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Find video protocols related to scientific articles indexed in Pubmed.
DPP-4 inhibitor and alpha-glucosidase inhibitor equally improve endothelial function in patients with type 2 diabetes: EDGE study.
Cardiovasc Diabetol
PUBLISHED: 06-29-2014
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Alpha glucosidase inhibitor (GI) attenuates postprandial hyperglycemia (PPH) and reduces the risk of cardiovascular events in patients with impaired glucose tolerance or type 2 diabetes. Dipeptidyl peptidase 4 (DPP-4) inhibitors also attenuate PPH. PPH is one of the factors leading to endothelial dysfunction which is an early event in the pathogenesis of atherosclerosis. Furthermore, DPP-4 inhibitors protect endothelial function through a GLP-1-dependent mechanism. However, the impact of these two types of drugs on endothelial dysfunction in patients with type 2 diabetes has not been fully elucidated. We compared the effects of sitagliptin, a DPP-4 inhibitor, and voglibose, an alpha GI, on endothelial function in patients with diabetes.
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Elevated left ventricular filling pressure estimated by E/E ratio after exercise predicts development of new-onset atrial fibrillation independently of left atrial enlargement among elderly patients without obvious myocardial ischemia.
J Cardiol
PUBLISHED: 03-30-2013
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To determine whether elevated left ventricular (LV) filling pressure estimated by raised Doppler E velocity to tissue Doppler E velocity ratio (E/E) after exercise is associated with increased risk of new-onset atrial fibrillation (AF) in non-ischemic elderly patients.
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Hydrodynamics and energy-saving swimming techniques of Pacific bluefin tuna.
J. Theor. Biol.
PUBLISHED: 01-31-2013
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Weihs theoretically revealed that during the movement of fish with negative buoyancy, more kinetic energy is saved in the glide and upward (GAU) swimming mode than in the continuous horizontal swimming mode. Because kinetic energy saving depends on dynamic parameters such as the drag and lift of the body, the effects of variations in these parameters on energy saving for different species remain unknown. Here, the kinetic energy saving of Pacific bluefin tuna (PBT), Thunnus orientalis, exhibiting the GAU swimming mode was investigated. The dynamic properties of PBT were estimated by carrying out CFD analysis. The CFD model was produced by using a three-dimensional laser surface profiler, and the model was controlled such that it exhibited swimming motion similar to that of a live PBT swimming in a flume tank. The drag generated by tail beating, which significantly affects the kinetic energy during motion, was twice that generated in the glide mode. The faster the upward swimming speed, the lesser is the kinetic energy saving; therefore, when the upward swimming speed is more than twice the glide speed, there is no gain in the GAU mode. However, when SMR (Standard Metabolic Rate) is considered, if the energy based on SMR is assumed to be 30% of the total energy spent during motion, the most efficient upward swimming speed is 1.4 times the glide speed. The GAU swimming mode of PBT leads to energy saving during motion, and the upward swimming speed and the lift force produced by the pectoral fins for the most efficient drive are unique for different species of different sizes.
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Therapies targeting inflammation after stent implantation.
Curr Vasc Pharmacol
PUBLISHED: 01-29-2013
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Since the introduction of coronary vessel scaffold by metallic stent, percutaneous coronary intervention has become widely performed all over the world. Although drug-eluting stent technology has further decrease the incidence of in-stent restenosis, there still remaining issues related to stent implantation. Vessel inflammation is one of the causes that may be related to stent restenosis as well as stent thrombosis. Therefore, systemic therapies targeting inflammation emerged as adjunctive pharmacological intervention to improve outcome. Statins, corticosteroids, antiplatelets, and immunosuppresive or anti-cancer drugs are reported to favorably impact outcome after bare-metal stent implantation. In type 2 diabetic patients, pioglitazone may be the most promising drug that can lower neointimal proliferation and, as a result, lower incidence of restenosis and target lesion revascularization. On the other hand, several new stent platforms that might decrease inflammatory response after drug-eluting stent implantation have been introduced. Because durable polymer used in the first generation drug-eluting stents are recognized to be responsible for unfavorable vessel response, biocompatible or bioabsorbable polymer has been introduce and already used clinically. Furthermore, polymer-free drug-eluting stent and bioresorbable scaffold are under investigation. Although vessel inflammation may be reduced by using these new drug-eluting stents or scaffold, long-term impact needs to be investigated further.
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Employing relative entropy techniques for assessing modifications in animal behavior.
PLoS ONE
PUBLISHED: 07-06-2011
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In order to make quantitative statements regarding behavior patterns in animals, it is important to establish whether new observations are statistically consistent with the animals equilibrium behavior. For example, traumatic stress from the presence of a telemetry transmitter may modify the baseline behavior of an animal, which in turn can lead to a bias in results. From the perspective of information theory such a bias can be interpreted as the amount of information gained from a new measurement, relative to an existing equilibrium distribution. One important concept in information theory is the relative entropy, from which we develop a framework for quantifying time-dependent differences between new observations and equilibrium. We demonstrate the utility of the relative entropy by analyzing observed speed distributions of Pacific bluefin tuna, recorded within a 48-hour time span after capture and release. When the observed and equilibrium distributions are gaussian, we show that the tunas behavior is modified by traumatic stress, and that the resulting modification is dominated by the difference in central tendencies of the two distributions. Within a 95% confidence level, we find that the tunas behavior is significantly altered for approximately 5 hours after release. Our analysis reveals a periodic fluctuation in speed corresponding to the moment just before sunrise on each day, a phenomenon related to the tunas daily diving pattern that occurs in response to changes in ambient light.
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Evaluation of genetic trends and determination of the optimal number of cumulative records of parity required in reproductive traits in a Large White pig population.
Anim. Sci. J.
PUBLISHED: 06-15-2011
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Genetic improvement of the reproductive performance of pigs is important for pig breeding despite their low heritabilities. The objectives of this study were to investigate the effectiveness of selection concerning reproductive traits and to determine the optimal number of parity records required for accurate estimation of breeding values (BVs) in the open population of a commercial pig breeding company. The study used records of 2220 purebred Large White pigs (9845 litters) farrowed between 1998 and 2009 in the two herds of the Pacific Ocean Breeding Co. Ltd. The traits studied included farrowing interval (FI), total number of piglets at birth (TNB), average weaning weight per litter (AWW), and raising rate (RR). A statistical model was applied to the 4-trait repeatability animal model. The heritabilities of FI, TNB, AWW and RR were low. The genetic trends in TNB (h(2) = 0.09) showed approximately 1.0 increase in 6 years from 2003 to 2008. The predicted error variances indicated that up to fourth parity records are necessary for accurate genetic evaluation. The present study results indicated that even reproductive traits with low heritability can be improved.
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Strain measurements during adenosine triphosphate infusion before and after percutaneous coronary intervention.
Circ. J.
PUBLISHED: 07-01-2010
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In regional myocardial ischemia, contractile delay develops, which can be assessed by measuring time to peak strain (TPS) on tissue Doppler imaging. The aims of the present study were to clarify the usefulness of TPS measurements during adenosine triphosphate (ATP) stress in assessing myocardial ischemia and to evaluate whether prolongation of TPS disappears immediately after percutaneous coronary intervention (PCI) or not.
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Detection of coronary artery disease using delayed strain imaging at 5 min after the termination of exercise stress: head to head comparison with conventional treadmill stress echocardiography.
J Cardiol
PUBLISHED: 05-07-2009
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Prolongation of the time to peak strain (TPS) is a sensitive marker of myocardial ischemia. The purpose of this study was to evaluate whether delayed strain imaging obtained at 5 min after the termination of exercise stress can detect patients with significant coronary artery disease (CAD).
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Newly diagnosed glucose intolerance and prognosis after acute myocardial infarction: comparison of post-challenge versus fasting glucose concentrations.
Heart
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Recent studies have demonstrated that newly diagnosed glucose intolerance is common among patients with acute myocardial infarction (AMI). The purpose of this study was to assess the long-term clinical cardiovascular outcomes in participants with AMI with abnormal fasting glucose compared with normal fasting glucose and an abnormal oral glucose tolerance test (OGTT) compared with a normal OGTT.
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Altered trans-mitral flow velocity pattern after exercise predicts development of new-onset atrial fibrillation in elderly patients with impaired left ventricular relaxation at rest: prognostic value of diastolic stress echocardiography.
J Cardiol
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This study attempted to determine whether exercise induced left ventricular (LV) diastolic dysfunction estimated by altered trans-mitral flow (TMF) velocity pattern after exercise is associated with increased risk of cardiac events including new-onset atrial fibrillation (AF) in elderly patients with impaired LV relaxation at rest.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.