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Find video protocols related to scientific articles indexed in Pubmed.
Efficacy and safety of canagliflozin compared with placebo in older patients with type 2 diabetes mellitus: a pooled analysis of clinical studies.
BMC Endocr Disord
PUBLISHED: 04-10-2014
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Canagliflozin is a sodium glucose co-transporter 2 inhibitor developed for the treatment of patients with type 2 diabetes mellitus (T2DM). The efficacy and safety of canagliflozin were evaluated in patients with T2DM <65 and ?65 years of age.
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An innovative model of diabetes care and delivery: the St. Joseph's Primary Care Diabetes Support Program (SJHC PCDSP).
Can J Diabetes
PUBLISHED: 03-24-2014
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The majority of diabetes care in Canada is provided within the primary healthcare setting. It is delivered in a variety of models ranging from the physician working in a solo fee-for-service practice to an interprofessional team setting with specialist collaboration. To augment diabetes-related health services, the Ontario government has provided substantial funding to support community diabetes education programs. These models and initiatives are improving diabetes outcomes, and continued evolution of these programs can provide even greater outcomes. The St. Joseph's Primary Care Diabetes Support Program (SJHC PCDSP) is an innovative model that incorporates multidisciplinary allied health professionals together with physician support to provide care for more than 3000 patients in London, Ontario, Canada. It embodies the Canadian Diabetes Association (CDA)'s Organizations of Care recommendations to combine patient education and self-management with active medical support at each clinic encounter, all while embodying the tenets of primary care. A brief review of primary healthcare reform is provided to explain how the SJHC PCDSP combines features of current models in a unique format so as to deliver exceptional patient care. By providing a detailed description of the services delivered at the SJHC PCDSP, it is hoped that both specialists and primary care providers consider using and adapting approaches to diabetes management based on this innovative model to optimize their practices.
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Prevalence and epidemiology of diabetes in Canadian primary care practices: a report from the Canadian Primary Care Sentinel Surveillance Network.
Can J Diabetes
PUBLISHED: 02-14-2014
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The Canadian Primary Care Sentinel Surveillance Network (CPCSSN) is a large, validated national primary care Electronic Medical Records (EMR)-based database. Our objective was to describe the epidemiology of diabetes in this Canadian sample.
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The effect of hypoglycemia on health-related quality of life: Canadian results from a multinational time trade-off survey.
Can J Diabetes
PUBLISHED: 02-04-2014
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The aim of this study was to investigate the impact of hypoglycemia according to severity and time of onset on health-related quality of life (HRQoL) in a Canadian population.
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Improving chronic care through continuing education of interprofessional primary healthcare teams: a process evaluation.
J Interprof Care
PUBLISHED: 01-07-2014
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Process evaluations assess program structures and implementation processes so that outcomes can be accurately interpreted. This article reports the results of a process evaluation of Partnerships for Health, an initiative targeting interprofessional primary healthcare teams to improve chronic care in Southwestern Ontario, Canada. Program documentation, participant observation, and in-depth interviews were used to capture details about the program structure, implementation process, and experience of implementers and participants. Results suggest that the intended program was modified during implementation to better meet the needs of participants and to overcome participation barriers. Elements of program activities perceived as most effective included series of off-site learning/classroom sessions, practice-based/workplace information-technology (IT) support, and practice coaching because they provided: dedicated time to learn how to improve chronic care; team-building/networking within and across teams; hands-on IT training/guidance; and flexibility to meet individual practice needs. This process evaluation highlighted key program activities that were essential to the continuing education (CE) of interprofessional primary healthcare teams as they attempted to transform primary healthcare to improve chronic care.
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Results of a mixed-methods evaluation of partnerships for health: a quality improvement initiative for diabetes care.
J Am Board Fam Med
PUBLISHED: 11-09-2013
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Quality improvement (QI) initiatives have been implemented to facilitate transition to a chronic disease management approach in primary health care. However, the effect of QI initiatives on diabetes clinical processes and outcomes remains unclear. This article reports the effect of Partnerships for Health, a QI program implemented in Southwestern Ontario, Canada, on diabetes clinical process and outcome measures and describes program participants views of elements that influenced their ability to reach desired improvements.
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Does a patient-managed insulin intensification strategy with insulin glargine and insulin glulisine provide similar glycemic control as a physician-managed strategy? Results of the START (Self-Titration with Apidra(R) to Reach Target) Study - A randomized
Diabetes Care
PUBLISHED: 10-29-2013
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ObjectiveDiabetes self-management is universally regarded as a foundation of diabetes care. We determined whether comparable glycemic control could be achieved by self-titration versus physician titration of a once-daily bolus insulin dose in patients with type 2 diabetes unable to achieve optimal glycemia control with a basal insulin.Research Design and MethodsPatients with type 2 diabetes, a HbA1c above 7% (53 mmol/mol) and with either nocturnal hypoglycemia episodes or on sufficient basal insulin glargine (±oral agents) to achieve a fasting plasma glucose ?6 mmol/L (108 mg/dL) were studied. Participants all had bolus insulin glulisine added at breakfast and were allocated to either algorithm-guided patient self-titration versus physician titration. The primary outcome was HbA1c ?7% (53 mmol/mol) without severe hypoglycemia.ResultsAfter a mean (SD) follow-up of 159.4 days (36.2), 28.4% of participants in the self-titration arm versus 21.2% in the physician titration arm achieved HbA1c ?7% (53 mmol/mol) without severe hypoglycemia (between-group absolute difference = 7.2%; 95% CI: -3.2 to 17.7). The lower end of this 95% composite interval was within the predetermined noninferiority boundary of -5% (p noninferiority=0.011).ConclusionsIn patients with type 2 diabetes on stable doses of basal insulin glargine who require bolus insulin, a simple bolus insulin patient-driven titration algorithm is as effective as a physician-driven algorithm.
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Short leg length, a marker of early childhood deprivation, is associated with metabolic disorders underlying type 2 diabetes: the PROMISE cohort study.
Diabetes Care
PUBLISHED: 10-02-2013
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Short leg length, a marker of early childhood deprivation, has been used in studies of the association of early life conditions with adult chronic disease risk. The objective of this study was to determine the cross-sectional associations of leg length with measures of insulin sensitivity and ?-cell function.
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Health-related quality of life associated with daytime and nocturnal hypoglycaemic events: a time trade-off survey in five countries.
Health Qual Life Outcomes
PUBLISHED: 03-07-2013
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Hypoglycaemic events, particularly nocturnal, affect health-related quality of life (HRQoL) via acute symptoms, altered behaviour and fear of future events. We examined the respective disutility associated with a single event of daytime, nocturnal, severe and non-severe hypoglycaemia.
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Can community retail pharmacist and diabetes expert support facilitate insulin initiation by family physicians? Results of the AIM@GP randomized controlled trial.
BMC Health Serv Res
PUBLISHED: 02-11-2013
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Limited evidence exists on the effectiveness of external diabetes support provided by diabetes specialists and community retail pharmacists to facilitate insulin-prescribing in family practice.
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Type 2 diabetes mellitus management in Canada: is it improving?
Can J Diabetes
PUBLISHED: 01-25-2013
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To gain insight into the current management of patients with type 2 diabetes mellitus by Canadian primary care physicians.
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Similarities and differences in cardiometabolic risk factors among remote Aboriginal Australian and Canadian cohorts.
Diabetes Res. Clin. Pract.
PUBLISHED: 01-09-2013
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Indigenous populations of Australia and Canada experience disproportionately high rates of chronic disease. We hypothesized that despite the common outcome of increased diabetes prevalence, differences in cardiometabolic risk profile may exist between these populations.
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Prospective association of 25(OH)D with metabolic syndrome.
Clin. Endocrinol. (Oxf)
PUBLISHED: 01-02-2013
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CONTEXT: Vitamin D may play a role in the aetiology of the metabolic syndrome (MetS), yet the majority of previous studies have been cross-sectional, and the limited number of prospective studies has yielded inconsistent results. OBJECTIVE: To examine the prospective association of vitamin D [25-hydroxyvitamin D, 25(OH)D] with MetS in a multi-ethnic cohort of adults in Ontario, Canada. DESIGN: Nondiabetic individuals with pre-existing MetS risk factors were recruited for participation in the PROspective Metabolism and ISlet cell Evaluation (PROMISE) cohort study, a longitudinal study of the determinants of insulin resistance and MetS. METHODS: Of the 654 participants enrolled at baseline, 489 attended a 3-year follow-up visit. There were 301 participants eligible for the analysis of 25(OH)D with incident MetS (age 49·2 ± 9·3 years old, 75·4% female), after excluding 188 (38·5%) prevalent MetS cases at baseline. Longitudinal change in MetS components was assessed in the entire follow-up cohort. RESULTS: There were 76 (15·5%) participants who developed MetS over the 3-years of follow-up. Multivariate logistic regression analyses indicated a decreased risk of MetS at follow-up per standard deviation increase in baseline 25(OH)D after adjustment for sociodemographics, season, baseline and change in supplement use and physical activity and insulin resistance (OR = 0·63, 95% CI 0·44-0·90). Multivariate linear regression analyses revealed a significant inverse association of baseline 25(OH)D with fasting glucose at follow-up (? = -0·0005, P = 0·025). CONCLUSIONS: There was a significant inverse association of baseline 25(OH)D with incident MetS, which may be partly driven by its association with glucose homoeostasis.
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Sandy lake health and diabetes project: a community-based intervention targeting type 2 diabetes and its risk factors in a first nations community.
Front Endocrinol (Lausanne)
PUBLISHED: 01-01-2013
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The Sandy Lake Health and Diabetes Project (SLHDP) was initiated in 1991 as a partnership between Sandy Lake First Nation and researchers interested in addressing the high rates of type 2 diabetes mellitus (T2DM) in the community. Following the expressed wishes of the community, the SLHDP has encompassed a variety of community-wide interventions and activities including: community surveys to document T2DM prevalence and risk factors, the Northern Store program aimed at increasing the availability and knowledge of healthy food options, a home visit program for the prevention and management of T2DM, a local diabetes radio show, a school diabetes curriculum for grades 3 and 4, a community-wide walking trail to encourage increased physical activity, youth diabetes summer camps, and a variety of community events focusing on nutrition and physical activity. Over the 22?year existence of the SLHDP, the community has taken ownership of the program and activities have evolved in alignment with community needs and priorities. This paper discusses the history, implementation, evaluation, and outcomes of the SLHDP and describes its sustainability. The SLHDP is a model of culturally appropriate participatory research that is iterative, with reciprocal capacity building for both key community stakeholders and academic partners.
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Descriptions of health states associated with increasing severity and frequency of hypoglycemia: a patient-level perspective.
Patient Prefer Adherence
PUBLISHED: 01-01-2013
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We sought to develop descriptions of health states associated with daytime and nocturnal hypoglycemia in a structured fashion from the patients perspective under different combinations of severity and frequency of hypoglycemic events.
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Providers perceptions of barriers to the management of type 2 diabetes in remote Aboriginal settings.
Int J Circumpolar Health
PUBLISHED: 11-01-2011
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To examine providers perspectives of the barriers to providing diabetes care in remote First Nation communities in the Sioux Lookout Zone (SLZ) of Northwestern Ontario, Canada.
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Challenges to the provision of diabetes care in first nations communities: results from a national survey of healthcare providers in Canada.
BMC Health Serv Res
PUBLISHED: 10-21-2011
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Aboriginal peoples globally, and First Nations peoples in Canada particularly, suffer from high rates of type 2 diabetes and related complications compared with the general population. Research into the unique barriers faced by healthcare providers working in on-reserve First Nations communities is essential for developing effective quality improvement strategies.
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Hypertension in people with type 2 diabetes: Update on pharmacologic management.
Can Fam Physician
PUBLISHED: 09-16-2011
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To summarize the evidence for the need to improve pharmacologic management of hypertension in people with type 2 diabetes and to provide expert advice on how blood pressure (BP) treatment can be improved in primary care.
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Prospective associations of vitamin D with ?-cell function and glycemia: the PROspective Metabolism and ISlet cell Evaluation (PROMISE) cohort study.
Diabetes
PUBLISHED: 09-12-2011
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To examine the prospective associations of baseline vitamin D [25-hydroxyvitamin D; 25(OH)D] with insulin resistance (IR), ?-cell function, and glucose homeostasis in subjects at risk for type 2 diabetes.
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Changes over time in glycemic control, insulin sensitivity, and beta-cell function in response to low-dose metformin and thiazolidinedione combination therapy in patients with impaired glucose tolerance.
Diabetes Care
PUBLISHED: 06-29-2011
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In the Canadian Normoglycemia Outcome Evaluation (CANOE) trial, low-dose rosiglitazone/metformin reduced the risk of diabetes in subjects with impaired glucose tolerance by 66% over a median of 3.9 years. We evaluate the temporal changes in glycemic control, insulin sensitivity, and ?-cell function during this trial.
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Screen-related sedentary behaviours of school-aged children: Principals and teachers perspectives.
Health Educ J
PUBLISHED: 04-07-2011
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OBJECTIVE: To solicit school principals and teachers perspectives on childrens screen-related sedentary behaviour and to identify possible solutions to reduce sedentary behaviours among school-aged children. METHOD: In-person interviews using a semi-structured interview guide were conducted with school principals and grades five and six classroom teachers in 14 randomly selected elementary schools in London and Middlesex County, Ontario. Fourteen principals and 39 classroom teachers participated in the study. Inductive content analysis was performed independently by two researchers. RESULTS: Both principals and teachers were very concerned about childrens excessive screen activities, but they did not perceive that they could play a key role in reducing these behaviours. Key barriers were identified to reducing screen-related sedentary behaviour and to childrens active living both at and away from school. They included competing demands from other subjects, limited gym resources/space within the school, a lack of control over the home environment, and a perception that parents were poor role models. Notwithstanding the above barriers, principals and teachers still recommended increasing childrens daily physical activity both within and outside of school hours. Furthermore, they stressed the need for parents to play a key role in reducing their childrens screen-related sedentary behaviours and increasing their level of physical activity. CONCLUSION: School principals and teachers were very concerned about excessive screen-behaviour among school-aged children when away from school and suggested that interventions should emphasize increasing daily physical education, promoting recreational sports at or away from school, and engaging parents in regulating screen time at home.
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Identification and management of cardiometabolic risk in Canada: a position paper by the cardiometabolic risk working group (executive summary).
Can J Cardiol
PUBLISHED: 04-05-2011
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With the objectives of clarifying the concepts related to "cardiometabolic risk," "metabolic syndrome" and "risk stratification" and presenting practical strategies to identify and reduce cardiovascular risk in multiethnic patient populations, the Cardiometabolic Working Group presents an executive summary of a detailed analysis and position paper that offers a comprehensive and consolidated approach to the identification and management of cardiometabolic risk. The above concepts overlap and relate to the atherogenic process and development of type 2 diabetes. However, there is confusion about what these terms mean and how they can best be used to improve our understanding of cardiovascular disease treatment and prevention. The concepts related to cardiometabolic risk, pathophysiology, and strategies for identification and management (including health behaviours, pharmacotherapy, and surgery) in the multiethnic Canadian population are presented. "Global cardiometabolic risk" is proposed as an umbrella term for a comprehensive list of existing and emerging factors that predict cardiovascular disease and/or type 2 diabetes. Health behaviour interventions (weight loss, physical activity, diet, smoking cessation) in people identified at high cardiometabolic risk are of critical importance given the emerging crisis of obesity and the consequent epidemic of type 2 diabetes. Vascular protective measures (health behaviours for all patients and pharmacotherapy in appropriate patients) are essential to reduce cardiometabolic risk, and there is growing consensus that a multidisciplinary approach is needed to adequately address cardiometabolic risk factors. Health care professionals must also consider ethnicity-related risk factors in order to appropriately evaluate all individuals in their diverse patient populations.
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Cardiometabolic risk in Canada: a detailed analysis and position paper by the cardiometabolic risk working group.
Can J Cardiol
PUBLISHED: 04-05-2011
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The concepts of "cardiometabolic risk," "metabolic syndrome," and "risk stratification" overlap and relate to the atherogenic process and development of type 2 diabetes. There is confusion about what these terms mean and how they can best be used to improve our understanding of cardiovascular disease treatment and prevention. With the objectives of clarifying these concepts and presenting practical strategies to identify and reduce cardiovascular risk in multiethnic patient populations, the Cardiometabolic Working Group reviewed the evidence related to emerging cardiovascular risk factors and Canadian guideline recommendations in order to present a detailed analysis and consolidated approach to the identification and management of cardiometabolic risk. The concepts related to cardiometabolic risk, pathophysiology, and strategies for identification and management (including health behaviours, pharmacotherapy, and surgery) in the multiethnic Canadian population are presented. "Global cardiometabolic risk" is proposed as an umbrella term for a comprehensive list of existing and emerging factors that predict cardiovascular disease and/or type 2 diabetes. Health behaviour interventions (weight loss, physical activity, diet, smoking cessation) in people identified at high cardiometabolic risk are of critical importance given the emerging crisis of obesity and the consequent epidemic of type 2 diabetes. Vascular protective measures (health behaviours for all patients and pharmacotherapy in appropriate patients) are essential to reduce cardiometabolic risk, and there is growing consensus that a multidisciplinary approach is needed to adequately address cardiometabolic risk factors. Health care professionals must also consider risk factors related to ethnicity in order to appropriately evaluate everyone in their diverse patient populations.
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Number of HbA1c tests unrelated to quality of diabetes control: an electronic medical record data linkage study.
Diabetes Res. Clin. Pract.
PUBLISHED: 04-04-2011
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Process measures are heavily relied on to assess physician performance/quality of diabetes control. A unique primary care electronic medical record-health administrative database linkage found no clinically meaningful relationship between control (HbA1c value) and number of tests performed, casting doubt on the usefulness in diabetes performance and quality of care assessment.
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Major gaps in diabetes clinical care among Canadas First Nations: results of the CIRCLE study.
Diabetes Res. Clin. Pract.
PUBLISHED: 01-27-2011
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The aim of this cross-sectional study was to document the clinical management of type 2 diabetes and related complications in Canadas First Nations.
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HNF1A G319S variant, active cigarette smoking and incident type 2 diabetes in Aboriginal Canadians: a population-based epidemiological study.
BMC Med. Genet.
PUBLISHED: 01-05-2011
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In a recent report of large-scale association analysis, a type 2 diabetes susceptibility locus near HNF1A was identified in predominantly European descent populations. A population-specific G319S polymorphism in HNF1A was previously identified in Aboriginal Canadians who have a high prevalence of type 2 diabetes. We aimed to investigate the association of the HNF1A G319S polymorphism with incident type 2 diabetes and to assess whether clinical risk variables for type 2 diabetes influence the association in an Aboriginal population.
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Lessons learned in using community-based participatory research to build a national diabetes collaborative in Canada.
Prog Community Health Partnersh
PUBLISHED: 01-01-2011
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Using community-based participatory research (CBPR) principles, the Canadian First Nations Diabetes Clinical Management Epidemiologic (CIRCLE) study documents the current clinical management of type 2 diabetes (T2DM) and complications in 19 partnering First Nations (FN) communities.
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Clinical inertia in patients with T2DM requiring insulin in family practice.
Can Fam Physician
PUBLISHED: 12-16-2010
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To describe the clinical status of patients with type 2 diabetes mellitus (T2DM) in the primary care setting at insulin initiation and during follow-up, and to assess the efficacy of insulin initiation and intensification.
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Association of 25(OH)D and PTH with metabolic syndrome and its traditional and nontraditional components.
J. Clin. Endocrinol. Metab.
PUBLISHED: 10-27-2010
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Emerging evidence suggests that 25-hydroxy vitamin D [25(OH)D] and PTH may play a role in the etiology of the metabolic syndrome (MetS). However, evidence to date is limited and inconsistent, and few studies have examined associations with nontraditional MetS components.
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Investigating concordance in diabetes diagnosis between primary care charts (electronic medical records) and health administrative data: a retrospective cohort study.
BMC Health Serv Res
PUBLISHED: 08-04-2010
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Electronic medical records contain valuable clinical information not readily available elsewhere. Accordingly, they hold important potential for contributing to and enhancing chronic disease registries with the goal of improving chronic disease management; however a standard for diagnoses of conditions such as diabetes remains to be developed. The purpose of this study was to establish a validated electronic medical record definition for diabetes.
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Assessing the association of the HNF1A G319S variant with C-reactive protein in Aboriginal Canadians: a population-based epidemiological study.
Cardiovasc Diabetol
PUBLISHED: 07-06-2010
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C-reactive protein (CRP), a biomarker of inflammation, has been associated with increased risk of developing cardiovascular disease. Common variants of the hepatocyte nuclear factor 1A (HNF1A) gene encoding HNF-1alpha have been associated with plasma CRP in predominantly European Caucasian samples. HNF1A might therefore have an impact on vascular disease and diabetes risk that is mediated by CRP. In an Aboriginal Canadian population, a private polymorphism, HNF1A G319S, was associated with increased prevalence of type 2 diabetes. However, it has not been investigated whether this association is mediated by CRP. We aimed to investigate whether CRP was mediating the association between HNF1A G319S and type 2 diabetes in an Aboriginal Canadian population with a high prevalence of diabetes.
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Controlled trial of an intervention to improve cholesterol management in diabetes patients in remote Aboriginal communities.
Int J Circumpolar Health
PUBLISHED: 06-18-2010
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Aboriginal communities have a high prevalence of diabetes and heart disease, and limited resources to address them. The objective of this study was to test the effectiveness of prioritizing care with audit and feedback on cholesterol management of diabetic patients.
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Treatment gaps in the management of cardiovascular risk factors in patients with type 2 diabetes in Canada.
Can J Cardiol
PUBLISHED: 06-16-2010
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To evaluate vascular protection treatment patterns and attainment of the 2003 Canadian Diabetes Associations recommended targets in ambulatory patients with type 2 diabetes.
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Low-dose combination therapy with rosiglitazone and metformin to prevent type 2 diabetes mellitus (CANOE trial): a double-blind randomised controlled study.
Lancet
PUBLISHED: 06-03-2010
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The evolving epidemic of type 2 diabetes has challenged health-care providers to assess the safety and efficacy of various diabetes prevention strategies. The CANOE (CAnadian Normoglycemia Outcomes Evaluation) trial investigated whether low-dose combination therapy would affect development of type 2 diabetes.
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Childhood overweight and obesity management: A national perspective of primary health care providers views, practices, perceived barriers and needs.
Paediatr Child Health
PUBLISHED: 05-17-2010
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Obesity and overweight in children are an escalating problem in Canada and worldwide. Currently, little is known about the manner in which primary health care providers are responding to Canadas obesity epidemic.
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Canadian global village reality: anthropometric surrogate cutoffs and metabolic abnormalities among Canadians of East Asian, South Asian, and European descent.
Can Fam Physician
PUBLISHED: 05-14-2010
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To test the appropriateness of body mass index (BMI) and waist circumference (WC) cutoff points derived in largely white populations (ie, those of European descent) for detecting obesity-related metabolic abnormalities among East Asian and South Asian Canadians.
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The geography of diabetes in London, Canada: the need for local level policy for prevention and management.
Int J Environ Res Public Health
PUBLISHED: 03-11-2010
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Recent reports aimed at improving diabetes care in socially disadvantaged populations suggest that interventions must be tailored to meet the unique needs of the local community-specifically, the communitys geography. We have examined the spatial distribution of diabetes in the context of socioeconomic determinants of health in London (Ontario, Canada) to characterize neighbourhoods in an effort to target these neighbourhoods for local level community-based program planning and intervention. Multivariate spatial-statistical techniques and geographic information systems were used to examine diabetes rates and socioeconomic variables aggregated at the census tract level. Creation of a deprivation index facilitated investigation across multiple determinants of health. Findings from our research identified at risk neighbourhoods in London with socioeconomic disadvantage and high diabetes. Future endeavours must continue to identify local level trends in order to support policy development, resource planning and care for improved health outcomes and improved equity in access to care across geographic regions.
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Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes.
Diabetes Care
PUBLISHED: 03-09-2010
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To examine cross-sectional associations of serum vitamin D [25-hydroxyvitamin D, 25(OH)D] concentration with insulin resistance (IR) and beta-cell dysfunction in 712 subjects at risk for type 2 diabetes.
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Association of apolipoprotein B with incident type 2 diabetes in an aboriginal Canadian population.
Clin. Chem.
PUBLISHED: 01-28-2010
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Expanding evidence indicates that apolipoprotein B (apo B) is superior to LDL cholesterol as a marker of vascular disease. Although traditional lipid measures are known to predict type 2 diabetes, limited data are available regarding apo B. We assessed the association of apo B with incident type 2 diabetes and compared it with traditional lipid variables as a risk predictor in aboriginal Canadians.
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Nutrition and exercise prevent excess weight gain in overweight pregnant women.
Med Sci Sports Exerc
PUBLISHED: 01-20-2010
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To determine the effect of a Nutrition and Exercise Lifestyle Intervention Program (NELIP) for overweight (OW) and obese (OB) pregnant women on pregnancy weight gain, birth weight, and maternal weight retention at 2 months postpartum.
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Screen-related sedentary behaviors: childrens and parents attitudes, motivations, and practices.
J Nutr Educ Behav
PUBLISHED: 11-14-2009
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To investigate school-aged childrens and parents attitudes, social influences, and intentions toward excessive screen-related sedentary behavior (S-RSB).
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APOC1 T45S polymorphism is associated with reduced obesity indices and lower plasma concentrations of leptin and apolipoprotein C-I in aboriginal Canadians.
J. Lipid Res.
PUBLISHED: 10-06-2009
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Apolipoprotein (apo) C-I is a constituent of chylomicrons, very low density lipoprotein, and high density lipoprotein. The role of apo C-I in human metabolism is incompletely defined. We took advantage of a naturally occurring amino acid polymorphism that is present in aboriginal North Americans, namely apo C-I T45S. We assessed the hypothesis that metabolic traits, including obesity-related and lipoprotein-related traits, would differ between carriers and noncarriers of apo C-I T45S. A genotyping assay was developed for APOC1 T45S and genotypes were determined in a sample of 410 Canadian Oji-Cree subjects. The allele frequency of the apo C-I S45 allele was approximately 8% in this sample. We observed the apo C-I S45 allele was significantly associated with 1) lower percent body fat (P < 0.05), 2) lower waist circumference (P = 0.058), 3) lower serum leptin levels (P < 0.05), and 4) lower plasma apo C-I levels (P < 0.0001), using a newly developed ELISA-based method. Taken together, these results suggest that at the whole human phenotype level, apo C-I is associated with the complex metabolic trait of obesity as well as with serum leptin levels.
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Association of hematological parameters with insulin resistance and beta-cell dysfunction in nondiabetic subjects.
J. Clin. Endocrinol. Metab.
PUBLISHED: 07-21-2009
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Previous studies reported independent associations of hematological parameters with risk of incident type 2 diabetes, although limited data are available on associations of these parameters with insulin resistance (IR) and (especially) pancreatic beta-cell dysfunction in large epidemiological studies. Our objective was to evaluate the associations of hematological parameters, including hematocrit (HCT), hemoglobin (Hgb), red blood cell count (RBC), and white blood cell count with IR and beta-cell dysfunction in a cohort of nondiabetic subjects at high metabolic risk.
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Understanding screen-related sedentary behavior and its contributing factors among school-aged children: a social-ecologic exploration.
Am J Health Promot
PUBLISHED: 05-19-2009
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To explore the factors that contribute to childrens screen-related sedentary (S-RS) behaviors.
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Treatment satisfaction of diabetic patients: what are the contributing factors?
Fam Pract
PUBLISHED: 03-02-2009
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Treatment satisfaction is an important factor of quality of care, especially in treating chronic diseases such as diabetes mellitus. Identifying factors that independently influence treatment satisfaction may help in improving clinical outcomes.
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Association of the novel cardiovascular risk factors paraoxonase 1 and cystatin C in type 2 diabetes.
J. Lipid Res.
PUBLISHED: 01-18-2009
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Paraoxonase 1 (PON1) has been reported to be associated with proteinuria in subjects with type 2 diabetes mellitus (T2DM). Plasma cystatin C is more accurate than creatinine for identifying stage 3 kidney disease in T2DM. We tested the hypothesis that PON1 and cystatin C would be associated in T2DM subjects from an Aboriginal Canadian community, who are at high risk for the development of nephropathy. PON1 A(-162)G and PON2 Ala148Gly genotypes, cystatin C, HbA1c, high density lipoprotein cholesterol (HDLC), waist circumference (waist), and duration of diabetes were included in the regression analysis with log(e) (ln) of PON1 mass as the dependent variable. A regression model including PON2 Ala148Gly genotype, HDLC, and ln cystatin C explained 25.8% of the variance in PON1 mass. Conversely, waist, age, ln HbA1c, ln duration of diabetes, and ln PON1 mass, but not PON2 genotype, explained 38% of the variance in cystatin C. Subjects with cystatin C estimated glomerular filtration rate (eGFR) <60 ml/min per 1.73 m(2) (stage 3 kidney disease) had significantly lower PON1 mass compared with subjects with cystatin C-eGFR >60 ml/min per 1.73 m(2). The lower mass of PON1, an anti-inflammatory HDL-associated enzyme, in T2DM with cystatin C-eGFR <60 ml/min per 1.73 m(2) may contribute to their increased risk for cardiovascular disease.
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Prevalence, determinants and co-morbidities of chronic kidney disease among First Nations adults with diabetes: results from the CIRCLE study.
BMC Nephrol
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Indigenous peoples worldwide are experiencing elevated rates of type 2 diabetes and its complications. To better understand the disproportionate burden of diabetic end stage renal disease (ESRD) among Canadian First Nations people (FN), we examined prevalence, determinants, and co-morbidities of chronic kidney disease (CKD) within this population.
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Cardiovascular disease risk profile and microvascular complications of diabetes: comparison of Indigenous cohorts with diabetes in Australia and Canada.
Cardiovasc Diabetol
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Indigenous populations of Australia and Canada experience disproportionately high rates of chronic disease. Our goal was to compare cardiovascular (CVD) risk profile and diabetes complications from three recent comprehensive studies of diabetes complications in different Indigenous populations in Australia and Canada.
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White Blood Cell Subtypes, Insulin Resistance and ?-cell Dysfunction in High Risk Individuals - the PROMISE Cohort.
Clin. Endocrinol. (Oxf)
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Higher white blood cell count (WBC) is associated with incident type 2 diabetes, however little is known about the potential relationship of WBC subtypes with metabolic abnormalities underlying diabetes.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.