Mohammad F. Kiani Departments of Mechanical Engineering, Bioengineering, and Radiation Oncology Temple University Biography Publications Institution JoVE Articles Mohammad F. Kiani Dr. Mohammad F. Kiani is a professor in the Department of Mechanical Engineering, with joint appointments in the Department of Bioengineering and Department of Radiation Oncology, at Temple University. He served as the chair of Department of Mechanical Engineering at Temple University (2004-2014) and Department of Biomedical Engineering at the University of Tennessee Health Science Center (2003-2004). He received a B.S. in electrical engineering from the University of Oklahoma and M.S. and Ph.D. in biomedical engineering from Louisiana Tech University. He was an NIH postdoctoral fellow at the University of Rochester from 1990 to 1993. The current focus of his research is the development of organoids and microphysiological systems for rapid drug development and screening and targeted drug delivery. Publications Emerging Approaches to Understanding Microvascular Endothelial Heterogeneity: A Roadmap for Developing Anti-Inflammatory Therapeutics International Journal of Molecular Sciences. Jul, 2021 | Pubmed ID: 34360536 Mechanisms of Radiation-induced Endothelium Damage: Emerging Models and Technologies Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology. 05, 2021 | Pubmed ID: 33581220 Experimental Approaches to Evaluate Leukocyte-Endothelial Cell Interactions in Sepsis and Inflammation Shock (Augusta, Ga.). 05, 2020 | Pubmed ID: 32080065 Neutrophil-endothelial Interactions of Murine Cells is Not a Good Predictor of Their Interactions in Human Cells FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 02, 2020 | Pubmed ID: 31908006 Reversible Cavitation-Induced Junctional Opening in an Artificial Endothelial Layer Small (Weinheim an Der Bergstrasse, Germany). 12, 2019 | Pubmed ID: 31762158 The Role of Tyrosine Phosphorylation of Protein Kinase C Delta in Infection and Inflammation International Journal of Molecular Sciences. Mar, 2019 | Pubmed ID: 30917487 Protein Kinase C-Delta (PKCδ) Tyrosine Phosphorylation is a Critical Regulator of Neutrophil-Endothelial Cell Interaction in Inflammation Shock (Augusta, Ga.). 05, 2019 | Pubmed ID: 30095599 Protein Kinase C-delta Inhibition Protects Blood-brain Barrier from Sepsis-induced Vascular Damage Journal of Neuroinflammation. Nov, 2018 | Pubmed ID: 30400800 PKCδ Inhibition As a Novel Medical Countermeasure for Radiation-induced Vascular Damage FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2018 | Pubmed ID: 29897816 Murine Glomerular Transcriptome Links Endothelial Cell-specific Molecule-1 Deficiency with Susceptibility to Diabetic Nephropathy PloS One. Month, 2017 | Pubmed ID: 28934365 A Biomimetic Microfluidic Tumor Microenvironment Platform Mimicking the EPR Effect for Rapid Screening of Drug Delivery Systems Scientific Reports. 08, 2017 | Pubmed ID: 28839211 Targeted Multidrug Delivery System to Overcome Chemoresistance in Breast Cancer International Journal of Nanomedicine. Month, 2017 | Pubmed ID: 28176940 Fourier Transform Infrared Spectroscopic Imaging-Derived Collagen Content and Maturity Correlates with Stress in the Aortic Wall of Abdominal Aortic Aneurysm Patients Cardiovascular Engineering and Technology. 03, 2017 | Pubmed ID: 27995569 Classification, Treatment Strategy, and Associated Drug Resistance in Breast Cancer Clinical Breast Cancer. 10, 2016 | Pubmed ID: 27268750 A Novel Microfluidic Assay Reveals a Key Role for Protein Kinase C δ in Regulating Human Neutrophil-endothelium Interaction Journal of Leukocyte Biology. 11, 2016 | Pubmed ID: 27190303 A Novel Dynamic Neonatal Blood-Brain Barrier on a Chip PloS One. Month, 2015 | Pubmed ID: 26555149 Fast, Stable Induction of P-Glycoprotein-mediated Drug Resistance in BT-474 Breast Cancer Cells by Stable Transfection of ABCB1 Gene Anticancer Research. May, 2015 | Pubmed ID: 25964526 Correlations Between Transmural Mechanical and Morphological Properties in Porcine Thoracic Descending Aorta Journal of the Mechanical Behavior of Biomedical Materials. Jul, 2015 | Pubmed ID: 25837340 Adhesion Patterns in the Microvasculature Are Dependent on Bifurcation Angle Microvascular Research. May, 2015 | Pubmed ID: 25708050 Bioinspired Microfluidic Assay for in Vitro Modeling of Leukocyte-endothelium Interactions Analytical Chemistry. Aug, 2014 | Pubmed ID: 25135319 Targeted Delivery of Vascular Endothelial Growth Factor Improves Stem Cell Therapy in a Rat Myocardial Infarction Model Nanomedicine : Nanotechnology, Biology, and Medicine. Nov, 2014 | Pubmed ID: 24941463 Fourier Transform Infrared Spectroscopy to Quantify Collagen and Elastin in an in Vitro Model of Extracellular Matrix Degradation in Aorta The Analyst. Jun, 2014 | Pubmed ID: 24761431 Adhesive Interaction of Functionalized Particles and Endothelium in Idealized Microvascular Networks Microvascular Research. Sep, 2013 | Pubmed ID: 23557880 Targeted Delivery of VEGF to Treat Myocardial Infarction Advances in Experimental Medicine and Biology. Month, 2013 | Pubmed ID: 22879049 Targeted Delivery of VEGF After a Myocardial Infarction Reduces Collagen Deposition and Improves Cardiac Function Cardiovascular Engineering and Technology. Jun, 2012 | Pubmed ID: 22844388 Cholesterol Superlattice Modulates CA4P Release from Liposomes and CA4P Cytotoxicity on Mammary Cancer Cells Biophysical Journal. May, 2012 | Pubmed ID: 22824272 Fourier Transform Infrared Spectroscopic Imaging of Cardiac Tissue to Detect Collagen Deposition After Myocardial Infarction Journal of Biomedical Optics. May, 2012 | Pubmed ID: 22612137 Microfluidic Devices for Modeling Cell-cell and Particle-cell Interactions in the Microvasculature Microvascular Research. Nov, 2011 | Pubmed ID: 21763328 Bifurcations: Focal Points of Particle Adhesion in Microvascular Networks Microcirculation (New York, N.Y. : 1994). Jul, 2011 | Pubmed ID: 21418388 Towards a Targeted Multi-drug Delivery Approach to Improve Therapeutic Efficacy in Breast Cancer Expert Opinion on Drug Delivery. Oct, 2010 | Pubmed ID: 20738211 Preferential Adhesion of Leukocytes Near Bifurcations is Endothelium Independent Microvascular Research. Dec, 2010 | Pubmed ID: 20624406 Targeting VEGF-encapsulated Immunoliposomes to MI Heart Improves Vascularity and Cardiac Function FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Oct, 2009 | Pubmed ID: 19535683 A Physiologically Realistic in Vitro Model of Microvascular Networks Biomedical Microdevices. Oct, 2009 | Pubmed ID: 19452279 Radiation-guided Targeting of Combretastatin Encapsulated Immunoliposomes to Mammary Tumors Pharmaceutical Research. May, 2009 | Pubmed ID: 19172383 Aiming for the Heart: Targeted Delivery of Drugs to Diseased Cardiac Tissue Expert Opinion on Drug Delivery. Apr, 2008 | Pubmed ID: 18426386 Synthetic Microvascular Networks for Quantitative Analysis of Particle Adhesion Biomedical Microdevices. Aug, 2008 | Pubmed ID: 18327641 Modeling Oxygenation and Selective Delivery of Drug Carriers Post-myocardial Infarction Advances in Experimental Medicine and Biology. Month, 2008 | Pubmed ID: 18290344 Microvascular Transport Model Predicts Oxygenation Changes in the Infarcted Heart After Treatment American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2007 | Pubmed ID: 17951368 Anti-TNFA (TNF-alpha) Treatment Abrogates Radiation-induced Changes in Vacular Density and Tissue Oxygenation Radiation Research. Jan, 2007 | Pubmed ID: 17243316 Targeted Delivery of Antibody Conjugated Liposomal Drug Carriers to Rat Myocardial Infarction Biotechnology and Bioengineering. Mar, 2007 | Pubmed ID: 17051598 Local and Average Gloss from Flat-faced Sodium Chloride Tablets AAPS PharmSciTech. Jan, 2006 | Pubmed ID: 16584166 Targeting of the Antivascular Drug Combretastatin to Irradiated Tumors Results in Tumor Growth Delay Pharmaceutical Research. Jul, 2005 | Pubmed ID: 16028012 A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation Qingliang Yang1, Jordan C. Langston2, Yuan Tang3, Balabhaskar Prabhakarpandian4, Laurie E. Kilpatrick5, Mohammad F. Kiani1,2,6 1Department of Mechanical Engineering, Temple University, 2Department of Bioengineering, Temple University, 3Department of Bioengineering, University of Toledo, 4Biomedical Technology, CFD Research Corporation, 5Center for Inflammation and Lung Research, Department of Microbiology, Immunology and Inflammation, Lewis Katz School of Medicine, Temple University, 6Department of Radiation Oncology, Lewis Katz School of Medicine, Temple University JoVE 63312 Bioengineering
A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation Qingliang Yang1, Jordan C. Langston2, Yuan Tang3, Balabhaskar Prabhakarpandian4, Laurie E. Kilpatrick5, Mohammad F. Kiani1,2,6 1Department of Mechanical Engineering, Temple University, 2Department of Bioengineering, Temple University, 3Department of Bioengineering, University of Toledo, 4Biomedical Technology, CFD Research Corporation, 5Center for Inflammation and Lung Research, Department of Microbiology, Immunology and Inflammation, Lewis Katz School of Medicine, Temple University, 6Department of Radiation Oncology, Lewis Katz School of Medicine, Temple University JoVE 63312 Bioengineering