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Find video protocols related to scientific articles indexed in Pubmed.
The effect of male sex on survival in systemic sclerosis.
J. Rheumatol.
PUBLISHED: 10-01-2014
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Systemic sclerosis (SSc) has a female predominance, however, little is understood about the effect of sex on SSc manifestations and survival. The objectives of our study were to evaluate differences in disease manifestations, and survival rates between males and females with SSc.
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Multicriteria decision analysis methods with 1000Minds for developing systemic sclerosis classification criteria.
J Clin Epidemiol
PUBLISHED: 04-08-2014
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Classification criteria for systemic sclerosis (SSc) are being developed. The objectives were to develop an instrument for collating case data and evaluate its sensibility; use forced-choice methods to reduce and weight criteria; and explore agreement among experts on the probability that cases were classified as SSc.
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A new toolkit for conducting clinical trials in rare disorders.
J Popul Ther Clin Pharmacol
PUBLISHED: 02-23-2014
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Evidence based medicine requires strong scientific evidence upon which to base treatment. Because the available study populations for rare diseases are small, this evidence is difficult to accrue. Investigators need to consider a flexible toolkit of methods to deal with the problems inherent in the study of rare disease. We present some potential solutions in this paper.
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Low bone density in systemic sclerosis. A systematic review.
J. Rheumatol.
PUBLISHED: 09-15-2013
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The effect of systemic sclerosis (SSc) on bone density is not well understood. Through systematic review of the literature, the objectives of this study were to synthesize data about the prevalence of low bone mineral density (BMD), risk factors for low BMD, and occurrence of fracture and fracture-related mortality in SSc.
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Development, sensibility, and reliability of the Toronto Axial Spondyloarthritis Questionnaire in inflammatory bowel disease.
J. Rheumatol.
PUBLISHED: 09-01-2013
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There is an unacceptable delay in the diagnosis of axial spondyloarthritis (axSpA) in its early stages among patients at high risk, in particular those with inflammatory bowel disease (IBD). Our objectives were to develop a sensible and reliable questionnaire to identify undetected axSpA among patients with IBD.
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Inflammatory arthritis, sacroiliitis, and morphea: evidence of a systemic inflammatory disease.
Case Rep Rheumatol
PUBLISHED: 06-04-2013
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Morphea is a skin disease characterized by local skin inflammation and fibrosis. Extracutaneous manifestations have been described with this disease including inflammatory arthritis. We describe a case of morphea who developed inflammatory polyarthritis and sacroiliitis coincident with new skin lesions.
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Bone disease in systemic sclerosis: outcomes and associations.
Clin. Exp. Rheumatol.
PUBLISHED: 05-30-2013
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The relationship between systemic sclerosis (SSc) and low bone mineral density (BMD) is poorly understood. The aim of this study is to improve our understanding of low bone density in SSc and its potential consequences.
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Survival after lung transplantation in systemic sclerosis. A systematic review.
Respir Med
PUBLISHED: 05-06-2013
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Lung transplantation is a life-saving option for systemic sclerosis (SSc)-associated pulmonary arterial hypertension (PAH) and interstitial lung disease (SSc-ILD) patients. However, some programs may be concerned about the possibility of excess post-transplantation mortality related to the extra-pulmonary manifestations of SSc. The objective of this study was to evaluate survival of SSc patients post-lung transplantation. We secondarily evaluated SSc lung transplant recipient characteristics (age, sex, and type of SSc lung disease), and discussed post-lung transplantation survival of SSc patients and non-SSc patients (idiopathic PAH, and ILD).
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Effect of warfarin on survival in scleroderma-associated pulmonary arterial hypertension (SSc-PAH) and idiopathic PAH. Belief elicitation for Bayesian priors.
J. Rheumatol.
PUBLISHED: 12-15-2010
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Warfarin use in scleroderma (SSc)-associated pulmonary arterial hypertension (PAH) and idiopathic PAH (IPAH) is controversial. A prerequisite for a trial is the demonstration of community uncertainty. We evaluated experts beliefs about the effect of warfarin on 3-year survival in SSc-PAH and IPAH, and factors that influence warfarin use.
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Biologic therapy for systemic sclerosis: a systematic review.
J. Rheumatol.
PUBLISHED: 11-01-2010
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Biologic agents are increasingly used in the rheumatic diseases. Their role in patients with systemic sclerosis (SSc) is uncertain. Our aim was to evaluate the effectiveness and safety of biologic agents in SSc. We review the evidence for the use of biologic agents to improve inflammatory arthritis, disability, and skin score, and we review adverse effects with biologic agents in patients with SSc.
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Factors that prognosticate mortality in idiopathic pulmonary arterial hypertension: a systematic review of the literature.
Respir Med
PUBLISHED: 04-26-2010
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There is a lack of consensus on factors that predict mortality in idiopathic pulmonary arterial hypertension (IPAH). Tests that can accurately predict prognosis are needed to guide treatment and counsel patients.
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Predictors for remission in rheumatoid arthritis patients: A systematic review.
Arthritis Care Res (Hoboken)
PUBLISHED: 03-18-2010
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To summarize the potential predictors of remission in patients with rheumatoid arthritis (RA).
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Methods to elicit beliefs for Bayesian priors: a systematic review.
J Clin Epidemiol
PUBLISHED: 06-04-2009
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Bayesian analysis can incorporate clinicians beliefs about treatment effectiveness into models that estimate treatment effects. Many elicitation methods are available, but it is unclear if any confer advantages based on principles of measurement science. We review belief-elicitation methods for Bayesian analysis and determine if any of them had an incremental value over the others based on its validity, reliability, and responsiveness.
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Shifting our thinking about uncommon disease trials: the case of methotrexate in scleroderma.
J. Rheumatol.
PUBLISHED: 04-22-2009
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Randomized trials for uncommon diseases suffer from methodological challenges: difficulty in recruiting sufficient numbers of patients and low power to detect important treatment effects. Using traditional (frequentist) analysis, p values > 0.05 mean investigators are unable to reject the null hypothesis (of no treatment effect). The medical community often labels trials with p values > 0.05 as "negative." Our study demonstrates how Bayesian analysis conveys more relevant information to clinicians - using the example of methotrexate (MTX) in systemic sclerosis (SSc).
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Magnetic resonance imaging of the hand in systemic sclerosis.
J. Rheumatol.
PUBLISHED: 03-30-2009
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To evaluate the utility of magnetic resonance imaging (MRI) in systemic sclerosis (SSc)-associated arthropathy.
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Ethnic influence on disease manifestations and autoantibodies in Chinese-descent patients with systemic sclerosis.
J. Rheumatol.
PUBLISHED: 02-17-2009
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To investigate ethnic influence on disease manifestations and autoantibody profile in patients of Chinese descent with systemic sclerosis (SSc).
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A valid and reliable belief elicitation method for Bayesian priors.
J Clin Epidemiol
PUBLISHED: 01-12-2009
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Bayesian inference has the advantage of formally incorporating prior beliefs about the effect of an intervention into analyses of treatment effect through the use of prior probability distributions or "priors." Multiple methods to elicit beliefs from experts for inclusion in a Bayesian study have been used; however, the measurement properties of these methods have been infrequently evaluated. The objectives of this study were to evaluate the feasibility, validity, and reliability of a belief elicitation method for Bayesian priors.
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Long-term safety and effectiveness of tumour necrosis factor inhibitors in systemic sclerosis patients with inflammatory arthritis.
Clin. Exp. Rheumatol.
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To assess the long-term safety and effectiveness of tumour necrosis factor (TNF) inhibitors in the treatment of systemic sclerosis (SSc) patients with inflammatory arthritis.
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Clinical evidence, practice guidelines, and ?-blocker utilization before major noncardiac surgery.
Circ Cardiovasc Qual Outcomes
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Largely on the basis of 2 randomized trials published in the 1990s, ?-blockers were initially promoted as an evidence-based intervention for preventing cardiac complications of noncardiac surgery. However, subsequent studies raised concerns about a widespread use of perioperative ?-blockade. Little is known regarding how this changing evidence influenced the use of perioperative ?-blockers in clinical practice.
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Dual therapy in IPAH and SSc-PAH. A qualitative systematic review.
Respir Med
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Use of endothelin receptor antagonists (ERA), phosphodiesterase type-5 (PDE-5) inhibitors and prostaglandin analogues has resulted in improved outcomes in idiopathic pulmonary arterial hypertension (IPAH) and systemic sclerosis-associated PAH (SSc-PAH) patients. However, patients often deteriorate on monotherapy. The objective of this study is to evaluate the effect of dual therapy on outcomes in IPAH and SSc-PAH.
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Warfarin in systemic sclerosis-associated and idiopathic pulmonary arterial hypertension. A Bayesian approach to evaluating treatment for uncommon disease.
J. Rheumatol.
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Warfarin is recommended in systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) and idiopathic PAH (IPAH) to improve survival. There is no evidence to support this in SSc-PAH and the evidence in IPAH is conflicting. We evaluated the ability of warfarin to improve survival using 2 large SSc-PAH and IPAH cohorts.
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ANCA-associated vasculitis in systemic sclerosis report of 3 cases.
Rheumatol. Int.
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The aim of the study was to describe the occurrence of anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) in systemic sclerosis (SSc) patients. SSc patients who developed biopsy-proven AAV were identified. Their clinical manifestations, autoantibodies, presentation with vasculitis, treatment and outcome were described and compared with previously reported patients with these two conditions. Of 985 patients, 3 were identified. All patients had interstitial lung disease, and all presented with acute renal failure, proteinuria and hematuria, and were P-ANCA- and anti-Scl-70-positive. One required hemodialysis. Two were hypertensive; additionally, one patient had sinusitis, and another had monoarthritis and a macular rash. All were treated with high-dose corticosteroids and responded to therapy and attained remission at 6 months. At 1 year, one patient died of pneumonia. ANCA-associated vasculitis is a rare but serious finding in SSc patients. Positive anti-Scl-70 antibody is found commonly in these patients. Different treatment modalities are effective. Serious infections can complicate therapy and lead to death.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.