Manfred S. Weiss Macromolecular Crystallography Helmholtz-Zentrum Berlin Biography Publications Institution JoVE Articles Manfred S. Weiss 1989 - 1992 Ph.D. student at the Albert-Ludwigs-University Freiburg i. Br.1992 - 1996 Postdoc at University of California at Los Angeles1996 - 2001 Senior Research Assistant at the Institute of Molecular Biotechnology in Jena2001 - 2009 Team Leader at the EMBL Hamburg Outstation2009-present Helmholtz-Zentrum Berlin Publications The Hypothetical Periplasmic Protein PA1624 from Pseudomonas Aeruginosa Folds into a Unique Two-domain Structure Acta Crystallographica. Section F, Structural Biology Communications. Dec, 2020 | Pubmed ID: 33263573 Insulin Polymorphism Induced by Two Polyphenols: New Crystal Forms and Advances in Macromolecular Powder Diffraction Acta Crystallographica. Section D, Structural Biology. Nov, 2020 | Pubmed ID: 33135678 Prolidase - A Protein with Many Faces Biochimie. Oct, 2020 | Pubmed ID: 33045291 The Susceptibility of Disulfide Bonds Towards Radiation Damage May Be Explained by S⋯O Interactions IUCrJ. Sep, 2020 | Pubmed ID: 32939274 Co-expression with Chaperones Can Affect Protein 3D Structure As Exemplified by Loss-of-function Variants of Human Prolidase FEBS Letters. Sep, 2020 | Pubmed ID: 32598484 F2X-Universal and F2X-Entry: Structurally Diverse Compound Libraries for Crystallographic Fragment Screening Structure (London, England : 1993). 06, 2020 | Pubmed ID: 32413289 Regioselectivity of Hyoscyamine 6β-hydroxylase-catalysed Hydroxylation As Revealed by High-resolution Structural Information and QM/MM Calculations Dalton Transactions (Cambridge, England : 2003). Apr, 2020 | Pubmed ID: 32182320 In Situ Imine-Based Linker Formation for the Synthesis of Zirconium MOFs: A Route to CO Capture Materials and Ethylene Oligomerization Catalysts Inorganic Chemistry. Jan, 2020 | Pubmed ID: 31820946 Structure-Based Screening of Tetrazolylhydrazide Inhibitors Versus KDM4 Histone Demethylases ChemMedChem. 11, 2019 | Pubmed ID: 31475772 Underlying Molecular Alterations in Human Dihydrolipoamide Dehydrogenase Deficiency Revealed by Structural Analyses of Disease-causing Enzyme Variants Human Molecular Genetics. 10, 2019 | Pubmed ID: 31334547 Findable Accessible Interoperable Re-usable (FAIR) Diffraction Data Are Coming to Protein Crystallography Journal of Applied Crystallography. Jun, 2019 | Pubmed ID: 31236090 Findable Accessible Interoperable Re-usable (FAIR) Diffraction Data Are Coming to Protein Crystallography IUCrJ. May, 2019 | Pubmed ID: 31098014 Findable Accessible Interoperable Re-usable (FAIR) Diffraction Data Are Coming to Protein Crystallography Acta Crystallographica. Section D, Structural Biology. May, 2019 | Pubmed ID: 31063147 Findable Accessible Interoperable Re-usable (FAIR) Diffraction Data Are Coming to Protein Crystallography Acta Crystallographica. Section F, Structural Biology Communications. May, 2019 | Pubmed ID: 31045560 Structure of the Plastic-degrading Ideonella Sakaiensis MHETase Bound to a Substrate Nature Communications. 04, 2019 | Pubmed ID: 30979881 MXCuBE2: the Dawn of MXCuBE Collaboration Journal of Synchrotron Radiation. Mar, 2019 | Pubmed ID: 30855248 Elucidating the Formation and Transformation Mechanisms of the Switchable Metal-Organic Framework ELM-11 by Powder and Single-Crystal EPR Study Inorganic Chemistry. Oct, 2018 | Pubmed ID: 30207461 Structural Basis for Prolidase Deficiency Disease Mechanisms The FEBS Journal. 09, 2018 | Pubmed ID: 30066404 Crystal Structures of the Disease-causing D444V Mutant and the Relevant Wild Type Human Dihydrolipoamide Dehydrogenase Free Radical Biology & Medicine. 08, 2018 | Pubmed ID: 29908278 Substrate Specificity and Reaction Mechanism of Human Prolidase The FEBS Journal. 09, 2017 | Pubmed ID: 28677335 Long-Wavelength X-Ray Diffraction and Its Applications in Macromolecular Crystallography Methods in Molecular Biology (Clifton, N.J.). Month, 2017 | Pubmed ID: 28573583 Active Site Mapping of an Aspartic Protease by Multiple Fragment Crystal Structures: Versatile Warheads To Address a Catalytic Dyad Journal of Medicinal Chemistry. 11, 2016 | Pubmed ID: 27726357 A Critical Examination of the Recently Reported Crystal Structures of the Human SMN Protein Human Molecular Genetics. 08, 2016 | Pubmed ID: 27577872 Experimental Active-Site Mapping by Fragments: Hot Spots Remote from the Catalytic Center of Endothiapepsin Journal of Medicinal Chemistry. 08, 2016 | Pubmed ID: 27463859 High-Throughput Crystallography: Reliable and Efficient Identification of Fragment Hits Structure (London, England : 1993). 08, 2016 | Pubmed ID: 27452405 Structure-based Epitope Mapping of Mycobacterium Tuberculosis Secretary Antigen MTC28 The Journal of Biological Chemistry. Jul, 2016 | Pubmed ID: 27189947 Structures of Endothiapepsin-fragment Complexes from Crystallographic Fragment Screening Using a Novel, Diverse and Affordable 96-compound Fragment Library Acta Crystallographica. Section F, Structural Biology Communications. 05, 2016 | Pubmed ID: 27139825 Six Biophysical Screening Methods Miss a Large Proportion of Crystallographically Discovered Fragment Hits: A Case Study ACS Chemical Biology. 06, 2016 | Pubmed ID: 27028906 Dual Role of the Active Site Residues of Thermus Thermophilus 3-Isopropylmalate Dehydrogenase: Chemical Catalysis and Domain Closure Biochemistry. Jan, 2016 | Pubmed ID: 26731489 Combining Dehydration, Construct Optimization and Improved Data Collection to Solve the Crystal Structure of a CRM1-RanGTP-SPN1-Nup214 Quaternary Nuclear Export Complex Acta Crystallographica. Section F, Structural Biology Communications. Dec, 2015 | Pubmed ID: 26625290 Native SAD is Maturing IUCrJ. Jul, 2015 | Pubmed ID: 26175902 Macromolecular Crystallography and What It Can Contribute to Antiparasite Drug Discovery Acta Crystallographica. Section F, Structural Biology Communications. May, 2015 | Pubmed ID: 25945700 Against the Odds? De Novo Structure Determination of a Pilin with Two Cysteine Residues by Sulfur SAD Acta Crystallographica. Section D, Biological Crystallography. May, 2015 | Pubmed ID: 25945575 Glutamate 270 Plays an Essential Role in K(+)-activation and Domain Closure of Thermus Thermophilus Isopropylmalate Dehydrogenase FEBS Letters. Jan, 2015 | Pubmed ID: 25497013 The Times They Are A-changin' - News from Acta Crystallographica Section F Acta Crystallographica. Section F, Structural Biology Communications. Dec, 2014 | Pubmed ID: 25484202 Protein Crystalline Frameworks with Controllable Interpenetration Directed by Dual Supramolecular Interactions Nature Communications. Aug, 2014 | Pubmed ID: 25144207 Structural Sampling of Glycan Interaction Profiles Reveals Mucosal Receptors for Fimbrial Adhesins of Enterotoxigenic Escherichia Coli Biology. Jul, 2013 | Pubmed ID: 24833052 Big Changes Are Ahead--a New Format for Crystallization Communications in Acta Cryst. F Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Dec, 2013 | Pubmed ID: 24316820 Cloning, Expression, Purification, Crystallization and Preliminary X-ray Diffraction Analysis of AHP2, a Signal Transmitter Protein from Arabidopsis Thaliana Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Feb, 2013 | Pubmed ID: 23385758 Structure Determination by Multiple-wavelength Anomalous Dispersion (MAD) at the Pr LIII Edge Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Aug, 2012 | Pubmed ID: 22869138 Facilities for Macromolecular Crystallography at The Helmholtz-Zentrum Berlin Journal of Synchrotron Radiation. May, 2012 | Pubmed ID: 22514183 Review Panel for Acta Crystallographica Section F Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Nov, 2011 | Pubmed ID: 22102222 Publishing Structural Genomics Results Continued: the SSGCID Special Issue Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Oct, 2011 | Pubmed ID: 22102017 Crystallization and Preliminary X-ray Diffraction Analysis of the Wild-type Haloalkane Dehalogenase DhaA and Its Variant DhaA13 Complexed with Different Ligands Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Feb, 2011 | Pubmed ID: 21301099 Citations in Supplementary Material Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Dec, 2010 | Pubmed ID: 21139193 Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin Jan Wollenhaupt1, Tatjana Barthel1,2, Gustavo M. A. Lima3, Alexander Metz4, Dirk Wallacher5, Elmir Jagudin3, Franziska U. Huschmann1,4, Thomas Hauß1, Christian G. Feiler1, Martin Gerlach1, Michael Hellmig1, Ronald Förster1, Michael Steffien1, Andreas Heine4, Gerhard Klebe4, Uwe Mueller1, Manfred S. Weiss1 1Macromolecular Crystallography, Helmholtz-Zentrum Berlin, 2Structural Biochemistry Group, Institute for Chemistry and Biochemistry, Freie Universität Berlin, 3BioMAX, MAX IV Laboratory, 4Drug Design Group, Institute of Pharmaceutical Chemistry, Philipps-Universität Marburg, 5Department Sample Environment, Helmholtz-Zentrum Berlin JoVE 62208 Biochemistry An All-in-one Sample Holder for Macromolecular X-ray Crystallography with Minimal Background Scattering Christian G. Feiler1, Dirk Wallacher2, Manfred S. Weiss1 1Macromolecular Crystallography (HZB-MX), Helmholtz-Zentrum Berlin, 2Department Sample Environment, Helmholtz-Zentrum Berlin JoVE 59722 Biochemistry
Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin Jan Wollenhaupt1, Tatjana Barthel1,2, Gustavo M. A. Lima3, Alexander Metz4, Dirk Wallacher5, Elmir Jagudin3, Franziska U. Huschmann1,4, Thomas Hauß1, Christian G. Feiler1, Martin Gerlach1, Michael Hellmig1, Ronald Förster1, Michael Steffien1, Andreas Heine4, Gerhard Klebe4, Uwe Mueller1, Manfred S. Weiss1 1Macromolecular Crystallography, Helmholtz-Zentrum Berlin, 2Structural Biochemistry Group, Institute for Chemistry and Biochemistry, Freie Universität Berlin, 3BioMAX, MAX IV Laboratory, 4Drug Design Group, Institute of Pharmaceutical Chemistry, Philipps-Universität Marburg, 5Department Sample Environment, Helmholtz-Zentrum Berlin JoVE 62208 Biochemistry
An All-in-one Sample Holder for Macromolecular X-ray Crystallography with Minimal Background Scattering Christian G. Feiler1, Dirk Wallacher2, Manfred S. Weiss1 1Macromolecular Crystallography (HZB-MX), Helmholtz-Zentrum Berlin, 2Department Sample Environment, Helmholtz-Zentrum Berlin JoVE 59722 Biochemistry