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Journal / Medicine / Helper bağımlı adenoviral vektör-Gen Transferi…
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Helper bağımlı adenoviral vektör-Gen Transferi ile Diyabetik Sıçanların Karaciğerinde Neo-Islet Oluşumu
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Helper bağımlı adenoviral vektör-Gen Transferi ile Diyabetik Sıçanların Karaciğerinde Neo-Islet Oluşumu

Article DOI: 10.3791/4321-v • 16:59 min • October 10th, 2012
October 10th, 2012 •
1,2, 1,2,3, 1,2,3
1Department of Medicine, Baylor College of Medicine, 2Division of Diabetes, Endocrinology & Metabolism, Diabetes & Endocrinology Research Center, Baylor College of Medicine, 3Department of Molecular & Cellular Biology, Baylor College of Medicine

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Biz hepatik neo-adacık STZ formasyonu (streptozotosin)-indüklenen helper bağımlı adenoviral vektör (HDAd) ve hiperglisemi ters kullanılarak gen Neurogenin3 transferi (Ngn3) ve Betacellulin (BTC) ile diyabet oluşturulan farelerde. Tarif Bizim metodumuz vivo iletimi ve uzun ömürlü gen ekspresyonu kendi yüksek verimli olan helper-bağımlı adenoviral vektörlerin avantajları alır.

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Tıp Sayı 68 Genetik Fizyoloji Gen terapisi Neurogenin3 Betacellulin helper-bağımlı adenoviral vektörlerin Tip 1 diyabet adacık neogenesis
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