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Find video protocols related to scientific articles indexed in Pubmed.
Restoring tactile and erogenous penile sensation in low-spinal-lesion patients: procedural and technical aspects following 43 TOMAX nerve transfer procedures.
Plast. Reconstr. Surg.
PUBLISHED: 07-29-2014
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The "TOMAX" (TO MAX-imize sensation, sexuality, and quality of life) procedure restores genital sensation in men with low spinal lesions, improving sexual health, as shown previously. It connects the dorsal nerve of the penis to the intact ipsilateral ilioinguinal nerve, unilaterally or bilaterally. This study reports on the technical aspects based on 43 TOMAX nerve transfers.
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New insights into domestication of carrot from root transcriptome analyses.
BMC Genomics
PUBLISHED: 07-10-2014
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Understanding the molecular basis of domestication can provide insights into the processes of rapid evolution and crop improvement. Here we demonstrated the processes of carrot domestication and identified genes under selection based on transcriptome analyses.
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Laparoscopic burch colposuspension in children: technical challenges and primary results.
J Laparoendosc Adv Surg Tech A
PUBLISHED: 05-20-2014
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To present the primary results of laparoscopic, Burch-type colposuspension (LBC) in children.
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Cross-sectional study of determinants of upper and lower urinary tract outcomes in adults with spinal dysraphism--new recommendations for urodynamic followup guidelines?
J. Urol.
PUBLISHED: 02-26-2014
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Although annual urodynamic study is currently recommended for all adults with spinal dysraphism, this followup might be overly intensive. Therefore, in this cross-sectional study we examine which determinants of upper and lower urinary tract outcomes are associated with relevant urodynamic findings.
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Long-term follow-up after transurethral treatment of infravesical obstruction in boys.
Urology
PUBLISHED: 02-16-2014
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To study whether boys who underwent transurethral treatment of (mild) infravesical obstruction during childhood have lower urinary tract symptoms and complications at young adult age.
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Diffusion tensor magnetic resonance imaging and fiber tractography of the sacral plexus in children with spina bifida.
J. Urol.
PUBLISHED: 02-10-2014
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It is still largely unknown how neural tube defects in spina bifida affect the nerves at the level of the sacral plexus. Visualizing the sacral plexus in 3 dimensions could improve our anatomical understanding of neurological problems in patients with spina bifida. We investigated anatomical and microstructural properties of the sacral plexus of patients with spina bifida using diffusion tensor imaging and fiber tractography.
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Restoring penis sensation in patients with low spinal cord lesions: The role of the remaining function of the dorsal nerve in a unilateral or bilateral TOMAX procedure.
Neurourol. Urodyn.
PUBLISHED: 01-06-2014
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Aims: The recently developed TOMAX-procedure restores unilateral genital sensation, improving sexual health in men with a low spinal lesion (LSL). It connects one dorsal nerve of the penis (DNP) to the intact ipsilateral ilioinguinal nerve. We proposed bilateral neurotization for full sensation of the glans but this entails cutting both DNPs, risking patients' erection/ejaculation ability. The objective was to select patients for a bilateral TOMAX-procedure by measuring remaining DNP function, and perform the first bilateral cases.
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A systematic review on the accuracy of diagnostic procedures for infravesical obstruction in boys.
PLoS ONE
PUBLISHED: 01-01-2014
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Infravesical obstruction leads to kidney and bladder dysfunction in a significant proportion of boys. The aim of this review is to determine the value of diagnostic tests for ascertainment of infravesical obstruction in boys.
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Vesicoscopic bladder neck procedure in children: what we have learned from the first series.
J Laparoendosc Adv Surg Tech A
PUBLISHED: 08-17-2013
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To assess the results of endoscopic bladder neck procedure on the anterior bladder wall in children.
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Behavioral effects of long-term antimuscarinic use in patients with spinal dysraphism: a case control study.
J. Urol.
PUBLISHED: 06-12-2013
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We explored possible associations between long-term antimuscarinic use and behavioral problems in children with spinal dysraphism and neurogenic bladder.
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Hemorrhagic cystitis in a cohort of pediatric transplantations: incidence, treatment, outcome, and risk factors.
Biol. Blood Marrow Transplant.
PUBLISHED: 04-17-2013
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Hemorrhagic cystitis (HC) can be a severe complication in hematopoietic stem cell transplantation (HSCT). To identify risk factors and etiology and to improve treatment, a number of factors were analyzed retrospectively in a cohort of 74 consecutive pediatric HSCTs between 2007 and 2009 in a single institution. The 74 transplantations were done in 67 children. Potential risk factors for HC were age, gender, underlying disease, ablative conditioning, graft-versus-host disease prophylaxis, unrelated donor, stem cell source, conditioning regime, acute graft-versus-host disease and cytomegalovirus reactivation. Fourteen patients developed HC (19%). In all but 4 cases (71%), HC appeared after engraftment. Severity was assessed as grade 1 in 1, grade 2 in 8, and grade 3 in 5 cases. In 79% of the patients with HC, urine samples showed BK virus. This may provide guidance for future prevention policies. In 11 children, treatment included forced hydration, spasmolytics, and bladder irrigation. Three children required cystoscopy, intravesical therapy and/or antiviral therapy. Statistical analysis revealed age over six years to be a risk factor for the development of HC. We conclude that current conditioning regimens lead to a still considerable incidence of HC in pediatric HSCT, necessitating the evaluation of screening protocols and preventive measures.
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Cultural bias in the AAPs 2012 Technical Report and Policy Statement on male circumcision.
Pediatrics
PUBLISHED: 03-18-2013
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The American Academy of Pediatrics recently released its new Technical Report and Policy Statement on male circumcision, concluding that current evidence indicates that the health benefits of newborn male circumcision outweigh the risks. The technical report is based on the scrutiny of a large number of complex scientific articles. Therefore, while striving for objectivity, the conclusions drawn by the 8 task force members reflect what these individual physicians perceived as trustworthy evidence. Seen from the outside, cultural bias reflecting the normality of nontherapeutic male circumcision in the United States seems obvious, and the reports conclusions are different from those reached by physicians in other parts of the Western world, including Europe, Canada, and Australia. In this commentary, a different view is presented by non-US-based physicians and representatives of general medical associations and societies for pediatrics, pediatric surgery, and pediatric urology in Northern Europe. To these authors, only 1 of the arguments put forward by the American Academy of Pediatrics has some theoretical relevance in relation to infant male circumcision; namely, the possible protection against urinary tract infections in infant boys, which can easily be treated with antibiotics without tissue loss. The other claimed health benefits, including protection against HIV/AIDS, genital herpes, genital warts, and penile cancer, are questionable, weak, and likely to have little public health relevance in a Western context, and they do not represent compelling reasons for surgery before boys are old enough to decide for themselves.
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Efficacy and safety of urethral de-obstruction in boys with overactive bladder complaints.
J Pediatr Urol
PUBLISHED: 03-14-2013
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To gain insight into the efficacy and safety of urethral de-obstruction in boys with overactive bladder (OAB) complaints refractory to conservative treatment.
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Rectal examination in children: digital versus transabdominal ultrasound.
J. Urol.
PUBLISHED: 02-27-2013
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We investigate 2 diagnostic tests to assess the rectal filling state.
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Spinal cord transection before scoliosis correction in myelomeningocele may improve bladder function.
Neurourol. Urodyn.
PUBLISHED: 01-21-2013
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In patients with myelomeningocele (MMC) and coexistent scoliosis, a spinal cord transection (SC-transection) is sometimes performed before scoliosis correction to prevent traction on the myelum after stretching the spinal column. Performing a SC-transection may have positive effects on bladder function, especially in case of refractory detrusor-sphincter dyssynergia. This study investigates the effects of SC-transection on lower and upper urinary tract outcomes.
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Multi-center randomized controlled trial of cognitive treatment, placebo, oxybutynin, bladder training, and pelvic floor training in children with functional urinary incontinence.
Neurourol. Urodyn.
PUBLISHED: 01-04-2013
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OBJECTIVE: Functional urinary incontinence causes considerable morbidity in 8.4% of school-age children, mainly girls. To compare oxybutynin, placebo, and bladder training in overactive bladder (OAB), and cognitive treatment and pelvic floor training in dysfunctional voiding (DV), a multi-center controlled trial was designed, the European Bladder Dysfunction Study. METHODS: Seventy girls and 27 boys with clinically diagnosed OAB and urge incontinence were randomly allocated to placebo, oxybutynin, or bladder training (branch I), and 89 girls and 16 boys with clinically diagnosed DV to either cognitive treatment or pelvic floor training (branch II). All children received standardized cognitive treatment, to which these interventions were added. The main outcome variable was daytime incontinence with/without urinary tract infections. Urodynamic studies were performed before and after treatment. RESULTS: In branch I, the 15% full response evolved to cure rates of 39% for placebo, 43% for oxybutynin, and 44% for bladder training. In branch II, the 25% full response evolved to cure rates of 52% for controls and 49% for pelvic floor training. Before treatment, detrusor overactivity (OAB) or pelvic floor overactivity (DV) did not correlate with the clinical diagnosis. After treatment these urodynamic patterns occurred de novo in at least 20%. CONCLUSION: The mismatch between urodynamic patterns and clinical symptoms explains why cognitive treatment was the key to success, not the added interventions. Unpredictable changes in urodynamic patterns over time, the response to cognitive treatment, and the gender-specific prevalence suggest social stress might be a cause for the symptoms, mediated by corticotropin-releasing factor signaling pathways. Neurourol. Urodynam. © 2013 Wiley Periodicals, Inc.
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Is joint hypermobility associated with vesico-ureteral reflux? An assessment of 50 patients.
BJU Int.
PUBLISHED: 08-24-2011
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To assess whether there is an increased prevalence of joint hypermobility in patients with vesico-ureteric reflux (VUR).
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Long-term follow-up of incontinence and urge complaints after intensive urotherapy in childhood (75 patients followed up for 16.2-21.8 years).
Urology
PUBLISHED: 07-27-2011
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To reassess the incontinence and urge complaints in adults who had undergone inpatient urotherapy during childhood and compare the results with the short-term outcomes.
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Antibiotic prophylaxis for urinary tract infections in children with spina bifida on intermittent catheterization.
J. Urol.
PUBLISHED: 04-28-2011
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Antibiotic prophylaxis (low dose chemoprophylaxis) has been prescribed since the introduction of clean intermittent catheterization in children with spina bifida. We hypothesized that stopping low dose chemoprophylaxis does not increase the number of urinary tract infections in these patients.
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A comparative analysis of pediatric uroflowmetry curves.
Neurourol. Urodyn.
PUBLISHED: 04-19-2011
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This study was conducted to try to objectify assessment of pediatric uroflowmetry curves.
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Nondismembered pyeloplasty in a pediatric population: results of 34 open and laparoscopic procedures.
Urology
PUBLISHED: 03-18-2011
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To assess the outcomes of nondismembered pyeloplasty for ureteropelvic junction obstruction in a pediatric population of children and adolescents.
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Secondary endoscopic pyelotomy in children with failed pyeloplasty.
Urology
PUBLISHED: 01-22-2011
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To assess the results of secondary endopyelotomies (SEP) that were performed in our center in children who had earlier failed pyeloplasty.
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Antegrade pressure measurement as a diagnostic tool in modern pediatric urology.
World J Urol
PUBLISHED: 01-10-2011
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The antegrade pressure measurement (APM) or perfusion pressure-flow test (Whitaker test) is a method of antegrade measurement of pressure in the upper urinary tract. In this study, we present the long-term follow-up results of APMs performed in our institution in the late 1980s and early 1990s to see whether the diagnostic decisions that were based on the outcomes of the test prove to be correct in the long term.
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Modelling pollen-mediated gene flow in rice: risk assessment and management of transgene escape.
Plant Biotechnol. J.
PUBLISHED: 02-03-2010
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Fast development and commercialization of genetically modified plants have aroused concerns of transgene escape and its environmental consequences. A model that can effectively predict pollen-mediated gene flow (PMGF) is essential for assessing and managing risks from transgene escape. A pollen-trap method was used to measure the wind-borne pollen dispersal in cultivated rice and common wild rice, and effects of relative humidity, temperature and wind speed on pollen dispersal were estimated. A PMGF model was constructed based on the pollen dispersal pattern in rice, taking outcrossing rates of recipients and cross-compatibility between rice and its wild relatives into consideration. Published rice gene flow data were used to validate the model. Pollen density decreased in a simple exponential pattern with distances to the rice field. High relative humidity reduced pollen dispersal distances. Model simulation showed an increased PMGF frequency with the increase of pollen source size (the area of a rice field), but this effect levelled off with a large pollen-source size. Cross-compatibility is essential when modelling PMGF from rice to its wild relatives. The model fits the data well, including PMGF from rice to its wild relatives. Therefore, it can be used to predict PMGF in rice under diverse conditions (e.g. different outcrossing rates and cross-compatibilities), facilitating the determination of isolation distances to minimize transgene escape. The PMGF model may be extended to other wind-pollinated plant species such as wheat and barley.
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Urodynamic studies in pediatric urology.
Nat Rev Urol
PUBLISHED: 11-06-2009
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In any type of lower urinary tract dysfunction it is mandatory to obtain as much information as possible on the function of the urinary tract. By definition of the International Continence Society, any investigation that produces such information is part of urodynamics. Thus, voiding and defecation history, physical examination, voiding frequency charts and defecation diaries are all essential parts of urodynamics. Repeated free uroflowmetry is considered an essential routine investigation by the International Childrens Continence Society. Static and dynamic ultrasonography of the lower urinary tract and the pelvic floor can give important information on lower urinary tract anatomy and function, in a noninvasive manner. Invasive urodynamic studies such as voiding cystourethrography and cystometry are reserved for patients for whom the outcome of such studies is expected to change the therapeutic regime. Invasive urodynamic tests are performed primarily for one of two reasons. First, to confirm an expected diagnosis in new patients. Second, to ensure that the storage pressures in the bladder remain safe for normal functioning of the kidneys in children with chronic disease.
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Urodynamic findings and functional or anatomical obstructions in children who developed bladder diverticula after reimplantation of the ureter.
Neurourol. Urodyn.
PUBLISHED: 07-16-2009
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To study the clinical and urodynamic parameters of children who developed bladder diverticula (BD) after ureteral reimplantation.
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Sling suspension of the bladder neck for pediatric urinary incontinence.
J Pediatr Urol
PUBLISHED: 07-14-2009
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Surgery for urinary incontinence in childhood is in the process of an ongoing search for better results because a procedure that guarantees dryness still does not exist. This study has been conducted to assess the overall results of the fascia sling procedure for incontinence in children.
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Urethral length in girls with lower urinary tract symptoms and forme fruste of female epispadias.
J Pediatr Urol
PUBLISHED: 06-19-2009
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To investigate systematically the length of the urethra in girls with lower urinary tract symptoms.
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Urinary tract infections in children with spina bifida: an inventory of 41 European centers.
Pediatr. Nephrol.
PUBLISHED: 06-06-2009
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The introduction of clean intermittent catheterization (CIC) in 1972 and low-dose chemoprophylaxis (LDCP, antibiotic prophylaxis), anticholinergic medication and urological surgery in the mid-1980s has improved the long-term outcome of renal function in children with neurogenic bladder sphincter dysfunction (NBSD) due to spina bifida (SB). We have conducted a European survey of the protocols for diagnosing and treating urinary tract infections (UTIs) in these children, using a web-based questionnaire. The responses from 41 centers in 14 European countries confirm that although most centers have standardized protocols for treating UTIs, there is no consensus among European centers in terms of protocols for preventing, diagnosing and treating UTIs in children with NBSD and for CIC.
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Behavior and development in children and age at the time of first anesthetic exposure.
Anesthesiology
PUBLISHED: 03-19-2009
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Several experimental studies have suggested that early exposure to anesthetic agents, i.e., before completion of synaptogenesis, can result in widespread apoptotic neuronal degeneration and late cognitive impairment, but human data are lacking. The authors performed a retrospective pilot study to test the feasibility and calculate sample sizes for a larger epidemiologic study of disturbed neurobehavioral development as a function of age at the time of first anesthetic exposure. Pediatric urological procedures were selected because the timing of surgery depends mainly on the age at which a diagnosis is made.
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Long-term followup of hypospadias: functional and cosmetic results.
J. Urol.
PUBLISHED: 01-23-2009
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We assessed long-term results after hypospadias surgery with respect to urinary and sexual function, cosmetic appearance and intimate relationships.
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Compensatory growth of congenital solitary kidneys in pigs reflects increased nephron numbers rather than hypertrophy.
PLoS ONE
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Patients with unilateral MultiCystic Kidney Dysplasia (MCKD) or unilateral renal agenesis (URA) have a congenital solitary functioning kidney (CSFK) that is compensatory enlarged. The question whether this enlargement is due to increased nephron numbers and/or to nephron hypertrophy is unresolved. This question is of utmost clinical importance, since hypertrophy is associated with a risk of developing hypertension and proteinuria later in life with consequent development of CKD and cardiovascular disease.
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Functional defecation disorders in children with lower urinary tract symptoms.
J. Urol.
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We assessed the prevalence of functional defecation disorders, such as functional constipation and functional nonretentive fecal incontinence, in children referred to a tertiary pediatric urology outpatient clinic for lower urinary tract symptoms.
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A systematic review on renal and bladder dysfunction after endoscopic treatment of infravesical obstruction in boys.
PLoS ONE
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Posterior urethral valves (PUV) may cause subtle to severe obstruction of the urethra, resulting in a broad clinical spectrum. PUV are the most common cause of chronic renal disease in boys. Our purpose was to report the incidences of kidney and bladder dysfunction in boys treated with endoscopic valve resection for PUV.
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Enterocystoplasty vs detrusorectomy: outcome in the adult with spina bifida.
J. Urol.
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Bladder augmentation by enterocystoplasty or detrusorectomy might prevent renal damage, help achieve dryness and decrease the need for antimuscarinics. We compared the long-term outcomes of enterocystoplasty and detrusorectomy in adults with spina bifida.
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Urinary, sexual, and cosmetic results after puberty in hypospadias repair: current results and trends.
Curr Opin Urol
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To give an overview of the recently published long-term outcomes of hypospadias surgery performed at childhood, of patients who have had multiple previous repairs, and results of surgery done to treat late complications following hypospadias repair.
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Genes in the ureteric budding pathway: association study on vesico-ureteral reflux patients.
PLoS ONE
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Vesico-ureteral reflux (VUR) is the retrograde passage of urine from the bladder to the urinary tract and causes 8.5% of end-stage renal disease in children. It is a complex genetic developmental disorder, in which ectopic embryonal ureteric budding is implicated in the pathogenesis. VUR is part of the spectrum of Congenital Anomalies of the Kidney and Urinary Tract (CAKUT). We performed an extensive association study for primary VUR using a two-stage, case-control design, investigating 44 candidate genes in the ureteric budding pathway in 409 Dutch VUR patients. The 44 genes were selected from the literature and a set of 567 single nucleotide polymorphisms (SNPs) capturing their genetic variation was genotyped in 207 cases and 554 controls. The 14 SNPs with p<0.005 were included in a follow-up study in 202 cases and 892 controls. Of the total cohort, ~50% showed a clear-cut primary VUR phenotype and ~25% had both a duplex collecting system and VUR. We also looked for association in these two extreme phenotype groups. None of the SNPs reached a significant p-value. Common genetic variants in four genes (GREM1, EYA1, ROBO2 and UPK3A) show a trend towards association with the development of primary VUR (GREM1, EYA1, ROBO2) or duplex collecting system (EYA1 and UPK3A). SNPs in three genes (TGFB1, GNB3 and VEGFA) have been shown to be associated with VUR in other populations. Only the result of rs1800469 in TGFB1 hinted at association in our study. This is the first extensive study of common variants in the genes of the ureteric budding pathway and the genetic susceptibility to primary VUR.
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International Childrens Continence Societys recommendations for initial diagnostic evaluation and follow-up in congenital neuropathic bladder and bowel dysfunction in children.
Neurourol. Urodyn.
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The objective of this ICCS standardization document is to report the initial diagnostic evaluation and subsequent work-up of children with neuropathic bladder dysfunction.
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Selection against hybrids in mixed populations of Brassica rapa and Brassica napus: model and synthesis.
New Phytol.
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Pollen of the crop oilseed rape (Brassica napus, AACC) can cross-fertilize ovules of Brassica rapa (AA), which leads to an influx of unpaired C-chromosomes into wild B. rapa populations. The presence of such extra chromosomes is thought to be an indicator of introgression. Backcrosses and F(1) hybrids were found in Danish populations but, surprisingly, only F(1) hybrids were found in the UK and the Netherlands. Here, a model tests how the level of selection and biased vs unbiased transmission affect the population frequency of C-chromosomes. In the biased-transmission scenario the experimental results of the first backcross are extrapolated to estimate survival of gametes with different numbers of C-chromosomes from all crosses in the population. With biased transmission, the frequency of C-chromosomes always rapidly declines to zero. With unbiased transmission, the continued presence of plants with extra C-chromosomes depends on selection in the adult stage and we argue that this is the most realistic option for modeling populations. We suggest that selection in the field against plants with unpaired C-chromosomes is strong in Dutch and UK populations. The model highlights what we do not know and makes suggestions for further research on introgression.
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Urethral meatus deformities in girls as a factor in dysfunctional voiding.
Neurourol. Urodyn.
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Girls with an anterior deflected urinary stream (ADUS) cannot void in the ideal toileting position, resulting in lower success rates of behavioral training programs. Purpose was to study prospectively the clinical effects of surgical meatus correction for ADUS in girls with dysfunctional voiding (DV).
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Detrusorectomy reduces the need for augmentation and use of antimuscarinics in children with neuropathic bladders.
J Pediatr Urol
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To assess bladder behaviour and long-term outcome after detrusorectomy in children.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

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We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

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In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.