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Find video protocols related to scientific articles indexed in Pubmed.
Emerging new trends in neurosurgical technologies.
Cell Biochem. Biophys.
PUBLISHED: 03-19-2014
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There has been tremendous progress in the modern day technologies causing a rapid evolution in the field of neurosurgery. The neurosurgeons have been equipped with the latest advancements such as the use of robotics in surgery, the image-guided neurosurgical procedures, and the stereotactic neurosurgery. In addition, the preoperative screening techniques have drastically improved the success of the surgical procedure. Neuronavigation has allowed the precise localization of the deep-seated brain structures thereby helping in the accurate operation of the affected regions without stirring the normal brain tissues. Such preciseness has helped in the improvement of the patient outcome. All these aspects have been discussed in detail in this review with a focus on their developmental background.
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Observation of dark states in a superconductor diamond quantum hybrid system.
Nat Commun
PUBLISHED: 02-26-2014
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The hybridization of distinct quantum systems has opened new avenues to exploit the best properties of these individual systems. Superconducting circuits and electron spin ensembles are one such example. Strong coupling and the coherent transfer and storage of quantum information has been achieved with nitrogen vacancy centres in diamond. Recently, we have observed a remarkably sharp resonance (~1?MHz) at 2.878?GHz in the spectrum of flux qubit negatively charged nitrogen vacancy diamond hybrid quantum system under zero external magnetic field. This width is much narrower than that of both the flux qubit and spin ensemble. Here we show that this resonance is evidence of a collective dark state in the ensemble, which is coherently driven by the superposition of clockwise and counter-clockwise macroscopic persistent supercurrents flowing in the flux qubit. The collective dark state is a unique physical system and could provide a long-lived quantum memory.
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Electrochemical mineral scale prevention and removal on electrically conducting carbon nanotube--polyamide reverse osmosis membranes.
Environ Sci Process Impacts
PUBLISHED: 02-25-2014
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The electrochemical prevention and removal of CaSO4 and CaCO3 mineral scales on electrically conducting carbon nanotube - polyamide reverse osmosis membrane was investigated. Different electrical potentials were applied to the membrane surface while filtering model scaling solutions with high saturation indices. Scaling progression was monitored through flux measurements. CaCO3 scale was efficiently removed from the membrane surface through the intermittent application of a 2.5 V potential to the membrane surface, when the membrane acted as an anode. Water oxidation at the anode, which led to proton formation, resulted in the dissolution of deposited CaCO3 crystals. CaSO4 scale formation was significantly retarded through the continuous application of 1.5 V DC to the membrane surface, when the membrane was operated as an anode. The continuous application of a sufficient electrical potential to the membrane surface leads to the formation of a thick layer of counter-ions along the membrane surface that pushed CaSO4 crystal formation away from the membrane surface, allowing the formed crystals to be carried away by the cross-flow. We developed a simple model, based on a modified Poisson-Boltzmann equation, which qualitatively explained our observed experimental results.
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Ferric chloride-Graphite Intercalation Compounds as Anode Materials for Li-ion Batteries.
ChemSusChem
PUBLISHED: 08-16-2013
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Ferric chloride-graphite intercalation compounds (FeCl3 -GICs) with stage?1 and stage?2 structures were synthesized by reacting FeCl3 and expanded graphite (EG) in air in a stainless-steel autoclave. As rechargeable Li-ion batteries, these FeCl3 -GICs exhibit high capacity, excellent cycling stability, and superior rate capability, which could be attributed to their unique intercalation features. This work may enable new possibilities for the fabrication of Li-ion batteries.
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Neuroprotective effects of anti-high-mobility group box 1 antibody in juvenile rat hippocampus after kainic acid-induced status epilepticus.
Neuroreport
PUBLISHED: 07-11-2013
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High-mobility group box 1 (HMGB1) is a potent cytokine that has been proved to participate in diverse neurological diseases including seizures. Blockade of HMGB1 with neutralizing antibody has shown protective effects against different kinds of insults. However, the potential role of anti-HMGB1 antibody in status epilepticus (SE) has not yet been addressed. In the present study, we investigated the effects of anti-HMGB1 antibody on hippocampal damage and inflammatory reaction after SE induced by an intracerebroventricular kainic acid (KA) injection in postnatal day 21 rats. We found that KA-induced SE markedly increased the mRNA expression of interleukin-1? and tumor necrosis factor-?, microglial activation, and neuronal damage in the hippocampus. An intracerebroventricular injection of anti-HMGB1 antibody dose dependently inhibited the synthesis of cytokines, microglial activation, and neuronal losses in the hippocampus after SE. In conclusion, our findings suggest that HMGB1 blocking therapy exerts neuroprotective effects during the early phase of KA-induced SE in juvenile rats.
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Cell debris self-immobilized thermophilic lipase: a biocatalyst for synthesizing aliphatic polyesters.
Appl. Biochem. Biotechnol.
PUBLISHED: 02-18-2013
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The paper explored the catalytic activity of a cell debris self-immobilized thermophilic lipase for polyester synthesis, using the ring-opening polymerization of ?-caprolactone as model. Effects of biocatalyst concentration, temperature, and reaction medium on monomer conversion and product molecular weight were systematically evaluated. The biocatalyst displayed high catalytic activity at high temperatures (70-90 °C), with 100 % monomer conversion. High monomer conversion values (>90 %) were achieved in both hydrophobic and hydrophilic solvents, and also in solvent-free system, with the exception of dichloromethane. Poly(?-caprolactone) was obtained in 100 % monomer conversion, with a number-average molecular weight of 1,680 g/mol and a polydispersity index of 1.35 in cyclohexane at 70 °C for 72 h. Furthermore, the biocatalyst exhibited excellent operational stability, with monomer conversion values exceeding 90 % over the course of 15 batch reactions.
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Coherent coupling of a superconducting flux qubit to an electron spin ensemble in diamond.
Nature
PUBLISHED: 05-30-2011
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During the past decade, research into superconducting quantum bits (qubits) based on Josephson junctions has made rapid progress. Many foundational experiments have been performed, and superconducting qubits are now considered one of the most promising systems for quantum information processing. However, the experimentally reported coherence times are likely to be insufficient for future large-scale quantum computation. A natural solution to this problem is a dedicated engineered quantum memory based on atomic and molecular systems. The question of whether coherent quantum coupling is possible between such natural systems and a single macroscopic artificial atom has attracted considerable attention since the first demonstration of macroscopic quantum coherence in Josephson junction circuits. Here we report evidence of coherent strong coupling between a single macroscopic superconducting artificial atom (a flux qubit) and an ensemble of electron spins in the form of nitrogen-vacancy colour centres in diamond. Furthermore, we have observed coherent exchange of a single quantum of energy between a flux qubit and a macroscopic ensemble consisting of about 3?×?10(7) such colour centres. This provides a foundation for future quantum memories and hybrid devices coupling microwave and optical systems.
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[Synthesis of heptakis(2,3,6-tri-O-methoxymethyl)-beta-cyclodextrin and its application in gas chromatography].
Se Pu
PUBLISHED: 05-18-2011
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A new chiral stationary phase for gas chromatography, heptakis (2, 3, 6-tri-O-methoxymethyl)-beta-cyclodextrin, was synthesized by substituting the 2,3,6-OH groups of beta-cyclodextrin with methoxymethyl groups, and a coated capillary column for gas chromatography was made by coating this new stationary phase with static method. The chromatographic properties and separation abilities of the prepared stationary phase were studied. The test results showed that it possessed good separation abilities to Grob test mixture, disubstituted benzene isomers (e. g. nitrotoluenes, bromotoluenes, dichlorobenzenes, dimethylbenzenes) and some chiral compounds such as methyl 2-hydroxypropionates, ethyl 2-hydroxypropionates, methyl 2-methylsulfonylpropionates. The comparison of chiral separation results between 2,3,6-tri-O-methoxymethyl-beta-cyclodextrin and 2,3,6-tri-O-methyl-beta-cyclodextrin showed that the separation abilities of the two stationary phases were different and complementary to each other for some chiral ester enantiomers.
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A prospective study on the treatment of infantile spasms with first-line topiramate followed by low-dose ACTH.
Epilepsy Res.
PUBLISHED: 01-03-2011
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A prospective study was conducted for the purpose of identifying the efficacy and safety of a protocol, first-line topiramate (TPM) followed by low-dose adrenocorticotropic hormone (ACTH) as the second drug, in the treatment of infantile spasms.
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Differential expression of claudins in retinas during normal development and the angiogenesis of oxygen-induced retinopathy.
Invest. Ophthalmol. Vis. Sci.
PUBLISHED: 01-01-2011
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Angiogenesis accompanies several retinal pathologies that impair the inner blood-retinal barrier. Claudins are key structural and functional proteins of the barrier. This study compared the expression of claudins during the normal angiogenesis of development with that of oxygen-induced retinopathy.
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[Preparation and quality evaluation of ginkgolide B-loaded self microemulsifying drug delivery system].
Zhongguo Zhong Yao Za Zhi
PUBLISHED: 09-27-2010
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To prepare ginkgolide B-loaded self microemulsifying drug delivery system (SMEDDS) and evaluate its quality.
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Quantum-dot-based immunofluorescent imaging of HER2 and ER provides new insights into breast cancer heterogeneity.
Nanotechnology
PUBLISHED: 01-29-2010
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Breast cancer (BC) is a heterogeneous tumor, and better understanding of its heterogeneity is essential to improving treatment effect. Quantum dot (QD)-based immunofluorescent nanotechnology (QD-IHC) for molecular pathology has potential advantages in delineating tumor heterogeneity. This potential is explored in this paper by QD-IHC imaging of HER2 and ER. BC heterogeneity can be displayed more clearly and sensitively by QD-IHC than conventional IHC in BC tissue microarrays. Furthermore, the simultaneous imaging of ER and HER2 might help understand their interactions during the process of evolution of heterogeneous BC.
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Comparison of quantum dots immunofluorescence histochemistry and conventional immunohistochemistry for the detection of caveolin-1 and PCNA in the lung cancer tissue microarray.
J. Mol. Histol.
PUBLISHED: 07-21-2009
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Luminescent semiconductor quantum dots (QDs) are a new class of fluorescent label with wide ranges of applications in cell imaging. In this study, we evaluated the capability of QDs immunofluorescence histochemistry (QDs-IHC) for detecting antigens of caveolin-1 and PCNA in the lung cancer tissue microarray (TMA) in comparison with the conventional immunohistochemistry (IHC) technique. Both methods revealed consistent antigen localization and statistically non-significant detection rates of caveolin-1 and PCNA expressions in our study. However, the sensitivity of QDs-IHC was higher than IHC. The positive detection rates of caveolin-1 and PCNA by QDs-IHC were 57% (40/70) and 86% (60/70), respectively, which were higher than the detection rates of 47% (33/70) and 77% (54/70), respectively, by IHC. Moreover, QDs exhibited a much better photostability, a broader excitation spectrum and a longer fluorescence lifetime. We showed here the advantages of QDs-IHC over IHC for the detection of caveolin-1 and PCNA in lung cancer TMA.
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Phosphomannopentaose sulfate (PI-88) inhibits retinal leukostasis in diabetic rat.
Biochem. Biophys. Res. Commun.
PUBLISHED: 01-11-2009
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Retinal leukostasis, mediated by intracellular adhesion molecule-1 (ICAM-1) and vascular endothelial growth factor (VEGF), has been implicated in the pathogenesis of early diabetic retinopathy. Phosphomannopentaose sulfate (PI-88) is a highly sulfonated oligosaccharide which inhibits heparanase activity and competes with heparan sulfate binding to growth factors. In this study, we evaluated whether PI-88 could inhibit retinal leukostasis in strepotzotocin(STZ)-induced diabetic rat and elucidated the possible mechanisms. Diabetes was induced in Sprague-Dawley rats by intraperitoneal injection (i.p.) of STZ. Three months after induction, diabetic rats were administered PI-88 (25 mg/kg body weight) or vehicle solution daily via i.p. for 14 consecutive days. Leukostasis was analyzed on retinal flatmounts by concanavalin A and CD45 immunofluorescence staining. Retinal function was analyzed by electroretinography (ERG). ICAM-1 and VEGF levels in retinas were studied by Western blot and enzyme-linked immunosorbent assay (ELISA) respectively. The systemic administration of PI-88, but not vehicle, significantly decreased the number of adherent leukocytes in retinas by 52.24% (P<0.001) and led to significant preservation (about 50%, P<0.001) of scotopic ERG a- and b-wave amplitudes in treated diabetic rats as compared to those of diabetic control rats. These changes were associated with downregulation of ICAM-1 (45%, P<0.001) and VEGF (26.83+/-2.01 versus 40.8+/-3.24 pg/mg, P<0.01) in retinas of PI-88 treated diabetic rats as compared to those of diabetic control rats. PI-88 significantly inhibited retinal leukostasis and reversed retinal dysfunction by a mechanism that may include decreased ICAM-1 and VEGF expression in diabetic rats. Our data suggests that PI-88 is a promising agent for the treatment of diabetic retinopathy.
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Ultrasonic drive of small mechanical components on a tapered metal strip.
Ultrasonics
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In this report, we demonstrate that small mechanical components such as bars, bar composites, disks and cogwheels, centered at a nodal point of tapered metal strip in flexural ultrasonic vibration, can be ultrasonically driven to rotate by the tapered metal strip. It is experimentally found that revolution speed of the small mechanical components is affected by the metal strip vibration, and the structure and size of the small mechanical components. The revolution speed increases as the metal strip vibration increases and the size of the small mechanical components decreases, and it may be higher than 600rpm. Measuring the transient response of angular speed, driving torque on the small disk with 4.7mm diameter and 0.1mm thickness is estimated to be 0.91?Nm when the driving voltage is 100V(p-p) and the actuator is in resonance. Travelling waves are found around the nodal point of the metal strip, which may be the cause of the rotary drive.
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Upregulation of heparanase in high-glucose-treated endothelial cells promotes endothelial cell migration and proliferation and correlates with Akt and extracellular-signal-regulated kinase phosphorylation.
Mol. Vis.
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The objectives of this study were to determine whether high-glucose-induced upregulation of heparanase (HPSE) expression and differential heparanase expression in human retinal vascular endothelial cells (HRECs) can alter HREC migration and proliferation. We also aimed to determine whether HREC migration and proliferation correlate with the levels of protein kinase B (Akt) and extracellular-signal-regulated kinase (ERK) phosphorylation and activation.
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Spatial attention can transfer to the contralateral hemisphere in neonatal stroke patients: a case report following hemispherectomy.
Neurocase
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Patients suffer hemispatial neglect after stroke. However, whether the function of spatial attention is reorganized to the contralateral brain remains poorly understood. Here we present a case report of neonatal stroke to demonstrate the reorganization of spatial attention in the contralateral hemisphere using a series of tests including star cancellation task, line bisection test, the bells test, letter cancellation test, and drawing tests. The patient underwent right hemispherectomy for treatment of refractory epilepsy and did not have hemispatial neglect after surgery, supporting transfer of function prior to the operation. After analyzing the literature in this field, we proposed that the function of spatial attention may transfer to the contralateral side in childhood. Thus, this study sheds new light on the preserved function of spatial attention in neonatal stroke patients even when hemispherectomy is performed.
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Corona charge selective micelle degradation catalyzed by P. cepacia lipase isoforms.
Chem. Commun. (Camb.)
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Micelles derived from poly(?-caprolactone) (PCL) poly(ethylene glycol)(PEG) diblock copolymers (HO-PCLn-b-PEG32-RX, R = -O(CH2)3S(CH2)2-; X = -CO2(-), -SO3(-), -NH3(+)) show corona charge selective degradation catalyzed by P. cepacia lipase isoforms.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.