Jose L. Jorcano Division of Epithelial Biomedicine CIEMAT Biography Publications Institution JoVE Articles Jose L. Jorcano has not added a biography. If you are Jose L. Jorcano and would like to personalize this page please email our Author Liaison for assistance. Publications Tumor Initiation by Skin Ha-ras-ment Experimental Dermatology. Apr, 2015 | Pubmed ID: 25607847 Increased IKKα Expression in the Basal Layer of the Epidermis of Transgenic Mice Enhances the Malignant Potential of Skin Tumors PloS One. 2011 | Pubmed ID: 21755017 IKKbeta Leads to an Inflammatory Skin Disease Resembling Interface Dermatitis The Journal of Investigative Dermatology. Jun, 2010 | Pubmed ID: 20200541 IKKalpha Enhances Human Keratinocyte Differentiation and Determines the Histological Variant of Epidermal Squamous Cell Carcinomas Cell Cycle (Georgetown, Tex.). Jul, 2008 | Pubmed ID: 18604171 Modeling Normal and Pathological Processes Through Skin Tissue Engineering Molecular Carcinogenesis. Aug, 2007 | Pubmed ID: 17610222 Long-term Engraftment of Single Genetically Modified Human Epidermal Holoclones Enables Safety Pre-assessment of Cutaneous Gene Therapy Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2007 | Pubmed ID: 17579576 Epidermal Abnormalities and Increased Malignancy of Skin Tumors in Human Epidermal Keratin 8-expressing Transgenic Mice FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Oct, 2004 | Pubmed ID: 15319370 Inhibition of Xenografted Human Melanoma Growth and Prevention of Metastasis Development by Dual Antiangiogenic/antitumor Activities of Pigment Epithelium-derived Factor Cancer Research. Aug, 2004 | Pubmed ID: 15313901 A Keratin K5Cre Transgenic Line Appropriate for Tissue-specific or Generalized Cre-mediated Recombination Genesis (New York, N.Y. : 2000). May, 2004 | Pubmed ID: 15124227 Modulation of the Angiogenesis Response Through Ha-ras Control, Placenta Growth Factor, and Angiopoietin Expression in Mouse Skin Carcinogenesis Molecular Carcinogenesis. Jun, 2003 | Pubmed ID: 12766907 Abnormal Epidermal Differentiation and Impaired Epithelial-mesenchymal Tissue Interactions in Mice Lacking the Retinoblastoma Relatives P107 and P130 Development (Cambridge, England). Jun, 2003 | Pubmed ID: 12702649 Impaired NF-kappa B Activation and Increased Production of Tumor Necrosis Factor Alpha in Transgenic Mice Expressing Keratin K10 in the Basal Layer of the Epidermis The Journal of Biological Chemistry. Apr, 2003 | Pubmed ID: 12566451 Beyond Structure: Do Intermediate Filaments Modulate Cell Signalling? BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Sep, 2002 | Pubmed ID: 12210520 Severe Abnormalities in the Oral Mucosa Induced by Suprabasal Expression of Epidermal Keratin K10 in Transgenic Mice The Journal of Biological Chemistry. Sep, 2002 | Pubmed ID: 12119299 The Expression of Keratin K10 in the Basal Layer of the Epidermis Inhibits Cell Proliferation and Prevents Skin Tumorigenesis The Journal of Biological Chemistry. May, 2002 | Pubmed ID: 11889133 Analysis of the Ultraviolet B Response in Primary Human Keratinocytes Using Oligonucleotide Microarrays Proceedings of the National Academy of Sciences of the United States of America. Mar, 2002 | Pubmed ID: 11867738 Functional Roles of Akt Signaling in Mouse Skin Tumorigenesis Oncogene. Jan, 2002 | Pubmed ID: 11791176 Inhibition of Protein Kinase B (PKB) and PKCzeta Mediates Keratin K10-induced Cell Cycle Arrest Molecular and Cellular Biology. Nov, 2001 | Pubmed ID: 11585925 Increased Epidermal Tumors and Increased Skin Wound Healing in Transgenic Mice Overexpressing the Catalytic Subunit of Telomerase, MTERT, in Basal Keratinocytes The EMBO Journal. Jun, 2001 | Pubmed ID: 11387197 Skin and Hair Follicle Integrity is Crucially Dependent on Beta 1 Integrin Expression on Keratinocytes The EMBO Journal. Aug, 2000 | Pubmed ID: 10921880 Modulation of Cell Proliferation by Cytokeratins K10 and K16 Molecular and Cellular Biology. Apr, 1999 | Pubmed ID: 10082575 Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform Ignacio Risueño1, Leticia Valencia1, Miguel Holgado2, Jose L. Jorcano3, Diego Velasco1,4 1Department of Bioengineering and Aerospace Engineering, Universidad Carlos III de Madrid (UC3M), 2Group of Optics, Photonics and Biophotonics (GOFB). Center for Biomedical Technology, Universidad Politécnica de Madrid, 3Division of Epithelial Biomedicine, CIEMAT, 4Instituto de Investigación Sanitaria Gregorio Marañón JoVE 62353 Bioengineering
Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform Ignacio Risueño1, Leticia Valencia1, Miguel Holgado2, Jose L. Jorcano3, Diego Velasco1,4 1Department of Bioengineering and Aerospace Engineering, Universidad Carlos III de Madrid (UC3M), 2Group of Optics, Photonics and Biophotonics (GOFB). Center for Biomedical Technology, Universidad Politécnica de Madrid, 3Division of Epithelial Biomedicine, CIEMAT, 4Instituto de Investigación Sanitaria Gregorio Marañón JoVE 62353 Bioengineering