Zhixiang Wang Department of Medical Genetics, Signal Transduction Research Group, Faculty of Medicine and Dentistry University of Alberta Biography Publications Institution JoVE Articles Zhixiang Wang has not added a biography. If you are Zhixiang Wang and would like to personalize this page please email our Author Liaison for assistance. Publications Lentiviral CRISPR/Cas9 Vector Mediated MiR-21 Gene Editing Inhibits the Epithelial to Mesenchymal Transition in Ovarian Cancer Cells Journal of Cancer. 2017 | Pubmed ID: 28123598 UHF Signal Processing and Pattern Recognition of Partial Discharge in Gas-Insulated Switchgear Using Chromatic Methodology Sensors (Basel, Switzerland). Jan, 2017 | Pubmed ID: 28106806 Design, Facile Synthesis and Biological Evaluations of Novel Pyrano[3,2-a]phenazine Hybrid Molecules As Antitumor Agents European Journal of Medicinal Chemistry. Feb, 2017 | Pubmed ID: 27836197 NMMHC-IIA-dependent Nuclear Location of CXCR4 Promotes Migration and Invasion in Renal Cell Carcinoma Oncology Reports. Nov, 2016 | Pubmed ID: 27634189 Non-Ligand-Induced Dimerization is Sufficient to Initiate the Signalling and Endocytosis of EGF Receptor International Journal of Molecular Sciences. Jul, 2016 | Pubmed ID: 27463710 Amyloid Precursor Protein Cooperates with C-KIT Mutation/overexpression to Regulate Cell Apoptosis in AML1-ETO-positive Leukemia Via the PI3K/AKT Signaling Pathway Oncology Reports. Sep, 2016 | Pubmed ID: 27460334 Near-Infrared Quantum Cutting in Yb3+ Doped SrMoO4 Phosphors Journal of Nanoscience and Nanotechnology. Apr, 2016 | Pubmed ID: 27451655 Berberine Acts As a Putative Epigenetic Modulator by Affecting the Histone Code Toxicology in Vitro : an International Journal Published in Association with BIBRA. Oct, 2016 | Pubmed ID: 27311644 Gli-1/PI3K/AKT/NF-kB Pathway Mediates Resistance to Radiation and is a Target for Reversion of Responses in Refractory Acute Myeloid Leukemia Cells Oncotarget. May, 2016 | Pubmed ID: 27105509 Higher EZH2 Expression is Associated with Extramedullary Infiltration in Acute Myeloid Leukemia Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine. Aug, 2016 | Pubmed ID: 27000755 The Chloride Intracellular Channel 5A Stimulates Podocyte Rac1, Protecting Against Hypertension-induced Glomerular Injury Kidney International. Apr, 2016 | Pubmed ID: 26924049 Identification of Inhibitors for Vascular Endothelial Growth Factor Receptor by Using Dynamic Combinatorial Chemistry Bioorganic & Medicinal Chemistry Letters. Apr, 2016 | Pubmed ID: 26920800 Phosphorylation and Activation of RhoA by ERK in Response to Epidermal Growth Factor Stimulation PloS One. 2016 | Pubmed ID: 26816343 Transactivation of Epidermal Growth Factor Receptor by G Protein-Coupled Receptors: Recent Progress, Challenges and Future Research International Journal of Molecular Sciences. Jan, 2016 | Pubmed ID: 26771606 Palliative Chemotherapy Followed by Methylation Inhibitor in High-risk Acute Myeloid Leukemia: An in Vitro and Clinical Study Molecular and Clinical Oncology. Sep, 2015 | Pubmed ID: 26623066 The Hypomethylating Agent Decitabine Prior to Chemotherapy Improves the Therapy Efficacy in Refractory/relapsed Acute Myeloid Leukemia Patients Oncotarget. Oct, 2015 | Pubmed ID: 26384351 The Relationship Between Clinical Feature, Complex Immunophenotype, Chromosome Karyotype, and Outcome of Patients with Acute Myeloid Leukemia in China Disease Markers. 2015 | Pubmed ID: 25944974 Stabilizing Triplet Excited States for Ultralong Organic Phosphorescence Nature Materials. Jul, 2015 | Pubmed ID: 25849370 [An Inquiry into Treatment of Crush Syndrome Complicated with Multiple Organ Failure with Traditional Chinese Medicine Combined with Western Medicine During Yunnan Ludian Earthquake: a Report of 1 Case] Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. Feb, 2015 | Pubmed ID: 25665616 Dimerization Drives EGFR Endocytosis Through Two Sets of Compatible Endocytic Codes Journal of Cell Science. Mar, 2015 | Pubmed ID: 25588832 Effects of Lactobacillus Acidophilus Dietary Supplementation on the Performance, Intestinal Barrier Function, Rectal Microflora and Serum Immune Function in Weaned Piglets Challenged with Escherichia Coli Lipopolysaccharide Antonie Van Leeuwenhoek. Apr, 2015 | Pubmed ID: 25577203 Heteroatom-bridged Benzothiazolyls for Organic Solar Cells: a Theoretical Study The Journal of Physical Chemistry. B. Jan, 2015 | Pubmed ID: 25531907 EGF Stimulates the Activation of EGF Receptors and the Selective Activation of Major Signaling Pathways During Mitosis Cellular Signalling. Mar, 2015 | Pubmed ID: 25479591 Multiple Mechanisms Underlying Acquired Resistance to Taxanes in Selected Docetaxel-resistant MCF-7 Breast Cancer Cells BMC Cancer. Jan, 2014 | Pubmed ID: 24447372 Identification of Novel Molecular Markers for Prognosis Estimation of Acute Myeloid Leukemia: Over-expression of PDCD7, FIS1 and Ang2 May Indicate Poor Prognosis in Pretreatment Patients with Acute Myeloid Leukemia PloS One. 2014 | Pubmed ID: 24416201 A Three-dimensional Chiral Crystal Structure Constructed from a Chiral Triazolate Ligand Showing an SrSi2 Topology: Poly[bis(μ3-3,5-diethyl-1,2,4-triazolato-κ(3)N(1):N(2):N(4))trisilver Nitrate] Acta Crystallographica. Section C, Crystal Structure Communications. Dec, 2013 | Pubmed ID: 24311496 Phosphorylation of Rac1 T108 by Extracellular Signal-regulated Kinase in Response to Epidermal Growth Factor: a Novel Mechanism to Regulate Rac1 Function Molecular and Cellular Biology. Nov, 2013 | Pubmed ID: 24043306 The Hydrolysis of Carbonyl Sulfide at Low Temperature: a Review TheScientificWorldJournal. 2013 | Pubmed ID: 23956697 Dynamically Adaptive Characteristics of Resonance Variation for Selectively Enhancing Electrical Performance of Organic Semiconductors Angewandte Chemie (International Ed. in English). Sep, 2013 | Pubmed ID: 23946117 Engineering the Meso-diaminopimelate Dehydrogenase from Symbiobacterium Thermophilum by Site Saturation Mutagenesis for D-phenylalanine Synthesis Applied and Environmental Microbiology. Aug, 2013 | Pubmed ID: 23728814 Overexpression of Amyloid Precursor Protein in Acute Myeloid Leukemia Enhances Extramedullary Infiltration by MMP-2 Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine. Apr, 2013 | Pubmed ID: 23179400 Differential Regulation of Transcription Factors by Location-specific EGF Receptor Signaling Via a Spatio-temporal Interplay of ERK Activation PloS One. 2012 | Pubmed ID: 22984397 Noggin Suppression Decreases BMP-2-induced Osteogenesis of Human Bone Marrow-derived Mesenchymal Stem Cells in Vitro Journal of Cellular Biochemistry. Dec, 2012 | Pubmed ID: 22740073 Macrophages Inhibit Migration, Metabolic Activity and Osteogenic Differentiation of Human Mesenchymal Stem Cells in Vitro Cells, Tissues, Organs. 2012 | Pubmed ID: 22156615 Regulation of EGF-stimulated EGF Receptor Endocytosis During M Phase Traffic (Copenhagen, Denmark). Feb, 2011 | Pubmed ID: 21059162 A Systematic Study on Hemocyte Identification and Plasma Prophenoloxidase from Culex Pipiens Quinquefasciatus at Different Developmental Stages Experimental Parasitology. Jan, 2011 | Pubmed ID: 20637755 Thulium Laser Urethrotomy for Urethral Stricture: a Preliminary Report Lasers in Surgery and Medicine. Sep, 2010 | Pubmed ID: 20806387 Dimerization Drives PDGF Receptor Endocytosis Through a C-terminal Hydrophobic Motif Shared by EGF Receptor Experimental Cell Research. Aug, 2010 | Pubmed ID: 20580638 CXCR4 Nuclear Localization Follows Binding of Its Ligand SDF-1 and Occurs in Metastatic but Not Primary Renal Cell Carcinoma Oncology Reports. Dec, 2009 | Pubmed ID: 19885584 PLC-gamma1 and Rac1 Coregulate EGF-induced Cytoskeleton Remodeling and Cell Migration Molecular Endocrinology (Baltimore, Md.). Jun, 2009 | Pubmed ID: 19264842 The Fast-folding HP35 Double Mutant Has a Substantially Reduced Primary Folding Free Energy Barrier The Journal of Chemical Physics. Oct, 2008 | Pubmed ID: 19045234 The Binding of Thioflavin T and Its Neutral Analog BTA-1 to Protofibrils of the Alzheimer's Disease Abeta(16-22) Peptide Probed by Molecular Dynamics Simulations Journal of Molecular Biology. Dec, 2008 | Pubmed ID: 18851978 A Tale of Two Cbls: Interplay of C-Cbl and Cbl-b in Epidermal Growth Factor Receptor Downregulation Molecular and Cellular Biology. May, 2008 | Pubmed ID: 18316398 Identification of EGF Receptor C-terminal Sequences 1005-1017 and Di-leucine Motif 1010LL1011 As Essential in EGF Receptor Endocytosis Experimental Cell Research. Sep, 2007 | Pubmed ID: 17643422 Dual Binding Modes of Congo Red to Amyloid Protofibril Surface Observed in Molecular Dynamics Simulations Journal of the American Chemical Society. Feb, 2007 | Pubmed ID: 17263405 Phenol Red Interacts with the Protofibril-like Oligomers of an Amyloidogenic Hexapeptide NFGAIL Through Both Hydrophobic and Aromatic Contacts Biophysical Journal. Nov, 2006 | Pubmed ID: 16935948 Akt Binds to and Phosphorylates Phospholipase C-gamma1 in Response to Epidermal Growth Factor Molecular Biology of the Cell. May, 2006 | Pubmed ID: 16525023 Molecular Dynamics Simulations and Free Energy Analyses on the Dimer Formation of an Amyloidogenic Heptapeptide from Human Beta2-microglobulin: Implication for the Protofibril Structure Journal of Molecular Biology. Mar, 2006 | Pubmed ID: 16403526 Control of Epidermal Growth Factor Receptor Endocytosis by Receptor Dimerization, Rather Than Receptor Kinase Activation EMBO Reports. Oct, 2005 | Pubmed ID: 16113650 Platelet-derived Growth Factor Receptor-mediated Signal Transduction from Endosomes The Journal of Biological Chemistry. Feb, 2004 | Pubmed ID: 14660565 Regulation of EGF-induced Phospholipase C-gamma1 Translocation and Activation by Its SH2 and PH Domains Traffic (Copenhagen, Denmark). Sep, 2003 | Pubmed ID: 12911816 Stimulation of Cell Proliferation by Endosomal Epidermal Growth Factor Receptor As Revealed Through Two Distinct Phases of Signaling Molecular and Cellular Biology. Aug, 2003 | Pubmed ID: 12897150 Phospholipase C-gamma1: a Phospholipase and Guanine Nucleotide Exchange Factor Molecular Interventions. Oct, 2002 | Pubmed ID: 14993410 Internalization of Inactive EGF Receptor into Endosomes and the Subsequent Activation of Endosome-associated EGF Receptors. Epidermal Growth Factor Science's STKE : Signal Transduction Knowledge Environment. Dec, 2002 | Pubmed ID: 12464704 Endosomal Signaling of Epidermal Growth Factor Receptor Stimulates Signal Transduction Pathways Leading to Cell Survival Molecular and Cellular Biology. Oct, 2002 | Pubmed ID: 12242303 Live Imaging to Study Microtubule Dynamic Instability in Taxane-resistant Breast Cancers Richard Wang1, Harris Wang1, Zhixiang Wang1 1Department of Medical Genetics, Signal Transduction Research Group, Faculty of Medicine and Dentistry, University of Alberta JoVE 55027 Cancer Research
Live Imaging to Study Microtubule Dynamic Instability in Taxane-resistant Breast Cancers Richard Wang1, Harris Wang1, Zhixiang Wang1 1Department of Medical Genetics, Signal Transduction Research Group, Faculty of Medicine and Dentistry, University of Alberta JoVE 55027 Cancer Research