Leandro Castellano Department of Surgery and Cancer Imperial College London Biography Publications Institution JoVE Articles Leandro Castellano has not added a biography. If you are Leandro Castellano and would like to personalize this page please email our Author Liaison for assistance. Publications The Germline of the Malaria Mosquito Produces Abundant MiRNAs, Endo-siRNAs, PiRNAs and 29-nt Small RNAs BMC Genomics. Feb, 2015 | Pubmed ID: 25766668 Noncoding RNAs and the Control of Hormonal Signaling Via Nuclear Receptor Regulation Journal of Molecular Endocrinology. Oct, 2014 | Pubmed ID: 25062739 5' IsomiR Variation is of Functional and Evolutionary Importance Nucleic Acids Research. Aug, 2014 | Pubmed ID: 25056318 MiR-211 Modulates Gemcitabine Activity Through Downregulation of Ribonucleotide Reductase and Inhibits the Invasive Behavior of Pancreatic Cancer Cells Nucleosides, Nucleotides & Nucleic Acids. 2014 | Pubmed ID: 24940696 Growth Arrest-specific Transcript 5 Associated SnoRNA Levels Are Related to P53 Expression and DNA Damage in Colorectal Cancer PloS One. 2014 | Pubmed ID: 24926850 Quantification of Pancreatic Cancer Proteome and Phosphorylome: Indicates Molecular Events Likely Contributing to Cancer and Activity of Drug Targets PloS One. 2014 | Pubmed ID: 24670416 MiR-15b and MiR-17 Are Tumor-Derived Plasma MicroRNAs Dysregulated in Colorectal Neoplasia Annals of Surgery. Mar, 2014 | Pubmed ID: 24646542 Reduced Dissemination of Circulating Tumor Cells with No-touch Isolation Surgical Technique in Patients with Pancreatic Cancer JAMA Surgery. May, 2014 | Pubmed ID: 24599353 A MicroRNA Meta-signature for Pancreatic Ductal Adenocarcinoma Expert Review of Molecular Diagnostics. Apr, 2014 | Pubmed ID: 24575833 MicroRNAs Cooperatively Inhibit a Network of Tumor Suppressor Genes to Promote Pancreatic Tumor Growth and Progression Gastroenterology. Jan, 2014 | Pubmed ID: 24120476 Cell-free DNA for the Detection of Pancreatic, Liver and Upper Gastrointestinal Cancers: Has Progress Been Made? Future Oncology (London, England). Dec, 2013 | Pubmed ID: 24295416 MicroRNA-23b Regulates Cellular Architecture and Impairs Motogenic and Invasive Phenotypes During Cancer Progression Bioarchitecture. Jul-Aug, 2013 | Pubmed ID: 24002530 Downregulation of MicroRNA-515-5p by the Estrogen Receptor Modulates Sphingosine Kinase 1 and Breast Cancer Cell Proliferation Cancer Research. Oct, 2013 | Pubmed ID: 23928990 Emerging Roles of Competing Endogenous RNAs in Cancer: Insights from the Regulation of PTEN Molecular and Cellular Biology. Oct, 2013 | Pubmed ID: 23918803 The P53 MiRNA Interactome and Its Potential Role in the Cancer Clinic Epigenomics. Aug, 2013 | Pubmed ID: 23895654 Circulating Peripheral Blood Mononuclear Cells Exhibit Altered MiRNA Expression Patterns in Pancreatic Cancer Expert Review of Molecular Diagnostics. Jun, 2013 | Pubmed ID: 23782250 Distinct MiRNA Profiles Are Associated with Malignant Transformation of Pancreatic Cystic Tumors Revealing Potential Biomarkers for Clinical Use Expert Review of Molecular Diagnostics. May, 2013 | Pubmed ID: 23638815 MiR-23b Regulates Cytoskeletal Remodeling, Motility and Metastasis by Directly Targeting Multiple Transcripts Nucleic Acids Research. May, 2013 | Pubmed ID: 23580553 Blood-based MiRNAs As Noninvasive Diagnostic and Surrogative Biomarkers in Colorectal Cancer Expert Review of Molecular Diagnostics. Mar, 2013 | Pubmed ID: 23477554 Circulating Molecular Markers in Pancreatic Cancer: Ready for Clinical Use? Future Oncology (London, England). Feb, 2013 | Pubmed ID: 23414463 Deep Sequencing of Small RNAs Identifies Canonical and Non-canonical MiRNA and Endogenous SiRNAs in Mammalian Somatic Tissues Nucleic Acids Research. Mar, 2013 | Pubmed ID: 23325850 Altered Expression of the MiRNA Processing Endoribonuclease Dicer Has Prognostic Significance in Human Cancers Expert Review of Anticancer Therapy. Jan, 2013 | Pubmed ID: 23259424 Towards a Clinical Use of MiRNAs in Pancreatic Cancer Biopsies Expert Review of Molecular Diagnostics. Jan, 2013 | Pubmed ID: 23256701 Defining a Prognostic Molecular Profile for Ductal Adenocarcinoma of the Pancreas Highlights Known Key Signaling Pathways Expert Review of Anticancer Therapy. Oct, 2012 | Pubmed ID: 23176615 Breast Cancer Treatment and Adverse Cardiac Events: What Are the Molecular Mechanisms? Cardiology. 2012 | Pubmed ID: 22907032 Loss of MiR-126 is Crucial to Pancreatic Cancer Progression Expert Review of Anticancer Therapy. Jul, 2012 | Pubmed ID: 22845403 The Role of MiR-10b in Metastatic Pancreatic Ductal Adenocarcinoma Surgery. Nov, 2012 | Pubmed ID: 22682079 Retinoblastoma Protein Determines Aggressiveness in Triple-negative Breast Cancer Expert Review of Anticancer Therapy. May, 2012 | Pubmed ID: 22594893 Transcriptome-level Microarray Expression Profiling Implicates IGF-1 and Wnt Signalling Dysregulation in the Pathogenesis of Thyroid-associated Orbitopathy Journal of Clinical Pathology. Jul, 2012 | Pubmed ID: 22554965 MiRNAs in Breast Cancer: Ready for Real Time? Pharmacogenomics. Apr, 2012 | Pubmed ID: 22515613 The Clinico-pathologic Role of MicroRNAs MiR-9 and MiR-151-5p in Breast Cancer Metastasis Molecular Diagnosis & Therapy. Jun, 2012 | Pubmed ID: 22489664 MicroRNAs Targeting Oncogenes Are Down-regulated in Pancreatic Malignant Transformation from Benign Tumors PloS One. 2012 | Pubmed ID: 22384141 Integrated Analysis of MiRNA and MRNA Profiles Enables Target Acquisition in Human Cancers Expert Review of Anticancer Therapy. Mar, 2012 | Pubmed ID: 22369323 MicroRNAs As Markers of Survival and Chemoresistance in Pancreatic Ductal Adenocarcinoma Expert Review of Anticancer Therapy. Dec, 2011 | Pubmed ID: 22117151 Determination of Cut-offs for Circulating Tumor Cell Measurement in Metastatic Cancer Expert Review of Anticancer Therapy. Sep, 2011 | Pubmed ID: 21929309 Kinome Screening for Regulators of the Estrogen Receptor Identifies LMTK3 As a New Therapeutic Target in Breast Cancer Nature Medicine. Jun, 2011 | Pubmed ID: 21602804 No Evidence for a Polyomavirus Association or Aetiology in AIDS-associated Nonsmall Cell Lung Cancer AIDS (London, England). May, 2010 | Pubmed ID: 20400884 No Evidence for a Viral Association or Aetiology in Pancreatic Cancer Molecular Immunology. Jan, 2010 | Pubmed ID: 19932507 The Estrogen Receptor-alpha-induced MicroRNA Signature Regulates Itself and Its Transcriptional Response Proceedings of the National Academy of Sciences of the United States of America. Sep, 2009 | Pubmed ID: 19706389 CK1delta Modulates the Transcriptional Activity of ERalpha Via AIB1 in an Estrogen-dependent Manner and Regulates ERalpha-AIB1 Interactions Nucleic Acids Research. May, 2009 | Pubmed ID: 19339517 Bendamustine As a Model for the Activity of Alkylating Agents Future Oncology (London, England). Jun, 2008 | Pubmed ID: 18518757 Quantitative Technologies Establish a Novel MicroRNA Profile of Chronic Lymphocytic Leukemia Blood. Jun, 2007 | Pubmed ID: 17327404 Mammosphere Formation Assay from Human Breast Cancer Tissues and Cell Lines Ylenia Lombardo*1, Alexander de Giorgio*1, Charles R. Coombes1, Justin Stebbing1, Leandro Castellano1 1Department of Surgery and Cancer, Imperial College London JoVE 52671 Medicine
Mammosphere Formation Assay from Human Breast Cancer Tissues and Cell Lines Ylenia Lombardo*1, Alexander de Giorgio*1, Charles R. Coombes1, Justin Stebbing1, Leandro Castellano1 1Department of Surgery and Cancer, Imperial College London JoVE 52671 Medicine