cell nuclear antigen (PCNA) in 40 cholesteatoma samples and 20 samples of normal external auditory canal (EAC) epithelium by immunohistochemical method. Furthermore, in vitro studies were performed to investigate EGF-induced downstream signaling pathways in primary external auditory canal keratinocytes (EACKs). The expressions of p-EGFR, p-Akt, cyclinD1, and PCNA in cholesteatoma epithelium were significantly increased when compared with those of control subjects. We also demonstrated that EGF led to the activation of the EGFR/PI3K/Akt/cyclinD1 signaling pathway, which played a critical role in EGF-induced cell proliferation and cell cycle progression of EACKs. Both EGFR inhibitor AG1478 and PI3K inhibitor wortmannin inhibited the EGF-induced EGFR/PI3K/Akt/cyclinD1 signaling pathway concomitantly with inhibition of cell proliferation and cell cycle progression of EACKs. Taken together, our data suggest that the EGFR/PI3K/Akt/cyclinD1 signaling pathway is active in cholesteatoma and may play a crucial role in cholesteatoma epithelial hyper-proliferation. This study will facilitate the development of potential therapeutic targets for intratympanic drug therapy for cholesteatoma.
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Assessing the nutritional status of elderly Chinese lung cancer patients using the Mini-Nutritional Assessment (MNA(®)) tool.
Clin Interv Aging
PUBLISHED: 03-05-2013
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This study assessed the nutritional status of elderly Chinese lung cancer inpatients using a revised version of the Mini-Nutritional Assessment (MNA(®)) tool.
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A study of patient experience and perception regarding postoperative pain management in Chinese hospitals.
Patient Prefer Adherence
PUBLISHED: 01-01-2013
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This study aims to analyze the current status of postoperative pain management in the Peoples Republic of Chinas provincial-level hospitals, and the existing knowledge and opinions held by patients regarding these methods.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.