Martin Marsala Neuroregeneration Laboratory, Department of Anesthesiology University of California, San Diego Biography Publications Institution JoVE Articles Martin Marsala has not added a biography. If you are Martin Marsala and would like to personalize this page please email our Author Liaison for assistance. Publications Immunosurveillance and Immunoediting in MMTV-PyMT-induced Mammary Oncogenesis Oncoimmunology. 2017 | Pubmed ID: 28344881 A Robust Vitronectin-derived Peptide for the Scalable Long-term Expansion and Neuronal Differentiation of Human Pluripotent Stem Cell (hPSC)-derived Neural Progenitor Cells (hNPCs) Acta Biomaterialia. Jan, 2017 | Pubmed ID: 27989923 A Review of Stem Cell Therapy for Spinal Cord Injury: Large Animal Models and the Frontier in Humans World Neurosurgery. Feb, 2017 | Pubmed ID: 27876663 Potent Spinal Parenchymal AAV9-mediated Gene Delivery by Subpial Injection in Adult Rats and Pigs Molecular Therapy. Methods & Clinical Development. 2016 | Pubmed ID: 27462649 172 A Phase I, Open-Label, Single-Site, Safety Study of Human Spinal Cord-Derived Neural Stem Cell Transplantation for the Treatment of Chronic Spinal Cord Injury Neurosurgery. Aug, 2016 | Pubmed ID: 27399451 Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs Neuron. May, 2016 | Pubmed ID: 27112497 Surface N-glycoproteome Patterns Reveal Key Proteins of Neuronal Differentiation Journal of Proteomics. Jan, 2016 | Pubmed ID: 26581640 The α5 Subunit Containing GABAA Receptors Contribute to Chronic Pain Pain. Mar, 2016 | Pubmed ID: 26545088 Thoracic 9 Spinal Transection-Induced Model of Muscle Spasticity in the Rat: A Systematic Electrophysiological and Histopathological Characterization PloS One. 2015 | Pubmed ID: 26713446 Human Mutant Huntingtin Disrupts Vocal Learning in Transgenic Songbirds Nature Neuroscience. Nov, 2015 | Pubmed ID: 26436900 Large Animal and Primate Models of Spinal Cord Injury for the Testing of Novel Therapies Experimental Neurology. Apr, 2015 | Pubmed ID: 25902036 Macrophage Migration Inhibitory Factor As a Chaperone Inhibiting Accumulation of Misfolded SOD1 Neuron. Apr, 2015 | Pubmed ID: 25801706 Proteome-wide Analysis of Neural Stem Cell Differentiation to Facilitate Transition to Cell Replacement Therapies Expert Review of Proteomics. Feb, 2015 | Pubmed ID: 25363140 Baclofen or NNOS Inhibitor Affect Molecular and Behavioral Alterations Evoked by Traumatic Spinal Cord Injury in Rat Spinal Cord The Spine Journal : Official Journal of the North American Spine Society. Jun, 2015 | Pubmed ID: 25151131 Neural Stem Cells in Models of Spinal Cord Injury Experimental Neurology. Jul, 2014 | Pubmed ID: 25079369 Pig Models of Neurodegenerative Disorders: Utilization in Cell Replacement-based Preclinical Safety and Efficacy Studies The Journal of Comparative Neurology. Aug, 2014 | Pubmed ID: 24610493 Neural Stem Cell Dissemination After Grafting to CNS Injury Sites Cell. Jan, 2014 | Pubmed ID: 24485445 Repeated Baclofen Treatment Ameliorates Motor Dysfunction, Suppresses Reflex Activity and Decreases the Expression of Signaling Proteins in Reticular Nuclei and Lumbar Motoneurons After Spinal Trauma in Rats Acta Histochemica. Mar, 2014 | Pubmed ID: 24074748 A Transgenic Minipig Model of Huntington's Disease Journal of Huntington's Disease. 2013 | Pubmed ID: 25063429 Signaling Proteins in Spinal Parenchyma and Dorsal Root Ganglion in Rat with Spinal Injury-induced Spasticity Journal of Proteomics. Oct, 2013 | Pubmed ID: 23835433 Effective Long-term Immunosuppression in Rats by Subcutaneously Implanted Sustained-release Tacrolimus Pellet: Effect on Spinally Grafted Human Neural Precursor Survival Experimental Neurology. Oct, 2013 | Pubmed ID: 23748136 Amelioration of Motor/sensory Dysfunction and Spasticity in a Rat Model of Acute Lumbar Spinal Cord Injury by Human Neural Stem Cell Transplantation Stem Cell Research & Therapy. May, 2013 | Pubmed ID: 23710605 ALS-linked TDP-43 Mutations Produce Aberrant RNA Splicing and Adult-onset Motor Neuron Disease Without Aggregation or Loss of Nuclear TDP-43 Proceedings of the National Academy of Sciences of the United States of America. Feb, 2013 | Pubmed ID: 23382207 Long-distance Growth and Connectivity of Neural Stem Cells After Severe Spinal Cord Injury Cell. Sep, 2012 | Pubmed ID: 22980985 Human Neural Stem Cell Replacement Therapy for Amyotrophic Lateral Sclerosis by Spinal Transplantation PloS One. 2012 | Pubmed ID: 22916141 Development of AMPA Receptor and GABA B Receptor-sensitive Spinal Hyper-reflexia After Spinal Air Embolism in Rat: a Systematic Neurological, Electrophysiological and Qualitative Histopathological Study Experimental Neurology. Sep, 2012 | Pubmed ID: 22721766 Elevated PGC-1α Activity Sustains Mitochondrial Biogenesis and Muscle Function Without Extending Survival in a Mouse Model of Inherited ALS Cell Metabolism. May, 2012 | Pubmed ID: 22560226 In Vivo Gene Knockdown in Rat Dorsal Root Ganglia Mediated by Self-complementary Adeno-associated Virus Serotype 5 Following Intrathecal Delivery PloS One. 2012 | Pubmed ID: 22403675 Combinational Spinal GAD65 Gene Delivery and Systemic GABA-mimetic Treatment for Modulation of Spasticity PloS One. 2012 | Pubmed ID: 22291989 Probing Sporadic and Familial Alzheimer's Disease Using Induced Pluripotent Stem Cells Nature. Feb, 2012 | Pubmed ID: 22278060 Chronic Spinal Compression Model in Minipigs: a Systematic Behavioral, Qualitative, and Quantitative Neuropathological Study Journal of Neurotrauma. Feb, 2012 | Pubmed ID: 22029501 Spinal Cord Transection Modifies Neuronal Nitric Oxide Synthase Expression in Medullar Reticular Nuclei and in the Spinal Cord and Increases Parvalbumin Immunopositivity in Motoneurons Below the Site of Injury in Experimental Rabbits Acta Histochemica. Sep, 2012 | Pubmed ID: 22000862 Optimization of Immunosuppressive Therapy for Spinal Grafting of Human Spinal Stem Cells in a Rat Model of ALS Cell Transplantation. 2011 | Pubmed ID: 21669047 Cell-surface Marker Signatures for the Isolation of Neural Stem Cells, Glia and Neurons Derived from Human Pluripotent Stem Cells PloS One. 2011 | Pubmed ID: 21407814 Identification of NO/sGC Signalling in the Bulbospinal Respiratory Pathway After C2-C3 Hemisection of the Spinal Cord in Rats Acta Histochemica. Nov, 2011 | Pubmed ID: 21145575 Suppression of Stretch Reflex Activity After Spinal or Systemic Treatment with AMPA Receptor Antagonist NGX424 in Rats with Developed Baclofen Tolerance British Journal of Pharmacology. Nov, 2010 | Pubmed ID: 20977450 The ROCK Inhibitor Y-27632 Improves Recovery of Human Embryonic Stem Cells After Fluorescence-activated Cell Sorting with Multiple Cell Surface Markers PloS One. 2010 | Pubmed ID: 20730054 Analysis of Dosing Regimen and Reproducibility of Intraspinal Grafting of Human Spinal Stem Cells in Immunosuppressed Minipigs Cell Transplantation. 2010 | Pubmed ID: 20412634 The Pleotrophic Effects of Insulin-like Growth Factor-I on Human Spinal Cord Neural Progenitor Cells Stem Cells and Development. Dec, 2010 | Pubmed ID: 20406098 Down-regulation of the Potassium-chloride Cotransporter KCC2 Contributes to Spasticity After Spinal Cord Injury Nature Medicine. Mar, 2010 | Pubmed ID: 20190766 Transcriptional Signature and Memory Retention of Human-induced Pluripotent Stem Cells PloS One. Sep, 2009 | Pubmed ID: 19763270 Stem Cells: Comprehensive Treatments for Amyotrophic Lateral Sclerosis in Conjunction with Growth Factor Delivery Growth Factors (Chur, Switzerland). Jun, 2009 | Pubmed ID: 19294549 The Rheb-mTOR Pathway is Upregulated in Reactive Astrocytes of the Injured Spinal Cord The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2009 | Pubmed ID: 19176818 Mutant Dynein (Loa) Triggers Proprioceptive Axon Loss That Extends Survival Only in the SOD1 ALS Model with Highest Motor Neuron Death Proceedings of the National Academy of Sciences of the United States of America. Aug, 2008 | Pubmed ID: 18719118 The Effect of N-nitro-L-arginine and Aminoguanidine Treatment on Changes in Constitutive and Inducible Nitric Oxide Synthases in the Spinal Cord After Sciatic Nerve Transection International Journal of Molecular Medicine. Apr, 2008 | Pubmed ID: 18360686 Spinal Astrocyte Glutamate Receptor 1 Overexpression After Ischemic Insult Facilitates Behavioral Signs of Spasticity and Rigidity The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2007 | Pubmed ID: 17942713 Intravenous Infusion of Dexmedetomidine Can Prevent the Degeneration of Spinal Ventral Neurons Induced by Intrathecal Morphine After a Noninjurious Interval of Spinal Cord Ischemia in Rats Anesthesia and Analgesia. Oct, 2007 | Pubmed ID: 17898393 Cell Therapy and Stem Cells in Animal Models of Motor Neuron Disorders The European Journal of Neuroscience. Oct, 2007 | Pubmed ID: 17897390 Morphologic and Volumetric Studies of the Meibomian Glands in Elderly Human Eyelids Cornea. Jun, 2007 | Pubmed ID: 17525661 The Distribution of Primary Nitric Oxide Synthase- and Parvalbumin- Immunoreactive Afferents in the Dorsal Funiculus of the Lumbosacral Spinal Cord in a Dog Cellular and Molecular Neurobiology. Jun, 2007 | Pubmed ID: 17387607 Low-speed Subcellular Fractionation Method for Determining Noxious Stimulus-evoked Spinal Neurokinin-1 Receptor Internalization Journal of Neuroscience Methods. Mar, 2007 | Pubmed ID: 17083983 The Effect of a Spinal Cord Hemisection on Changes in Nitric Oxide Synthase Pools in the Site of Injury and in Regions Located Far Away from the Injured Site Cellular and Molecular Neurobiology. Oct-Nov, 2006 | Pubmed ID: 16786429 Nitrergic Proprioceptive Afferents Originating from Quadriceps Femoris Muscle Are Related to Monosynaptic Ia-motoneuron Stretch Reflex Circuit in the Dog Cellular and Molecular Neurobiology. Oct-Nov, 2006 | Pubmed ID: 16724275 Development of Baclofen Tolerance in a Rat Model of Chronic Spasticity and Rigidity Neuroscience Letters. Jul, 2006 | Pubmed ID: 16716507 Immunohistochemical, Histochemical and Radioassay Analysis of Nitric Oxide Synthase Immunoreactivity in the Lumbar and Sacral Dorsal Root Ganglia of the Dog Cellular and Molecular Neurobiology. Feb, 2006 | Pubmed ID: 16633899 Measurement of Peripheral Muscle Resistance in Rats with Chronic Ischemia-induced Paraplegia or Morphine-induced Rigidity Using a Semi-automated Computer-controlled Muscle Resistance Meter Journal of Neurotrauma. Nov, 2005 | Pubmed ID: 16305323 The Evidence for Nitric Oxide Synthase Immunopositivity in the Monosynaptic Ia-motoneuron Pathway of the Dog Experimental Neurology. Sep, 2005 | Pubmed ID: 15979072 The Activation of Spinal N-methyl-D-aspartate Receptors May Contribute to Degeneration of Spinal Motor Neurons Induced by Neuraxial Morphine After a Noninjurious Interval of Spinal Cord Ischemia Anesthesia and Analgesia. Feb, 2005 | Pubmed ID: 15673851 Synaptogenesis and Amino Acid Release from Long Term Embryonic Rat Spinal Cord Neuronal Culture Using Tissue Culture Inserts Journal of Neuroscience Methods. Jan, 2005 | Pubmed ID: 15585285 Spinal Implantation of HNT Neurons and Neuronal Precursors: Graft Survival and Functional Effects in Rats with Ischemic Spastic Paraplegia The European Journal of Neuroscience. Nov, 2004 | Pubmed ID: 15525281 Region-specific Cell Grafting into Cervical and Lumbar Spinal Cord in Rat: a Qualitative and Quantitative Stereological Study Experimental Neurology. Nov, 2004 | Pubmed ID: 15473986 Loop Dialysis Catheter: a Technology for Chronic Spinal Dialysis in a Freely Moving Rat Methods in Molecular Medicine. 2004 | Pubmed ID: 15131332 Premotor Nitric Oxide Synthase Immunoreactive Pathway Connecting Lumbar Segments with the Ventral Motor Nucleus of the Cervical Enlargement in the Dog Journal of Chemical Neuroanatomy. Mar, 2004 | Pubmed ID: 15036362 The Effect of Cauda Equina Constriction on Nitric Oxide Synthase Activity Neurochemical Research. Feb, 2004 | Pubmed ID: 15002741 Characterization of Spinal HSP72 Induction and Development of Ischemic Tolerance After Spinal Ischemia in Rats Experimental Neurology. Jan, 2004 | Pubmed ID: 14697321 Mediators of Ischemic Preconditioning Identified by Microarray Analysis of Rat Spinal Cord Experimental Neurology. Jan, 2004 | Pubmed ID: 14697320 Spinal Heat Shock Protein (70) Expression: Effect of Spinal Ischemia, Hyperthermia (42 Degrees C)/hypothermia (27 Degrees C), NMDA Receptor Activation and Potassium Evoked Depolarization on the Induction Neurochemistry International. Jan, 2004 | Pubmed ID: 12963088 Changes in Spinal GDNF, BDNF, and NT-3 Expression After Transient Spinal Cord Ischemia in the Rat Journal of Neuroscience Research. Nov, 2003 | Pubmed ID: 14598299 Effects of OP-1206 Alpha-CD on Walking Dysfunction in the Rat Neuropathic Intermittent Claudication Model: Comparison with Nifedipine, Ticlopidine and Cilostazol Prostaglandins & Other Lipid Mediators. Jul, 2003 | Pubmed ID: 14518565 Activation of P38 Mitogen-activated Protein Kinase in Spinal Microglia is a Critical Link in Inflammation-induced Spinal Pain Processing Journal of Neurochemistry. Sep, 2003 | Pubmed ID: 12950462 Effects of Orally Administered OP-1206 Alpha-CD with Loxoprofen-Na on Walking Dysfunction in the Rat Neuropathic Intermittent Claudication Model Prostaglandins, Leukotrienes, and Essential Fatty Acids. Oct, 2003 | Pubmed ID: 12907137 Localization and Distribution Patterns of Nicotinamide Adenine Dinucleotide Phosphate Diaphorase Exhibiting Axons in the White Matter of the Spinal Cord of the Rabbit Cellular and Molecular Neurobiology. Feb, 2003 | Pubmed ID: 12701884 Spinal Adenosine Agonist Reduces C-fos and Astrocyte Activation in Dorsal Horn of Rats with Adjuvant-induced Arthritis Neuroscience Letters. Apr, 2003 | Pubmed ID: 12668251 Neuraxial Morphine May Trigger Transient Motor Dysfunction After a Noninjurious Interval of Spinal Cord Ischemia: a Clinical and Experimental Study Anesthesiology. Apr, 2003 | Pubmed ID: 12657847 Spinal Amino Acid Release and Repeated Withdrawal in Spinal Morphine Tolerant Rats British Journal of Pharmacology. Feb, 2003 | Pubmed ID: 12598423 Peripheral Axotomy Affects Nicotinamide Adenine Dinucleotide Phosphate Diaphorase and Nitric Oxide Synthases in the Spinal Cord of the Rabbit Journal of Neuroscience Research. Jan, 2003 | Pubmed ID: 12503094 Localization of N-type Ca2+ Channels in the Rat Spinal Cord Following Chronic Constrictive Nerve Injury Experimental Brain Research. Dec, 2002 | Pubmed ID: 12444477 The Case for the Bulbospinal Respiratory Nitric Oxide Synthase-immunoreactive Pathway in the Dog Experimental Neurology. Sep, 2002 | Pubmed ID: 12429216 The Regional Distribution of Nitric Oxide Synthase Activity in the Spinal Cord of the Dog Brain Research Bulletin. Jun, 2002 | Pubmed ID: 12127014 Neuropathic Pain is Associated with Alterations of Nitric Oxide Synthase Immunoreactivity and Catalytic Activity in Dorsal Root Ganglia and Spinal Dorsal Horn Brain Research Bulletin. Jun, 2002 | Pubmed ID: 12127013 The Effects of OP-1206 Alpha-CD on Walking Dysfunction in the Rat Neuropathic Intermittent Claudication Model Anesthesia and Analgesia. Jun, 2002 | Pubmed ID: 12032022 Electroporation for Direct Spinal Gene Transfer in Rats Neuroscience Letters. Jan, 2002 | Pubmed ID: 11750982 Subpial Adeno-associated Virus 9 (AAV9) Vector Delivery in Adult Mice Takahiro Tadokoro1, Atsushi Miyanohara1, Michael Navarro1, Kota Kamizato1, Stefan Juhas2, Jana Juhasova2, Silvia Marsala1, Oleksandr Platoshyn1, Erik Curtis3, Brandon Gabel3, Joseph Ciacci3, Nada Lukacova4, Katarina Bimbova4, Martin Marsala1,4 1Neuroregeneration Laboratory, Department of Anesthesiology, University of California, San Diego, 2Institute of Animal Physiology and Genetics, Czech Academy of Sciences, 3Department of Neurosurgery, University of California, San Diego, 4Institute of Neurobiology, Slovak Academy of Sciences JoVE 55770 Neuroscience
Subpial Adeno-associated Virus 9 (AAV9) Vector Delivery in Adult Mice Takahiro Tadokoro1, Atsushi Miyanohara1, Michael Navarro1, Kota Kamizato1, Stefan Juhas2, Jana Juhasova2, Silvia Marsala1, Oleksandr Platoshyn1, Erik Curtis3, Brandon Gabel3, Joseph Ciacci3, Nada Lukacova4, Katarina Bimbova4, Martin Marsala1,4 1Neuroregeneration Laboratory, Department of Anesthesiology, University of California, San Diego, 2Institute of Animal Physiology and Genetics, Czech Academy of Sciences, 3Department of Neurosurgery, University of California, San Diego, 4Institute of Neurobiology, Slovak Academy of Sciences JoVE 55770 Neuroscience