Ji-Xin Cheng Department of Biomedical Engineering Boston University Biography Publications Institution JoVE Articles Ji-Xin Cheng has not added a biography. If you are Ji-Xin Cheng and would like to personalize this page please email our Author Liaison for assistance. Publications High-content Stimulated Raman Histology of Human Breast Cancer Theranostics. 2024 | Pubmed ID: 38389847 Nanoparticle Targeting in Chemo-Resistant Ovarian Cancer Reveals Dual Axis of Therapeutic Vulnerability Involving Cholesterol Uptake and Cell Redox Balance Advanced Science (Weinheim, Baden-Wurttemberg, Germany). Jan, 2024 | Pubmed ID: 38263873 Preclinical Evaluation of NTX-301, a Novel DNA Hypomethylating Agent in Ovarian Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2024 | Pubmed ID: 38231483 Mapping Enzyme Activity in Living Systems by Real-time Mid-infrared Photothermal Imaging of Nitrile Chameleons Nature Methods. Feb, 2024 | Pubmed ID: 38191931 The Parkinson's Drug Entacapone Disrupts Gut Microbiome Homeostasis Via Iron Sequestration BioRxiv : the Preprint Server for Biology. Nov, 2023 | Pubmed ID: 38014294 High-throughput Single-cell Sorting by Stimulated Raman-activated Cell Ejection BioRxiv : the Preprint Server for Biology. Oct, 2023 | Pubmed ID: 37904930 Stimulated Raman Photothermal Microscopy Toward Ultrasensitive Chemical Imaging Science Advances. Oct, 2023 | Pubmed ID: 37889965 Millimeter-deep Micron-resolution Vibrational Imaging by Shortwave Infrared Photothermal Microscopy Research Square. Oct, 2023 | Pubmed ID: 37886499 Single Virus Fingerprinting by Widefield Interferometric Defocus-enhanced Mid-infrared Photothermal Microscopy Nature Communications. Oct, 2023 | Pubmed ID: 37863905 Gap-enhanced Gold Nanodumbbells with Single-particle Surface-enhanced Raman Scattering Sensitivity RSC Advances. Sep, 2023 | Pubmed ID: 37711380 Profiling Single Cancer Cell Metabolism Via High-content SRS Imaging with Chemical Sparsity Science Advances. Aug, 2023 | Pubmed ID: 37585522 Electronic Preresonance Stimulated Raman Scattering Spectromicroscopy Using Multiple-Plate Continuum The Journal of Physical Chemistry. B. Aug, 2023 | Pubmed ID: 37494414 Multifunctional Fiber-Based Optoacoustic Emitter As a Bidirectional Brain Interface Advanced Healthcare Materials. Oct, 2023 | Pubmed ID: 37451259 3D Chemical Imaging by Fluorescence-detected Mid-Infrared Photothermal Fourier Light Field Microscopy Chemical & Biomedical Imaging. Jun, 2023 | Pubmed ID: 37388959 Mid-infrared Chemical Imaging of Intracellular Tau Fibrils Using Fluorescence-guided Computational Photothermal Microscopy Light, Science & Applications. Jun, 2023 | Pubmed ID: 37322011 Video-rate Mid-infrared Photothermal Imaging by Single-pulse Photothermal Detection Per Pixel Science Advances. Jun, 2023 | Pubmed ID: 37315131 Fingerprint Stimulated Raman Scattering Imaging Unveils Ergosteryl Ester As a Metabolic Signature of Azole-Resistant Analytical Chemistry. Jul, 2023 | Pubmed ID: 37310727 Nanoscale Bond-selective Imaging by Computational Fusion of Atomic Force Microscopy and Coherent Anti-Stokes Raman Scattering Microscopy The Analyst. Jun, 2023 | Pubmed ID: 37305950 Longitudinal Single-Cell Imaging of Engineered Strains with Stimulated Raman Scattering to Characterize Heterogeneity in Fatty Acid Production Advanced Science (Weinheim, Baden-Wurttemberg, Germany). Jul, 2023 | Pubmed ID: 37288534 Far-field Super-resolution Chemical Microscopy Light, Science & Applications. Jun, 2023 | Pubmed ID: 37277396 Mapping Enzyme Activity in Living Systems by Real-Time Mid-Infrared Photothermal Imaging of Nitrile Chameleons Research Square. Mar, 2023 | Pubmed ID: 36909612 Blue Light Improves Antimicrobial Efficiency of Silver Sulfadiazine Via Catalase Inactivation Photobiomodulation, Photomedicine, and Laser Surgery. Feb, 2023 | Pubmed ID: 36780574 A High-sensitivity High-resolution Intravascular Photoacoustic Catheter Through Mode Cleaning in a Graded-index Fiber Photoacoustics. Feb, 2023 | Pubmed ID: 36654962 Mid-Infrared Photothermal-Fluorescence In Situ Hybridization for Functional Analysis and Genetic Identification of Single Cells Analytical Chemistry. Jan, 2023 | Pubmed ID: 36652555 High-Throughput Antimicrobial Susceptibility Testing of by Wide-Field Mid-Infrared Photothermal Imaging of Protein Synthesis Analytical Chemistry. Jan, 2023 | Pubmed ID: 36651850 Blue Light Deactivation of Catalase Suppresses Candida Hyphae Development Through Lipogenesis Inhibition Photochemistry and Photobiology. 2023 | Pubmed ID: 36117418 Survival Intravascular Photoacoustic Imaging of Lipid-rich Plaque in Cholesterol Fed Rabbits Translational Biophotonics. Dec, 2022 | Pubmed ID: 38283396 Bond-selective Intensity Diffraction Tomography Nature Communications. Dec, 2022 | Pubmed ID: 36522316 High-precision Neural Stimulation by a Highly Efficient Candle Soot Fiber Optoacoustic Emitter Frontiers in Neuroscience. 2022 | Pubmed ID: 36408413 Optically-generated Focused Ultrasound for Noninvasive Brain Stimulation with Ultrahigh Precision Light, Science & Applications. Nov, 2022 | Pubmed ID: 36323662 Mid-Infrared Photothermal Microscopy: Principle, Instrumentation, and Applications The Journal of Physical Chemistry. B. Nov, 2022 | Pubmed ID: 36285985 Tilt-angle Stimulated Raman Projection Tomography Optics Express. Sep, 2022 | Pubmed ID: 36258628 Ovarian Cancer Cell Fate Regulation by the Dynamics Between Saturated and Unsaturated Fatty Acids Proceedings of the National Academy of Sciences of the United States of America. Oct, 2022 | Pubmed ID: 36197994 Visualization of a Limonene Synthesis Metabolon Inside Living Bacteria by Hyperspectral SRS Microscopy Advanced Science (Weinheim, Baden-Wurttemberg, Germany). Nov, 2022 | Pubmed ID: 36169112 Metabolic Reprogramming from Glycolysis to Fatty Acid Uptake and Beta-oxidation in Platinum-resistant Cancer Cells Nature Communications. Aug, 2022 | Pubmed ID: 35931676 SRS-FISH: A High-throughput Platform Linking Microbiome Metabolism to Identity at the Single-cell Level Proceedings of the National Academy of Sciences of the United States of America. Jun, 2022 | Pubmed ID: 35727976 New "HOPE" Laser for Photoacoustic Imaging of Water Light, Science & Applications. Apr, 2022 | Pubmed ID: 35468889 Photoinactivation of Catalase Sensitizes a Wide Range of Bacteria to ROS-producing Agents and Immune Cells JCI Insight. May, 2022 | Pubmed ID: 35446788 High-precision Neural Stimulation Through Optoacoustic Emitters Neurophotonics. Jul, 2022 | Pubmed ID: 35355658 Photoinactivation of Catalase Sensitizes Candida Albicans and Candida Auris to ROS-Producing Agents and Immune Cells Advanced Science (Weinheim, Baden-Wurttemberg, Germany). Feb, 2022 | Pubmed ID: 35119220 Multimodal Metabolic Imaging Reveals Pigment Reduction and Lipid Accumulation in Metastatic Melanoma BME Frontiers. 2021 | Pubmed ID: 37849907 Background-Suppressed High-Throughput Mid-Infrared Photothermal Microscopy Via Pupil Engineering ACS Photonics. Nov, 2021 | Pubmed ID: 35966035 Nanosecond-resolution Photothermal Dynamic Imaging Via MHZ Digitization and Match Filtering Nature Communications. 12, 2021 | Pubmed ID: 34876556 Multiwindow SRS Imaging Using a Rapid Widely Tunable Fiber Laser Analytical Chemistry. 11, 2021 | Pubmed ID: 34787995 Coherent Raman Scattering Imaging with a Near-infrared Achromatic Metalens APL Photonics. Sep, 2021 | Pubmed ID: 34553044 Interaction of Tau with HNRNPA2B1 and N-methyladenosine RNA Mediates the Progression of Tauopathy Molecular Cell. 10, 2021 | Pubmed ID: 34453888 Fluorescence-Detected Mid-Infrared Photothermal Microscopy Journal of the American Chemical Society. 08, 2021 | Pubmed ID: 34264654 Non-genetic Photoacoustic Stimulation of Single Neurons by a Tapered Fiber Optoacoustic Emitter Light, Science & Applications. Jul, 2021 | Pubmed ID: 34257273 Microsecond Fingerprint Stimulated Raman Spectroscopic Imaging by Ultrafast Tuning and Spatial-spectral Learning Nature Communications. 05, 2021 | Pubmed ID: 34031374 Bond-selective Imaging by Optically Sensing the Mid-infrared Photothermal Effect Science Advances. May, 2021 | Pubmed ID: 33990332 Ultrasensitive Vibrational Imaging of Retinoids by Visible Preresonance Stimulated Raman Scattering Microscopy Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 05, 2021 | Pubmed ID: 33977045 Unveiling Cancer Metabolism Through Spontaneous and Coherent Raman Spectroscopy and Stable Isotope Probing Cancers. Apr, 2021 | Pubmed ID: 33916413 Vibrational Spectroscopic Detection of a Single Virus by Mid-Infrared Photothermal Microscopy Analytical Chemistry. 03, 2021 | Pubmed ID: 33596049 Meta-optics Achieves RGB-achromatic Focusing for Virtual Reality Science Advances. Jan, 2021 | Pubmed ID: 33571130 Ambient Oxygen-Doped Conjugated Polymer for PH-Activatable Aggregation-Enhanced Photoacoustic Imaging in the Second Near-Infrared Window Analytical Chemistry. 02, 2021 | Pubmed ID: 33538589 Polarization-sensitive Stimulated Raman Scattering Imaging Resolves Amphotericin B Orientation in Membrane Science Advances. Jan, 2021 | Pubmed ID: 33523971 Granadaene Photobleaching Reduces the Virulence and Increases Antimicrobial Susceptibility of Streptococcus Agalactiae Photochemistry and Photobiology. 07, 2021 | Pubmed ID: 33502005 Plasmon-enhanced Coherent Anti-stokes Raman Scattering Vs Plasmon-enhanced Stimulated Raman Scattering: Comparison of Line Shape and Enhancement Factor The Journal of Chemical Physics. Jan, 2021 | Pubmed ID: 33499625 Frizzled-7 Identifies Platinum-Tolerant Ovarian Cancer Cells Susceptible to Ferroptosis Cancer Research. 01, 2021 | Pubmed ID: 33172933 Highly Sensitive Lipid Detection and Localization in Atherosclerotic Plaque with a Dual-frequency Intravascular Photoacoustic/ultrasound Catheter Translational Biophotonics. Aug, 2020 | Pubmed ID: 37745902 Real-time Imaging of Surface Chemical Reactions by Electrochemical Photothermal Reflectance Microscopy Chemical Science. Dec, 2020 | Pubmed ID: 34163957 Polymer Electrochromism Driven by Metabolic Activity Facilitates Rapid and Facile Bacterial Detection and Susceptibility Evaluation Advanced Functional Materials. Dec, 2020 | Pubmed ID: 33708032 Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2 Molecular Cell. 12, 2020 | Pubmed ID: 33259812 Volumetric Chemical Imaging in Vivo by a Remote-focusing Stimulated Raman Scattering Microscope Optics Express. Sep, 2020 | Pubmed ID: 33114904 A Fiber Optoacoustic Emitter with Controlled Ultrasound Frequency for Cell Membrane Sonoporation at Submillimeter Spatial Resolution Photoacoustics. Dec, 2020 | Pubmed ID: 33101926 Tau Oligomers and Fibrils Exhibit Differential Patterns of Seeding and Association With RNA Binding Proteins Frontiers in Neurology. 2020 | Pubmed ID: 33101187 Room-Temperature Phosphorescence and Low-Energy Induced Direct Triplet Excitation of Alq Engineered Crystals The Journal of Physical Chemistry Letters. Nov, 2020 | Pubmed ID: 33095025 Fingerprinting Bacterial Metabolic Response to Erythromycin by Raman-Integrated Mid-Infrared Photothermal Microscopy Analytical Chemistry. 11, 2020 | Pubmed ID: 33089997 Rapid Determination of Antimicrobial Susceptibility by Stimulated Raman Scattering Imaging of DO Metabolic Incorporation in a Single Bacterium Advanced Science (Weinheim, Baden-Wurttemberg, Germany). Oct, 2020 | Pubmed ID: 33042757 High-Speed Chemical Imaging by Dense-Net Learning of Femtosecond Stimulated Raman Scattering The Journal of Physical Chemistry Letters. Oct, 2020 | Pubmed ID: 32914982 Dual-wavelength Photo-killing of Methicillin-resistant Staphylococcus Aureus JCI Insight. 06, 2020 | Pubmed ID: 32493838 Imaging Chemical Kinetics of Radical Polymerization with an Ultrafast Coherent Raman Microscope Advanced Science (Weinheim, Baden-Wurttemberg, Germany). May, 2020 | Pubmed ID: 32440482 Functionalized NIR-II Semiconducting Polymer Nanoparticles for Single-cell to Whole-Organ Imaging of PSMA-Positive Prostate Cancer Small (Weinheim an Der Bergstrasse, Germany). 05, 2020 | Pubmed ID: 32307923 Photo-Disassembly of Membrane Microdomains Revives Conventional Antibiotics Against MRSA Advanced Science (Weinheim, Baden-Wurttemberg, Germany). Mar, 2020 | Pubmed ID: 32195102 Multiplex Stimulated Raman Scattering Imaging Cytometry Reveals Lipid-Rich Protrusions in Cancer Cells Under Stress Condition IScience. Mar, 2020 | Pubmed ID: 32179477 Optoacoustic Brain Stimulation at Submillimeter Spatial Precision Nature Communications. 02, 2020 | Pubmed ID: 32060282 Transient Absorption Microscopy: Technological Innovations and Applications in Materials Science and Life Science The Journal of Chemical Physics. Jan, 2020 | Pubmed ID: 31941290 Quinine Enhances Photo-Inactivation of Gram-Negative Bacteria The Journal of Infectious Diseases. 02, 2020 | Pubmed ID: 31565732 Accelerated Stimulated Raman Projection Tomography by Sparse Reconstruction From Sparse-View Data IEEE Transactions on Bio-medical Engineering. 05, 2020 | Pubmed ID: 31425010 Label-free Optical Imaging of Membrane Potential Current Opinion in Biomedical Engineering. Dec, 2019 | Pubmed ID: 32864527 Quantitative Imaging of Intraerythrocytic Hemozoin by Transient Absorption Microscopy Journal of Biomedical Optics. 12, 2019 | Pubmed ID: 31849205 Bond-selective Transient Phase Imaging Via Sensing of the Infrared Photothermal Effect Light, Science & Applications. 2019 | Pubmed ID: 31839936 Plasmon-enhanced Stimulated Raman Scattering Microscopy with Single-molecule Detection Sensitivity Nature Communications. 11, 2019 | Pubmed ID: 31754221 All-Glass, Large Metalens at Visible Wavelength Using Deep-Ultraviolet Projection Lithography Nano Letters. 12, 2019 | Pubmed ID: 31726010 Volumetric Stimulated Raman Scattering Imaging of Cleared Tissues Towards Three-dimensional Chemical Histopathology Biomedical Optics Express. Aug, 2019 | Pubmed ID: 31453014 Ultrafast Chemical Imaging by Widefield Photothermal Sensing of Infrared Absorption Science Advances. 07, 2019 | Pubmed ID: 31334347 Electronic Preresonance Stimulated Raman Scattering Imaging of Red-Shifted Proteorhodopsins: Toward Quantitation of the Membrane Potential The Journal of Physical Chemistry Letters. Aug, 2019 | Pubmed ID: 31313926 Photolysis of Staphyloxanthin in Methicillin-Resistant Potentiates Killing by Reactive Oxygen Species Advanced Science (Weinheim, Baden-Wurttemberg, Germany). Jun, 2019 | Pubmed ID: 31179216 Label-free Quantitation of Glycated Hemoglobin in Single Red Blood Cells by Transient Absorption Microscopy and Phasor Analysis Science Advances. 05, 2019 | Pubmed ID: 31093524 Cylindrical Illumination with Angular Coupling for Whole-prostate Photoacoustic Tomography Biomedical Optics Express. Mar, 2019 | Pubmed ID: 30891355 Comparative Quantification of Arterial Lipid by Intravascular Photoacoustic-Ultrasound Imaging and Near-Infrared Spectroscopy-Intravascular Ultrasound Journal of Cardiovascular Translational Research. 06, 2019 | Pubmed ID: 30488332 Nanoladders Facilitate Directional Axonal Outgrowth and Regeneration ACS Biomaterials Science & Engineering. Mar, 2018 | Pubmed ID: 33418787 High-speed Intraoperative Assessment of Breast Tumor Margins by Multimodal Ultrasound and Photoacoustic Tomography Medical Devices & Sensors. Jun, 2018 | Pubmed ID: 31435620 A Fiber Optoacoustic Guide with Augmented Reality for Precision Breast-conserving Surgery Light, Science & Applications. 2018 | Pubmed ID: 30839601 Spectroscopic Stimulated Raman Scattering Imaging of Highly Dynamic Specimens Through Matrix Completion Light, Science & Applications. 2018 | Pubmed ID: 30839525 Imaging of Demineralized Enamel in Intact Tooth by Epidetected Stimulated Raman Scattering Microscopy Journal of Biomedical Optics. 10, 2018 | Pubmed ID: 30350492 Photoacoustic Tomography of Intact Human Prostates and Vascular Texture Analysis Identify Prostate Cancer Biopsy Targets Photoacoustics. Sep, 2018 | Pubmed ID: 30109195 Fingerprint Stimulated Raman Scattering Imaging Reveals Retinoid Coupling Lipid Metabolism and Survival Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. 10, 2018 | Pubmed ID: 29911339 In Vitro Exploration of ACAT Contributions to Lipid Droplet Formation During Adipogenesis Journal of Lipid Research. 05, 2018 | Pubmed ID: 29549095 Cholesterol Esterification Inhibition Suppresses Prostate Cancer Metastasis by Impairing the Wnt/β-catenin Pathway Molecular Cancer Research : MCR. 06, 2018 | Pubmed ID: 29545473 Cholesterol Esterification Inhibition and Gemcitabine Synergistically Suppress Pancreatic Ductal Adenocarcinoma Proliferation PloS One. 2018 | Pubmed ID: 29489864 Quantitative Assessment of Liver Steatosis and Affected Pathways with Molecular Imaging and Proteomic Profiling Scientific Reports. 02, 2018 | Pubmed ID: 29483581 Antibiotic Susceptibility Determination Within One Cell Cycle at Single-Bacterium Level by Stimulated Raman Metabolic Imaging Analytical Chemistry. 03, 2018 | Pubmed ID: 29461044 Fast Assessment of Lipid Content in Arteries in Vivo by Intravascular Photoacoustic Tomography Scientific Reports. 02, 2018 | Pubmed ID: 29402963 Label-Free Imaging of Heme Dynamics in Living Organisms by Transient Absorption Microscopy Analytical Chemistry. 03, 2018 | Pubmed ID: 29401392 High-Speed Spectroscopic Transient Absorption Imaging of Defects in Graphene Nano Letters. 02, 2018 | Pubmed ID: 29342361 Bond-Selective Imaging of Cells by Mid-Infrared Photothermal Microscopy in High Wavenumber Region The Journal of Physical Chemistry. B. 11, 2017 | Pubmed ID: 29035533 Imaging Chemistry Inside Living Cells by Stimulated Raman Scattering Microscopy Methods (San Diego, Calif.). 09, 2017 | Pubmed ID: 28746829 Optical Photothermal Infrared - Fluorescence In Situ Hybridization (OPTIR-FISH) Zhongyue Guo*1, Yeran Bai*2,3, Fátima C. Pereira4, Ji-Xin Cheng1,5 1Department of Biomedical Engineering, Boston University, 2Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California Santa Barbara, 3Photothermal Spectroscopy Corp., 4School of Biological Sciences, University of Southampton, 5Department of Electrical & Computer Engineering, Photonics Center, Boston University JoVE 66562 Bioengineering Rapid Antimicrobial Susceptibility Testing by Stimulated Raman Scattering Imaging of Deuterium Incorporation in a Single Bacterium Meng Zhang1,2, Mohamed N. Seleem3, Ji-Xin Cheng1,2,4,5 1Department of Electrical and Computer Engineering, Boston University, 2Boston University Photonics Center, Boston University, 3Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, 4Department of Biomedical Engineering, Boston University, 5Department of Chemistry, Boston University JoVE 62398 Biology
Optical Photothermal Infrared - Fluorescence In Situ Hybridization (OPTIR-FISH) Zhongyue Guo*1, Yeran Bai*2,3, Fátima C. Pereira4, Ji-Xin Cheng1,5 1Department of Biomedical Engineering, Boston University, 2Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California Santa Barbara, 3Photothermal Spectroscopy Corp., 4School of Biological Sciences, University of Southampton, 5Department of Electrical & Computer Engineering, Photonics Center, Boston University JoVE 66562 Bioengineering
Rapid Antimicrobial Susceptibility Testing by Stimulated Raman Scattering Imaging of Deuterium Incorporation in a Single Bacterium Meng Zhang1,2, Mohamed N. Seleem3, Ji-Xin Cheng1,2,4,5 1Department of Electrical and Computer Engineering, Boston University, 2Boston University Photonics Center, Boston University, 3Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, 4Department of Biomedical Engineering, Boston University, 5Department of Chemistry, Boston University JoVE 62398 Biology