Robert A. Screaton Sunnybrook Research Institute University of Toronto Biography Publications Institution JoVE Articles Robert A. Screaton has not added a biography. If you are Robert A. Screaton and would like to personalize this page please email our Author Liaison for assistance. Publications Phenotypic Characterization of MIP-CreERT1Lphi Mice with Transgene-driven Islet Expression of Human Growth Hormone Diabetes. Jul, 2015 | Pubmed ID: 26153246 To Be(ta Cell) or Not to Be(ta Cell): New Mouse Models for Studying Gene Function in the Pancreatic β-Cell Endocrinology. Jul, 2015 | Pubmed ID: 26091426 Homozygous Mutations in MFN2 Cause Multiple Symmetric Lipomatosis Associated with Neuropathy Human Molecular Genetics. Jun, 2015 | Pubmed ID: 26085578 LKB1 Couples Glucose Metabolism to Insulin Secretion in Mice Diabetologia. Jul, 2015 | Pubmed ID: 25874445 Axl Phosphorylates Elmo Scaffold Proteins to Promote Rac Activation and Cell Invasion Molecular and Cellular Biology. Jan, 2015 | Pubmed ID: 25332238 High-content Functional Genomic Screening to Identify Novel Regulators of the PINK1-Parkin Pathway Methods in Enzymology. 2014 | Pubmed ID: 25416349 SGK1: Master and Commander of the Fate of Helper T Cells Nature Immunology. May, 2014 | Pubmed ID: 24747705 Role of the SIK2-p35-PJA2 Complex in Pancreatic β-cell Functional Compensation Nature Cell Biology. Mar, 2014 | Pubmed ID: 24561619 Essential Role of TID1 in Maintaining Mitochondrial Membrane Potential Homogeneity and Mitochondrial DNA Integrity Molecular and Cellular Biology. Apr, 2014 | Pubmed ID: 24492964 ROMO1 is an Essential Redox-dependent Regulator of Mitochondrial Dynamics Science Signaling. 2014 | Pubmed ID: 24473195 Genome-wide RNAi Screen Identifies ATPase Inhibitory Factor 1 (ATPIF1) As Essential for PARK2 Recruitment and Mitophagy Autophagy. Nov, 2013 | Pubmed ID: 24005319 CRTC2 is Required for β-cell Function and Proliferation Endocrinology. Jul, 2013 | Pubmed ID: 23677932 LKB1-regulated Adaptive Mechanisms Are Essential for Neuronal Survival Following Mitochondrial Dysfunction Human Molecular Genetics. Mar, 2013 | Pubmed ID: 23187960 Role of AMPK in Pancreatic Beta Cell Function Molecular and Cellular Endocrinology. Feb, 2013 | Pubmed ID: 22766107 Glucose Metabolism and Pancreatic Defects in Spinal Muscular Atrophy Annals of Neurology. Aug, 2012 | Pubmed ID: 22926856 Regulation of the CREB Coactivator TORC by the Dual Leucine Zipper Kinase at Different Levels Cellular Signalling. Feb, 2011 | Pubmed ID: 20940047 Depletion of Intranuclear Rodlets in Mouse Models of Diabetes Endocrine Pathology. Dec, 2010 | Pubmed ID: 20922502 Loss of Lkb1 in Adult Beta Cells Increases Beta Cell Mass and Enhances Glucose Tolerance in Mice Cell Metabolism. Oct, 2009 | Pubmed ID: 19808021 A Role for the CREB Co-activator CRTC2 in the Hypothalamic Mechanisms Linking Glucose Sensing with Gene Regulation EMBO Reports. Oct, 2009 | Pubmed ID: 19713961 Transcriptional Activation by MEIS1A in Response to Protein Kinase A Signaling Requires the Transducers of Regulated CREB Family of CREB Co-activators The Journal of Biological Chemistry. Jul, 2009 | Pubmed ID: 19473990 Using Kinomics to Delineate Signaling Pathways: Control of CRTC2/TORC2 by the AMPK Family Cell Cycle (Georgetown, Tex.). Dec, 2008 | Pubmed ID: 19098422 The Glucocorticoid Receptor Controls Hepatic Dyslipidemia Through Hes1 Cell Metabolism. Sep, 2008 | Pubmed ID: 18762022 Glucose Controls CREB Activity in Islet Cells Via Regulated Phosphorylation of TORC2 Proceedings of the National Academy of Sciences of the United States of America. Jul, 2008 | Pubmed ID: 18626018 The CREB Coactivator TORC2 is a Key Regulator of Fasting Glucose Metabolism Nature. Oct, 2005 | Pubmed ID: 16148943 The CREB Coactivator TORC2 Functions As a Calcium- and CAMP-sensitive Coincidence Detector Cell. Oct, 2004 | Pubmed ID: 15454081 CAMP Promotes Pancreatic Beta-cell Survival Via CREB-mediated Induction of IRS2 Genes & Development. Jul, 2003 | Pubmed ID: 12842910 Fas-associated Death Domain Protein Interacts with Methyl-CpG Binding Domain Protein 4: a Potential Link Between Genome Surveillance and Apoptosis Proceedings of the National Academy of Sciences of the United States of America. Apr, 2003 | Pubmed ID: 12702765 Deregulated Expression of the Human Tumor Marker CEA and CEA Family Member CEACAM6 Disrupts Tissue Architecture and Blocks Colonocyte Differentiation Neoplasia (New York, N.Y.). Mar-Apr, 2002 | Pubmed ID: 11896570 Identification of Kinase-substrate Pairs Using High Throughput Screening Courtney Reeks1, Robert A. Screaton2,3 1Children's Hospital of Eastern Ontario Research Institute, 2Sunnybrook Research Institute, University of Toronto, 3Department of Biochemistry, University of Toronto JoVE 53152 Biology
Identification of Kinase-substrate Pairs Using High Throughput Screening Courtney Reeks1, Robert A. Screaton2,3 1Children's Hospital of Eastern Ontario Research Institute, 2Sunnybrook Research Institute, University of Toronto, 3Department of Biochemistry, University of Toronto JoVE 53152 Biology