Roland Tisch Department of Microbiology and Immunology University of North Carolina at Chapel Hill Biography Publications Institution JoVE Articles Roland Tisch has not added a biography. If you are Roland Tisch and would like to personalize this page please email our Author Liaison for assistance. Publications Reestablishing T Cell Tolerance by Antibody-Based Therapy in Type 1 Diabetes Archivum Immunologiae Et Therapiae Experimentalis. Mar, 2015 | Pubmed ID: 25790749 IL-2 Protects Lupus-prone Mice from Multiple End-organ Damage by Limiting CD4-CD8- IL-17-producing T Cells Journal of Immunology (Baltimore, Md. : 1950). Sep, 2014 | Pubmed ID: 25063876 Cutting Edge: Antigen-specific Thymocyte Feedback Regulates Homeostatic Thymic Conventional Dendritic Cell Maturation Journal of Immunology (Baltimore, Md. : 1950). Jul, 2014 | Pubmed ID: 24890722 Thymic Development of Autoreactive T Cells in NOD Mice is Regulated in an Age-dependent Manner Journal of Immunology (Baltimore, Md. : 1950). Dec, 2013 | Pubmed ID: 24198282 β-cell-specific IL-2 Therapy Increases Islet Foxp3+Treg and Suppresses Type 1 Diabetes in NOD Mice Diabetes. Nov, 2013 | Pubmed ID: 23884888 Manipulating T Cell-mediated Pathology: Targets and Functions of Monoclonal Antibody Immunotherapy Clinical Immunology (Orlando, Fla.). Jul, 2013 | Pubmed ID: 23688653 Kinetics of Adeno-associated Virus Serotype 2 (AAV2) and AAV8 Capsid Antigen Presentation in Vivo Are Identical Human Gene Therapy. May, 2013 | Pubmed ID: 23534873 Autoreactive Effector/memory CD4+ and CD8+ T Cells Infiltrating Grafted and Endogenous Islets in Diabetic NOD Mice Exhibit Similar T Cell Receptor Usage PloS One. 2012 | Pubmed ID: 23251685 IFN-γ Receptor Deficiency Prevents Diabetes Induction by Diabetogenic CD4+, but Not CD8+, T Cells European Journal of Immunology. Aug, 2012 | Pubmed ID: 22865049 Long-term Remission of Diabetes in NOD Mice is Induced by Nondepleting Anti-CD4 and Anti-CD8 Antibodies Diabetes. Nov, 2012 | Pubmed ID: 22751694 Cumulative Autoimmunity: T Cell Clones Recognizing Several Self-epitopes Exhibit Enhanced Pathogenicity Frontiers in Immunology. 2011 | Pubmed ID: 22566837 Reduced IL-2 Expression in NOD Mice Leads to a Temporal Increase in CD62Llo FoxP3+ CD4+ T Cells with Limited Suppressor Activity European Journal of Immunology. May, 2011 | Pubmed ID: 21469091 Inducible Adeno-associated Virus-mediated IL-2 Gene Therapy Prevents Autoimmune Diabetes Journal of Immunology (Baltimore, Md. : 1950). Mar, 2011 | Pubmed ID: 21317396 Genetic Vaccination for Re-establishing T-cell Tolerance in Type 1 Diabetes Human Vaccines. Jan, 2011 | Pubmed ID: 21157183 Dysregulation of Thymic Clonal Deletion and the Escape of Autoreactive T Cells Archivum Immunologiae Et Therapiae Experimentalis. Dec, 2010 | Pubmed ID: 20872284 Adiponectin Lowers Glucose Production by Increasing SOGA The American Journal of Pathology. Oct, 2010 | Pubmed ID: 20813965 Immunogenic Versus Tolerogenic Dendritic Cells: a Matter of Maturation International Reviews of Immunology. Apr, 2010 | Pubmed ID: 20367138 Central Nervous System Destruction Mediated by Glutamic Acid Decarboxylase-specific CD4+ T Cells Journal of Immunology (Baltimore, Md. : 1950). May, 2010 | Pubmed ID: 20348424 Toxin-coupled MHC Class I Tetramers Can Specifically Ablate Autoreactive CD8+ T Cells and Delay Diabetes in Nonobese Diabetic Mice Journal of Immunology (Baltimore, Md. : 1950). Apr, 2010 | Pubmed ID: 20220085 Beta Cell-specific CD4+ T Cell Clonotypes in Peripheral Blood and the Pancreatic Islets Are Distinct Journal of Immunology (Baltimore, Md. : 1950). Dec, 2009 | Pubmed ID: 19917704 Islet Lymphocyte Subsets in Male and Female NOD Mice Are Qualitatively Similar but Quantitatively Distinct Autoimmunity. 2009 | Pubmed ID: 19886740 Suppression of Ongoing T Cell-mediated Autoimmunity by Peptide-MHC Class II Dimer Vaccination Journal of Immunology (Baltimore, Md. : 1950). Oct, 2009 | Pubmed ID: 19752238 A Novel Role for C-Src and STAT3 in Apoptotic Cell-mediated MerTK-dependent Immunoregulation of Dendritic Cells Blood. Oct, 2009 | Pubmed ID: 19667404 CD8(+) T Cells Specific for Beta Cells Encounter Their Cognate Antigens in the Islets of NOD Mice European Journal of Immunology. Oct, 2009 | Pubmed ID: 19658094 Cellular Immune Response to Cryptic Epitopes During Therapeutic Gene Transfer Proceedings of the National Academy of Sciences of the United States of America. Jun, 2009 | Pubmed ID: 19541644 Cytotoxic-T-lymphocyte-mediated Elimination of Target Cells Transduced with Engineered Adeno-associated Virus Type 2 Vector in Vivo Journal of Virology. Jul, 2009 | Pubmed ID: 19369348 MerTK Regulates Thymic Selection of Autoreactive T Cells Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009 | Pubmed ID: 19251650 Role of Plasmacytoid Dendritic Cells in Type 1 Diabetes: Friend or Foe? Diabetes. Jan, 2009 | Pubmed ID: 19114722 Parameters Influencing Antigen-specific Immunotherapy for Type 1 Diabetes Immunologic Research. 2008 | Pubmed ID: 19052699 Immunotherapy of Type 1 Diabetes Archivum Immunologiae Et Therapiae Experimentalis. Jul-Aug, 2008 | Pubmed ID: 18726144 Gene Gun-mediated DNA Vaccination Enhances Antigen-specific Immunotherapy at a Late Preclinical Stage of Type 1 Diabetes in Nonobese Diabetic Mice Clinical Immunology (Orlando, Fla.). Oct, 2008 | Pubmed ID: 18675592 ANCA Patients Have T Cells Responsive to Complementary PR-3 Antigen Kidney International. Nov, 2008 | Pubmed ID: 18596726 Parameters Influencing Antigen-specific Immunotherapy for Type 1 Diabetes Immunologic Research. 2008 | Pubmed ID: 18543112 T-cell Promiscuity in Autoimmune Diabetes Diabetes. Aug, 2008 | Pubmed ID: 18492786 On the Pathogenicity of Autoantigen-specific T-cell Receptors Diabetes. May, 2008 | Pubmed ID: 18299317 B Lymphocyte Depletion by CD20 Monoclonal Antibody Prevents Diabetes in Nonobese Diabetic Mice Despite Isotype-specific Differences in Fc Gamma R Effector Functions Journal of Immunology (Baltimore, Md. : 1950). Mar, 2008 | Pubmed ID: 18292508 MerTK is Required for Apoptotic Cell-induced T Cell Tolerance The Journal of Experimental Medicine. Jan, 2008 | Pubmed ID: 18195070 Therapeutic B Cell Depletion Impairs Adaptive and Autoreactive CD4+ T Cell Activation in Mice Proceedings of the National Academy of Sciences of the United States of America. Dec, 2007 | Pubmed ID: 18093919 Alphaviral Vector-transduced Dendritic Cells Are Successful Therapeutic Vaccines Against Neu-overexpressing Tumors in Wild-type Mice Vaccine. Sep, 2007 | Pubmed ID: 17675184 The Type and Frequency of Immunoregulatory CD4+ T-cells Govern the Efficacy of Antigen-specific Immunotherapy in Nonobese Diabetic Mice Diabetes. May, 2007 | Pubmed ID: 17317763 Identical Beta Cell-specific CD8(+) T Cell Clonotypes Typically Reside in Both Peripheral Blood Lymphocyte and Pancreatic Islets Journal of Immunology (Baltimore, Md. : 1950). Feb, 2007 | Pubmed ID: 17237386 Apoptotic Cells Induce Mer Tyrosine Kinase-dependent Blockade of NF-kappaB Activation in Dendritic Cells Blood. Jan, 2007 | Pubmed ID: 17008547 EBV Latent Membrane Protein 2A Induces Autoreactive B Cell Activation and TLR Hypersensitivity Journal of Immunology (Baltimore, Md. : 1950). Sep, 2006 | Pubmed ID: 16920914 Lymphopenia-driven CD8(+) T Cells Are Resistant to Antigen-induced Tolerance in NOD.scid Mice European Journal of Immunology. Aug, 2006 | Pubmed ID: 16821236 Early Autoimmune Destruction of Islet Grafts is Associated with a Restricted Repertoire of IGRP-specific CD8+ T Cells in Diabetic Nonobese Diabetic Mice Journal of Immunology (Baltimore, Md. : 1950). Feb, 2006 | Pubmed ID: 16424193 Low-avidity CD8lo T Cells Induced by Incomplete Antigen Stimulation in Vivo Regulate Naive Higher Avidity CD8hi T Cell Responses to the Same Antigen European Journal of Immunology. Feb, 2006 | Pubmed ID: 16402405 Immunotherapy for the Prevention and Treatment of Type 1 Diabetes International Reviews of Immunology. Sep-Dec, 2005 | Pubmed ID: 16318984 Immunoregulation of Dendritic Cells Clinical Medicine & Research. Aug, 2005 | Pubmed ID: 16160071 Single Cell Analysis Shows Decreasing FoxP3 and TGFbeta1 Coexpressing CD4+CD25+ Regulatory T Cells During Autoimmune Diabetes The Journal of Experimental Medicine. Apr, 2005 | Pubmed ID: 15837817 Immunoregulation of Dendritic Cells by IL-10 is Mediated Through Suppression of the PI3K/Akt Pathway and of IkappaB Kinase Activity Blood. Aug, 2004 | Pubmed ID: 15113757 Critical Roles of Tumor Necrosis Factor-related Apoptosis-inducing Ligand in Type 1 Diabetes Diabetes. Sep, 2003 | Pubmed ID: 12941766 More Stringent Conditions of Plasmid DNA Vaccination Are Required to Protect Grafted Versus Endogenous Islets in Nonobese Diabetic Mice Journal of Immunology (Baltimore, Md. : 1950). Jul, 2003 | Pubmed ID: 12817032 NF-kappa B Hyperactivation Has Differential Effects on the APC Function of Nonobese Diabetic Mouse Macrophages Journal of Immunology (Baltimore, Md. : 1950). Feb, 2003 | Pubmed ID: 12574341 The Preferential Ability of B Lymphocytes to Act As Diabetogenic APC in NOD Mice Depends on Expression of Self-antigen-specific Immunoglobulin Receptors European Journal of Immunology. Dec, 2002 | Pubmed ID: 12516557 L-selectin is Not Required for T Cell-mediated Autoimmune Diabetes Journal of Immunology (Baltimore, Md. : 1950). Mar, 2002 | Pubmed ID: 11884430 Elevated NF-kappaB Activation in Nonobese Diabetic Mouse Dendritic Cells Results in Enhanced APC Function Journal of Immunology (Baltimore, Md. : 1950). Jan, 2002 | Pubmed ID: 11751962 Isolation and Transplantation of Different Aged Murine Thymic Grafts. Y. Maurice Morillon II*1, Fatima Manzoor*1, Bo Wang1, Roland Tisch1 1Department of Microbiology and Immunology, University of North Carolina at Chapel Hill JoVE 52709 Immunology and Infection
Isolation and Transplantation of Different Aged Murine Thymic Grafts. Y. Maurice Morillon II*1, Fatima Manzoor*1, Bo Wang1, Roland Tisch1 1Department of Microbiology and Immunology, University of North Carolina at Chapel Hill JoVE 52709 Immunology and Infection