Feilim Mac Gabhann Department of Biomedical Engineering & Institute for Computational Medicine Johns Hopkins University Biography Publications Institution JoVE Articles Feilim Mac Gabhann has not added a biography. If you are Feilim Mac Gabhann and would like to personalize this page please email our Author Liaison for assistance. Publications Effects of Fiber Type and Size on the Heterogeneity of Oxygen Distribution in Exercising Skeletal Muscle PloS One. 2012 | Pubmed ID: 23028531 Vascular Morphogenesis of Adipose-derived Stem Cells is Mediated by Heterotypic Cell-cell Interactions Tissue Engineering. Part A. Aug, 2012 | Pubmed ID: 22462659 Integration of Experimental and Computational Approaches to Sprouting Angiogenesis Current Opinion in Hematology. May, 2012 | Pubmed ID: 22406822 Multi-scale Modeling of HIV Infection in Vitro and APOBEC3G-based Anti-retroviral Therapy PLoS Computational Biology. Feb, 2012 | Pubmed ID: 22346743 Computational Models of VEGF-associated Angiogenic Processes in Cancer Mathematical Medicine and Biology : a Journal of the IMA. Mar, 2012 | Pubmed ID: 21266494 Computational Modeling of Interacting VEGF and Soluble VEGF Receptor Concentration Gradients Frontiers in Physiology. 2011 | Pubmed ID: 22007175 Formation of VEGF Isoform-specific Spatial Distributions Governing Angiogenesis: Computational Analysis BMC Systems Biology. 2011 | Pubmed ID: 21535871 Module-based Multiscale Simulation of Angiogenesis in Skeletal Muscle Theoretical Biology & Medical Modelling. 2011 | Pubmed ID: 21463529 Systems Analysis of Small Signaling Modules Relevant to Eight Human Diseases Annals of Biomedical Engineering. Feb, 2011 | Pubmed ID: 21132372 Selective Activation of Sphingosine 1-phosphate Receptors 1 and 3 Promotes Local Microvascular Network Growth Tissue Engineering. Part A. Mar, 2011 | Pubmed ID: 20874260 Increase of Plasma VEGF After Intravenous Administration of Bevacizumab is Predicted by a Pharmacokinetic Model Cancer Research. Dec, 2010 | Pubmed ID: 21118974 Systems Biology of Pro-angiogenic Therapies Targeting the VEGF System Wiley Interdisciplinary Reviews. Systems Biology and Medicine. Nov-Dec, 2010 | Pubmed ID: 20890966 Gene Therapy from the Perspective of Systems Biology Current Opinion in Molecular Therapeutics. Oct, 2010 | Pubmed ID: 20886389 Quantifying the Proteolytic Release of Extracellular Matrix-sequestered VEGF with a Computational Model PloS One. 2010 | Pubmed ID: 20686621 Collateral Capillary Arterialization Following Arteriolar Ligation in Murine Skeletal Muscle Microcirculation (New York, N.Y. : 1994). Jul, 2010 | Pubmed ID: 20618691 VEGF and Soluble VEGF Receptor-1 (sFlt-1) Distributions in Peripheral Arterial Disease: an in Silico Model American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2010 | Pubmed ID: 20382861 A Systems Biology Perspective on SVEGFR1: Its Biological Function, Pathogenic Role and Therapeutic Use Journal of Cellular and Molecular Medicine. Mar, 2010 | Pubmed ID: 19840194 The Presence of VEGF Receptors on the Luminal Surface of Endothelial Cells Affects VEGF Distribution and VEGF Signaling PLoS Computational Biology. Dec, 2009 | Pubmed ID: 20041209 Modeling of Growth Factor-receptor Systems from Molecular-level Protein Interaction Networks to Whole-body Compartment Models Methods in Enzymology. 2009 | Pubmed ID: 19897104 A Compartment Model of VEGF Distribution in Humans in the Presence of Soluble VEGF Receptor-1 Acting As a Ligand Trap PloS One. 2009 | Pubmed ID: 19352513 Computational Kinetic Model of VEGF Trapping by Soluble VEGF Receptor-1: Effects of Transendothelial and Lymphatic Macromolecular Transport Physiological Genomics. Jun, 2009 | Pubmed ID: 19351908 Multiscale Models of Angiogenesis IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society. Mar-Apr, 2009 | Pubmed ID: 19349248 A Compartment Model of VEGF Distribution in Blood, Healthy and Diseased Tissues BMC Systems Biology. 2008 | Pubmed ID: 18713470 Systems Biology of Vascular Endothelial Growth Factors Microcirculation (New York, N.Y. : 1994). Nov, 2008 | Pubmed ID: 18608994 Trans-scleral Delivery of Antiangiogenic Proteins Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics. Feb, 2008 | Pubmed ID: 18370877 Skeletal Muscle VEGF Gradients in Peripheral Arterial Disease: Simulations of Rest and Exercise American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2007 | Pubmed ID: 17890434 Dimerization of VEGF Receptors and Implications for Signal Transduction: a Computational Study Biophysical Chemistry. Jul, 2007 | Pubmed ID: 17442480 Multi-scale Computational Models of Pro-angiogenic Treatments in Peripheral Arterial Disease Annals of Biomedical Engineering. Jun, 2007 | Pubmed ID: 17436110 Protein Transport to Choroid and Retina Following Periocular Injection: Theoretical and Experimental Study Annals of Biomedical Engineering. Apr, 2007 | Pubmed ID: 17277991 VEGF Gradients, Receptor Activation, and Sprout Guidance in Resting and Exercising Skeletal Muscle Journal of Applied Physiology (Bethesda, Md. : 1985). Feb, 2007 | Pubmed ID: 17038488 Interactions of VEGF Isoforms with VEGFR-1, VEGFR-2, and Neuropilin in Vivo: a Computational Model of Human Skeletal Muscle American Journal of Physiology. Heart and Circulatory Physiology. Jan, 2007 | Pubmed ID: 16980341 Targeting Neuropilin-1 to Inhibit VEGF Signaling in Cancer: Comparison of Therapeutic Approaches PLoS Computational Biology. Dec, 2006 | Pubmed ID: 17196035 Computational Model of Vascular Endothelial Growth Factor Spatial Distribution in Muscle and Pro-angiogenic Cell Therapy PLoS Computational Biology. Sep, 2006 | Pubmed ID: 17002494 Monte Carlo Simulations of VEGF Binding to Cell Surface Receptors in Vitro Biochimica Et Biophysica Acta. Dec, 2005 | Pubmed ID: 16257459 Differential Binding of VEGF Isoforms to VEGF Receptor 2 in the Presence of Neuropilin-1: a Computational Model American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2005 | Pubmed ID: 15708957 Model of Competitive Binding of Vascular Endothelial Growth Factor and Placental Growth Factor to VEGF Receptors on Endothelial Cells American Journal of Physiology. Heart and Circulatory Physiology. Jan, 2004 | Pubmed ID: 12714333 Murine Spinotrapezius Model to Assess the Impact of Arteriolar Ligation on Microvascular Function and Remodeling Alexander Michael Guendel*1, Kyle S. Martin*1, Joshua Cutts2, Patricia L. Foley3, Alexander M. Bailey1, Feilim Mac Gabhann4, Trevor R. Cardinal2, Shayn M. Peirce1 1Department of Biomedical Engineering, University of Virginia, 2Department of Biomedical Engineering, California Polytechnic State University, 3Office of Animal Welfare, University of Virginia, 4Department of Biomedical Engineering & Institute for Computational Medicine, Johns Hopkins University JoVE 50218 Medicine
Murine Spinotrapezius Model to Assess the Impact of Arteriolar Ligation on Microvascular Function and Remodeling Alexander Michael Guendel*1, Kyle S. Martin*1, Joshua Cutts2, Patricia L. Foley3, Alexander M. Bailey1, Feilim Mac Gabhann4, Trevor R. Cardinal2, Shayn M. Peirce1 1Department of Biomedical Engineering, University of Virginia, 2Department of Biomedical Engineering, California Polytechnic State University, 3Office of Animal Welfare, University of Virginia, 4Department of Biomedical Engineering & Institute for Computational Medicine, Johns Hopkins University JoVE 50218 Medicine