Steven Poelzing Virginia Tech Carilion Research Institute Virginia Tech Biography Publications Institution JoVE Articles Steven Poelzing has not added a biography. If you are Steven Poelzing and would like to personalize this page please email our Author Liaison for assistance. Publications The Role of the Gap Junction Perinexus in Cardiac Conduction: Potential As a Novel Anti-arrhythmic Drug Target Progress in Biophysics and Molecular Biology. Sep, 2018 | Pubmed ID: 30241906 The Adhesion Function of the Sodium Channel Beta Subunit (β1) Contributes to Cardiac Action Potential Propagation ELife. Aug, 2018 | Pubmed ID: 30106376 Intercalated Disk Extracellular Nanodomain Expansion in Patients With Atrial Fibrillation Frontiers in Physiology. Month, 2018 | Pubmed ID: 29780324 Whole-exome Sequencing Reveals Microsatellite DNA Markers for Response to Dofetilide Initiation in Patients with Persistent Atrial Fibrillation: A Pilot Study Clinical Cardiology. Jun, 2018 | Pubmed ID: 29671888 Design and Validation of a Tissue Bath 3-D Printed with PLA for Optically Mapping Suspended Whole Heart Preparations American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2017 | Pubmed ID: 28939646 TNFα Modulates Cardiac Conduction by Altering Electrical Coupling Between Myocytes Frontiers in Physiology. Month, 2017 | Pubmed ID: 28588504 Revealing the Concealed Nature of Long-QT Type 3 Syndrome Circulation. Arrhythmia and Electrophysiology. Feb, 2017 | Pubmed ID: 28213505 Electrophysiologic Effects of the IK1 Inhibitor PA-6 Are Modulated by Extracellular Potassium in Isolated Guinea Pig Hearts Physiological Reports. Jan, 2017 | Pubmed ID: 28087819 Potassium Channels in the Cx43 Gap Junction Perinexus Modulate Ephaptic Coupling: an Experimental and Modeling Study Pflugers Archiv : European Journal of Physiology. 10, 2016 | Pubmed ID: 27510622 Extracellular Sodium Dependence of the Conduction Velocity-calcium Relationship: Evidence of Ephaptic Self-attenuation American Journal of Physiology. Heart and Circulatory Physiology. 05, 2016 | Pubmed ID: 26945081 Heart Rate and Extracellular Sodium and Potassium Modulation of Gap Junction Mediated Conduction in Guinea Pigs Frontiers in Physiology. Month, 2016 | Pubmed ID: 26869934 Cardiac Conduction in Isolated Hearts of Genetically Modified Mice--Connexin43 and Salts Progress in Biophysics and Molecular Biology. Jan, 2016 | Pubmed ID: 26627143 Orientation Dependence of Microcirculation-induced Diffusion Signal in Anisotropic Tissues Magnetic Resonance in Medicine. 10, 2016 | Pubmed ID: 26511215 Temporal Response of Ectopic Activity in Guinea Pig Ventricular Myocardium in Response to Isoproterenol and Acetylcholine Frontiers in Physiology. Month, 2015 | Pubmed ID: 26539122 Visualizing Virus Particle Mobility in Liquid at the Nanoscale Chemical Communications (Cambridge, England). Nov, 2015 | Pubmed ID: 26355472 Extracellular Sodium and Potassium Levels Modulate Cardiac Conduction in Mice Heterozygous Null for the Connexin43 Gene Pflugers Archiv : European Journal of Physiology. Nov, 2015 | Pubmed ID: 25771952 Distinguishing Between Overdrive Excited and Suppressed Ventricular Beats in Guinea Pig Ventricular Myocardium Frontiers in Physiology. Month, 2015 | Pubmed ID: 25741282 Sodium Channels in the Cx43 Gap Junction Perinexus May Constitute a Cardiac Ephapse: an Experimental and Modeling Study Pflugers Archiv : European Journal of Physiology. Oct, 2015 | Pubmed ID: 25578859 Neuronal Na+ Channel Blockade Suppresses Arrhythmogenic Diastolic Ca2+ Release Cardiovascular Research. Apr, 2015 | Pubmed ID: 25538156 Moving Beyond the Reductionist Approach-Time to Put the Pieces Back Together in a Broken (infarcted) Heart Heart Rhythm. Jan, 2015 | Pubmed ID: 25446156 Sex Differences in β-adrenergic Responsiveness of Action Potentials and Intracellular Calcium Handling in Isolated Rabbit Hearts PloS One. Month, 2014 | Pubmed ID: 25340795 Novel Ligands for Zipping and Unzipping the Intercalated Disk: Today's Experimental Tools, Tomorrow's Therapies? Cardiovascular Research. Nov, 2014 | Pubmed ID: 25280893 Intercellular Electrical Communication in the Heart: a New, Active Role for the Intercalated Disk Cell Communication & Adhesion. Jun, 2014 | Pubmed ID: 24735129 Old Cogs, New Tricks: a Scaffolding Role for Connexin43 and a Junctional Role for Sodium Channels? FEBS Letters. Apr, 2014 | Pubmed ID: 24486012 Mechanisms of Cardiac Conduction: a History of Revisions American Journal of Physiology. Heart and Circulatory Physiology. Mar, 2014 | Pubmed ID: 24414064 Combined Inhibition of Na⁺ and Ca²⁺ Channels: a Novel Paradigm for the Treatment of Incessant Ventricular Arrhythmias in Andersen-Tawil Syndrome Heart Rhythm. Feb, 2014 | Pubmed ID: 24211314 The Perinexus: Sign-post on the Path to a New Model of Cardiac Conduction? Trends in Cardiovascular Medicine. Aug, 2013 | Pubmed ID: 23490883 Interstitial Volume Modulates the Conduction Velocity-gap Junction Relationship American Journal of Physiology. Heart and Circulatory Physiology. Jan, 2012 | Pubmed ID: 22021331 A Novel Strategy Using Cardiac Sodium Channel Polymorphic Fragments to Rescue Trafficking-deficient SCN5A Mutations Circulation. Cardiovascular Genetics. Oct, 2011 | Pubmed ID: 21840964 NCX is an Important Determinant for Premature Ventricular Activity in a Drug-induced Model of Andersen-Tawil Syndrome Cardiovascular Research. Oct, 2011 | Pubmed ID: 21697145 Cytosolic Calcium Accumulation and Delayed Repolarization Associated with Ventricular Arrhythmias in a Guinea Pig Model of Andersen-Tawil Syndrome Heart Rhythm : the Official Journal of the Heart Rhythm Society. Oct, 2010 | Pubmed ID: 20380896 Pharmacological Activation of IKr Impairs Conduction in Guinea Pig Hearts Journal of Cardiovascular Electrophysiology. Aug, 2010 | Pubmed ID: 20163495 Gap Junction Heterogeneity As Mechanism for Electrophysiologically Distinct Properties Across the Ventricular Wall American Journal of Physiology. Heart and Circulatory Physiology. Mar, 2010 | Pubmed ID: 20035026 Status Epilepticus Induces Cardiac Myofilament Damage and Increased Susceptibility to Arrhythmias in Rats American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2009 | Pubmed ID: 19820194 The Modulated Dispersion Hypothesis Confirmed in Humans Circulation. Arrhythmia and Electrophysiology. Apr, 2009 | Pubmed ID: 19808452 Are Electrophysiologically Distinct M-cells a Characteristic of the Wedge Preparation? Heart Rhythm : the Official Journal of the Heart Rhythm Society. Jul, 2009 | Pubmed ID: 19497787 Novel X-ray Attenuation Mechanism: Role of Interatomic Distance Medical Physics. Oct, 2008 | Pubmed ID: 18975684 Mechanisms Underlying Increased Right Ventricular Conduction Sensitivity to Flecainide Challenge Cardiovascular Research. Mar, 2008 | Pubmed ID: 18056761 Heterogeneous Ventricular Chamber Response to Hypokalemia and Inward Rectifier Potassium Channel Blockade Underlies Bifurcated T Wave in Guinea Pig American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2007 | Pubmed ID: 17307991 SCN5A Polymorphism Restores Trafficking of a Brugada Syndrome Mutation on a Separate Gene Circulation. Aug, 2006 | Pubmed ID: 16864729 Cellular Mechanisms of Torsade De Pointes Novartis Foundation Symposium. Month, 2005 | Pubmed ID: 16050270 IKs Blockade Reduces Dispersion of Repolarization in Heart Failure Heart Rhythm : the Official Journal of the Heart Rhythm Society. Jul, 2005 | Pubmed ID: 15992730 Optical Measurements Reveal Nature of Intercellular Coupling Across Ventricular Wall American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2005 | Pubmed ID: 15863452 Transmural Conduction is Not a Two-way Street Journal of Cardiovascular Electrophysiology. Apr, 2005 | Pubmed ID: 15828895 Nature, Significance, and Mechanisms of Electrical Heterogeneities in Ventricle The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology. Oct, 2004 | Pubmed ID: 15368342 Altered Connexin43 Expression Produces Arrhythmia Substrate in Heart Failure American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2004 | Pubmed ID: 15205174 Heterogeneous Connexin43 Expression Produces Electrophysiological Heterogeneities Across Ventricular Wall American Journal of Physiology. Heart and Circulatory Physiology. May, 2004 | Pubmed ID: 14704225 Quantifying Intermembrane Distances with Serial Image Dilations Tristan Raisch1,2, Momina Khan1, Steven Poelzing1,2 1Virginia Tech Carilion Research Institute, Virginia Tech, 2Translational Biology, Medicine and Health, Virginia Tech JoVE 58311 Bioengineering Recapitulation of an Ion Channel IV Curve Using Frequency Components John R. Rigby1, Steven Poelzing1 1Bioengineering, University of Utah JoVE 2361 Biology
Quantifying Intermembrane Distances with Serial Image Dilations Tristan Raisch1,2, Momina Khan1, Steven Poelzing1,2 1Virginia Tech Carilion Research Institute, Virginia Tech, 2Translational Biology, Medicine and Health, Virginia Tech JoVE 58311 Bioengineering
Recapitulation of an Ion Channel IV Curve Using Frequency Components John R. Rigby1, Steven Poelzing1 1Bioengineering, University of Utah JoVE 2361 Biology