Sung-Jan Lin Department of Biomedical Engineering National Taiwan University Biography Publications Institution JoVE Articles Sung-Jan LinProfessor Dr. Sung-Jan Lin is the Taiwan Bio-development Foundation (TBF) Chair in Biotechnology and Professor of Institute of Biomedical Engineering and the Deputy Director of Research Center for Developmental Biology and Regenerative Medicine at National Taiwan University. He is also a dermatologist in National Taiwan University Hospital. He received his MD and PhD from College of Medicine and College of Engineering in National Taiwan University. He takes hair follicles, a miniorgan with distinct structures and growth cycles, as a model to understand how a complex organ interacts with the environment and reacts to various insults and to decipher the principles and machinery of tissue regeneration. His lab employs a multidisciplinary approach by combing the knowledge learned in biology and tissue engineering to enhance tissue regeneration. He has published ~140 journal papers in associated journals, including Cell, Science, PNAS, Nature Communications, Biomaterials, Optics Letters, etc. His work has been recognized by Award for Junior Research Investigators in Life Science of Academia Sinica, Physician Scientist Award of Taiwan National Health Research Institutes, Distinguished Research Award of Taiwan Ministry of Science and Technology and Outstanding Professor Award of Far Eastern Y.Z. Hsu Science and Technology Memorial Foundation. In 2014, he was elected as Taiwan Bio-development Foundation (TBF) Chair in Biotechnology. Publications Functional Complexity of Hair Follicle Stem Cell Niche and Therapeutic Targeting of Niche Dysfunction for Hair Regeneration Journal of Biomedical Science. Mar, 2020 | Pubmed ID: 32171310 Proteomic Analysis Reveals Anti-Fibrotic Effects of Blue Light Photobiomodulation on Fibroblasts Lasers in Surgery and Medicine. Apr, 2020 | Pubmed ID: 31321797 HSD3B1 Gene Polymorphism and Female Pattern Hair Loss in Women with Polycystic Ovary Syndrome Journal of the Formosan Medical Association = Taiwan Yi Zhi. Aug, 2019 | Pubmed ID: 31056381 Long-Term Intravital Imaging of the Cornea, Skin, and Hair Follicle by Multiphoton Microscope Methods in Molecular Biology (Clifton, N.J.). Apr, 2019 | Pubmed ID: 30969402 Intravital Multiphoton Microscopic Imaging Platform for Ocular Surface Imaging Experimental Eye Research. 05, 2019 | Pubmed ID: 30822399 Anagen Hair Follicle Repair: Timely Regenerative Attempts from Plastic Extra-bulge Epithelial Cells Experimental Dermatology. 04, 2019 | Pubmed ID: 30664259 Promotion of Homology-directed DNA Repair by Polyamines Nature Communications. 01, 2019 | Pubmed ID: 30622262 How Chemotherapy and Radiotherapy Damage the Tissue: Comparative Biology Lessons from Feather and Hair Models Experimental Dermatology. 04, 2019 | Pubmed ID: 30457678 External Light Activates Hair Follicle Stem Cells Through Eyes Via an IpRGC-SCN-sympathetic Neural Pathway Proceedings of the National Academy of Sciences of the United States of America. 07, 2018 | Pubmed ID: 29959210 Efficacy and Safety of a Low-Level Light Therapy for Androgenetic Alopecia: A 24-Week, Randomized, Double-Blind, Self-Comparison, Sham Device-Controlled Trial Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]. 11, 2018 | Pubmed ID: 29957664 Inducing Hair Follicle Neogenesis with Secreted Proteins Enriched in Embryonic Skin Biomaterials. 06, 2018 | Pubmed ID: 29567388 Preclinical Evaluation of Melanocyte Transplantation by Chitosan-based Melanocyte Spheroid Patch to Skin Prepared by Controlled Sunburn Blistering Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 10, 2018 | Pubmed ID: 29322633 Activation of MTORC1 Signaling is Required for Timely Hair Follicle Regeneration from Radiation Injury Radiation Research. 12, 2017 | Pubmed ID: 29019741 Increased Risk of Chronic Kidney Disease in Patients with Rosacea: A Nationwide Population-based Matched Cohort Study PloS One. Month, 2017 | Pubmed ID: 28968402 Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy Cancer Research. 11, 2017 | Pubmed ID: 28939680 Stress-induced Premature Senescence of Dermal Papilla Cells Compromises Hair Follicle Epithelial-mesenchymal Interaction Journal of Dermatological Science. May, 2017 | Pubmed ID: 28117106 Minoxidil Improved Hair Density in an Asian Girl with Short Anagen Syndrome: a Case Report and Review of Literature International Journal of Dermatology. Nov, 2016 | Pubmed ID: 27420346 Extensive Cicatricial Alopecia in a Patient with Long-term Trichotillomania The Journal of Dermatology. Feb, 2016 | Pubmed ID: 26813077 ABCG2 Deficiency in Skin Impairs Re-epithelialization in Cutaneous Wound Healing Experimental Dermatology. 05, 2016 | Pubmed ID: 26739701 Correlation of IL36RN Mutation with Different Clinical Features of Pustular Psoriasis in Chinese Patients Archives of Dermatological Research. Jan, 2016 | Pubmed ID: 26589685 Programmable Laser-Assisted Surface Microfabrication on a Poly(Vinyl Alcohol)-Coated Glass Chip with Self-Changing Cell Adhesivity for Heterotypic Cell Patterning ACS Applied Materials & Interfaces. Oct, 2015 | Pubmed ID: 26393271 A Two-Stepped Culture Method for Efficient Production of Trichogenic Keratinocytes Tissue Engineering. Part C, Methods. Oct, 2015 | Pubmed ID: 25951188 Enhancing Hair Follicle Regeneration by Nonablative Fractional Laser: Assessment of Irradiation Parameters and Tissue Response Lasers in Surgery and Medicine. Apr, 2015 | Pubmed ID: 25866259 Risk Factor Analysis for the Immunogenicity of Adalimumab Associated with Decreased Clinical Response in Chinese Patients with Psoriasis Acta Dermato-venereologica. Jul, 2015 | Pubmed ID: 25673333 Regenerative Metamorphosis in Hairs and Feathers: Follicle As a Programmable Biological Printer Experimental Dermatology. Apr, 2015 | Pubmed ID: 25557541 Visible Red Light Enhances Physiological Anagen Entry in Vivo and Has Direct and Indirect Stimulative Effects in Vitro Lasers in Surgery and Medicine. Jan, 2015 | Pubmed ID: 25557083 Red Papules on the Tongue of a Patient with Hemiparesis JAMA. Aug, 2014 | Pubmed ID: 25138335 Extensive Scleredema Adultorum with Loss of Eccrine Glands Journal of the American Academy of Dermatology. Sep, 2014 | Pubmed ID: 25128148 A Painful Bulge in the Left Flank JAMA. Aug, 2013 | Pubmed ID: 23942683 Inducible Deletion of the Blimp-1 Gene in Adult Epidermis Causes Granulocyte-dominated Chronic Skin Inflammation in Mice Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013 | Pubmed ID: 23576729 Feather Regeneration As a Model for Organogenesis Development, Growth & Differentiation. Jan, 2013 | Pubmed ID: 23294361 Therapeutic Strategy for Hair Regeneration: Hair Cycle Activation, Niche Environment Modulation, Wound-induced Follicle Neogenesis, and Stem Cell Engineering Expert Opinion on Biological Therapy. Mar, 2013 | Pubmed ID: 23289545 Scalable Production of Controllable Dermal Papilla Spheroids on PVA Surfaces and the Effects of Spheroid Size on Hair Follicle Regeneration Biomaterials. Jan, 2013 | Pubmed ID: 23092862 Toward the Isolation and Culture of Melanocyte Stem Cells The Journal of Investigative Dermatology. Dec, 2011 | Pubmed ID: 22071538 Images in Clinical Medicine: Porphyria Cutanea Tarda The New England Journal of Medicine. Sep, 2011 | Pubmed ID: 21992125 In Search of the Golden Fleece: Unraveling Principles of Morphogenesis by Studying the Integrative Biology of Skin Appendages Integrative Biology : Quantitative Biosciences from Nano to Macro. Apr, 2011 | Pubmed ID: 21437328 Images in Clinical Medicine. Serpentine Supravenous Hyperpigmentation The New England Journal of Medicine. Jul, 2010 | Pubmed ID: 20830826 Factors from Human Embryonic Stem Cell-derived Fibroblast-like Cells Promote Topology-dependent Hepatic Differentiation in Primate Embryonic and Induced Pluripotent Stem Cells The Journal of Biological Chemistry. Oct, 2010 | Pubmed ID: 20720011 High-throughput Reconstitution of Epithelial-mesenchymal Interaction in Folliculoid Microtissues by Biomaterial-facilitated Self-assembly of Dissociated Heterotypic Adult Cells Biomaterials. May, 2010 | Pubmed ID: 20206989 Biomaterial Mediated Epithelial-mesenchymal Interaction of Salivary Tissue Under Serum Free Condition Biomaterials. Jan, 2010 | Pubmed ID: 19853295 Single-wavelength Reflected Confocal and Multiphoton Microscopy for Tissue Imaging Journal of Biomedical Optics. Sep-Oct, 2009 | Pubmed ID: 19895128 Differentiation of Normal and Cancerous Lung Tissues by Multiphoton Imaging Journal of Biomedical Optics. Jul-Aug, 2009 | Pubmed ID: 19725745 Clinical Images: Infestation by Norwegian Scabies CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne. Sep, 2009 | Pubmed ID: 19620272 The Enhancement of Dermal Papilla Cell Aggregation by Extracellular Matrix Proteins Through Effects on Cell-substratum Adhesivity and Cell Motility Biomaterials. Oct, 2009 | Pubmed ID: 19556003 Discrimination of Collagen in Normal and Pathological Skin Dermis Through Second-order Susceptibility Microscopy Optics Express. Jun, 2009 | Pubmed ID: 19550516 Tumor-associated Macrophage-induced Invasion and Angiogenesis of Human Basal Cell Carcinoma Cells by Cyclooxygenase-2 Induction The Journal of Investigative Dermatology. Apr, 2009 | Pubmed ID: 18843292 Label-free Imaging of Drosophila Larva by Multiphoton Autofluorescence and Second Harmonic Generation Microscopy Journal of Biomedical Optics. Sep-Oct, 2008 | Pubmed ID: 19021374 Characterizing Phase-separated Microstructure of Polymeric Blended Membrane Using Combined Multiphoton and Reflected Confocal Imaging Optics Express. Mar, 2008 | Pubmed ID: 18542477 Self-assembly of Dermal Papilla Cells into Inductive Spheroidal Microtissues on Poly(ethylene-co-vinyl Alcohol) Membranes for Hair Follicle Regeneration Biomaterials. Sep, 2008 | Pubmed ID: 18533254 The Effects of Depilatory Agents As Penetration Enhancers on Human Stratum Corneum Structures The Journal of Investigative Dermatology. Sep, 2008 | Pubmed ID: 18401425 Polarization Ellipticity Compensation in Polarization Second-harmonic Generation Microscopy Without Specimen Rotation Journal of Biomedical Optics. Jan-Feb, 2008 | Pubmed ID: 18315363 Imaging Tissue Engineering Scaffolds Using Multiphoton Microscopy Microscopy Research and Technique. Feb, 2008 | Pubmed ID: 17943985 Multiphoton Microscopy: a New Paradigm in Dermatological Imaging European Journal of Dermatology : EJD. Sep-Oct, 2007 | Pubmed ID: 17673377 Multiphoton Fluorescence and Second-harmonic-generation Microscopy for Imaging Structural Alterations in Corneal Scar Tissue in Penetrating Full-thickness Wound Archives of Ophthalmology (Chicago, Ill. : 1960). Jul, 2007 | Pubmed ID: 17620585 Evaluation of Dermal Thermal Damage by Multiphoton Autofluorescence and Second-harmonic-generation Microscopy Journal of Biomedical Optics. Nov-Dec, 2006 | Pubmed ID: 17212529 Effects of Different Immersion Media in Multiphoton Imaging of the Epithelium and Dermis of Human Skin Microscopy Research and Technique. Dec, 2006 | Pubmed ID: 16981195 Discrimination of Basal Cell Carcinoma from Normal Dermal Stroma by Quantitative Multiphoton Imaging Optics Letters. Sep, 2006 | Pubmed ID: 16936882 Investigating Mechanisms of Collagen Thermal Denaturation by High Resolution Second-harmonic Generation Imaging Biophysical Journal. Oct, 2006 | Pubmed ID: 16829565 Prediction of Heat-induced Collagen Shrinkage by Use of Second Harmonic Generation Microscopy Journal of Biomedical Optics. May-Jun, 2006 | Pubmed ID: 16822069 Study on the Effects of Nylon-chitosan-blended Membranes on the Spheroid-forming Activity of Human Melanocytes Biomaterials. Oct, 2006 | Pubmed ID: 16777216 Cyclooxygenase-2 Overexpression in Human Basal Cell Carcinoma Cell Line Increases Antiapoptosis, Angiogenesis, and Tumorigenesis The Journal of Investigative Dermatology. May, 2006 | Pubmed ID: 16528365 Multiphoton Autofluorescence and Second-harmonic Generation Imaging of the Ex Vivo Porcine Eye Investigative Ophthalmology & Visual Science. Mar, 2006 | Pubmed ID: 16505061 Enhanced Cell Survival of Melanocyte Spheroids in Serum Starvation Condition Biomaterials. Mar, 2006 | Pubmed ID: 16171860 Evaluating Cutaneous Photoaging by Use of Multiphoton Fluorescence and Second-harmonic Generation Microscopy Optics Letters. Sep, 2005 | Pubmed ID: 16190442 A Cervical Congenital Atrophic Band with a Nipplelike Projection Archives of Dermatology. Sep, 2005 | Pubmed ID: 16172320 Monitoring the Thermally Induced Structural Transitions of Collagen by Use of Second-harmonic Generation Microscopy Optics Letters. Mar, 2005 | Pubmed ID: 15791996 Formation of Melanocyte Spheroids on the Chitosan-coated Surface Biomaterials. Apr, 2005 | Pubmed ID: 15482829 Effects of Objective Numerical Apertures on Achievable Imaging Depths in Multiphoton Microscopy Microscopy Research and Technique. Dec, 2004 | Pubmed ID: 15662621 Multiphoton Polarization and Generalized Polarization Microscopy Reveal Oleic-acid-induced Structural Changes in Intercellular Lipid Layers of the Skin Optics Letters. Sep, 2004 | Pubmed ID: 15455764 An Asymptomatic Preauricular Subcutaneous Nodule in a 65-year-old Woman Archives of Dermatology. Mar, 2003 | Pubmed ID: 12622641 HLA-Cw6 Specificity and Polymorphic Residues Are Associated with Susceptibility Among Chinese Psoriatics in Taiwan Archives of Dermatological Research. Jul, 2002 | Pubmed ID: 12115024 マウス角膜と結膜のライブイメージングのためのカスタム多光子顕微鏡プラットフォーム Yueh-Feng Wu1, Rai-Teng Ye1, Ming-Kai Pan2,3, Sung-Jan Lin*1,3,4,5, Hsin-Yuan Tan*6,7 1Department of Biomedical Engineering, National Taiwan University, 2Institute of Pharmacology, College of Medicine, National Taiwan University, 3Molecular Imaging Center, National Taiwan University, 4Department of Dermatology, National Taiwan University Hospital, and College of Medicine, 5Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, 6Department of Ophthalmology, Chang Gung Memorial Hospital, 7College of Medicine, Chang Gung University JoVE 60944 Bioengineering
マウス角膜と結膜のライブイメージングのためのカスタム多光子顕微鏡プラットフォーム Yueh-Feng Wu1, Rai-Teng Ye1, Ming-Kai Pan2,3, Sung-Jan Lin*1,3,4,5, Hsin-Yuan Tan*6,7 1Department of Biomedical Engineering, National Taiwan University, 2Institute of Pharmacology, College of Medicine, National Taiwan University, 3Molecular Imaging Center, National Taiwan University, 4Department of Dermatology, National Taiwan University Hospital, and College of Medicine, 5Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, 6Department of Ophthalmology, Chang Gung Memorial Hospital, 7College of Medicine, Chang Gung University JoVE 60944 Bioengineering