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Find video protocols related to scientific articles indexed in Pubmed.
Lack of association between DSCAM gene polymorphisms and adolescent idiopathic scoliosis susceptibility in a Chinese Han population.
J Back Musculoskelet Rehabil
PUBLISHED: 11-20-2014
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In a recent genome wide association study, polymorphisms in the DSCAM and CNTNAP2 genes were reported to be related with susceptibility of AIS. Consequently, further replication studies are warranted in other populations due to ethnic difference in genetic background.OBJECTIVE: To explore whether single nucleotide polymorphisms (SNPs) of DSCAM (rs2222973) and CNTNAP2 (rs11770843) genes are associated with the susceptibility and curve severity of AIS in a Chinese Han population.METHODS: A total of 648 AIS patients and 573 age- and sex-matched healthy adolescents in rs2222973 were recruited, and in rs11770843 there were 100 AIS patients and 100 age- and sex-matched healthy adolescents included in present study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was repeatedly carried out to verify the linkage of AIS with SNPs rs2222973 in the DSCAM gene and rs11770843 in the CNTNAP2 gene. Case-control and case-only studies were respectively performed to define the contribution of the DSCAM gene polymorphisms to predisposition and disease severity of AIS.
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High-Mobility Solution-Processed Tin Oxide Thin-Film Transistors with High-? Alumina Dielectric Working in Enhancement Mode.
ACS Appl Mater Interfaces
PUBLISHED: 11-07-2014
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Solution-processed metal oxide thin-film transistors (TFTs) operating in enhancement mode are promising for the next-generation flat panel displays. In this work, we report high-mobility TFTs based on SnO2 active layer derived from a soluble tin(II) 2-ethylhexanoate precursor. Densely packed polycrystalline SnO2 thin films with moderate oxygen vacancies and only a few hydroxides are obtained via systemically optimizing precursor concentrations and processing conditions. The utilization of a solution-processed high-? Al2O3 insulating layer could generate a coherent dielectric/semiconductor interface, hence further improving the device performance. TFT devices with an average field-effect mobility of 96.4 cm¬¬2 V-1 s-1, a current on/off ratio of 2.2 × 106, a threshold voltage of 1.72 V and a subthreshold swing of 0.26 V dec-1 have been achieved, and the driving capability is demonstrated by implementing a single SnO2 TFT device to tune the brightness of an organic light-emitting diode. It is worth noting that these TFTs work in enhancement mode at low voltages less than 4 V, which sheds light on their potential application to the next-generation low-cost active matrix flat panel displays.
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Flavonoids of Rosa roxburghii Tratt Act as Radioprotectors.
Asian Pac. J. Cancer Prev.
PUBLISHED: 10-24-2014
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To study the radioprotective effects of flavonoids from Rosa roxburghii Tratt (FRT).
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The diagnosis and surgical treatment of central brain herniations caused by traumatic bifrontal contusions.
J Craniofac Surg
PUBLISHED: 10-12-2014
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The objective of this study was to investigate the diagnosis and surgical treatment of central brain herniations caused by traumatic bifrontal contusions. A total of 63 patients (45 men and 18 women; mean age of 43 years with a range from 20 to 72 years) who suffered from traumatic bifrontal contusions between January 2007 and December 2012 were inspected. The clinical and imaging results were studied for all patients, and we found that swelling of the mesencephalon and a downward shift of the bilateral red nucleus were significant signs of central brain herniation in the image of magnetic resonance imaging. All patients were given a simultaneous bilateral craniotomy for balanced decompressive surgery. The Glasgow Outcome Scale was used to monitor the patients during the follow-up period, which lasted from 6 to 52 months with a mean of 22 months. At the termination of the follow-up period, the following Glasgow Outcome Scale scores were obtained: 14 patients scored 5 points, 22 patients scored 4 points, 7 patients scored 3 points, 13 patients scored 2 points, and 7 patients scored 1 point. Therefore, our study suggested that an early magnetic resonance imaging scan could result in a more timely diagnosis of central brain herniation, and simultaneous bilateral craniotomy was found to be one of the best treatments for central brain herniation to improve patient outcomes.
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T1 Pelvic Angle (TPA): A New Predictor for Postoperative Sagittal Balance and Clinical Outcomes in Adult Scoliosis.
Spine
PUBLISHED: 10-02-2014
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Study Design. A retrospective radiographic study.Objective. To compare the prediction abilities of TPA and other parameters for postoperative sagittal balance, and investigate the relationships betweenthese parameters and health-related quality of life(HRQOL).Summary of Backgroud Data. Using SVA to assess sagittal alignment fails to take account the pelvic compensation. A new parameter -T1 pelvic angle (TPA) has been recommended to represent the global sagittal balance of adult scoliosis.Methods. A retrospective review was performed on patients with adult scoliosis undergoing correction surgery from May 2009 to March 2013. The Spearman rho was used to determine the correlations between the radiographic parameters (pre-operative, postoperative and changes) and overall ODI scores, VAS and SRS-22.Results. Significant correlations were found between the changes of TPA and the changes of LL, PT, SS, PI, SVA, SSA, ODI, VAS, SRS-22 and PSO degrees (P<0.05). The changes of SVA were significantly related to the changes of LL, TPA, C7/SFD, ODI, VAS, SRS-22 (P<0.05) but not PSO degrees (P>0.05). Significant correlations were found between the changes of SSA and the changes of TLK, TPA, ODI, VAS, SRS-22 and PSO degrees (P<0.05). The changes of C7/SFD were significantly related to the changes of SVA (P<0.05), but not the changes of ODI, VAS, SRS-22 or PSO degrees (P>0.05).Conclusion. TPA could better reflect the postoperative changes of sagittal alignment and HRQOL for patients with adult scoliosis. Moreover, the changes of TPA are strongly correlated to the osteotomy degrees for PSO and, TPA could be used as a reference parameter in surgical planning.
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Ideal Bipolar Host Materials with Bis-benzimidazole Unit for Highly Efficient Solution-Processed Green Electrophosphorescent Devices.
Org. Lett.
PUBLISHED: 09-26-2014
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An ideal host material with high triplet energy, suitable HOMO energy level, excellent thermal and electrochemical stability, and bipolar charge carrier transport ability was synthesized. A high external quantum efficiency of 13.7% and a luminance efficiency of 48.2 cd A(-1) with low efficiency roll-off were achieved in solution-processed green electrophosphorescent devices.
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Are there gender differences in sagittal spinal pelvic inclination before and after the adolescent pubertal growth spurt?
Eur Spine J
PUBLISHED: 09-04-2014
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Significant progression of spinal deformity could occur during the peak of pubertal growth in adolescent idiopathic scoliosis (AIS). Gender differences in spinal and vertebral inclination have been reported in asymptomatic young adults and are thought to affect the risk of curve progression in male and female AIS. The present study aimed to investigate whether there were gender differences in the sagittal spinal-pelvic profile and whether any differences occurred before or developed during the normal pubertal growth spurt.
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Synthesis of peroxo-titanium decorated H-titanate-nanotube-based hierarchical microspheres with enhanced visible-light photocatalytic activity in degradation of Rhodamine B.
Dalton Trans
PUBLISHED: 08-22-2014
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Peroxo-titanium decorated H-titanate-nanotube-based hierarchical microspheres (PTHM) with a large surface area (368 m(2) g(-1)) and mesoporous structure were prepared by an alkaline hydrothermal method in the presence of H2O2 followed by acid wash, and they exhibited improved activity in degradation of Rhodamine B under visible light irradiation.
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Abnormal response of the proliferation and differentiation of growth plate chondrocytes to melatonin in adolescent idiopathic scoliosis.
Int J Mol Sci
PUBLISHED: 07-31-2014
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Abnormalities in the melatonin signaling pathway and the involvement of melatonin receptor MT2 have been reported in patients with adolescent idiopathic scoliosis (AIS). Whether these abnormalities were involved in the systemic abnormal skeletal growth in AIS during the peripubertal period remain unknown. In this cross-sectional case-control study, growth plate chondrocytes (GPCs) were cultured from twenty AIS and ten normal control subjects. Although the MT2 receptor was identified in GPCs from both AIS and controls, its mRNA expression was significantly lower in AIS patients than the controls. GPCs were cultured in the presence of either the vehicle or various concentrations of melatonin, with or without the selective MT2 melatonin receptor antagonist 4-P-PDOT (10 µM). Then the cell viability and the mRNA expression of collagen type X (COLX) and alkaline phosphatase (ALP) were assessed by MTT and qPCR, respectively. In the control GPCs, melatonin at the concentrations of 1, 100 nM and 10 µM significantly reduced the population of viable cells, and the mRNA level of COLX and ALP compared to the vehicle. Similar changes were not observed in the presence of 4-P-PDOT. Further, neither proliferation nor differentiation of GPCs from AIS patients was affected by the melatonin treatment. These findings support the presence of a functional abnormality of the melatonin signaling pathway in AIS GPCs, which might be associated with the abnormal endochondral ossification in AIS patients.
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Combined post-modification of iodide ligands and wide band gap ZnS in quantum dot sensitized solar cells.
Phys Chem Chem Phys
PUBLISHED: 07-26-2014
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Combined post-modification strategy of iodide ligands and wide band gap ZnS layer were employed in quantum dot sensitized solar cells. J-V curves show that the combined post-modification could improve the photoconversion efficiency compared to the single post-modification of ZnS because of the more effective passivation. CdS-sensitized and CdS/CdSe-co-sensitized solar cells both reveal that the assembly structure of QDs/I(-)/ZnS is more beneficial for the efficiency of solar cells than that of QDs/ZnS/I(-). EIS results show that the former structure exhibit higher interface resistance and could suppress electron recombination more powerfully. XPS results reveal that the iodide ligands have different binding energy, which indicates a different coordination state of the iodide atom in these two structures. Finally, 3.28% efficiency and 18.16 mA cm(-2) were achieved for CdS/CdSe QDSCs by applying this combined post-modification.
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[Abnormal growth of spine in patients with adolescent idiopathic thoracic scoliosis].
Zhonghua Wai Ke Za Zhi
PUBLISHED: 07-19-2014
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To investigate if the growth patterns of the spine and pelvis are consistent in adolescent idiopathic scoliosis (AIS) patients with single thoracic curves.
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Syrinx resolution is correlated with the upward shifting of cerebellar tonsil following posterior fossa decompression in pediatric patients with Chiari malformation type I.
Eur Spine J
PUBLISHED: 06-23-2014
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Chiari malformation type I (CMI) is characterized by deformed hindbrain. This study aimed to quantitatively evaluate the alterations in position of hindbrain after Posterior fossa decompression (PFD), and to identify the factors associated with syrinx resolution in pediatric patients with CMI.
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Synthesis, characterization, and photophysical and electroluminescent properties of blue-emitting cationic iridium(III) complexes bearing nonconjugated ligands.
Inorg Chem
PUBLISHED: 06-10-2014
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The development of pure-blue-to-deep-blue-emitting ionic phosphors is an ultimate challenge for full-color displays and white-light sources. Herein we report two series of short-wavelength light-emitting cationic iridium(III) complexes with nonconjugated ancillary and cyclometalating ligands, respectively. In the first series, nonconjugated 1-[(diphenylphosphino)methyl]-3-methylimidazolin-2-ylidene-C,C2' (dppmmi) is used as the ancillary ligand and 2-phenylpyridine (ppy), 2-(2,4-difluorophenyl)pyridine (dfppy), and 1-(2,4-difluorophenyl)-1H-pyrazole (dfppz) are used as cyclometalating ligands. In the second one, nonconjugated 2,4-difluorobenzyl-N-pyrazole (dfbpz) is used as the cyclometalating ligand and 3-methyl-1-(2-pyridyl)benzimidazolin-2-ylidene-C,C(2)' (pymbi) as the ancillary ligand. The synthesis and photophysical and electrochemical properties, together with the X-ray crystal structures of these complexes, have been investigated. At room temperature, blue-emitting complexes [Ir(ppy)2(dppmmi)]PF6 (1) and [Ir(dfppy)2(dppmmi)]PF6 (2; PF6(-) is hexafluorophosphate) show much larger photoluminescence quantum yields of 24% and 46%, respectively. On the contrary, for complexes [Ir(dfppz)2(dppmmi)]PF6 (3) and [Ir(dfbpz)2(pymbi)]PF6 (4), deep-blue luminescence is only observed at low temperature (77 K). Density functional theory calculations are used to rationalize the differences in the photophysical behavior observed upon changes of the ligands. It is shown that the electronic transition dipoles of cationic iridium complexes 1 and 2 are mainly confined to cyclometalated ligands ((3)MLCT and LC (3)?-?*) and those of complex 3 are confined to all of the ligands ((3)MLCT, LC (3)?-?*, and (3)LLCT) because of the high LUMO energy level of dfppz. The emission of 4 mainly originates from the central iridium(III) ion and cyclometalated ligand to ancillary ligand charge transfer ((3)MLCT and (3)LLCT), in contrast to commonly designed cationic complexes using carbene-type ancillary ligands, where emission originates from the cyclometalated main ligands. Solution-processed organic light-emitting diodes based on complexes 1 and 2 gave blue-green (498 nm) and blue (478 nm) electroluminescence with maximum current efficiencies of 3.8 and 3.4 cd A(-1), respectively. The results indicate that introducing nonconjugated ligands into cationic iridium complexes is an effective means of achieving short-wavelength light-emitting phosphors.
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Lumbo-femoral angle: a novel sagittal parameter related to quality of life in patients with adult scoliosis.
Eur Spine J
PUBLISHED: 06-08-2014
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PT and PI-LL sometimes offer limited utility in daily practice when evaluating QOL, especially in outpatient clinics with limited time and equipment facility. This study proposes a novel spino-pelvic parameter, lumbo-femoral angle (LFA). The purpose of this study is to analyze the correlation between LFA and HRQOL in adult scoliosis patients.
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Multifunctional organic phototransistor-based nonvolatile memory achieved by UV/ozone treatment of the Ta?O? gate dielectric.
ACS Appl Mater Interfaces
PUBLISHED: 05-20-2014
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An organic phototransistor (OPT) shows nonvolatile memory effect due to its novel optical writing and electrical erasing processes. In this work, we utilize an organic light-emitting diode (OLED) as the light source to investigate OPT-based memory (OPTM) performance. It is found that the OPTM can be used as either flash memory or write-once read-many-times memory by adjusting the properties of the Ta2O5 gate dielectric layer. UV/ozone treatment is applied to effectively change dielectric properties of the Ta2O5 film. The mechanisms for this are examined by X-ray photoelectron spectroscopy and capacitance-voltage measurement. It turns out that the densities of oxygen vacancies and defects in the first 1.8 nm Ta2O5 films near the Ta2O5/semiconductor interface are reduced. Furthermore, for the first time, we use this multifunctional OPTM, which unites the photosensitive and memory properties in one single device, as an optical feedback system to tune the brightness of the OLED. Our study suggests that these OPTMs have potential applications in tuning the brightness uniformity, improving the display quality and prolonging the lifetime of flat panel displays.
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Trifluoromethylation of Tetraphenylborate Counterions in Cationic Iridium(III) Complexes: Enhanced Electrochemical Stabilities, Charge-Transport Abilities, and Device Performance.
Chemistry
PUBLISHED: 04-27-2014
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Trifluoromethylation of tetraphenlyborate counterions was successfully used to improve the electrochemical stabilities and device performance of cationic iridium(III) complexes. Melioration of the thermal, photoluminescent, electrochemical, and electrophosphorescent characteristics was achieved. Interionic hydrogen bonds were first found between the aromatic hydrogen atoms in the ancillary ligands of cations and the fluorine atoms in the trifluoromethyl groups of the anions. The strong impact of the counterions on the charge transport in the devices was investigated. A compound with two trifluoromethyl groups in the tetraphenlyborate ion shows the highest photoluminescent efficiency, the best electrochemical stability, and the greatest performance in green-blue-emitting devices, with a high current efficiency of 12.4?cd?A(-1) and an emission peak at ?=480?nm. The efficiencies achieved are the highest reported for OLEDs with ionic complexes emitting in the blue-green region.
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Optimal surgical care for adolescent idiopathic scoliosis: an international consensus.
Eur Spine J
PUBLISHED: 04-27-2014
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The surgical management of adolescent idiopathic scoliosis (AIS) has seen many developments in the last two decades. Little high-level evidence is available to support these changes and guide treatment. This study aimed to identify optimal operative care for adolescents with AIS curves between 40° and 90° Cobb angle.
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Single cell growth rate and morphological dynamics revealing an "opportunistic" persistence.
Analyst
PUBLISHED: 04-16-2014
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Bacteria persistence is a well-known phenomenon, where a small fraction of cells in an isogenic population are able to survive high doses of antibiotic treatment. Since the persistence is often associated with single cell behaviour, the ability to study the dynamic response of individual cells to antibiotics is critical. In this work, we developed a gradient microfluidic system that enables long-term tracking of single cell morphology under a wide range of inhibitor concentrations. From time-lapse images, we calculated bacterial growth rates based on the variations in cell mass and in cell number. Using E. coli and Comamonas denitrificans to amoxicillin inhibition as model systems, we found the IC50 determined via both methods are in a good agreement. Importantly, the growth rates together with morphological dynamics of individual cells has led to the discovery of a new form of persistence to amoxicillin. Normal cells that are sensitive to amoxicillin gain persistence or recover from the killing process, if they have had an opportunity to utilise the cytoplasm released from lysed cells close-by. We term this acquired persistence in normal growing cells "opportunistic persistence". This finding might shed new insights into biofilm resistance and the effect of antibiotics on environmental microbes.
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[Natural history of scoliosis after posterior fossa decompression in patients with Chiari malformation/syringomyelia].
Zhonghua Yi Xue Za Zhi
PUBLISHED: 04-12-2014
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To explore the natural history of scoliosis after posterior fossa decompression (PFD) in patients with Chiari malformation/syringomyelia and examine the risk factors associated with curve progression.
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A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups.
J. Med. Genet.
PUBLISHED: 04-10-2014
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Adolescent idiopathic scoliosis (AIS) is a common rotational deformity of the spine that presents in children worldwide, yet its etiology is poorly understood. Recent genome-wide association studies (GWAS) have identified a few candidate risk loci. One locus near the chromosome 10q24.31 LBX1 gene (OMIM #604255) was originally identified by a GWAS of Japanese subjects and replicated in additional Asian populations. To extend this result, and to create larger AIS cohorts for the purpose of large-scale meta-analyses in multiple ethnicities, we formed a collaborative group called the International Consortium for Scoliosis Genetics (ICSG).
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High-efficiency fluorescent organic light-emitting devices using sensitizing hosts with a small singlet-triplet exchange energy.
Adv. Mater. Weinheim
PUBLISHED: 04-02-2014
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Materials with small singlet-triplet splits (?EST s) are introduced as sensitizing hosts to excite fluorescent dopants, breaking the trade-off between small ?EST and high radiative decay rates. A highly efficient orange-fluorescent organic light-emitting diode (OLED) is prepared, showing a maximum external quantum efficiency of 12.2%.
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Sacrum pubic incidence and sacrum pubic posterior angle: two morphologic radiological parameters in assessing pelvic sagittal alignment in human adults.
Eur Spine J
PUBLISHED: 03-29-2014
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The morphology and position of pelvis are critical in regulating the biomechanical organization of spine-pelvis-leg in the sagittal plane. Several radiological parameters have been developed to present the sagittal morphology of the pelvis such as pelvic incidence (PI) and Jackson's angle (PRS1). In addition, the femoral sacral posterior angle (FSPA) was developed for patients with a dome-shaped deformity in the upper plate of the sacrum. The identification of hip axis, which was represented by the line connecting the centers of femoral heads in normal subjects, was important for these parameters measurement. However, in subjects with fused hip joint or deformed femoral heads, the accurate localization of hip axis become imprecise. Herein, the upper edge of the pubic symphysis, which is easy to identify on the lateral X-ray film, was selected as an alternative landmark of the hip axis, and two morphologic parameters, the sacrum pubic incidence (SPI) and sacrum pubic posterior angle (SPPA), were proposed accordingly. The present study aimed to understand the reliability of these two parameters and their value in predicting PI, PRS1 and FSPA.
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A novel mutation in COL2A1 leading to spondyloepiphyseal dysplasia congenita in a three-generation family.
Eur Spine J
PUBLISHED: 03-28-2014
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To investigate the genotype of COL2A1 in a three-generation spondyloepiphyseal dysplasia congenita (SEDC) family.
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Systematic investigation of surface modification by organosiloxane self-assembled on indium-tin oxide for improved hole injection in organic light-emitting diodes.
ACS Appl Mater Interfaces
PUBLISHED: 03-14-2014
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Various works on modification of the indium-tin oxide (ITO) substrate have been carried out so as to enhance hole injection in organic light-emitting devices. Herein, a simple and efficient approach to tuning the work function of the ITO substrate is described by surface modification of ITO with an organosiloxane self-assembled monolayer. The influences of the electronegativity on modification of the ITO substrate are systematically investigated by attaching electron-withdrawing groups (Cl, Br, and I) and an electron-donating group (NH2) to the organosiloxane materials. The preparation and modification of the ITO substrate has been studied using primarily atomic force microscopy and X-ray photoelectron spectroscopy and vacuum-ultraviolet spectroscopy, and remarkable changes have been observed after modification. The device based on a 3Cl-Si-ITO-modified anode exhibits the best efficiency among the devices, better than the control devices based on bare ITO, UV-treated ITO, and even Cl-ITO.
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Transcription factor Runx2 in the low bone mineral density of girls with adolescent idiopathic scoliosis.
Orthop Surg
PUBLISHED: 03-05-2014
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The molecular mechanism of low bone mass in girls with adolescent idiopathic scoliosis (AIS) has not been ascertained. Runx2 is a critical transcription factor regulating osteoblast differentiation and maturation. The present study aimed to explore the possible relationship between Runx2 expression in osteoblasts and bone mineral density (BMD) in subjects with AIS.
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Gradient microfluidics enables rapid bacterial growth inhibition testing.
Anal. Chem.
PUBLISHED: 03-03-2014
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Bacterial growth inhibition tests have become a standard measure of the adverse effects of inhibitors for a wide range of applications, such as toxicity testing in the medical and environmental sciences. However, conventional well-plate formats for these tests are laborious and provide limited information (often being restricted to an end-point assay). In this study, we have developed a microfluidic system that enables fast quantification of the effect of an inhibitor on bacteria growth and survival, within a single experiment. This format offers a unique combination of advantages, including long-term continuous flow culture, generation of concentration gradients, and single cell morphology tracking. Using Escherichia coli and the inhibitor amoxicillin as one model system, we show excellent agreement between an on-chip single cell-based assay and conventional methods to obtain quantitative measures of antibiotic inhibition (for example, minimum inhibition concentration). Furthermore, we show that our methods can provide additional information, over and above that of the standard well-plate assay, including kinetic information on growth inhibition and measurements of bacterial morphological dynamics over a wide range of inhibitor concentrations. Finally, using a second model system, we show that this chip-based systems does not require the bacteria to be labeled and is well suited for the study of naturally occurring species. We illustrate this using Nitrosomonas europaea, an environmentally important bacteria, and show that the chip system can lead to a significant reduction in the period required for growth and inhibition measurements (<4 days, compared to weeks in a culture flask).
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Brace treatment versus observation alone for scoliosis associated with Chiari I malformation following posterior fossa decompression: a cohort study of 54 patients.
Eur Spine J
PUBLISHED: 02-24-2014
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To be deemed effective in preventing curve progression, brace treatment should show alteration of the expected natural history. Most of the reported studies on the effect of bracing on the evolution of Chiari malformation-associated scoliosis (CMS) following posterior fossa decompression (PFD) were small series with inconclusive results. The goal of this study was to investigate whether post-PFD brace treatment for CMS produces better outcomes than observation alone.
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Conservative treatment for osteoid osteoma of the odontoid process of the axis: a case report.
World J Surg Oncol
PUBLISHED: 02-15-2014
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Osteoid osteoma is a primary benign bone lesion, which constitutes about 10% of all primary benign bone tumors and 3% of all primary bone tumors. The spine is involved in 10% of the cases, and the lumbar spine is the most commonly affected whereas the tumor is rarely seen in the cervical spine. With regard to the osteoid osteoma being located at the odontoid process of the axis, limited cases have been reported in the literature.
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Inter- and intraobserver reliability assessment of the axial trunk rotation: manual versus smartphone-aided measurement tools.
BMC Musculoskelet Disord
PUBLISHED: 02-14-2014
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Scoliogauge, has been developed for the measurement of ATR on iPhone smartphones. This study was to evaluate the reliability for the smartphone-aided ATR measurement method and to compare its reliability with that of the manual method.
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Alcohol-soluble electron-transport small molecule for fully solution-processed multilayer white electrophosphorescent devices.
Org. Lett.
PUBLISHED: 02-11-2014
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A novel alcohol-soluble electron-transport material was designed and synthesized. This material not only possesses a high triplet energy and a low HOMO level but also exhibits excellent electron-transport properties and good film-forming ability. Efficient fully solution-processed multilayer white electrophosphorescent devices have been fabricated by using this alcohol-processable material as an orthogonal electron-transport layer.
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Lack of association between the CHL1 gene and adolescent idiopathic scoliosis susceptibility in Han Chinese: a case-control study.
BMC Musculoskelet Disord
PUBLISHED: 02-06-2014
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A previous genome-wide association study (GWAS) suggested a strong association between the single nucleotide polymorphism (SNP) rs10510181 in the proximity of the gene encoding a cell adhesion molecule with homology to L1CAM (CHL1) and adolescent idiopathic scoliosis (AIS) in Caucasians. To clarify the role of CHL1 in the etiopathogenesis of AIS, we performed a case-control replication study in a Han Chinese population.
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Does curve convexity affect the surgical outcomes of thoracic adolescent idiopathic scoliosis?
Eur J Orthop Surg Traumatol
PUBLISHED: 02-02-2014
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Major left thoracic (LT) curve is an atypical type in adolescent idiopathic scoliosis (AIS) and showed independent clinical characteristics and natural history compared to major right thoracic (RT) curve. However, it's unclear whether the convexity of major thoracic curve would affect the surgical outcomes and risk of complications. A retrospective follow-up study was conducted to investigate whether the convexity of major thoracic curve would affect the surgical outcomes of patients with main thoracic AIS.
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Association of receptor activator of nuclear factor-kappaB ligand (RANKL) gene polymorphisms with the susceptibility to ankylosing spondylitis: a case-control study.
J Orthop Sci
PUBLISHED: 01-21-2014
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To investigate the association between receptor activator of nuclear factor-kappaB ligand (RANKL) gene polymorphisms and the susceptibility to ankylosing spondylitis (AS) in a Chinese Han population.
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Sagittal spinopelvic alignment in adolescents associated with Scheuermann's kyphosis: a comparison with normal population.
Eur Spine J
PUBLISHED: 01-20-2014
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Spinopelvic alignment is increasingly considered as a main factor in the energy-efficient posture of the individual in normal and pathological status. However, the spinopelvic characteristics in Scheuermann's kyphosis (SK) are poorly defined in the literature. The purpose of this study was to determine whether differences of the spinopelvic parameters exist between adolescents with SK and age-matched normal controls.
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Lack of association between suppressor of cytokine signaling-3 gene polymorphism and susceptibility and curve severity of adolescent idiopathic scoliosis.
Eur Spine J
PUBLISHED: 01-02-2014
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To explore whether the suppressor of cytokine signaling-3 (SOCS3) gene polymorphisms are associated with the susceptibility and abnormal growth pattern of adolescent idiopathic scoliosis (AIS).
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Are volumetric bone mineral density and bone micro-architecture associated with leptin and soluble leptin receptor levels in adolescent idiopathic scoliosis?--A case-control study.
PLoS ONE
PUBLISHED: 01-01-2014
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Adolescent idiopathic scoliosis (AIS) is associated with low bone mineral density (BMD). The underlying etiology and how it may relate to the development of osteopenia remains unknown. Leptin has been postulated as one of the etiologic factors of AIS because of its profound effects on bone metabolism and pubertal growth. Its modulator, soluble leptin receptor (sOB-R), may affect leptin bioavailability and signaling. This study aimed to investigate whether serum leptin and sOB-R levels may be associated with bone quality, and whether these relationships may differ between young adolescent girls with and without AIS.
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Increased phosphorescent quantum yields of cationic iridium(iii) complexes by wisely controlling the counter anions.
Chem. Commun. (Camb.)
PUBLISHED: 11-22-2013
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Phosphorescent quantum yields have been increased by 12 times by choosing bulky boracic anions as counterions for blue-emitting cationic iridium(iii) complexes.
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[The correlation between T1 tilt and cosmetic shoulder balance in Lenke type 2 adolescent idiopathic scoliosis patients].
Zhonghua Wai Ke Za Zhi
PUBLISHED: 11-21-2013
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To study the relationship between T1 tilt and cosmetic shoulder balance in adolescent idiopathic scoliosis (AIS) patients.
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[Traffic-related PM2.5 regulates IL-2 releasing in Jurkat T cells by calcium signaling pathway].
Wei Sheng Yan Jiu
PUBLISHED: 11-14-2013
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To explore the effects of traffic-related PM2.5 on interleukin-2 (IL-2) in Jurkat T cells and the regulatory action of calcium signaling pathway.
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Inorganic halogen ligands in quantum dots: I-, Br-, Cl- and film fabrication through electrophoretic deposition.
Phys Chem Chem Phys
PUBLISHED: 08-20-2013
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Halogen ions (I(-), Br(-), Cl(-)) were added into a colloidal solution of CdSe and PbS quantum dots (QDs) to form QDs capped with these inorganic ligands. Halogen ions attached to QDs through electrostatic interactions and the varying coordination strength between the inorganic ligands and QDs led to different degrees of redispersion and stabilization in polar solvents. Moreover, we successfully conducted electrophoretic deposition (EPD) of QDs capped with inorganic ligands. Negatively charged QDs were adsorbed onto a positively charged TiO2 anode. The assembled QDs films were used in photovoltaic devices and offered better efficiency than QDs capped with organic ligands. This work demonstrates that halogen ions are indeed promising ligands to improve the stability of QDs with inorganic ligands and the EPD method shows prospects in assembling QDs films for practical applications.
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Characteristics of the pelvic axial rotation in adolescent idiopathic scoliosis: a comparison between major thoracic curve and major thoracolumbar/lumbar curve.
Spine J
PUBLISHED: 08-12-2013
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As the biomechanical foundation of the spine, the pelvis was found to display rotation in the transverse plane in AIS. However, the possible factors influencing the pelvic axial rotation (PAR) and its mechanism in adolescent idiopathic scoliosis (AIS) patients were not clear.
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[Analysis of factors associated with postoperative shoulder balance in Lenke Type 1 adolescent idiopathic scoliosis].
Zhonghua Wai Ke Za Zhi
PUBLISHED: 07-31-2013
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To study the factors associated with postoperative shoulder balance in Lenke Type 1 adolescent idiopathic scoliosis (AIS) patients with preoperative right-elevated shoulder after posterior thoracic fusion.
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Comparison of somatosensory evoked potentials between adolescent idiopathic scoliosis and congenital scoliosis without neural axis abnormalities.
Spine J
PUBLISHED: 07-05-2013
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Abnormal somatosensory evoked potentials (SEPs) have been documented in patients with adolescent idiopathic scoliosis (AIS) with different cure severity. However, few studies investigated whether abnormal SEPs were the cause or effect of idiopathic scoliosis.
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Antagonistic role of vertebral translation against vertebral rotation in the spontaneous post-operative modulation of the anterior chest wall contour in thoracic idiopathic scoliosis.
Spine
PUBLISHED: 06-14-2013
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Study Design. A computed tomography (CT) study.Objective. To identify the best scoliotic deformity components that show impact upon the spontaneous post-operative modulation of the deformed anterior chest wall contour in right-convex thoracic adolescent idiopathic scoliosis (AIS).Summary of Background Data. Spontaneous post-operative aggravation of the anterior concave costal projection was a common occurrence in AIS, yet the risk factors that effectively bridged the gap between what the surgeons did in the interior and how the rib cages reacted on the exterior were still open to debate.Methods. Pre and post-operative CT scans of 77 right thoracic AIS patients were retrieved and analyzed. According to the post-operative variation of anterior chest wall angle (CWA), the patients were divided into two groups with either aggravated or improved CWA. Multiple scoliotic deformity parameters and their surgical correction rates were evaluated, correlated and then compared between the two groups. Moreover, patients with apex located at T9 were isolated and evaluated independently. A logistic regression analysis was used to figure out the independent predictors of the spontaneous post-operative modulation of the anterior chest wall contour.Results. The surgical correction rate of Cobb angle (supine), the RAsag angle, the RAml angle, the MLdev angle, the posterior hemithorax ratio (PHR), the vertebral translation (VT) and the thoracic rotation (TR) averaged 64.6%, 19.5%, 30.8%, 39.2%, 15.0%, 41.2% and 28.7%, respectively. Ratio of aggravated anterior chest wall contour was the highest at the T7 apex group(84.6%) as compared with T8 apex group(47.1%), T9 apex group(19.5%) and T10 apex group(0.0%). The pre-operative CWA was significantly lower in the aggravated CWA group when compared with the improved group (2.1±1.8° vs. 6.6±2.4°, p<0.001). Besides, in the aggravated CWA group, significantly greater surgical correction of VT and lesser correction of RAsag angle were demonstrated when compared with the improved CWA group (VT: 53.0% vs. 34.8%, p = 0.001; RAsag: 2.5% vs. 28.7%, p = 0.000). In the T9 subgroup, remarkably different correction rate of VT and RAsag were similarly observed (VT: 54.9% vs. 35.3%, p = 0.046; RAsag: 4.9% vs. 23.5%, p = 0.034). In terms of other deformity parameters, no significantly different correction rate was consistently detected. In the logistic regression analysis, apex location, CWA and correction rate of RAsag were demonstrated to be independent factors predictive of the alteration of chest wall contour.Conclusion. In addition to the smaller preoperative CWA and higher apex location, lesser correction of vertebral rotation, if accompanied by great surgical correction of apical vertebral translation, could also largely result in a poor post-operative anterior chest wall contour.
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Lack of associations between two previously identified susceptible single nucleotide polymorphisms of interleukin-23 receptor gene and ankylosing spondylitis: a replication study in a Chinese Han population.
BMC Musculoskelet Disord
PUBLISHED: 06-10-2013
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The human leukocyte antigen (HLA)-B27 gene is considered to be a major gene associated with predisposition to ankylosing spondylitis (AS); however, studies have demonstrated that non-HLA-B27 genes also contribute substantially to the susceptibility to AS. Two single nucleotide polymorphisms (SNPs), rs1004819 and rs10889677, of the interleukin-23 receptor (IL-23R) gene have been shown to be associated with AS susceptibility in European populations. However, ethnicity factors contribute to population splitting and genetic variation, and ethnic-specific genetic association studies are needed to validate these associations in patients from different ethnic backgrounds. This study therefore aimed to replicate the associations between these two SNPs and AS susceptibility in a Chinese Han population.
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[Osteotomy for severe thoracolumbar kyphosis in advanced ankylosing spondylitis: skipping two-level pedicle subtraction osteotomy].
Zhonghua Yi Xue Za Zhi
PUBLISHED: 05-11-2013
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To explore the feasibility of single-stage skipping two-level pedicle subtraction osteotomy (PSO) for severe thoracolumbar kyphosis (Cobb > 100°) in advanced ankylosing spondylitis (AS).
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Osteopenia predicts curve progression of adolescent idiopathic scoliosis in girls treated with brace treatment.
J Pediatr Orthop
PUBLISHED: 05-09-2013
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Previous studies have shown a significant association between osteopenia and adolescent idiopathic scoliosis (AIS). And initial bone mineral density (BMD) was proposed to serve as a new prognostic factor of curve progression in AIS. However, it remains unknown whether there is a link between the initial bone mineral status and the outcome of brace treatment. This study aimed to investigate whether the initial bone mineral status could influence the final outcome of brace treatment in AIS.
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Haploinsufficiency of endogenous parathyroid hormone-related peptide impairs bone fracture healing.
Clin. Exp. Pharmacol. Physiol.
PUBLISHED: 05-01-2013
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Previous studies have demonstrated that endogenous parathyroid hormone-related peptide (PTHrP) plays a central role in the physiological regulation of bone formation. However, it is unclear whether endogenous PTHrP plays an important function in enhancing bone fracture healing. To determine whether endogenous PTHrP haploinsufficiency impaired bone fracture healing, closed mid-diaphyseal femur fractures were created in 8-week-old wild-type and Pthrp(±) mice. Callus tissue properties were analysed 1, 2 and 4 weeks after fracture by radiography, histology, histochemistry, immunohistochemistry and molecular biology. The size of the calluses was reduced 2 weeks after fracture, and the fracture repairs were poor 4 weeks after fractures, in Pthrp(±) compared with wild-type mice. Cartilaginous callus areas were reduced 1 week after fracture, but were increased 2 weeks after fracture in Pthrp(±) mice. There was a reduction in the number of ostoblasts, alkaline phosphatase (ALP)-positive areas, Type I collagen immunopositive areas, mRNA levels of ALP, Runt-related transcription factor 2 (Runx2) and Type I collagen, Runx2 and insulin-like growth factor-1 protein levels, the number of osteoclasts and the surface in callus tissues in Pthrp(±) compared with wild-type mice. These results demonstrate that endogenous PTHrP haploinsufficiency impairs the fracture repair process by reducing cartilaginous and bony callus formation, with downregulation of osteoblastic gene and protein expression and a reduction in endochondral bone formation, osteoblastic bone formation and osteoclastic bone resorption. Together, the results indicate that endogenous PTHrP plays an important role in fracture healing.
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Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis.
Nat. Genet.
PUBLISHED: 04-19-2013
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Adolescent idiopathic scoliosis (AIS) is the most common pediatric skeletal disease. We previously reported a locus on chromosome 10q24.31 associated with AIS susceptibility in Japanese using a genome-wide association study (GWAS) consisting of 1,033 cases and 1,473 controls. To identify additional AIS-associated loci, we expanded the study by adding X-chromosome SNPs in the GWAS and increasing the size of the replication cohorts. Through a stepwise association study including 1,819 cases and 25,939 controls, we identified a new susceptibility locus on chromosome 6q24.1 in Japanese (P = 2.25 × 10(-10); odds ratio (OR) = 1.28). The most significantly associated SNP, rs6570507, was in GPR126 (encoding G protein-coupled receptor 126). Its association was replicated in Han Chinese and European-ancestry populations (combined P = 1.27 × 10(-14); OR = 1.27). GPR126 was highly expressed in cartilage, and the knockdown of gpr126 in zebrafish caused delayed ossification of the developing spine. Our results should provide insights into the etiology and pathogenesis of AIS.
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Sagittal spinopelvic alignment in adolescent thoracic scoliosis secondary to Chiari I malformation: a comparison between the left and the right curves.
Eur Spine J
PUBLISHED: 03-20-2013
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To investigate whether the sagittal morphology differs between the left and right thoracic curves in patients with Chiari malformation-associated scoliosis (CMS).
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Validation of the Simplified Chinese version of the Core Outcome Measures Index (COMI).
Eur Spine J
PUBLISHED: 03-18-2013
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To translate the Core Outcome Measures Index (COMI) into Simplified Chinese and then validate it for Mainland Chinese patients with low back pain (LBP).
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[Measurement and analysis of micropore aeration systems oxygenating ability under operation condition in waste water treatment plant].
Huan Jing Ke Xue
PUBLISHED: 03-16-2013
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Using the aeration pool in the fourth-stage at Wuxi Lucun Waste Water Treatment Plant (WWTP) as experimental setup, off-gas method was selected to measure the oxygenating ability parameters of micropore aerators in a real WWTP operating condition and these values were compared with those in fresh water to evaluate the performance of the micropore aerators. Results showed that the micropore aerators which were distributed in different galleries of the aeration pool had significantly different oxygenating abilities under operation condition. The oxygenating ability of the micropore aerators distributed in the same gallery changed slightly during one day. Comparing with the oxygenating ability in fresh water, it decreased a lot in the real aeration pool, in more details, under the real WWTP operating condition, the values of oxygen transfer coefficient K(La) oxygenation capacity OC and oxygen utilization E(a) decreased by 43%, 57% and 76%, respectively.
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An exon polymorphism of programmed cell death 1 gene is associated with both the susceptibility and thoracolumbar kyphosis severity of ankylosing spondylitis in a Chinese Han population.
J Orthop Sci
PUBLISHED: 03-12-2013
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Although human leukocyte antigen (HLA)-B27 gene is the major susceptible gene associated with ankylosing spondylitis (AS), it has been recognized that non-HLA-B27 genes also play key roles in the development of AS. The purpose of this study is to investigate whether a single nucleotide polymorphism (SNP) in the exon region of the programmed cell death 1 (PDCD-1) gene is associated with the susceptibility or the thoracolumbar kyphosis severity of AS in a Chinese Han population.
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Metal artifacts reduction using monochromatic images from spectral CT: evaluation of pedicle screws in patients with scoliosis.
Eur J Radiol
PUBLISHED: 02-14-2013
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To evaluate the effectiveness of spectral CT in reducing metal artifacts caused by pedicle screws in patients with scoliosis.
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