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 JoVE Neuroscience

سريع تحديد العتبة Nociceptive الحرارية في الفئران المصابة بمرض السكر

1, 2, 2, 1

1Department of Pharmacology and Toxicology, Wright State University, 2Human Movement Laboratory, Universidade São Judas Tadeu

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Cite this Article: سريع تحديد العتبة Nociceptive الحرارية في الفئران المصابة بمرض السكر

Alshahrani, S., Fernandez-Conti, F., Araujo, A., DiFulvio, M. Rapid Determination of the Thermal Nociceptive Threshold in Diabetic Rats. J. Vis. Exp. (63), e3785, doi:10.3791/3785 (2012).

Disclosures: سريع تحديد العتبة Nociceptive الحرارية في الفئران المصابة بمرض السكر

Materials: سريع تحديد العتبة Nociceptive الحرارية في الفئران المصابة بمرض السكر

Name Company Catalog Number Comments
Incremental Hot-Plate Analgesia Meter IITC Inc. Life Science Part #PE34
Soft Series 8 IITC Inc. Life Science Part # Series8
Streptozotocin Calbiochem 572201

References: سريع تحديد العتبة Nociceptive الحرارية في الفئران المصابة بمرض السكر

  1. Baron R. Peripheral neuropathic pain: From mechanisms to symptoms. Clin. J. Pain. 16, S12-20 (2000).
  2. Calcutt, N.A., Jorge, M.C., Yaksh, T.L., & Chaplan, S.R. Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: Effects of insulin, aldose reductase inhibition and lidocaine. Pain. 68, 293-299 (1996).
  3. Bolcskei, K., Petho, G., & Szolcsanyi, J. Noxious heat threshold measured with slowly increasing temperatures: Novel rat thermal hyperalgesia models. Methods Mol. Biol. 617, 57-66 (2010).
  4. Ankier, S.I. New hot plate tests to quantify antinociceptive and narcotic antagonist activities. Eur. J. Pharmacol. 27, 1-4 (1974).
  5. Almasi, R., Petho, G., Bolcskei, K., & Szolcsanyi, J. Effect of resiniferatoxin on the noxious heat threshold temperature in the rat: A novel heat allodynia model sensitive to analgesics. Br. J. Pharmacol. 139, 49-58 (2003).
  6. Bolcskei, K., Horvath, D., Szolcsanyi, J., & Petho, G. Heat injury-induced drop of the noxious heat threshold measured with an increasing-temperature water bath: A novel rat thermal hyperalgesia model. Eur. J. Pharmacol. 564, 80-87 (2007).
  7. Chesler, E.J., Wilson, S.G., Lariviere, W.R., Rodriguez-Zas, S.L., & Mogil, J.S. Identification and ranking of genetic and laboratory environment factors influencing a behavioral trait, thermal nociception, via computational analysis of a large data archive. Neurosci. Biobehav. Rev. 26, 907-923 (2002).
  8. Langford, D.J., Crager, S.E., Shehzad, Z., Smith, S.B., Sotocinal, S.G., Levenstadt, J.S., Chanda, M.L, Levitin, D.J., & Mogil, J.S. Social modulation of pain as evidence for empathy in mice. Science. 312, 1967-1970 (2006).
  9. Hunt, S.P. & Koltzenburg, M. The neurobiology of pain. Oxford University Press, New York, (2005).
  10. Willis, W.D. The pain system : The neural basis of nociceptive transmission in the mammalian nervous system. Basel, New York, Karger, (1985).
  11. Calcutt, N. Modeling diabetic sensory neuropathy in rats. In: Methods in molecular medicine. Pain research: Methods and protocols. Humana Press, Totowa, N.J., (2004).
  12. Le Bars, D., Gozariu, M., & Cadden, S.W. Animal models of nociception. Pharmacol. Rev. 53, 597-652 (2001).
  13. Shaikh, A.S. & Somani, R.S. Animal models and biomarkers of neuropathy in diabetic rodents. Indian J. Pharmacol. 42, 129-134 (2010).
  14. Hargreaves, K., Dubner, R., Brown, F., Flores, C., & Joris, J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain. 32, 77-88 (1988).
  15. Hardy, J.D. Method for the rapid measurement of skin temperature during exposure to intense thermal radiation. J. Appl. Physiol. 5, 559-566 (1953).
  16. Sumino, R., Dubner, R., & Starkman, S. Responses of small myelinated "warm" fibers to noxious heat stimuli applied to the monkey's face. Brain Res. 62, 260-263 (1973).
  17. Hammond, D.L. & Ruda, M.A. Developmental alterations in thermal nociceptive threshold and the distribution of immunoreactive calcitonin gene-related peptide and substance p after neonatal administration of capsaicin in the rat. Neurosci. Lett. 97, 57-62 (1989).

Ask the Author: سريع تحديد العتبة Nociceptive الحرارية في الفئران المصابة بمرض السكر

1 Comment

Professor Mauricio DiFulvio,

I´m a student from UFPE, Pernambuco in Brasil and I would like to request a copy of the video: "Rapid Determination of the Thermal Nociceptive Threshold in Diabetic Rats". Will be very useful for my education. Could you send for my email (francineiane@hotmail.com), please?

Thanks for your attention,
Francine Iane

4

Reply

Posted by: Francine I.February 4, 2013, 4:01 PM

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