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Find video protocols related to scientific articles indexed in Pubmed.
Platelet function monitoring guided antiplatelet therapy in patients receiving high-risk coronary interventions.
Chin. Med. J.
PUBLISHED: 10-02-2014
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Large-scale clinical trials have shown that routine monitoring of the platelet function in patients after percutanous coronary intervention (PCI) is not necessary. However, it is still unclear whether patients received high-risk PCI would benefit from a therapy which is guided by a selective platelet function monitoring. This explanatory study sought to assess the benefit of a therapy guided by platelet function monitoring for these patients.
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[The effects of tirofiban on acute non-ST segment elevation myocardial infarction patients not receiving early reperfusion intervention].
Zhonghua Nei Ke Za Zhi
PUBLISHED: 04-29-2014
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To study the efficacy and safety of tirofiban in patients with acute non-ST- segment elevation myocardial infarction (NSTEMI) without early reperfusion intervention.
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Removal of heavy metals and dyes by supported nano zero-valent iron on barium ferrite microfibers.
J Nanosci Nanotechnol
PUBLISHED: 04-25-2014
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The binary nano zero-valent iron/barium ferrite (NZVI/BFO) microfibers with uniform diameters and high porosity were prepared by the organic gel-thermal selective reduction process. The composite microfibers are fabricated from nano zero-valent iron and nano BaFe12O19 grains. The effects of pH, adsorbent dosage, and contact time on the adsorption of heavy metals and dyes have been investigated. The adsorption isotherms of heavy metals and dyes on the microfibers are well described by the Langmuir model, in which the estimated adsorption capacities are 14.5, 29.9, 68.3 and 110.4 mg/g for Pb(II), As(V), Congo red and methylene blue, respectively. After five cycles, these microfibers still exhibit a high removal efficiency for As(V), Pb(II), Congo red and methylene blue. The enhanced adsorption characteristics can be attributed to the porous structure, strong surface activity and electronic hopping. Therefore, the magnetic NZVI/BFO microfibers can be used as an efficient, fast and high capacity adsorbent for heavy metals and dyes removal.
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Preparation of alpha-Fe2O3 nanotubes by calcination of electrospun precursors.
J Nanosci Nanotechnol
PUBLISHED: 04-22-2014
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The alpha-Fe2O3 nanotubes with diameters of 400-700 nm were prepared by calcination of electrospun precursors. The morphology of alpha-Fe2O3 nanotubes is mainly influenced by the water content in solution and heating rate during the calcination process. When the water content is about 17 wt.%, heating rate is 5 degrees C/min and calcination temperature at 500 degrees C for 2 h, the optimized alpha-Fe2O3 nanotubes are obtained. These alpha-Fe2O3 nanotubes have a magnetization (M(s)) of 0.36 emu x (9-1) and coercivity (H(o)) of 1942 Oe and can be used in the nanospace technology.
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Microwave absorption of sandwich structure based on nanocrystalline SrFe12O19, Ni0.5ZnO.5Fe2O4 and alpha-Fe hollow microfibers.
J Nanosci Nanotechnol
PUBLISHED: 04-22-2014
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The microwave absorption properties of sandwich structural absorbers based on the nanocrystalline strontium ferrite (SrFe12O19), NiZn ferrite (Ni0.5Zn0.5Fe2O4) and alpha-iron (alpha-Fe) hollow microfibers with diameters of 1-3 microm have been investigated in the frequency range of 2-18 GHz. The sandwich absorbers composed of nanocrystalline ferrite hollow microfibers as the outer or inner layer, and the nanocrystalline alpha-Fe hollow microfibers as the interlayer, have strong microwave absorption with a broad band and thin thickness. Their microwave absorption properties in 2-18 GHz are mainly influenced by the arrangement, each layer thickness and total thickness. It finds that the sandwich absorber with 1.6 mm thick SrFe12O19 microfibers as the outer layer, 0.2 mm thick alpha-Fe microfibers as the interlayer and 0.2 mm thick Ni0.5Zn0.5Fe2O4 microfibers as the inner layer, exhibits an optimal reflection loss (RL) value of -120.1 dB at 13.2 GHz and the bandwidth with RL exceeding -10 dB covers 83% of X-band (8.2-12.4 GHz) and the whole K(u)-band (12.4-18 GHz). This enhancement microwave absorption can be attributed to the unique coupling of the nanocrystalline ferrite and alpha-Fe hollow microfibers arising from the shape anisotropy, interface and small size effects.
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Three-layer structure microwave absorbers based on nanocrystalline alpha-Fe, Fe0.2(Co0.2Ni0.8)0.8 and Ni0.5Zn0.5Fe2O4 porous microfibers.
J Nanosci Nanotechnol
PUBLISHED: 04-17-2014
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The three-layer structure microwave absorbers with thickness of 2 mm were designed based on nanocrystalline alpha-Fe, Fe0.2(Co0.2Ni0.8)0.8 and Ni0.5Zno.sFe204 porous microfibers with diameters about 2-5 microm. The electromagnetic parameters and microwave absorption properties were investigated by vector network analyzer in the frequency range of 2-18 GHz. The results show that the three-layer structure microwave absorbers display stronger absorption properties in a wide frequency range than the single-layer and double-layer microwave absorber. For the three-layer structure, the microwave absorption properties are mainly influenced by the microfibers layer arrangement order, total thickness and each layer thickness. When the Ni0.5Zn0.5Fe2O4 porous microfibers layer is arranged as the impedance-matching surface layer, with a total thickness of 2 mm consisting of 0.7 mm thick alpha-Fe porous microfibers inner layer, 0.9 mm thick Fe0.2(Co0.2Ni0.8)0.8 porous microfibers medium layer and 0.4 mm thick impedance-matching surface layer, the three-layer structure has a strongest microwave absorption of 45.7 dB at 12.8 GHz, the absorption bandwidth (with RL < -10 dB ) of 10.2 GHz from 7.8 GHz to 18 GHz and bandwidth (with RL < -20 dB) of 4.4 GHz from 11.1 GHz to 15.5 GHz respectively. This three-layer structure is promising microwave absorbers to meet the requirements of thin thickness, light weight and wide band for military and civil applications.
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[Effect of intracoronary tirofiban combined with nitroprusside injection through thrombus aspiration catheter during primary percutaneous coronary intervention on acute anterior myocardial infarction patients with heavy thrombosis burden].
Zhonghua Xin Xue Guan Bing Za Zhi
PUBLISHED: 04-01-2014
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To explore the impact of intracoronary bolus administration of tirofiban combined with nitroprusside through thrombus aspiration catheter or thrombus aspiration alone on myocardial reperfusion and major adverse cardiovascular events rate in acute anterior myocardial infarction patients with heavy thrombosis burden.
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Characterization and influencing factors of visit-to-visit blood pressure variability of the population in a northern Chinese industrial city.
Chin. Med. J.
PUBLISHED: 03-14-2014
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Blood pressure variability (BPV) is a reliable prognostic factor for cardiovascular events. Currently there is a worldwide lack of large sample size studies in visit-to-visit BPV. Based on the Kailuan Study, we analyzed the visit-to-visit BPV of patients to investigate the range and influencing factors of BPV.
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Genetic variants associated with myocardial infarction and the risk factors in Chinese population.
PLoS ONE
PUBLISHED: 01-01-2014
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Recent genome-wide association (GWA) studies in Caucasians identified multiple single nucleotide polymorphisms (SNPs) associated with coronary artery disease (CAD). The associations of those SNPs with myocardial infarction (MI) have not been replicated in Asian populations. Among those previously identified SNPs, we selected nine (rs10953541, rs1122608, rs12190287, rs12413409, rs1412444, rs1746048, rs3798220, rs4977574, rs579459, in or near genes 7q22, LDLR, TCF21, CYP17A1, LIPA, CXCL12, LPA, CDKN2A, ABO, respectively) because of the relatively high minor allele frequencies in Chinese individuals and tested the associations of the SNPs with MI and MI related risk factors in Chinese population.
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The correlation between peripartum cardiomyopathy and autoantibodies against cardiovascular receptors.
PLoS ONE
PUBLISHED: 01-01-2014
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Peripartum cardiomyopathy (PPCM) is characterized by left ventricular systolic dysfunction and heart failure. However, its pathogenesis is not clear. Our preliminary study revealed that autoantibodies against ?1-adrenergic receptors (?1R-AABs) and M2-muscarinic receptors (M2R-AABs) participated in heart failure regardless of primary heart disease. Whether ?1R-AABs and M2R-AABs participate in the pathogenesis of PPCM is still unknown.
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Influence of islet function on typing and prognosis of new-onset diabetes after intensive insulin therapy.
Med. Sci. Monit.
PUBLISHED: 09-24-2013
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It is difficult in clinical practice to differentiate patients with newly diagnosed diabetes and ketosis. The aim of this study was to investigate the effect of intensive insulin therapy on islet function in patients with new-onset diabetes and concomitant ketosis, and to determine the value of alternation in islet function in the typing of diabetes.
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Association between interleukin 6 and interleukin 16 gene polymorphisms and coronary heart disease risk in a Chinese population.
J. Int. Med. Res.
PUBLISHED: 07-23-2013
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To investigate the role of interleukin 6 (IL6) and IL16 single nucleotide polymorphisms (SNPs) in coronary artery disease (CAD) risk in a Chinese population.
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J wave is associated with increased risk of sudden cardiac arrest in patients with hypertrophic cardiomyopathy.
J. Int. Med. Res.
PUBLISHED: 07-18-2013
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A retrospective, case-control study to investigate the J wave, a J-point elevation on resting 12-lead electrocardiograms, as a risk factor for sudden cardiac arrest (SCA) in patients diagnosed with hypertrophic cardiomyopathy (HCM).
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Bandwidth enhancement in microwave absorption of binary nanocomposite ferrites hollow microfibers.
J Nanosci Nanotechnol
PUBLISHED: 06-15-2013
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The binary Ba0.5Sr0.5Fe12O19 (BSFO)/Ni0.5Zn0.5Fe2O4 (NZFO) nanocomposite ferrites hollow microfibers with high aspect ratios have been prepared by the gel precursor transformation process. These microfibers possess a high specific surface area about 45.2 m2 g(-1), and a ratio of the hollow diameter to the fiber diameter estimated about 5/7. The binary nanocomposite ferrites are formed after the precursor calcined at 750 degrees C for 3 h. Their minimum reflection loss (RL) is -38.1 dB at 10.4 GHz. The microwave absorption bandwidth with RL value exceeding -20 dB covers the whole X-band (8.2-12.4 GHz) and Ku-band (12.4-18 GHz). This enhancement in microwave absorption can be attributed to the exchange-coupling interaction, interfacial polarization and small size effect in nanocomposite hollow microfibers.
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Adsorption kinetics and isotherms of arsenic(V) from aqueous solution onto Ni0.5Zn0.5Fe2O4 nanoparticles.
J Nanosci Nanotechnol
PUBLISHED: 06-15-2013
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Magnetic Ni0.5Zn0.5Fe2O4 nanoparticles were synthesized by the facile citrate-gel process. Their morphology, chemical composition, microstructure, and magnetic properties were investigated by XRD, TEM, EDX, BET, and VSM. The as-prepared magnetic Ni0.5Zn0.5Fe2O4 nanoparticles consisting of grains about 20 nm were characterized with specific surface area of 49.0 m2/g and magnetization of 46.1 A m2/kg. The arsenic(V) adsorption onto these magnetic Ni0.5Zn0.5Fe2O4 nanoparticles at room temperature was determined by the ICP-AES measurement of arsenic(V) in aqueous solution. The results show that the pseudo-second-order kinetic model is fitted well to describe the arsenic(V) adsorption process with a determination coefficient (R2 = 0.9862). By comparing with the two- and three-parameter models for adsorption isotherms of arsenic(V) onto the magnetic Ni0.5Zn0.5Fe2O4 nanoparticles at room temperature, the Temkin and Redlich-Peterson model can be used to evaluate the arsenic(V) adsorption isotherm at room temperature. The arsenic(V) equilibrium adsorption quantity is up to 7.2 mg/g for these magnetic Ni0.5Zn0.5Fe2O4 nanoparticles when the initial arsenic(V) concentration is 3 mg/L in aqueous solution.
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Identification of micro-RNA networks in end-stage heart failure because of dilated cardiomyopathy.
J. Cell. Mol. Med.
PUBLISHED: 02-03-2013
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Micro-RNAs regulate gene expression by directly binding to the target mRNAs. The goal of the study was to examine the expression profiling of miRNAs in human failing hearts and identify the key miRNAs that regulate molecular signalling networks and thus contribute to this pathological process. The levels of miRNAs and expressed genes were analysed in myocardial biopsy samples from patients with end-stage heart failure (n = 14) and those from normal heart samples (n = 8). Four networks were built including the Gene regulatory network, Signal-Network, miRNA-GO-Network and miRNA-Gene-Network. According to the fold change in the network and probability values in the microarray cohort, RT-PCR was performed to measure the expression of five of the 72 differentially regulated miRNAs. miR-340 achieved statistically significant. miR-340 was identified for the first time in cardiac pathophysiological condition. We overexpressed miR-340 in cultured neonatal rat cardiomyocytes to identify whether miR-340 plays a determining role in the progression of heart failure. ANP, BNP and caspase-3 were significantly elevated in the miR-340 transfected cells compared with controls (P < 0.05). The cross-sectional area of overexpressing miR-340 cardiomyocytes (1952.22 ± 106.59) was greater (P < 0.0001) than controls (1059.99 ± 45.59) documented by Laser Confocal Microscopy. The changes of cellular structure and the volume were statistical significance. Our study provided a comprehensive miRNA expression profiling in the end-stage heart failure and identified miR-340 as a key miRNA contributing to the occurrence and progression of heart failure. Our discoveries provide novel therapeutic targets for patients with heart failure.
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Predictive value of pre-procedural autoantibodies against M2-muscarinic acetylcholine receptor for recurrence of atrial fibrillation one year after radiofrequency catheter ablation.
J Transl Med
PUBLISHED: 01-02-2013
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Increasing evidences have suggested that autoantibodies against muscarinic-2 acetylcholine receptor (anti-M2-R) may play an important role in the development of atrial fibrillation (AF). Predictive value of pre-procedural anti-M2-R for the recurrence of AF after radiofrequency catheter ablation is still unclear.
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Signature microRNA expression profile of essential hypertension and its novel link to human cytomegalovirus infection.
Circulation
PUBLISHED: 06-20-2011
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Essential hypertension has been recognized as a disease resulting from a combination of environmental and genetic factors. Recent studies demonstrated that microRNAs (miRNAs) are involved in cardiac hypertrophy and heart failure. However, little is known about the roles of miRNAs in essential hypertension.
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CXC chemokine ligand 16 as a prognostic marker in patients with intermediate coronary artery lesions: a 2-year follow-up study.
Tohoku J. Exp. Med.
PUBLISHED: 04-07-2011
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There is no reliable way to identify the high-risk patients with intermediate coronary artery lesions (diameter stenosis 20%-70%) in early stage. Soluble CXC chemokine ligand 16 (CXCL16) is a newly discovered chemokine that can mediate inflammatory responses. It is released by proteolytic cleavage of its membrane-bound form, named scavenger receptor for phosphatidylserine and oxidized lipoprotein (SR-PSOX) that can promote the uptake of oxidized low-density lipoprotein cholesterol by macrophages. We have hypothesized that CXCL16 is an indicator of the prognosis of intermediate coronary artery lesions, and thus assessed the association between plasma CXCL16 concentrations and the 2-year prognosis in 616 patients with intermediate coronary artery lesions. The primary endpoint was a composite of all-cause death, non-fatal myocardial infarction, revascularization and angina pectoris requiring re-hospitalization. During the median follow-up time of 24 months, 69 events occurred. The plasma concentrations of CXCL16 (median 7712.88 pg/ml vs. 6792.43 pg/ml, P = 0.014) and high-sensitivity C-reactive protein (hs-CRP) (median 2.82 mg/L vs. 1.68 mg/L, P < 0.001) were higher in patients with events than patients without events. Cox hazard proportion analysis showed patients in upper CXCL16 quartile were more likely to suffer from adverse outcome than patients in lower quartile (RR = 1.271, P = 0.029, 95% CI: 1.025-1.577) after adjusting for sex, age, smoking, hypertension, diabetes, fat, dyslipidemia, hs-CRP, and medication use. In conclusion, plasma level of CXCL16 is an independent predictor of the prognosis of the patients with intermediate coronary lesions. Elevated plasma CXCL16 is associated with higher risk for these patients.
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Independent no-reflow predictors in female patients with ST-elevation acute myocardial infarction treated with primary percutaneous coronary intervention.
Heart Vessels
PUBLISHED: 04-01-2011
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Independent no-reflow predictors should be evaluated in female patients with ST-segment elevation acute myocardial infarction (STEMI) and successfully treated with primary percutaneous coronary intervention (PPCI) in the current interventional equipment and techniques, thus to be constructed a no-reflow predicting model. In this study, 320 female patients with STEMI were successfully treated with PPCI within 12 h after the onset of AMI from 2007 to 2010. All clinical, angiographic, and procedural data were collected. Multiple logistic regression analysis was used to identify independent no-reflow predictors. The no-reflow was found in 81 (25.3%) of 320 female patients. Univariate and multivariate stepwise logistic regression analysis identified that low SBP on admission <100 mmHg (OR 1.991, 95% CI 1.018-3.896; p = 0.004), target lesion length >20 mm (OR 1.948, 95% CI 1.908-1.990; p = 0.016), collateral circulation 0-1 (OR 1.952, 95% CI 1.914-1.992; p = 0.019), pre-PCI thrombus score ? 4 (OR 4.184, 95% CI 1.482-11.813; p = 0.007), and IABP use before PCI (OR 1.949, 95% CI 1.168-3.253; p = 0.011) were independent no-reflow predictors. The no-reflow incidence significantly increased as the numbers of independent predictors increased [0% (0/2), 10.8% (9/84), 14.5% (17/117), 37.7% (29/77), 56.7% (17/30), and 81.8% (9/11) in female patients with 0, 1, 2, 3, 4, and 5 independent predictors, respectively; p < 0.0001]. The five no-reflow predicting variables were admission SBP <100 mmHg, target lesion length >20 mm, collateral circulation 0-1, pre-PCI thrombus score ? 4, and IABP use before PCI in female patients with STEMI treated with PPCI.
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Human cytomegalovirus infection is a novel etiology for essential hypertension.
Med. Hypotheses
PUBLISHED: 01-18-2011
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Essential hypertension is a major risk factor for cardiovascular, cerebrovascular, and renal diseases. However, the underlying cause and pathologic mechanisms of essential hypertension are poorly understood. Vascular inflammation and endothelial dysfunction are implicated in the pathogenesis of hypertension based on associations with elevated expression of adhesion molecules and chemokines and dysfunctional nitric oxide synthase. Human cytomegalovirus (HCMV) has been implicated in several cardiovascular disorders, including atherosclerosis, coronary heart disease, and cardiac transplant arteriopathy. Recent studies have suggested that HCMV is associated with cardiovascular disorders through impaired endothelial nitric oxide synthase function and subsequent endothelial dysfunction, which manifest as impaired vasculature dilation in vivo. However, direct links between human cytomegalovirus infection and essential hypertension remain undefined. Based on current studies, we present a hypothesis that human cytomegalovirus is an opportunistic pathogen that causes essential hypertension by disrupting nitric oxide synthesis and immune defense and by activating inflammation and the renin-angiotensin system.
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Quinidine depresses the transmural electrical heterogeneity of transient outward potassium current of the right ventricular outflow tract free wall.
J Cardiovasc Dis Res
PUBLISHED: 12-29-2010
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BACKGROUND#ENTITYSTARTX02014;: Electrical heterogeneity of the right ventricular outflow tract (RVOT) is regarded as one of the main electrophysiological substrates for Brugada syndrome. Recently quinidine has shown efficacy in patients with Brugada syndrome due to its ability to inhibit potassium current especially 4-aminopyridine-sensitive, non-Ca(2+) -dependent transient outward potassium current (Ito). However, much less is known on how extent quinidine in clinical therapeutic concentration range can inhibit this kind of electrical heterogeneity of RVOT Ito. METHODS AND RESULTS#ENTITYSTARTX02014;: Single RVOT free wall epicardial (Epi) cell, midmyocardial (M) cell and endocarcial (Endo) cells were used for whole-cell voltage clamping and Ito was recorded at 37°C, 0.2 Hz depolarization pulse. Evident Ito tranmural heterogeneity existed in RVOT free wall. Under the condition of baseline, of 10 ?M quinidine perfusion 5 minutes (mins), and of 10 ?M quinidine perfusion 7-10 mins, from 0 mV to 70 mV the whole transmural average Ito values of RVOT free wall were 10.2 pA/pF, 5.5 pA/pF and 3.5 pA/pF, respectively (between groups, P< 0.01). The inhibitory percentage of 10 ?M quinidine at 5 mins and 7-10 mins steady-state level on the the whole Ito transmural heterogeneity of RVOT free wall were 46.3%±6% and 66.5%±11%, respectively. CONCLUSIONS#ENTITYSTARTX02014;: There exists a robust Ito transmural electrical heterogeneity in RVOT free wall and quinidine in clinical therapeutic concentration can depress this kind of heterogeneity effectively.
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High-dose glucose-insulin-potassium has hemodynamic benefits and can improve cardiac remodeling in acute myocardial infarction treated with primary percutaneous coronary intervention: From a randomized controlled study.
J Cardiovasc Dis Res
PUBLISHED: 12-29-2010
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To evaluate the effects of high-dose glucose-insulin-potassium (GIK) solution on hemodynamics and cardiac remodeling in patients with acute myocardial infarction (AMI) treated with primary percutaneous coronary intervention (PCI).
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Non-ST-segment elevation myocardial infarction in a patient with essential thrombocythemia treated with glycoprotein IIb/IIIa inhibitor: a case report.
Clin. Appl. Thromb. Hemost.
PUBLISHED: 08-19-2010
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Essential thrombocythemia (ET) can cause systemic vascular thrombosis but rarely cause obstruction of coronary arteries or acute myocardial infarction (MI). Treatment of acute MI in patients with ET may be a problem due to the important role of platelets in the pathogenesis of infarction. In this report, a 63-year-old man presented with acute chest pain and a greatly increased platelet count. The patient was successfully treated with intravenous tirofiban, a glycoprotein IIb/IIIa receptor blocker. Essential thrombocythemia was diagnosed based on bone marrow findings, clinical presentation, and laboratory analysis. Thrombocythemia had been controlled with hydroxyurea.
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Multicolor fluorescent switches in gel systems controlled by alkoxyl chain and solvent.
Org. Biomol. Chem.
PUBLISHED: 08-11-2010
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Two simple molecules, 1 and 2 with D-pi-A structure and alkoxyl groups, respectively, were designed and synthesized. Both compounds can gelatinize THF-water and DMSO. And compound 2 forms gel in acetone by ultrasonic stimulus. Interestingly, these gels exhibit aggregation-induced emission (AIE) during the sol-gel phase transformation. Moreover, the molecular self-assembled and photophysical properties can be controlled by the number of the alkoxyl chains and the type of the solvents. For example, 1 has an identical packing model and fluorescent colour in THF-water and DMSO gels. Contrarily, the self-assembly of molecule 2 strongly depends on the solvent. Furthermore, the gel phases of 2 formed in three solvents possess different fluorescent colours. Such as, THF-water gel emits yellow fluorescence, acetone gel has orange emission and red fluorescence appears in DMSO.
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A Phase II, randomized, double-blind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure.
J. Am. Coll. Cardiol.
PUBLISHED: 05-01-2010
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The purpose of this study was to assess the safety and efficacy of recombinant human neuregulin-1 (rhNRG-1) in chronic heart failure (CHF) patients.
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Rigid dendritic gelators based on oligocarbazoles.
Chem. Commun. (Camb.)
PUBLISHED: 12-16-2009
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The first rigid dendritic gel with strong emission based on oligocarbazole was reported. It is interesting that the second generation of dendron exhibited gelation ability under ultrasound, and two-component gel could be formed from the first generation of dendron assisted by 1,6-diaminohexane.
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Strategy to control the chromism and fluorescence emission of a perylene dye in composite organogel phases.
Langmuir
PUBLISHED: 09-11-2009
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Composite organogels based on 1,3,5-tris(4-dodecyloxybenzoylamino)phenylbenzene (DBAPB), a known gelator, and N,N-di(octadecyl)-perylene-3,4,9,10-tetracarboxylic diimide (C18PTCDI), a nongelator dye, have been achieved, leading to controllable color and emitting color changes. SEM images and XRD patterns revealed that the packing of the DBAPB-based gelator could almost be maintained in the composite gels. The temperature-dependent UV-vis absorption and temperature-dependent fluorescence emission spectra illustrated that the color and emitting color of the composite gels could be controlled by the content of C18PTCDI as well as the temperature in the gel phases. When the content of C18PTCDI was 1 mol %, C18PTCDI could be isolated as unimolecules in the composite gel, which was yellow and gave bright greenish-yellow emission under 365 nm light. For the mixed systems containing 2-10 mol % C18PTCDI, the fresh gels, which were obtained after cooling the hot solutions for a short time, were yellow and produced greenish-yellow emission under 365 nm illumination. However, the corresponding stable composite gels, which were obtained via prolonging the cooling time, were red and emitted weak red emission excited by UV light as a result of the formation of C18PTCDI aggregates. The reversible color and emitting color changes could be realized in the gel phases over a narrow temperature range. Moreover, the excitation energy of DBAPB could be transferred to C18PTCDI in the composite gels, leading to obvious emission quenching of the former.
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Self-assembly of a chiral lipid gelator controlled by solvent and speed of gelation.
Chemistry
PUBLISHED: 08-15-2009
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Glutamine derivative 1 with two-photon absorbing units has been synthesized and was found to show gelation ability in some solvents. Its self-assembly in the gel phase could be controlled by the solvent and speed of gelation. For example, in DMSO the organogelator self-assembled into H-aggregates with weak exciton coupling between the aromatic moieties. On the other hand, in DMSO/diphenyl ether (1:9, v/v) the molecules formed 1D aggregates, but with strong exciton coupling due to the small distance between the chromophores. Moreover, the formation of these two kinds of aggregates could be adjusted by the ratio of DMSO to diphenyl ether. In DMSO/toluene, DMSO/butanol, DMSO/butyl acetate, and DMSO/acetic acid systems similar results were observed. Therefore, conversion of the packing model occurs irrespective of the nature of the solvent. Notably, a unique sign inversion in the CD spectra could be realized by controlling the speed of gelation in the DMSO/diphenyl ether (1:9, v/v) system. It was found that a low speed of gelation induces the gelator to adopt a packing model with strong pi-pi interactions between the aromatic units. Moreover, the gels, when excited at 800 nm, emit strong green fluorescence and the quantum chemical calculations suggest that intramolecular charge transfer leads to two-photon absorption of the gelator molecule.
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Aggregation-induced blue shift of fluorescence emission due to suppression of TICT in a phenothiazine-based organogel.
J Colloid Interface Sci
PUBLISHED: 06-09-2009
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A new D-pi-A type gelator based on a phenothiazine derivative, which can gel cyclohexane, hexane, and ethanol/water under ultrasound treatment, has been synthesized. Because such gelators can act as twisted intermolecular charge transfer (TICT) probes, their emission in solution can be tuned by varying the polarity of the solvents. It is notable that an unusual aggregation-induced blue shift of the emission has been detected on account of the suppression of TICT in the gel phase.
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Silica cross-linked nanoparticles encapsulating fluorescent conjugated dyes for energy transfer-based white light emission and porphyrin sensing.
Nanoscale
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This work demonstrated that water-soluble fluorescent hybrid materials can be successfully synthesized by use of silica cross-linked micellar nanoparticles (SCMNPs) as scaffolds to encapsulate fluorescent conjugated dyes for pH sensing, porphyrin sensing and tunable colour emission. Three dyes were separately encapsulated inside SCMNPs (short to dye-SCMNPs). Each of the dye-SCMNPs indicated longer lifetime in water than that of free dye dissolved in organic solvent. The 7-(hexadecyloxy) coumarin-3-ethylformate (HCE) encapsulated inside SCMNPs (HCE-SCMNPs) exhibited fluorescence quenching by pH change in aqueous media. Furthermore, it was confirmed that the radiative and nonradiative energy transfer processes both occurred between HCE-SCMNPs and tetraphenyl-porphyrin (TPP), which were used to synthesize the water-soluble TPP sensor. Significantly, HCE-SCMNPs doped with 5,12-dicotyl-quinacridone (8CQA) and TPP showed water-soluble white light emission (CIE (0.29, 0.34)) upon singlet excitation of 376 nm due to colour adjustment of 8CQA and energy transfer from HCE (donor) to TPP (acceptor).
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Cardiovascular events in a prehypertensive Chinese population: four-year follow-up study.
Int. J. Cardiol.
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This study aimed to determine the occurrence of cardiovascular (CV) events in a prehypertensive Chinese population.
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Prevalence of ideal cardiovascular health and its relationship with the 4-year cardiovascular events in a northern Chinese industrial city.
Circ Cardiovasc Qual Outcomes
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The American Heart Association Committee recently developed definitions of "ideal," "intermediate," and "poor" cardiovascular health based on 7 cardiovascular disease (CVD) risk factors or health behaviors. This study evaluated the prevalence of "ideal" American Heart Association cardiovascular health metrics from June 2006 to October 2007 in the Kailuan cohort (n=101?510; age 18-98 years) in northern China and its relationship with the 4-year CVD incidence.
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Aging might augment reactive oxygen species (ROS) formation and affect reactive nitrogen species (RNS) level after myocardial ischemia/reperfusion in both humans and rats.
Age (Dordr)
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Previous studies indicate aging results in significantly decreased cardiac function and increased myocardial apoptosis after myocardial ischemia/reperfusion (MI/R) in humans or rats. The underlying mechanisms of aging-exacerbated effects remain unknown. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are known to play vital roles in aging-related MI/R injury. Heretofore, the effects of aging upon ROS and RNS formation were not investigated in humans, which is the focus of the current study. Due to experimental limitations with clinical trials, an additional animal experiment was performed. All enrolled acute myocardial infarction (AMI) patients received percutaneous coronary intervention (PCI) therapy. AMI patients were assigned into two groups: adult (age <65, n?=?34) and elderly (age ?65, n?=?45) AMI patients. Blood samples were obtained from all study participants at 24 h and 3 days post-PCI. Plasma/white blood cell (WBC) ROS and RNS markers (malondialdehyde (MDA), myeloperoxidase (MPO), reduced glutathione (GSH), inducible nitric oxide synthase (iNOS) activity, NOx, and nitrotyrosine) were determined. The same markers were determined in rat cardiac tissue after 24 h MI/R. Compared to the adult group, elderly patients manifested increased plasma MDA and MPO and decreased plasma GSH concentrations. No significant differences in plasma NOx or nitrotyrosine concentration existed between adult and elderly patients. Furthermore, WBC iNOS activity in elderly patients was significantly decreased compared to the adult group. The measurement of ROS markers in the rat experiments was consistent and supported human study data. Surprisingly, RNS markers (NOx and nitrotyrosine) in blood and heart tissue increased from young to middle-aged rats but decreased from middle age to old age. Aging augments ROS, which might exacerbate MI/R injury. Additionally, our data support aging-induced changes of RNS levels in humans and rats in vivo.
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