Chapter 17
Cell Proliferation
![What is the Cell Cycle?](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/10757.jpg)
The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two…
![Interphase](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/10761.jpg)
The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases of…
![Positive Regulator Molecules](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/12044.jpg)
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of…
![Inhibition of Cdk Activity](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/12045.jpg)
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be…
![M-Cdk Drives Transition Into Mitosis](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/12047.jpg)
Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or…
![Mitogens and the Cell Cycle](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/12048.jpg)
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell…
![Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk1](https://cloudfront.jove.com/files/thumbs/53417_t.png)
Although mitochondria possess their own transcriptional machinery, merely 1% of mitochondrial proteins are synthesized inside the organelle. The…
![Techniques to Induce and Quantify Cellular Senescence](https://cloudfront.jove.com/files/thumbs/55533_t.png)
In response to cellular stress or damage, proliferating cells can induce a specific program that initiates a state of long-term cell-cycle arrest,…