JoVE Visualize What is visualize?
Stop Reading. Start Watching.
Advanced Search
Stop Reading. Start Watching.
Regular Search
Find video protocols related to scientific articles indexed in Pubmed.
[Synergistic effect of hypertension and aging on left atrial volume and function].
Zhonghua Nei Ke Za Zhi
PUBLISHED: 11-08-2014
Show Abstract
Hide Abstract
To assess the effect of combined hypertension (HT) and aging on left atrial (LA) size and phasic function.
Related JoVE Video
Complete Genome Sequence of the Oral Spirochete Bacterium Treponema putidum Strain OMZ 758T (ATCC 700334T).
Genome Announc
PUBLISHED: 10-25-2014
Show Abstract
Hide Abstract
The oral spirochete bacterium Treponema putidum inhabits human periodontal niches. The complete genome sequence of the OMZ 758(T) (ATCC 700334(T)) strain of this species was determined, revealing a 2,796,913-bp chromosome, with a G+C content of 37.30% and a single plasmid (pTPu1; 3,649 bp) identical to pTS1 from Treponema denticola.
Related JoVE Video
Predictors of one-year mortality at hospital discharge after acute coronary syndromes: A new risk score from the EPICOR (long-tErm follow uP of antithrombotic management patterns In acute CORonary syndrome patients) study.
Eur Heart J Acute Cardiovasc Care
PUBLISHED: 10-09-2014
Show Abstract
Hide Abstract
A reliable prediction tool is needed to identify acute coronary syndrome (ACS) patients with high mortality risk after their initial hospitalization.
Related JoVE Video
Stent for Life Initiative: leading example in building STEMI systems of care in emerging countries.
EuroIntervention
PUBLISHED: 09-27-2014
Show Abstract
Hide Abstract
This paper describes the opportunities and challenges in building ST-elevation acute myocardial infarction (STEMI) systems of care in Stent for Life affiliated and collaborating so-called emerging countries, namely India, China, South Africa and Mexico, where CAD mortality is increasing and becoming a significant healthcare problem. The Stent for Life model supports the implementation of ESC STEMI Guidelines in Europe and endeavours to impact on morbidity and mortality by improving services and developing regional STEMI systems of care, whereby STEMI patients' timely access to a primary percutaneous coronary intervention (PPCI) is assured. In India, the STEMI India model incorporates a dual approach of combining PPCI with a pharmacoinvasive strategy of reperfusion. The architecture of the system is based on a hub and spoke model with each unit called a STEMI cluster. The project is driven by a private non-profit organisation. In China, the STEMI PCI programme is led by the Chinese College of Cardiovascular Physicians and supported by the national government. Although primary PCI is performed nationwide, a thrombolytic treatment strategy is still the first option in many rural areas because of logistic considerations. Establishing local STEMI transfer networks and then implementing a pharmacoinvasive strategy of reperfusion are being considered and promoted currently. In South Africa, the pharmacoinvasive approach currently dominates as STEMI treatment option in many areas. A pilot study shows that low symptom awareness leads to long patient delays. The education of all role players, from patients to healthcare professionals and including institutions and governmental structures, is needed to achieve prompt diagnosis and treatment. In Mexico, improving the treatment of STEMI requires considering myocardial infarction to be an emergency that must be treated by an entire system and not just by a particular service. Patients need to receive quick treatment from clinical and interventional cardiologists, and the emergency medical system (EMS) must understand the importance of early reperfusion therapy when appropriate. Mexican health authorities have used registries as their main strategy for improving the use of health resources for ACS patients. In general, building regional STEMI systems of care and an EMS system infrastructure are critical success factors in the stepwise development of STEMI systems of care at a national level in emerging countries as they are in Europe. An in-depth understanding of healthcare system-level barriers to timely and appropriate reperfusion therapy facilitates the development of more effective strategies for improving the quality of STEMI care in each region and country.
Related JoVE Video
[Relationship between high normal blood pressure and carotid artery atherosclerosis in Beijing residents].
Zhonghua Xin Xue Guan Bing Za Zhi
PUBLISHED: 08-29-2014
Show Abstract
Hide Abstract
To analyze the relationship between normal high blood pressure and carotid artery atherosclerosis.
Related JoVE Video
Expert consensus document: World Heart Federation expert consensus statement on antiplatelet therapy in East Asian patients with ACS or undergoing PCI.
Nat Rev Cardiol
PUBLISHED: 08-26-2014
Show Abstract
Hide Abstract
Guideline recommendations on the use of dual antiplatelet therapy (DAPT) in patients with acute coronary syndromes and in those undergoing percutaneous coronary intervention (PCI) have been formulated by both the ACC/AHA and the ESC. These recommendations are based primarily on large, phase III, randomized, controlled trials of the P2Y12 inhibitors clopidogrel, prasugrel, and ticagrelor. However, few East Asian patients have been included in the trials to assess the use of these agents, particularly the newer agents prasugrel and ticagrelor. Additionally, an increasing body of data suggests that East Asian patients have differing risk profiles for both thrombophilia and bleeding compared with white patients, and that a different 'therapeutic window' of on-treatment platelet reactivity might be appropriate in East Asian patients. Furthermore, a phenomenon referred to as the 'East Asian paradox' has been described, in which East Asian patients have a similar or even a lower rate of ischaemic events after PCI compared with white patients, despite a higher level of platelet reactivity during DAPT. Recognizing these concerns, the World Heart Federation has undertaken this evidence-based review and produced this expert consensus statement to determine the antiplatelet treatment strategies that are most appropriate for East Asian patients.
Related JoVE Video
[Speckle tracking analysis of left atrial phasic function in patients with hypertension].
Beijing Da Xue Xue Bao
PUBLISHED: 08-19-2014
Show Abstract
Hide Abstract
To assess left atrial (LA) phasic function in hypertension (HT) and to evaluate its relationship with left ventricular diastolic function.
Related JoVE Video
Novel completed biodegradable polymer sirolimus-eluting stent versus durable polymer sirolimus-eluting stent in de novo lesions: nine-month angiographic and three-year clinical outcomes of HOPE trial.
Chin. Med. J.
PUBLISHED: 07-22-2014
Show Abstract
Hide Abstract
Drug-eluting stents (DES) with durable polymer have significantly reduced restenosis and target vessel revascularization compared with bare metal stents. Durable polymer has been linked with persistent inflammation of vessel wall and delayed endothelial healing that may increase the risk of late and very late stent thrombosis. This study sought to evaluate the efficacy and safety of HELIOS completed biodegradable polymer sirolimus-eluting stent (SES) in de novo coronary lesions.
Related JoVE Video
[Correlation between anthropometric parameters and arteriosclerosis biomarker in the middle-aged and the elderly].
Beijing Da Xue Xue Bao
PUBLISHED: 06-20-2014
Show Abstract
Hide Abstract
To investigate the correlation between anthropometric indices and arteriosclerosis detection indicators in the middle-aged and the elderly.
Related JoVE Video
Impaired regulator of G protein signaling 2 transcription facilitates vascular remodeling in injured rat aorta.
J Cardiovasc Med (Hagerstown)
PUBLISHED: 06-11-2014
Show Abstract
Hide Abstract
The activation of Gq-protein-coupled receptors induces proliferation of vascular smooth muscle cells (VSMCs) proliferation and is involved in vascular remodeling. The regulator of G protein signaling 2 (RGS2), which accelerates the termination of Gq protein signaling, may play a role in vascular remodeling. However, this role remains unclear.
Related JoVE Video
Nine-month angiographic and two-year clinical follow-up of polymer-free sirolimus-eluting stent versus durable-polymer sirolimus-eluting stent for coronary artery disease: the Nano randomized trial.
Chin. Med. J.
PUBLISHED: 06-04-2014
Show Abstract
Hide Abstract
First generation drug-eluting stents (DES) were associated with a high incidence of late stent thrombosis (ST), mainly due to delayed healing and re-endothelization by the durable polymer coating. This study sought to assess the safety and efficacy of the Nano polymer-free sirolimus-eluting stent (SES) in the treatment of patients with de novo coronary artery lesions.
Related JoVE Video
Regulators of G protein signaling are up-regulated in aspirin-resistant platelets from patients with metabolic syndrome.
Pharmazie
PUBLISHED: 05-27-2014
Show Abstract
Hide Abstract
G protein-coupled receptor signaling plays a crucial role in platelet function. Regulators of G protein signaling (RGSs), which accelerate the deactivation of G protein signaling, are expressed in platelets. However, RGS expression has not been studied in the context of aspirin resistance. We compared RGS mRNA levels in platelets from 39 aspirin-resistant patients and 50 aspirin-sensitive patients with metabolic syndrome. Although there were no clinical differences between the two groups, transcripts of RGS2, RGS10, and RGS18 were significantly higher in aspirin-resistant patients than in aspirin-sensitive patients. This study is the first to demonstrate that RGS transcripts are elevated in aspirin-resistant platelets from patients with metabolic syndrome.
Related JoVE Video
Connective tissue disease-associated pulmonary arterial hypertension in Chinese patients.
Eur. Respir. J.
PUBLISHED: 05-02-2014
Show Abstract
Hide Abstract
We sought to investigate the characteristics, survival and risk factors for mortality in Chinese patients with connective tissue disease (CTD)-associated pulmonary arterial hypertension (APAH) in modern therapy era. 129 consecutive adult patients who visited one of three referral centres in China with a diagnosis of CTD-APAH confirmed by right heart catheterisation during the previous 5 years were enrolled. The end-point was all-cause death or data censoring. Systemic lupus erythematosus was the most common underlying CTD (49%) and systemic sclerosis just accounted for 6% in this cohort. The overall survival at 1 and 3 years was 92% and 80%, respectively. Pericardial effusion, a shorter 6-min walk distance, lower mixed venous oxygen saturation, higher pulmonary vascular resistance (PVR) and alkaline phosphatase (ALP), and lower total cholesterol levels were all associated with a higher risk of death among the study population. Higher PVR and ALP were independent predictors of mortality. In conclusion, unlike in western patients, systemic lupus erythematosus is the most common underlying disease in Chinese patients with CTD-APAH. The survival of Chinese patients with CTD-APAH in the modern treatment era is similar to that in western countries. Elevated PVR and ALP are independent risk factors for poor outcomes.
Related JoVE Video
A novel high nitrogen nickel-free coronary stents system: evaluation in a porcine model.
Biomed. Environ. Sci.
PUBLISHED: 04-25-2014
Show Abstract
Hide Abstract
To study the safety of the novel high nitrogen nickel-free austenitic stainless steel bare metal stents (BMS) in a recognized porcine coronary model and to select a better grid structure of it.
Related JoVE Video
[A cross-sectional study of factors related to traditional Chinese medicine use for hospitalized acute coronary syndrome patients in China's level 2 hospitals].
Zhonghua Xin Xue Guan Bing Za Zhi
PUBLISHED: 04-17-2014
Show Abstract
Hide Abstract
To explore the current status on traditional Chinese medicine (TCM) use for hospitalized acute coronary syndrome patients in China's level 2 hospitals, and to explore associated factors of TCM use for these patients.
Related JoVE Video
Rationale for and design of the Acarbose Cardiovascular Evaluation (ACE) trial.
Am. Heart J.
PUBLISHED: 03-17-2014
Show Abstract
Hide Abstract
Patients with cardiovascular disease and impaired glucose tolerance are at increased risk of cardiovascular events and type 2 diabetes mellitus (T2DM). Lifestyle modification or pharmacological intervention can delay progression to T2DM, but there is no clear evidence that they reduce cardiovascular risk in this population. Acarbose, an ?-glucosidase inhibitor that lowers postprandial blood glucose, has been shown to reduce T2DM risk by 25%, and possibly cardiovascular risk in impaired glucose tolerance subjects without cardiovascular disease.
Related JoVE Video
Safety and efficacy of a novel abluminal groove-filled biodegradable polymer sirolimus-eluting stent for the treatment of de novo coronary lesions: 12-month results from the TARGET II trial.
Chin. Med. J.
PUBLISHED: 03-14-2014
Show Abstract
Hide Abstract
In the TARGET I randomized controlled trial, the novel abluminal groove-filled biodegradable polymer sirolimus-eluting stent FIREHAWK proved non-inferior to the everolimus-eluting stent in nine-month in-stent late loss in single de novo coronary lesions. This study was aimed at evaluating clinical safety and effectiveness of FIREHAWK in a moderately complex population (including patients with small vessels, long lesions and multi-vessels), and at validating the ability of the SYNTAX score (SS) to predict clinical outcomes in patients treated with this latest generation drug-eluting stent.
Related JoVE Video
Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations.
Am. J. Hum. Genet.
PUBLISHED: 03-13-2014
Show Abstract
Hide Abstract
Blood pressure (BP) is a heritable, quantitative trait with intraindividual variability and susceptibility to measurement error. Genetic studies of BP generally use single-visit measurements and thus cannot remove variability occurring over months or years. We leveraged the idea that averaging BP measured across time would improve phenotypic accuracy and thereby increase statistical power to detect genetic associations. We studied systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP) averaged over multiple years in 46,629 individuals of European ancestry. We identified 39 trait-variant associations across 19 independent loci (p < 5 × 10(-8)); five associations (in four loci) uniquely identified by our LTA analyses included those of SBP and MAP at 2p23 (rs1275988, near KCNK3), DBP at 2q11.2 (rs7599598, in FER1L5), and PP at 6p21 (rs10948071, near CRIP3) and 7p13 (rs2949837, near IGFBP3). Replication analyses conducted in cohorts with single-visit BP data showed positive replication of associations and a nominal association (p < 0.05). We estimated a 20% gain in statistical power with long-term average (LTA) as compared to single-visit BP association studies. Using LTA analysis, we identified genetic loci influencing BP. LTA might be one way of increasing the power of genetic associations for continuous traits in extant samples for other phenotypes that are measured serially over time.
Related JoVE Video
Predicting Hyperhomocysteinemia by Methylenetetrahydrofolate Reductase C677T Polymorphism in Chinese Patients With Hypertension.
Clin. Appl. Thromb. Hemost.
PUBLISHED: 01-25-2014
Show Abstract
Hide Abstract
Objective: To evaluate the performance of methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism in predicting hyperhomocysteinemia (HHcy) in Chinese patients with hypertension. Methods: We measured plasma total homocysteine tHcy level and C677T genotype in 1058 Chinese patients with hypertension from 4 previous studies. We used 10, 15, and 20 ?mol/L as cutoff values for the definition of mild, modest, and severe HHcy, respectively. Logistic models for HHcy were built from the study sample using the C677T genotype as well as age and gender as predictors. The receiver-operating characteristics of the models were evaluated. Results: Our major findings are that (1) C677T TT genotype is consistently associated with a higher tHcy across the 4 studies, with an increase in size ranging from 38% to 68% in the 4 studies and 51% overall. The C677T polymorphism independently explained about 14% of the total variance of the normalized tHcy. (2) The TT genotype is associated with a large increase in odds ratio (OR) for HHcy. Overall, the multivariate-adjusted ORs for the TT genotype are 3.9 (95% confidence interval [CI]: 2.4-6.4), 6.5 (95% CI: 4.0-10.6), and 17.9 (95% CI: 8.4-38.1) for mild, modest, and severe HHcy, respectively. (3) Overall, the predicting performance increased with HHcy severity, with sensitivity improving from 31.0% for mild HHcy to 70.3% for severe HHcy, and with specificity slightly decreasing from 85.4% to 80.3%. Inclusion of gender and age as predictors significantly improves the sensitivity, especially for predicting mild HHcy. Conclusion: With an excellent sensitivity and a modest specificity, C677T could be a useful screening marker for severe HHcy.
Related JoVE Video
The effect of moderate-dose versus double-dose statins on patients with acute coronary syndrome in China: Results of the CHILLAS trial.
Atherosclerosis
PUBLISHED: 01-08-2014
Show Abstract
Hide Abstract
Current guidelines recommend intensive low-density lipoprotein (LDL) cholesterol lowering with statins, with a target of 70 mg/dL (1.81 mmol/L) LDL cholesterol for those with a very high risk of coronary artery events. However, there is no multicenter study assessing the effect of intensive lipid-lowering therapy with statins on acute coronary syndrome (ACS) in a Chinese population with low baseline LDL cholesterol levels.
Related JoVE Video
Correlation between fragmented QRS and the short-term prognosis of patients with acute myocardial infarction.
J Zhejiang Univ Sci B
PUBLISHED: 01-07-2014
Show Abstract
Hide Abstract
This study is aimed to investigate the clinical significance and the short-term prognostic value of fragmented QRS (fQRS) for patients with acute myocardial infarction (AMI). Three hundred patients with AMI were tested with retrospective analysis on the patients' clinical information, hospitalized treatment, fQRS onset time, location of lesions, and other relevant data, in order to assess the relationship between the presence of fQRS and its prognosis. The rates of malignant cardiac arrhythmia, left ventricular systolic dysfunction (LVSD), and mortality in the positive fQRS group were 13.6%, 29.2%, and 23.7%, respectively, with all showing a p value <0.05. For the ST segment elevation myocardial infarction (STEMI) subgroup, all the rates showed significant differences with a p value <0.01, while for the non-STEMI (NSTEMI) subgroup showed no significant differences. In patients with a positive fQRS, there were no differences in malignant cardiac arrhythmia between patients with and without percutaneous coronary intervention (PCI) (p>0.05). As for the LVSD and mortality, the p values between patients with and without PCI were 0.031 and 0.000, respectively, suggesting statistical significance. The results imply that AMI patients with positive fQRS especially for the patients with STEMI had higher rates of malignant cardiac arrhythmia, LVSD, and mortality than the non-fQRS group. Patients of AMI with positive fQRS, who underwent early revascularization, could lower the incidence of the cardiovascular event. In addition, the presence of fQRS could be used as an indication of early intervention treatment for patients.
Related JoVE Video
Folic acid supplementation with and without vitamin B6 and revascularization risk: a meta-analysis of randomized controlled trials.
Clin Nutr
PUBLISHED: 01-05-2014
Show Abstract
Hide Abstract
There is a growing amount of data and a continuing controversy over the effect of folic acid supplementation with and without vitamin B6 on revascularization risk.
Related JoVE Video
[Relationship between radial augmentation index and other indices for evaluating arteriosclerosis].
Beijing Da Xue Xue Bao
PUBLISHED: 12-18-2013
Show Abstract
Hide Abstract
To investigate the relationship between radial augmentation index (AI) and other noninvasive indices for evaluating arteriosclerosis.
Related JoVE Video
Efficacy and safety of a novel nano-porous polymer-free sirolimus-eluting stent in pigs.
Chin. Med. J.
PUBLISHED: 12-18-2013
Show Abstract
Hide Abstract
Drug-eluting stents represent a major advance in interventional cardiology. However, the current drug-eluting stents have significant limitations. One of the major problems is very late stent thrombosis, which is likely caused by inflammation and a hypersensitivity reaction related to a polymer on the stent. A polymer-free sirolimus-eluting stent with a unique nano-porous surface has been developed. This study aimed to evaluate this novel polymer-free sirolimus-eluting stent for its efficacy and safety in a pig model.
Related JoVE Video
[Blood pressure control and glucose metabolism status in hypertension specialty clinics in China].
Zhonghua Nei Ke Za Zhi
PUBLISHED: 11-09-2013
Show Abstract
Hide Abstract
To investigate blood pressure control the glucose metabolism, cardiovascular risk factors of patients who were regularly followed up at professional hypertension clinics in China.
Related JoVE Video
[Plasma osteopontin level and left ventricular remodeling in patients with acute myocardial infarction].
Beijing Da Xue Xue Bao
PUBLISHED: 08-14-2013
Show Abstract
Hide Abstract
To investigate the change of plasma osteopontin level during the progress of acute ST-segment elevation myocardial infarction, as well as its association with the left ventricular remodeling and prognosis.
Related JoVE Video
Factors underlying the association of body mass index with serum ALT in Chinese hypertensive adults without known hepatic diseases.
J Zhejiang Univ Sci B
PUBLISHED: 07-31-2013
Show Abstract
Hide Abstract
High body mass index (BMI) is considered as the most important risk factor for elevated serum alanine aminotransferase (ALT) concentration. This study examined an array of factors, including waist circumference (WC) and folate deficiency, which may mediate the association of BMI with serum ALT concentration in Chinese hypertensive adults without known hepatic diseases.
Related JoVE Video
A systematic literature review of risk factors for stroke in China.
Cardiol Rev
PUBLISHED: 07-26-2013
Show Abstract
Hide Abstract
Other countries have seen a decline in stroke incidence after improved treatment and prevention of known risk factors for stroke. China is still experiencing significant increases in the incidence rate of total stroke. We systematically reviewed the evidence on the impact of 5 modifiable risk factors (hypertension, dyslipidemia, obesity, diabetes, and smoking) for the risk of stroke in the Chinese population, with the aim to develop more effective prevention and disease management programs. A literature search was conducted in MEDLINE and EMBASE for all observational studies that reported on the association between risk of stroke and any of the 5 risk factors and the composite risk factor. Selected articles were published in either English or Chinese from January 2004 to December 2010. Evidence of the association between hypertension and stroke was the strongest of the 5 factors reported in studies, with adjusted odds ratios ranging between 2.75 and 5.47. The association among obesity, diabetes, smoking, and the risk for stroke was evident, but not as strong as for hypertension. The risk ratios of hypertension to stroke were higher in the Chinese population than those in other countries.
Related JoVE Video
A randomised comparison of a novel abluminal groove-filled biodegradable polymer sirolimus-eluting stent with a durable polymer everolimus-eluting stent: clinical and angiographic follow-up of the TARGET I trial.
EuroIntervention
PUBLISHED: 05-21-2013
Show Abstract
Hide Abstract
The study sought to evaluate the safety and efficacy of FIREHAWK, a novel abluminal groove-filled biodegradable polymer sirolimus-eluting stent (SES) for treating patients with single de novo coronary lesions compared with the durable polymer everolimus-eluting stent (EES) XIENCE V.
Related JoVE Video
Adrenomedullin and adrenotensin increase the transcription of regulator of G?protein signaling 2 in vascular smooth muscle cells via the cAMP?dependent and PKC pathways.
Mol Med Rep
PUBLISHED: 04-12-2013
Show Abstract
Hide Abstract
The regulator of G?protein signaling 2 (RGS2) has been shown to be crucial in the regulation of vascular tone and blood pressure. The vascular activities of adrenomedullin (ADM) and adrenotension (ADT), two natural peptides, are dependent upon the modulation of RGS2 expression. However, the effects and pathways involved in their modulation remain unknown. This study aimed to observe the changes of RGS2 expression in response to ADM and ADT in cultured vascular smooth muscle cells and to clarify the potential signaling pathways in vitro. In the present study, vascular smooth muscle cells (VSMCs) were cultured with ADM and ADT of various concentrations for different time periods, and the gene expression of RGS2 was analyzed by PCR. ADM significantly increased the gene expression at 0.5 h to ~35?fold of that at baseline, whereas ADT marginally increased the expression after 1?2 h. SQ22,536 and chelerythrine were used to block the protein kinase A (PKA) and PKC pathways activated by incubation with ADM. The gene expression of RGS2 was reduced by SQ22,536 only. Furthermore, when SQ22,536 and chelerythrine were added to the cells incubated with ADT, the gene expression was markedly reduced by both SQ22,536 and chelerythrine. In conclusion, ADM immediately showed a marked increase in the gene expression of RGS2 in cultured VSMCs via a cAMP?dependent pathway and ADT gradually showed a marginal increase in the gene expression via a cAMP?dependent pathway and a PKC pathway.
Related JoVE Video
Clinical effect of Maixuekang Capsule () on long-term prognosis in patients with acute coronary syndrome after percutaneous coronary intervention.
Chin J Integr Med
PUBLISHED: 04-01-2013
Show Abstract
Hide Abstract
To study the changes of adenosine diphosphate (ADP)-induced platelet aggregation rate, and evaluate the effects of Maixuekang Capsule (, MKC) on platelet aggregation rate and long-term prognosis of patients with acute coronary syndrome after percutaneous coronary intervention (PCI).
Related JoVE Video
Efficacy and safety of FIREHAWK® abluminal groove filled biodegradable polymer sirolimus-eluting stents for the treatment of long coronary lesions: nine-month angiographic and one-year clinical results from TARGET I trial long cohort.
Chin. Med. J.
PUBLISHED: 03-20-2013
Show Abstract
Hide Abstract
Previous studies indicated that long coronary lesions are one of the key predictors of drug-eluting stent (DES) failure. The purpose of this study was to evaluate the efficacy and the safety of the long length FIREHAWK(®) stent in long coronary artery disease.
Related JoVE Video
Short-Term Rosuvastatin Therapy for Prevention of Contrast-Induced Acute Kidney Injury in Patients with Diabetes and Chronic Kidney Disease.
J. Am. Coll. Cardiol.
PUBLISHED: 03-15-2013
Show Abstract
Hide Abstract
The aim of this study was to evaluate the safety and efficacy of rosuvastatin inpreventing Contrast-induced acute kidney injury (CIAKI) in patients with diabetes mellitus(DM) and chronic kidney disease(CKD).
Related JoVE Video
Primacy of the 3B approach to control risk factors for cardiovascular disease in type 2 diabetes patients.
Am. J. Med.
PUBLISHED: 02-20-2013
Show Abstract
Hide Abstract
Individually, diabetes mellitus, hypertension, and dyslipidemia have been shown to increase the risk of cardiovascular disease. While traditional management of Type 2 diabetes has focused mainly on glycemic control, robust evidence supports the integration of hypertension and dyslipidemia management to reduce the risk of cardiovascular disease. The primary objective of this study was to assess the level of control of blood glucose, blood pressure, and blood lipids (3Bs) among patients with type 2 diabetes. An additional objective was to investigate the impact of hospital type, physician specialty, treatment pattern, and patient profile on clinical outcomes.
Related JoVE Video
Multilocus sequence analysis of Treponema denticola strains of diverse origin.
BMC Microbiol.
PUBLISHED: 01-24-2013
Show Abstract
Hide Abstract
The oral spirochete bacterium Treponema denticola is associated with both the incidence and severity of periodontal disease. Although the biological or phenotypic properties of a significant number of T. denticola isolates have been reported in the literature, their genetic diversity or phylogeny has never been systematically investigated. Here, we describe a multilocus sequence analysis (MLSA) of 20 of the most highly studied reference strains and clinical isolates of T. denticola; which were originally isolated from subgingival plaque samples taken from subjects from China, Japan, the Netherlands, Canada and the USA.
Related JoVE Video
Folic acid supplementation and cancer risk: a meta-analysis of randomized controlled trials.
Int. J. Cancer
PUBLISHED: 01-03-2013
Show Abstract
Hide Abstract
There are growing data and a continuing controversy over the effect of folic acid supplementation on cancer risk. We conducted a meta-analysis based on up-to-date published relevant randomized trials to further examine this issue. Relative risk (RR) was used to measure the effect of folic acid supplementation on risk of cancer using a random-effects model. Overall, folic acid supplementation had no significant effect on total cancer incidence (13 trials, n?=?49,406, RR?=?1.05; 95% CI: 0.99-1.11, p?=?0.13), colorectal cancer (seven trials, n?=?33,824, 1.01; 0.82-1.23, p?=?0.95), other gastrointestinal cancer (two trials, n?=?20,228, 1.00; 0.75-1.33, p?=?0.99), prostate cancer (five trials, n?=?27,065, 1.17; 0.84-1.62, p?=?0.35), other genitourinary cancer (two trials, n?=?20,228, 0.97; 0.75-1.27, p?=?0.84), lung cancer (five trials, n?=?31,864, 1.00; 0.84-1.21, p?=?0.97), breast cancer (four trials, n?=?19,800, 0.82; 0.63-1.07, p?=?0.15), hematological malignancy (three trials, n?=?25,670, 0.87; 0.64-1.17, p?=?0.35) and total cancer mortality (six trials, n?=?31,930, 1.02; 0.90-1.15, p?=?0.81). However, a significantly reduced risk was observed for melanoma (three trials, n?=?19,128, 0.47; 0.23-0.94, p?=?0.03). Furthermore, higher total cancer incidence risk was observed among those trials with a higher percent use of lipid-lowering drugs (>60%, 1.10; 1.00-1.20, p?=?0.04), or with lower percent baseline hypertension (?70%, 1.08; 1.00-1.16, p?=?0.057).Consistently, meta-regression analyses suggested that the similar trend between percent use of lipid-lowering drugs (p?=?0.084) or percent baseline hypertension (p?=?0.056) and log-RR for total cancer incidence associated with folic acid supplementation. Our findings indicate that folic acid supplementation has no significant effect on total cancer incidence, colorectal cancer, prostate cancer, lung cancer, breast cancer or hematological malignancy, but reduces the risk of melanoma.
Related JoVE Video
Unique and Varied Contributions of Traditional CVD Risk Factors: A Systematic Literature Review of CAD Risk Factors in China.
Clin Med Insights Cardiol
PUBLISHED: 01-01-2013
Show Abstract
Hide Abstract
This study is the first systematic review of risk factors for stroke in China and supports the importance of current public health initiatives to manage the risk factors appropriately to reduce risk of stroke in high risk patients. Additionally, this study has been co-authored by prominent Chinese and US physicians and researchers with expertise in cardiovascular disease, neurologic disorders, epidemiology, and real world data. While there have been several systematic reviews of real world associations of risk factors for coronary artery disease, none focus specifically on the population of China, where there is growing evidence that such risk factors are poorly treated or uncontrolled, especially in rural areas.
Related JoVE Video
Effects of ethanol-wet bonding technique on root dentine adhesion.
Chin J Dent Res
PUBLISHED: 12-29-2011
Show Abstract
Hide Abstract
To investigate the effects of ethanol-wet bonding on the adhesion of experimental hydrophobic and commercial hydrophilic adhesives to root dentine.
Related JoVE Video
[Effects of immA and immB coding putative bacteriocin immunity proteins on the antimicrobial sensitivity in planktonic Streptococcus mutans and biofilm formation].
Zhonghua Kou Qiang Yi Xue Za Zhi
PUBLISHED: 12-16-2011
Show Abstract
Hide Abstract
To investigate the effects of putative bacteriocin immunity proteins on the growth mode of Streptococcus mutans (Sm). To observe the differences of antimicrobial sensitivity in planktonic Sm wild-type strains and mutant strains caused by the inactivation of bacteriocin immunity proteins and their influence on the biofilm formation.
Related JoVE Video
Real world clinical performance of the zotarolimus eluting coronary stent system in Chinese patients: a prospective, multicenter registry study.
Chin. Med. J.
PUBLISHED: 11-18-2011
Show Abstract
Hide Abstract
Early clinical trials with the Endeavor zotarolimus eluting stent (ZES) in western populations demonstrated low rates of target lesion revascularization with a favorable safety profile including low late stent thrombosis with up to 5 years of follow-up. The aim of this clinical registry study was to evaluate real world clinical performance of the ZES coronary system in Chinese patients.
Related JoVE Video
Effect of folic acid supplementation on the progression of carotid intima-media thickness: a meta-analysis of randomized controlled trials.
Atherosclerosis
PUBLISHED: 11-02-2011
Show Abstract
Hide Abstract
We conducted a meta-analysis of relevant randomized trials to assess whether folic acid supplementation reduces the progression of atherosclerosis as measured by carotid intima-media thickness (CIMT).
Related JoVE Video
[Relation between aortic root dimension and cardiovascular disease].
Zhonghua Xin Xue Guan Bing Za Zhi
PUBLISHED: 09-20-2011
Show Abstract
Hide Abstract
To analyze the relation among aortic root dimension (ARD) measured by echocardiography, cardiovascular disease risk factors and cardiovascular disease in adult Beijing community population.
Related JoVE Video
Knowledge of secondary prevention guidelines for coronary heart disease: results from a physicians survey in China.
Eur J Prev Cardiol
PUBLISHED: 08-22-2011
Show Abstract
Hide Abstract
There is gap between guideline requirements and clinical practice in coronary disease secondary prevention. A physicians awareness and familiarity are essential to put these guidelines in practice.
Related JoVE Video
Early reperfusion strategy for acute myocardial infarction: a need for clinical implementation.
J Zhejiang Univ Sci B
PUBLISHED: 07-29-2011
Show Abstract
Hide Abstract
Reperfusion is the key strategy in acute ST-segment elevation myocardial infarction (STEMI) care, and it is time-dependent. Shortening the time from symptom to reperfusion and choosing the optimal reperfusion strategy for STEMI patients are great challenges in practice. We need to improve upon the problems of low reperfusion rate, non-standardized treatment, and economic burden in STEMI care. This article briefly reviews the current status of reperfusion strategy in STEMI care, and also introduces what we will do to bridge the gap between the guidelines and implementation in the clinical setting through the upcoming China STEMI early reperfusion program.
Related JoVE Video
Combination of carotid intima-media thickness and plaque for better predicting risk of ischaemic cardiovascular events.
Heart
PUBLISHED: 06-07-2011
Show Abstract
Hide Abstract
Several indices of carotid atherosclerosis have been studied to investigate their associations with the risk of cardiovascular disease. However, the best index of carotid atherosclerosis that predicts the risk of cardiovascular disease remains unclear.
Related JoVE Video
Association study of HLA-B alleles with idiopathic male infertility in Han population of China.
J. Assist. Reprod. Genet.
PUBLISHED: 05-26-2011
Show Abstract
Hide Abstract
To investigate the distributions of HLA-B alleles and estimate their associations with idiopathic male infertility in Chinese Han population.
Related JoVE Video
A prospective multicenter parallel-controlled trial of TIVOLI biodegradable-polymer-based sirolimus-eluting stent compared to ENDEAVOR zotarolimus-eluting stent for the treatment of coronary artery disease: 8-month angiographic and 2-year clinical follow-
Chin. Med. J.
PUBLISHED: 04-27-2011
Show Abstract
Hide Abstract
Available drug-eluting stents (DES) have achieved great success in reducing restenosis rates. Recently, investigators have demonstrated that the durable polymer carrier plays a significant role in DES-related hypersensitive reaction and delays vessel healing. TIVOLI stent is a novel sirolimus-eluting coronary stent with biodegradable coating containing sirolimus and polylactic-co-glycolic acid (PLGA) polymer. The present study sought to evaluate the effectiveness and safety of the TIVOLI biodegradable-polymer-based sirolimus-eluting stent in treating patients with coronary artery disease.
Related JoVE Video
Plasma catecholamine release-inhibitory peptide catestatin in patients with essential hypertension.
J Cardiovasc Med (Hagerstown)
PUBLISHED: 04-22-2011
Show Abstract
Hide Abstract
Catestatin plays an important role in the adjustment of blood pressure and cardiac function. We investigated levels of plasma catestatin in essential hypertension and the relationship between catestatin and left ventricular hypertrophy.
Related JoVE Video
CXC chemokine ligand 16 as a prognostic marker in patients with intermediate coronary artery lesions: a 2-year follow-up study.
Tohoku J. Exp. Med.
PUBLISHED: 04-07-2011
Show Abstract
Hide Abstract
There is no reliable way to identify the high-risk patients with intermediate coronary artery lesions (diameter stenosis 20%-70%) in early stage. Soluble CXC chemokine ligand 16 (CXCL16) is a newly discovered chemokine that can mediate inflammatory responses. It is released by proteolytic cleavage of its membrane-bound form, named scavenger receptor for phosphatidylserine and oxidized lipoprotein (SR-PSOX) that can promote the uptake of oxidized low-density lipoprotein cholesterol by macrophages. We have hypothesized that CXCL16 is an indicator of the prognosis of intermediate coronary artery lesions, and thus assessed the association between plasma CXCL16 concentrations and the 2-year prognosis in 616 patients with intermediate coronary artery lesions. The primary endpoint was a composite of all-cause death, non-fatal myocardial infarction, revascularization and angina pectoris requiring re-hospitalization. During the median follow-up time of 24 months, 69 events occurred. The plasma concentrations of CXCL16 (median 7712.88 pg/ml vs. 6792.43 pg/ml, P = 0.014) and high-sensitivity C-reactive protein (hs-CRP) (median 2.82 mg/L vs. 1.68 mg/L, P < 0.001) were higher in patients with events than patients without events. Cox hazard proportion analysis showed patients in upper CXCL16 quartile were more likely to suffer from adverse outcome than patients in lower quartile (RR = 1.271, P = 0.029, 95% CI: 1.025-1.577) after adjusting for sex, age, smoking, hypertension, diabetes, fat, dyslipidemia, hs-CRP, and medication use. In conclusion, plasma level of CXCL16 is an independent predictor of the prognosis of the patients with intermediate coronary lesions. Elevated plasma CXCL16 is associated with higher risk for these patients.
Related JoVE Video
A longitudinal study of carotid plaque and risk of ischemic cardiovascular disease in the Chinese population.
J Am Soc Echocardiogr
PUBLISHED: 03-25-2011
Show Abstract
Hide Abstract
The aim of this study was to investigate the role of carotid plaque in predicting ischemic cardiovascular risk, which has been intensively reported in Western populations but not yet in the Chinese population, in which the cardiovascular disease profile is significantly different.
Related JoVE Video
A right heart angiosarcoma with rapidly progressing hemorrhagic pericardial effusion.
Intern. Med.
PUBLISHED: 03-01-2011
Show Abstract
Hide Abstract
Primary tumors of the heart are rare. Among them angiosarcoma is the most common malignant tumor of the heart and is characterized by rapid growth, local invasion, and distant metastasis. Its clinical presentation is variable. We describe a 66-year-old man who suffered from cough and hemoptysis and then experienced rapidly progressing hemorrhagic pericardial effusion. After a set of examinations he was diagnosed as right heart angiosarcoma. His outcome was poor.
Related JoVE Video
Plasma osteoprotegerin levels and long-term prognosis in patients with intermediate coronary artery lesions.
Clin Cardiol
PUBLISHED: 02-19-2011
Show Abstract
Hide Abstract
Osteoprotegerin (OPG) is a member of the tumor necrosis factor superfamily and plays an important regulatory role in the skeletal, immune, and vascular systems. Intermediate coronary artery lesions that have a diameter stenosis of approximately 20%-70% might cause serious consequences. However, the prognostic value of plasma OPG levels in patients with intermediate coronary artery lesions has been less reported.
Related JoVE Video
Superiority of the Bryan(®) disc prosthesis for cervical myelopathy: a randomized study with 3-year followup.
Clin. Orthop. Relat. Res.
PUBLISHED: 02-07-2011
Show Abstract
Hide Abstract
The current standard of care for cervical myopathy is anterior discectomy and fusion (ACDF). Although well tolerated in the short term, this treatment might ultimately result in progressive degeneration of adjacent motion segments. Artificial disc arthroplasty offers the theoretical advantage of preservation of motion at the operative level with consequent stress reduction at adjacent levels.
Related JoVE Video
Intensive statin therapy for Chinese patients with coronary artery disease undergoing percutaneous coronary intervention (ISCAP study): rationale and design.
Catheter Cardiovasc Interv
PUBLISHED: 01-06-2011
Show Abstract
Hide Abstract
Myocardial necrosis is related to higher incidence of cardiovascular events and higher mortality rates during follow-up. Statins have been demonstrated to lower the risk of periprocedural myocardial infarction. The aim of this study is to evaluate the safety and efficacy of intensive statin therapy and the long-term outcome of patients in the Asian population.
Related JoVE Video
Folic acid therapy and cardiovascular disease in ESRD or advanced chronic kidney disease: a meta-analysis.
Clin J Am Soc Nephrol
PUBLISHED: 11-18-2010
Show Abstract
Hide Abstract
The efficacy of folic acid therapy to lower homocysteine (Hcy) levels in an effort to reduce cardiovascular disease (CVD) risk in patients with ESRD or advanced chronic kidney disease (ACKD; creatinine clearance, <30 ml/min) remains inconclusive. We conducted a meta-analysis of relevant randomized trials to further examine this issue.
Related JoVE Video
[Using the combination of traditional risk factors and quantitative coronary angiography (QCA) in predicting the risk of individuals with subclinical artherosclerosis].
Zhonghua Liu Xing Bing Xue Za Zhi
PUBLISHED: 11-13-2010
Show Abstract
Hide Abstract
To determine whether the combination of traditional risk factors and quantitative coronary angiography (QCA) assessment could provide accurate prognostic information on a population-based study including 1137 adults with subclinical artherosclerosis and with coronary risk factors.
Related JoVE Video
[Distribution characteristics and risk factors of carotid atherosclerosis in middle-aged and elderly Chinese].
Zhonghua Xin Xue Guan Bing Za Zhi
PUBLISHED: 11-02-2010
Show Abstract
Hide Abstract
To describe the distribution characteristics of carotid atherosclerosis and to analyze its association with cardiovascular risk factors in middle-aged and elderly Chinese.
Related JoVE Video
Current status and development of percutaneous coronary intervention in China.
J Zhejiang Univ Sci B
PUBLISHED: 07-30-2010
Show Abstract
Hide Abstract
Dr. Gruntzig et al. (1979) successfully completed the worlds first percutaneous coronary intervention (PCI), a percutaneous transluminal coronary angioplasty (PTCA), in 1977. The first reported PTCA in China was in 1984. With the development of PCI techniques, while more and more patients have benefited, there are ongoing challenges as well.
Related JoVE Video
Effect of enalapril on plasma homocysteine levels in patients with essential hypertension.
J Zhejiang Univ Sci B
PUBLISHED: 07-30-2010
Show Abstract
Hide Abstract
To investigate the effect of enalapril on plasma homocysteine (Hcy) levels and the association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with the changes of Hcy levels in response to enalapril among patients with essential hypertension.
Related JoVE Video
[Prediction value of blood lipid levels on newly identified carotid plaque in middle-aged and elderly Chinese population].
Zhonghua Xin Xue Guan Bing Za Zhi
PUBLISHED: 03-15-2010
Show Abstract
Hide Abstract
To evaluate the prediction value of blood lipid levels on the newly-identified carotid plaque in middle-aged and elderly Chinese population.
Related JoVE Video
[Effects of progesterone on intracellular free Ca2+ concentration in the spermatozoa of fertile men and patients with unexplained infertility].
Zhonghua Nan Ke Xue
PUBLISHED: 12-19-2009
Show Abstract
Hide Abstract
To investigate the difference in the responsiveness of intracellular free Ca2+ concentration ([Ca2+]i) to progesterone in the spermatozoa of normal fertile men and patients with unexplained infertility.
Related JoVE Video
Long-term effects of novel biodegradable, polymer-coated, sirolimus-eluting stents on neointimal formation in a porcine coronary model.
Int Heart J
PUBLISHED: 12-03-2009
Show Abstract
Hide Abstract
The postulated relationship between nonbiodegradable polymers and late stent thrombosis has led to a concerted effort to seek alternative biodegradable polymers for drug delivery. The purpose of this study was to evaluate the long-term effects of novel sirolimus-eluting stents (SES) with biodegradable polylactic-co-glycolic acid (PLGA) polymer on neointimal thickening in a porcine coronary model. Three types of stents were implanted in different coronary arteries of the same mini-swine: bare cobalt-chromium stents (BMS); PLGA-coated-only stents (PCOS); and PLGA-coated, sirolimus-eluting stents (PCSES). A total of 26 animals underwent successful placement of 78 oversized stents (each stent-group, n = 26) in the coronary arteries with histopathologic analysis and Western blot at 28 days, 3 months, or 1 year. At 28 days and 3 months, the mean neointimal area was about two-fold lower in PCSES versus BMS or PCOS. At 1 year, the mean intimal area was similar for PCSES (1.76 +/- 0.28 mm(2)) and BMS (2.06 +/- 0.23 mm(2), P = 0.051). Western blot analysis demonstrated decreased expression of p27(kip1) in the vessel wall 3 months after PCSES implantation as compared with 28 days. PCSES effectively reduced in-stent neointimal formation for the first 3 months in this porcine coronary model. Beyond 3 months, neointimal proliferation was not substantially inhibited by PCSES. The observed delayed neointimal hyperplasia with PCSES may be partly related to the potential side effects of sirolimus and/or late insufficient arterial drug levels.
Related JoVE Video
E112D polymorphism in the prolylcarboxypeptidase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients.
Chin. Med. J.
PUBLISHED: 08-06-2009
Show Abstract
Hide Abstract
Marked interindividual variation exists in blood pressure response to benazepril, which is considered to have genetic basis. Our objectives were to evaluate whether the E112D polymorphism in the prolylcarboxypeptidase (PRCP) gene has impact on blood pressure response to benazepril.
Related JoVE Video
[Experimental varicocele affects VEGF and Flt-1 protein expressions in the testis and epididymis of adolescent rats].
Zhonghua Nan Ke Xue
PUBLISHED: 07-15-2009
Show Abstract
Hide Abstract
To investigate the effects of experimental left varicocele (ELV) on the vascular endothelial growth factor (VEGF) and its receptor fms-like tyrosine kinase-1 (Flt-1) proteins in the testis and epididymis of adolescent rats, and to find out the correlation of the two proteins with varicocele-induced male infertility.
Related JoVE Video
[An analysis of clinical factors for coronary artery calcification score].
Zhonghua Nei Ke Za Zhi
PUBLISHED: 07-07-2009
Show Abstract
Hide Abstract
To evaluate the correlating clinical factors of coronary artery calcification score (CACS).
Related JoVE Video
Electroacupuncture at Qiuxu (GB 40) for treatment of migraine--a clinical multicentral random controlled study.
J Tradit Chin Med
PUBLISHED: 06-12-2009
Show Abstract
Hide Abstract
To observe the therapeutic effects of electroacupuncture (EA) at Qiuxu (GB 40) for treatment of migraine so as to provide clinical evidence for compilation of the Acupoints Dictionary of the Peoples Republic of China.
Related JoVE Video
Effect of hepatocyte growth-promoting factors on myocardial ischemia during exercise in patients with severe coronary artery disease.
Int Heart J
PUBLISHED: 06-10-2009
Show Abstract
Hide Abstract
Hepatocyte growth-promoting factor (pHGF) has the greatest potential as a therapeutic agent for vascular growth factor. The aim of this study was to investigate the effect of pHGF on myocardial ischemia and exercise capacity in patients with severe coronary artery disease (CAD). Forty-nine patients were enrolled for a two week treatment period. Treadmill graded exercise tests with gas analysis were conducted before and after therapy. Serum levels of HGF were significantly elevated after therapy. The degrees of exercise-induced ST segment depression were decreased more significantly in the pHGF group. Similar differences were also found in the maximum heart rate and the maximum heart rate when the ST segment was depressed 1 mm while undergoing the treadmill graded exercise test. Both were increased more significantly in the pHGF group. Total exercise time, systolic blood pressure in the peak of exercise, the length of time that ST segment depression of 1 mm is needed, and total work all were increased in both groups after intervention. Furthermore, total exercise time and total work were increased more significantly in the pHGF group. The levels of HGF increased significantly after pHGF treatment. pHGF could favorably improve exercise-induced myocardial ischemia and enhance exercise capacity in patients with severe CAD.
Related JoVE Video
The expression of Usp26 gene in mouse testis and brain.
Asian J. Androl.
PUBLISHED: 06-08-2009
Show Abstract
Hide Abstract
Deubiquitinating enzymes (DUBs) play an important role in ubiquitin-dependent processes as negative regulators of protein ubiquitination. Ubiquitin-specific protease 26 (USP26) is a member of this family. The expression of Usp26 in mammalian testis and in other tissues has yet to be fully elucidated. To study the expression of Usp26 mRNA and protein in various murine tissues, reverse transcription (RT)-PCR and immunohistochemistry analyses were carried out. The RT-PCR analysis showed that the Usp26 transcript was expressed in all of the tested tissues. USP26 protein localization was examined by immunohistochemistry, and it was shown that USP26 was not detectable at 20 days postpartum, with the expression restricted to the cytoplasm of condensing spermatids (steps 9-16), Leydig cells and nerve fibers in the brain. In addition, the USP26 protein was detected at moderate levels in myocardial cells, the corpus of epidydimis, epithelium of the renal tubules and the seminal gland of postnatal day 35 mice. Its spatial and temporal expression pattern suggests that Usp26 may play an important role in development or function of the testis and brain. Further research into these possibilities is in progress.
Related JoVE Video
Arg347Cys polymorphism of alpha1A-adrenoceptor gene is associated with blood pressure response to nifedipine GITS in Chinese hypertensive patients.
J. Hum. Genet.
PUBLISHED: 05-15-2009
Show Abstract
Hide Abstract
Our objectives were to evaluate whether polymorphisms in the alpha1A- and beta2-adrenoceptor genes influence blood pressure response to nifedipine gastrointestinal therapeutic system (GITS). Hypertensive patients received daily treatment with an oral dosage of 30 mg nifedipine GITS for 16 days. Genotypes of the Arg347Cys polymorphism in the alpha1A-adrenoceptor gene and the Arg16Gly and Gln27Glu polymorphisms in the beta2-adrenoceptor gene were determined by TaqMan single-nucleotide polymorphism genotyping assay. The sixteenth-day steady-state plasma concentration of nifedipine was measured using HPLC with UV detection. Multivariate linear regression was performed in a total of 447 patients to evaluate the effects of these polymorphisms on blood pressure response to nifedipine GITS. Patients carrying the Cys347 allele of the alpha1A-adrenoceptor gene had a greater systolic blood pressure reduction than did those carrying two Arg347 alleles of the alpha1A-adrenoceptor gene (32.5+/-14.0 versus 27.3+/-15.5 mm Hg, respectively, P=0.006). However, diastolic blood pressure reduction was not associated with the Arg347Cys polymorphism in the alpha1A-adrenoceptor gene. In addition, no significant associations were observed between blood pressure reduction and two polymorphisms in the beta2-adrenoceptor gene. Our data suggest that the Arg347Cys polymorphism in the alpha1A-adrenoceptor gene may be used to predict blood pressure response to nifedipine GITS in Chinese hypertensive patients.
Related JoVE Video

What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.