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Journal / Bioengineering / Creazione di un ginocchio joint-on-a-chip per la…
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JoVE Journal Bioengineering
Creazione di un ginocchio joint-on-a-chip per la modellazione delle malattie articolari e la sperimentazione di farmaci
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Creazione di un ginocchio joint-on-a-chip per la modellazione delle malattie articolari e la sperimentazione di farmaci

Article DOI: 10.3791/64186-v • 12:44 min • January 27th, 2023
January 27th, 2023 •
1,2, 1,3, 1, 1, 1, 1, 1, 1, 4, 5, 4,6, 1,8, 1,7, 1,2,7
1Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, 2Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, 3Department of Neurobiology, University of Pittsburgh School of Medicine, 4Department of Orthopaedic Surgery, Stanford University, 5Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, 6Department of Bioengineering, Stanford University, 7McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, 8The Chinese University of Hong Kong

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Forniamo metodi dettagliati per generare quattro tipi di tessuti da cellule staminali mesenchimali umane, che vengono utilizzate per ricapitolare la cartilagine, l'osso, il cuscinetto adiposo e la sinovia nell'articolazione del ginocchio umano. Questi quattro tessuti sono integrati in un bioreattore personalizzato e collegati attraverso la microfluidica, generando così un'articolazione del ginocchio su un chip.

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Bioingegneria Numero 191 osteoartrite chip tissutale farmaci per l'osteoartrite modificanti la malattia sistema microfisiologico
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