Christopher S. Chen Department of Bioengineering University of Pennsylvania Biography Publications Institution JoVE Articles Christopher S. Chen has not added a biography. If you are Christopher S. Chen and would like to personalize this page please email our Author Liaison for assistance. Publications MiR-125b is an Adhesion-Regulated MicroRNA That Protects Mesenchymal Stem Cells from Anoikis Stem Cells (Dayton, Ohio). Feb, 2012 | Pubmed ID: 22331826 Probing Cellular Traction Forces with Magnetic Nanowires and Microfabricated Force Sensor Arrays Nanotechnology. Feb, 2012 | Pubmed ID: 22260885 Matrix Rigidity Regulates a Switch Between TGF-β1-induced Apoptosis and Epithelial-mesenchymal Transition Molecular Biology of the Cell. Jan, 2012 | Pubmed ID: 22238361 A Microfabricated Platform to Measure and Manipulate the Mechanics of Engineered Cardiac Microtissues Tissue Engineering. Part A. Jan, 2012 | Pubmed ID: 22092279 Measuring Traction Forces of Motile Dendritic Cells on Micropost Arrays Biophysical Journal. Dec, 2011 | Pubmed ID: 22261049 Bioresponsive Mesoporous Silica Nanoparticles for Triggered Drug Release Journal of the American Chemical Society. Dec, 2011 | Pubmed ID: 21981330 Bone Morphogenetic Protein-2-Induced Signaling and Osteogenesis Is Regulated by Cell Shape, RhoA/ROCK, and Cytoskeletal Tension Stem Cells and Development. Oct, 2011 | Pubmed ID: 21967638 Repressor Transcription Factor 7-like 1 Promotes Adipogenic Competency in Precursor Cells Proceedings of the National Academy of Sciences of the United States of America. Sep, 2011 | Pubmed ID: 21914845 A Hitchhiker's Guide to Mechanobiology Developmental Cell. Jul, 2011 | Pubmed ID: 21763607 Decreased Cell Adhesion Promotes Angiogenesis in a Pyk2-dependent Manner Experimental Cell Research. Aug, 2011 | Pubmed ID: 21640103 Measurement and Analysis of Traction Force Dynamics in Response to Vasoactive Agonists Integrative Biology : Quantitative Biosciences from Nano to Macro. Jun, 2011 | Pubmed ID: 21445393 The Cdc42 Guanine Nucleotide Exchange Factor FGD1 Regulates Osteogenesis in Human Mesenchymal Stem Cells The American Journal of Pathology. Mar, 2011 | Pubmed ID: 21356349 Cell Shape and Substrate Rigidity Both Regulate Cell Stiffness Biophysical Journal. Mar, 2011 | Pubmed ID: 21354386 Subcellular Spatial Segregation of Integrin Subtypes by Patterned Multicomponent Surfaces Integrative Biology : Quantitative Biosciences from Nano to Macro. May, 2011 | Pubmed ID: 21298148 Nature Protocols. Feb, 2011 | Pubmed ID: 21293460 Measurement of Mechanical Tractions Exerted by Cells in Three-dimensional Matrices Nature Methods. Dec, 2010 | Pubmed ID: 21076420 Engineered Materials and the Cellular Microenvironment: a Strengthening Interface Between Cell Biology and Bioengineering Trends in Cell Biology. Dec, 2010 | Pubmed ID: 20965727 Micropatterned Dynamically Adhesive Substrates for Cell Migration Langmuir : the ACS Journal of Surfaces and Colloids. Nov, 2010 | Pubmed ID: 20886900 Mechanical Forces in Endothelial Cells During Firm Adhesion and Early Transmigration of Human Monocytes Cellular and Molecular Bioengineering. Mar, 2010 | Pubmed ID: 20862208 Decoupling Diffusional from Dimensional Control of Signaling in 3D Culture Reveals a Role for Myosin in Tubulogenesis Journal of Cell Science. Sep, 2010 | Pubmed ID: 20682635 Mechanical Regulation of Cell Function with Geometrically Modulated Elastomeric Substrates Nature Methods. Sep, 2010 | Pubmed ID: 20676108 Measuring Mechanical Tension Across Vinculin Reveals Regulation of Focal Adhesion Dynamics Nature. Jul, 2010 | Pubmed ID: 20613844 Mechanical Tugging Force Regulates the Size of Cell-cell Junctions Proceedings of the National Academy of Sciences of the United States of America. Jun, 2010 | Pubmed ID: 20463286 Geometrically Controlled Endothelial Tubulogenesis in Micropatterned Gels Tissue Engineering. Part A. Jul, 2010 | Pubmed ID: 20180698 Bioactive Hydrogels Made from Step-growth Derived PEG-peptide Macromers Biomaterials. May, 2010 | Pubmed ID: 20138664 Stem Cell Shape Regulates a Chondrogenic Versus Myogenic Fate Through Rac1 and N-cadherin Stem Cells (Dayton, Ohio). Mar, 2010 | Pubmed ID: 20082286 Cytoskeleton-based Forecasting of Stem Cell Lineage Fates Proceedings of the National Academy of Sciences of the United States of America. Jan, 2010 | Pubmed ID: 20080726 Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix Cell Stem Cell. Jul, 2009 | Pubmed ID: 19570510 Microfabricated Tissue Gauges to Measure and Manipulate Forces from 3D Microtissues Proceedings of the National Academy of Sciences of the United States of America. Jun, 2009 | Pubmed ID: 19541627 Cell Polarity Triggered by Cell-cell Adhesion Via E-cadherin Journal of Cell Science. Apr, 2009 | Pubmed ID: 19258396 Using Self-assembled Monolayers to Pattern ECM Proteins and Cells on Substrates Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 19247618 Mechanotransduction in Development: a Growing Role for Contractility Nature Reviews. Molecular Cell Biology. Jan, 2009 | Pubmed ID: 19197330 Cell Traction Forces Direct Fibronectin Matrix Assembly Biophysical Journal. Jan, 2009 | Pubmed ID: 19167317 Mechanotransduction - a Field Pulling Together? Journal of Cell Science. Oct, 2008 | Pubmed ID: 18843115 Immobilization of Growth Factors on Collagen Scaffolds Mediated by Polyanionic Collagen Mimetic Peptides and Its Effect on Endothelial Cell Morphogenesis Biomacromolecules. Oct, 2008 | Pubmed ID: 18816098 Emergence of Patterned Stem Cell Differentiation Within Multicellular Structures Stem Cells (Dayton, Ohio). Nov, 2008 | Pubmed ID: 18703661 Biotechnology: Remote Control of Living Cells Nature Nanotechnology. Jan, 2008 | Pubmed ID: 18654443 Engineering Amount of Cell-cell Contact Demonstrates Biphasic Proliferative Regulation Through RhoA and the Actin Cytoskeleton Experimental Cell Research. Sep, 2008 | Pubmed ID: 18652824 Myofibrillar Architecture in Engineered Cardiac Myocytes Circulation Research. Aug, 2008 | Pubmed ID: 18635822 Magnetic Microposts for Mechanical Stimulation of Biological Cells: Fabrication, Characterization, and Analysis The Review of Scientific Instruments. Apr, 2008 | Pubmed ID: 18447536 Spatial Patterning of Gene Expression Using Surface-immobilized Recombinant Adenovirus Biomedical Microdevices. Aug, 2008 | Pubmed ID: 18246428 Rac-dependent Cyclin D1 Gene Expression Regulated by Cadherin- and Integrin-mediated Adhesion Journal of Cell Science. Jan, 2008 | Pubmed ID: 18187454 Versatile, Fully Automated, Microfluidic Cell Culture System Analytical Chemistry. Nov, 2007 | Pubmed ID: 17953452 Cellular and Multicellular Form and Function Advanced Drug Delivery Reviews. Nov, 2007 | Pubmed ID: 17884241 Magnetic Microposts As an Approach to Apply Forces to Living Cells Proceedings of the National Academy of Sciences of the United States of America. Sep, 2007 | Pubmed ID: 17804810 Cadherins, RhoA, and Rac1 Are Differentially Required for Stretch-mediated Proliferation in Endothelial Versus Smooth Muscle Cells Circulation Research. Aug, 2007 | Pubmed ID: 17712140 Activation of ROCK by RhoA is Regulated by Cell Adhesion, Shape, and Cytoskeletal Tension Experimental Cell Research. Oct, 2007 | Pubmed ID: 17673200 Microfabricated Silicone Elastomeric Post Arrays for Measuring Traction Forces of Adherent Cells Methods in Cell Biology. 2007 | Pubmed ID: 17613314 Bait and Switch: Synthetic GEFs Divert an Input Signal to Diverse Cellular Responses Developmental Cell. Jul, 2007 | Pubmed ID: 17609105 Manipulation of Cell-cell Adhesion Using Bowtie-shaped Microwells Methods in Molecular Biology (Clifton, N.J.). 2007 | Pubmed ID: 17416983 Separate but Not Equal: Differential Mechanical Roles for Myosin Isoforms Biophysical Journal. May, 2007 | Pubmed ID: 17325018 An Inhibitory Role for FAK in Regulating Proliferation: a Link Between Limited Adhesion and RhoA-ROCK Signaling The Journal of Cell Biology. Jul, 2006 | Pubmed ID: 16847103 Heparin Binding Directs Activation of T Cells Against Adeno-associated Virus Serotype 2 Capsid Nature Medicine. Aug, 2006 | Pubmed ID: 16845388 E-cadherin Engagement Stimulates Proliferation Via Rac1 The Journal of Cell Biology. May, 2006 | Pubmed ID: 16682529 Nanotechnology for Cell-substrate Interactions Annals of Biomedical Engineering. Jan, 2006 | Pubmed ID: 16525764 Shear Force at the Cell-matrix Interface: Enhanced Analysis for Microfabricated Post Array Detectors Mechanics & Chemistry of Biosystems : MCB. 2005 | Pubmed ID: 16708468 Finite-element Analysis of the Adhesion-cytoskeleton-nucleus Mechanotransduction Pathway During Endothelial Cell Rounding: Axisymmetric Model Journal of Biomechanical Engineering. Aug, 2005 | Pubmed ID: 16121529 Emergent Patterns of Growth Controlled by Multicellular Form and Mechanics Proceedings of the National Academy of Sciences of the United States of America. Aug, 2005 | Pubmed ID: 16049098 T Cell-to-T Cell Clustering Enhances NF-kappaB Activity by a PI3K Signal Mediated by Cbl-b and Rho Biochemical and Biophysical Research Communications. Jul, 2005 | Pubmed ID: 15922296 Assembly of Multicellular Constructs and Microarrays of Cells Using Magnetic Nanowires Lab on a Chip. Jun, 2005 | Pubmed ID: 15915251 Nanopattern-induced Changes in Morphology and Motility of Smooth Muscle Cells Biomaterials. Sep, 2005 | Pubmed ID: 15814139 Optimization of Yield in Magnetic Cell Separations Using Nickel Nanowires of Different Lengths Biotechnology Progress. Mar-Apr, 2005 | Pubmed ID: 15801791 Facile Modification of Collagen Directed by Collagen Mimetic Peptides Journal of the American Chemical Society. Mar, 2005 | Pubmed ID: 15783169 Using Microenvironment to Engineer Stem Cell Function Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. 2004 | Pubmed ID: 17271427 Strategies for Engineering the Adhesive Microenvironment Journal of Mammary Gland Biology and Neoplasia. Oct, 2004 | Pubmed ID: 15838609 Characterization of the Nuclear Deformation Caused by Changes in Endothelial Cell Shape Journal of Biomechanical Engineering. Oct, 2004 | Pubmed ID: 15648807 Simple Approach to Micropattern Cells on Common Culture Substrates by Tuning Substrate Wettability Tissue Engineering. May-Jun, 2004 | Pubmed ID: 15265304 Mechanotransduction at Cell-matrix and Cell-cell Contacts Annual Review of Biomedical Engineering. 2004 | Pubmed ID: 15255771 Dielectrophoretic Registration of Living Cells to a Microelectrode Array Biosensors & Bioelectronics. Jul, 2004 | Pubmed ID: 15198083 Vascular Endothelial-cadherin Regulates Cytoskeletal Tension, Cell Spreading, and Focal Adhesions by Stimulating RhoA Molecular Biology of the Cell. Jun, 2004 | Pubmed ID: 15075376 Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment Developmental Cell. Apr, 2004 | Pubmed ID: 15068789 Dielectrophoretic Registration of Living Cells to a Microelectrode Array Biosensors & Bioelectronics. Feb, 2004 | Pubmed ID: 14709396 Repositioning of Cells by Mechanotaxis on Surfaces with Micropatterned Young's Modulus Journal of Biomedical Materials Research. Part A. Sep, 2003 | Pubmed ID: 12918044 VE-cadherin Simultaneously Stimulates and Inhibits Cell Proliferation by Altering Cytoskeletal Structure and Tension Journal of Cell Science. Sep, 2003 | Pubmed ID: 12876221 Cell Shape Provides Global Control of Focal Adhesion Assembly Biochemical and Biophysical Research Communications. Jul, 2003 | Pubmed ID: 12859964 Cells Lying on a Bed of Microneedles: an Approach to Isolate Mechanical Force Proceedings of the National Academy of Sciences of the United States of America. Feb, 2003 | Pubmed ID: 12552122 Engineering Cellular Microenvironments to Improve Cell-based Drug Testing Drug Discovery Today. Jun, 2002 | Pubmed ID: 12047872 Cell-cell Signaling by Direct Contact Increases Cell Proliferation Via a PI3K-dependent Signal FEBS Letters. Mar, 2002 | Pubmed ID: 11943158 Patterning the Cellular Microenvironment IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society. Jan-Feb, 2002 | Pubmed ID: 11935995 Fabrication of Aligned Microstructures with a Single Elastomeric Stamp Proceedings of the National Academy of Sciences of the United States of America. Feb, 2002 | Pubmed ID: 11842197 Microfabricated Post-Array-Detectors (mPADs): an Approach to Isolate Mechanical Forces Ravi A. Desai1, Michael T. Yang1, Nathan J. Sniadecki2, Wesley R. Legant1, Christopher S. Chen1 1Department of Bioengineering, University of Pennsylvania, 2University of Washington JoVE 311 Biology
Microfabricated Post-Array-Detectors (mPADs): an Approach to Isolate Mechanical Forces Ravi A. Desai1, Michael T. Yang1, Nathan J. Sniadecki2, Wesley R. Legant1, Christopher S. Chen1 1Department of Bioengineering, University of Pennsylvania, 2University of Washington JoVE 311 Biology