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Find video protocols related to scientific articles indexed in Pubmed.
[Prognostic analyses of intramedullary high grade astrocytomas].
Zhonghua Yi Xue Za Zhi
PUBLISHED: 08-22-2014
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To explore the prognostic factors of intramedullary high grade astrocytomas.
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Gangliocytomas in the sellar region.
Clin Neurol Neurosurg
PUBLISHED: 05-21-2014
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Gangliocytomas occurring in the sellar region are extremely rare. We examined a cohort of these tumors to examine their clinical presentations and prognoses. Between January 2000 and December 2012, 23 patients were diagnosed with sellar region gangliocytomas in Huashan Hospital. These patients were retrospectively reviewed for medical histories, endocrinological examinations, preoperative magnetic resonance imaging (MRI), pathological findings and follow-ups. Endocrinological tests revealed elevated prolactin (PRL) levels in 10 cases (43.5%) and elevated growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels in 9 cases (39.1%). Scattered ganglion cells admixed with adenomatous components were observed in 16 cases (69.6%). In the remaining 7 cases (30.4%), only fragments with ganglion cells dispersed in the fibrillar matrix without adenohypophyseal components were detected. Immunohistochemistry revealed PRL-positive adenomas in 6 cases (26.1%) and GH-positive adenomas in 8 cases (34.8%). The average follow-up period was 4.2 years (range: 1-12.7 years). Gross total resection was achieved in 20 cases (87.0%). One patient recurred five years after tumor resection (4.3%). One patient died of acute myocardial infarction six years after operation. Gangliocytomas located in the sellar region may represent a unique immunopathological entity. The surgical results and prognoses of the gangliocytomas were comparable with those of pituitary adenomas.
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Anatomical study of suboccipital vertebral arteries and surrounding bony structures using virtual reality technology.
Med. Sci. Monit.
PUBLISHED: 05-16-2014
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This work aimed to evaluate the efficacy of virtual reality (VR) technology in neurosurgical anatomy through a comparison of the virtual 3D microanatomy of the suboccipital vertebral arteries and their bony structures as part of the resection of tumors in the craniovertebral junction (CVJ) of 20 patients compared to the actual microanatomy of the vertebral arteries of 15 cadaveric headsets.
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Identifying hedgehog signaling specific microRNAs in glioblastomas.
Int J Med Sci
PUBLISHED: 01-01-2014
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Aberrant activation of hedgehog (Hh) signaling pathway plays an important role in the development and proliferation of glioblastoma (GBM) cells. However, its mechanism remains unknown. MicroRNAs (miRNAs) are short non-coding RNA molecules which are involved in the post-transcriptional regulation of genes, and enrolled in signaling transduction network in tumors. This study was designed to investigate the role of miRNAs targeting the Hh signaling pathway in GBMs. According to the expression level of Gli1 mRNA measured by real time PCR, GBM samples were assigned to Gli1 high or low expression group. MiRNA microarray was applied to screen the dysregulated miRNA. As a result, 17 miRNAs were differentially expressed between Gli1 high expression and low expression groups (p < 0.005). Thirteen miRNAs including miR-125b-1 were downregulated, while only 4 miRNAs including miR-144 were upregulated in Gli1 high expression group. In summary, our study presents a subset of miRNAs which target the Hh signaling pathway in GBMs, and throws some light on the aberrant activation mechanism.
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Surgical treatment of recurrent torcular meningiomas: case report and review of the literature.
J Neurol Surg A Cent Eur Neurosurg
PUBLISHED: 07-29-2013
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Torcular meningiomas intimately involving major dural sinuses such as superior sagittal sinuses, transverse sinuses, and straight sinuses and the confluence are a great challenge for neurosurgeons. Simpson grade I total resection, which can bring complete cure, is the ultimate goal, but under many circumstances, it is difficult to achieve. The patency of the sinuses around these tumors is the key factor for successful tumor resection, and decides the surgical strategy. We report the experience of complete resection of a huge recurrent torcular meningioma. Related literature is reviewed.
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Outcomes in treatment for primary spinal anaplastic ependymomas: a retrospective series of 20 patients.
J Neurosurg Spine
PUBLISHED: 05-10-2013
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Little is known regarding the anaplastic variant of primary ependymomas that involve the spinal cord. The aim of this study was to evaluate the clinical characteristics and treatment outcomes of primary spinal anaplastic ependymomas (PSAEs).
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Diagnosis and surgical treatment of sporadic meningioangiomatosis.
Clin Neurol Neurosurg
PUBLISHED: 01-20-2013
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To discuss the clinical characteristics, radiological features, surgical treatment and prognosis of sporadic meningioangiomatosis (MA).
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Clinicopathological analysis of metaplastic meningioma: report of 15 cases in Huashan Hospital.
Chin. J. Cancer Res.
PUBLISHED: 01-16-2013
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Metaplastic meningioma is a rare subtype of benign meningiomas, classified as WHO grade I with well prognosis. Here we presented our experiences on 15 cases of metaplastic meningioma, to investigate the clinicopathological features, therapies and prognosis of these cases.
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Sonic Hedgehog/GLI? signaling pathway inhibition restricts cell migration and invasion in human gliomas.
Neurol. Res.
PUBLISHED: 05-04-2010
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Recent studies have shown that aberrant activation of Sonic Hedgehog (SHH)/GLI1 signaling pathway is involved in many kinds of human malignancies. Both in vitro and in vivo experiments demonstrate that inhibiting the pathway results in tumor regression for a fraction of gliomas which harbor an active pathway. However, little is known about the linkage between the SHH/GLI1 signaling pathway and cell migration and invasion in gliomas. In this study, we showed that GLI1 expression closely correlates with pathological grades of human gliomas by immunohistochemistry analysis of 110 cases of surgically-resected glioma tissues. Moreover, we used cyclopamine and RNA interference technique to block the SHH/GLI1 signaling to investigate the in vitro changes of glioma cells. The result showed that suppression of the pathway markedly inhibited glioma cell migration and invasion. The following quantitative RT-PCR analysis showed that decreased expressions of Snail, MMP9, and increased E-cadherin expression coincided with GLI1 knockout. Collectively, our results raise the possibility that SHH/GLI1 is a potentially anti-invasive target for therapeutic intervention in human gliomas.
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Gli1 is a potential target for alleviating multidrug resistance of gliomas.
J. Neurol. Sci.
PUBLISHED: 05-11-2009
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Although chemotherapy plays an important role in combined treatment of human gliomas, it fails to bring about satisfactory outcomes in a number of patients. One of the major obstacles in this treatment is the development of multidrug resistance (MDR) during treatment. Regulation of MDR in the context of gliomas is poorly understood, and clinical efforts to inhibit it have not been fruitful. Activation of the Hedgehog (HH) pathway has been shown to contribute to the growth, maintenance and relapse of various cancers. As data were not available on the role of Gli1 expression in glioma progression, we analyzed the correlation between Gli1 expression and tumor recurrence after chemotherapy in 60 glioma samples. The effects of inhibiting or activating the HH pathway on sensitizing or rendering glioma cell lines resistant to VCR, VP16, CDDP and ACNU, which are widely used in clinical chemotherapy, were determined. Additionally, the impact of the HH pathway on the expressions of MDR1, MRP1, MVP, MGMT, Bcl-2 and Survivin genes was determined. Our results indicate that overexpression of Gli1 is correlated with glioma recurrence after chemotherapy. We further show that the HH pathway activity can promote clonogenic survival of glioma cell lines in chemotherapy. Additionally, we found that blocking the HH pathway enhanced cytotoxicity of chemotherapeutic agents in glioma cells, through down-regulating the expressions of MDR1, MRP1, MVP, MGMT, Bcl-2 and Survivin genes. Taken together, these results suggest that Gli1 plays a dominant role in chemoresistance of glioma cells, and that suppression of Gli1 expression might be a valid therapeutic option for overcoming MDR and for increasing the success of chemotherapy.
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Gli1 inhibition induces cell-cycle arrest and enhanced apoptosis in brain glioma cell lines.
J. Neurooncol.
PUBLISHED: 05-09-2009
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The Hedgehog (HH)-Gli1 signaling pathway plays an important role in the patterning and development of the central nervous system during embryogenesis. Recent data have shown its possible involvement in a subset of human gliomas, and inhibition of the pathway resulted in tumor suppression in both in vitro and in vivo studies. The underlying mechanisms of tumor suppression, however, remain to be fully elucidated. Here, we investigated Gli1 expression in 65 surgically resected malignant glioma tissues and found the Ki-67 labeling index to be higher in Gli1-positive gliomas than in Gli1-negative gliomas. Depletion of Gli1 expression by small interfering RNA (siRNA) interference led to remarkably decreased cell proliferation and enhanced apoptosis in U87 glioma cell line. To explore the molecular mechanisms of the phenotypic changes, we performed real-time quantitative RT-PCR analysis to monitor the changes of a series of genes which play critical roles in the regulation of cell cycle and apoptosis. The result showed that downregulation of G(1) cyclins, downregulation of Bcl-2, and upregulation of p21 were detected after Gli1 downregulation. Additionally, cyclopamine was used to inhibit the HH signaling activity as an indirect approach to decrease Gli1 expression, and we observed that cyclopamine exclusively inhibited cell growth in HH-pathway-active glioma cell lines. The cell phenotypic and molecular changes induced by cyclopamine were consistent with those caused by siGli1 interference. In conclusion, our findings support an important role of Gli1 in cell-cycle and apoptosis regulation in human brain gliomas; hence, it can serve as a potential target of new therapeutic strategies for these diseases.
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Clinicopathological analysis of rhabdoid meningiomas: report of 12 cases and a systematic review of the literature.
World Neurosurg
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Rhabdoid meningioma (RM) is a rare subtype of meningioma, classified as World Health Organization grade III with a poor prognosis. Here we present our experience on RM and review relevant literature in an attempt to investigate the clinical features, treatment, and prognosis of these tumors.
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Gamma knife surgery-induced ependymoma after the treatment of meningioma - a case report.
Neurol. Neurochir. Pol.
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Gamma knife surgery is widely used for a number of neurological disorders. However, little is known about its long-term complications such as carcinogenic risks. Here, we present a case of a radiosurgery-induced ependymoma by gamma knife surgery for the treatment of a spinal meningioma in a 7-year-old patient. In light of reviewing the previous reports, we advocate high caution in making young patients receive this treatment.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.