Richard Lin Massachusetts Institute of Technology Biography Publications Institution JoVE Articles Richard Lin has not added a biography. If you are Richard Lin and would like to personalize this page please email our Author Liaison for assistance. Publications Class III PI3K Vps34 Plays an Essential Role in Autophagy and in Heart and Liver Function Proceedings of the National Academy of Sciences of the United States of America. Feb, 2012 | Pubmed ID: 22308354 Alternative Activation in Systemic Juvenile Idiopathic Arthritis Monocytes Clinical Immunology (Orlando, Fla.). Dec, 2011 | Pubmed ID: 22281427 Direct Observation of Bed Utilization in the Pediatric Intensive Care Unit Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine. Nov, 2011 | Pubmed ID: 22106012 Identification of Candidate Serum Biomarkers for Severe Septic Shock-associated Kidney Injury Via Microarray Critical Care (London, England). Nov, 2011 | Pubmed ID: 22098946 VIP and Endothelin Receptor Antagonist: an Effective Combination Against Experimental Pulmonary Arterial Hypertension Respiratory Research. 2011 | Pubmed ID: 22029879 My Very First Narcotics Prescription Journal of Palliative Medicine. Oct, 2011 | Pubmed ID: 22004152 Hypoxia-induced Transcriptional Repression of the Melanoma-associated Oncogene MITF Proceedings of the National Academy of Sciences of the United States of America. Oct, 2011 | Pubmed ID: 21949374 PI3Ks Maintain the Structural Integrity of T-tubules in Cardiac Myocytes PloS One. 2011 | Pubmed ID: 21912691 Restoration of Defective L-type Ca2+ Current in Cardiac Myocytes of Type 2 Diabetic Db/db Mice by Akt and PKC-ι Journal of Cardiovascular Pharmacology. Oct, 2011 | Pubmed ID: 21753738 The Influence of Developmental Age on the Early Transcriptomic Response of Children with Septic Shock Molecular Medicine (Cambridge, Mass.). Jul, 2011 | Pubmed ID: 21738952 Validation of a Gene Expression-based Subclassification Strategy for Pediatric Septic Shock Critical Care Medicine. Nov, 2011 | Pubmed ID: 21705885 The New England Journal of Medicine. Jun, 2011 | Pubmed ID: 21631351 Ablation of PI3K P110-α Prevents High-fat Diet-induced Liver Steatosis Diabetes. May, 2011 | Pubmed ID: 21464441 The Beta Identity of Class I PtdIns3K: A Positive Role of P110β in Autophagy Revealed Autophagy. Feb, 2011 | Pubmed ID: 21160279 An Unusual Cause of Chest Pain: Mycobacterium Avium Complex and the Immune Reconstitution Inflammatory Syndrome Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine. May, 2011 | Pubmed ID: 20652963 The Class IA Phosphatidylinositol 3-kinase P110-beta Subunit is a Positive Regulator of Autophagy The Journal of Cell Biology. Nov, 2010 | Pubmed ID: 21059846 Ischaemia Modified Albumin Cannot Be Used for Rapid Exclusion of Acute Coronary Syndrome Emergency Medicine Journal : EMJ. Sep, 2010 | Pubmed ID: 20466824 Prenatal Cocaine Exposure Related to Cortisol Stress Reactivity in 11-year-old Children The Journal of Pediatrics. Aug, 2010 | Pubmed ID: 20400094 Lenalidomide for the Treatment of Cryoglobulinemia and Undifferentiated Spondyloarthropathy in a Patient with Multiple Myeloma Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases. Mar, 2010 | Pubmed ID: 20130475 Sarcoidosis-associated Unilateral Retinal Arteritis Ocular Immunology and Inflammation. Jan, 2010 | Pubmed ID: 20128642 Orbital Recurrence of B-progenitor Acute Lymphoblastic Leukemia in a Child Journal of Pediatric Ophthalmology and Strabismus. Jan-Feb, 2010 | Pubmed ID: 20128555 Regulation of Morphological Differentiation in S. Coelicolor by RNase III (AbsB) Cleavage of MRNA Encoding the AdpA Transcription Factor Molecular Microbiology. Feb, 2010 | Pubmed ID: 20059679 Rapid Automated Cell Quantification on HIV Microfluidic Devices Lab on a Chip. Dec, 2009 | Pubmed ID: 19904402 Engineered 3D Tissue Models for Cell-laden Microfluidic Channels Analytical and Bioanalytical Chemistry. Sep, 2009 | Pubmed ID: 19629459 Identification of Pediatric Septic Shock Subclasses Based on Genome-wide Expression Profiling BMC Medicine. 2009 | Pubmed ID: 19624809 Loss of Cardiac Phosphoinositide 3-kinase P110 Alpha Results in Contractile Dysfunction Circulation. Jul, 2009 | Pubmed ID: 19597047 Expression, Bioactivity, and Safety 1 Year After Adeno-associated Viral Vector Type 2-mediated Delivery of Neurturin to the Monkey Nigrostriatal System Support Cere-120 for Parkinson's Disease Neurosurgery. Apr, 2009 | Pubmed ID: 19349823 Genomic Expression Profiling Across the Pediatric Systemic Inflammatory Response Syndrome, Sepsis, and Septic Shock Spectrum Critical Care Medicine. May, 2009 | Pubmed ID: 19325468 Neuron-specific Enolase and S-100B Are Associated with Neurologic Outcome After Pediatric Cardiac Arrest Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. Jul, 2009 | Pubmed ID: 19307814 Rapamycin and MTOR Kinase Inhibitors Journal of Chemical Biology. Nov, 2008 | Pubmed ID: 19568796 PI3K Signaling Supports Amphetamine-induced Dopamine Efflux Biochemical and Biophysical Research Communications. Aug, 2008 | Pubmed ID: 18510945 Validating the Genomic Signature of Pediatric Septic Shock Physiological Genomics. Jun, 2008 | Pubmed ID: 18460642 Successful Treatment of Postoperative Fungal Endophthalmitis Using Intravitreal and Intracameral Voriconazole Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics. Apr, 2008 | Pubmed ID: 18321199 Glioma Cells on the Run - the Migratory Transcriptome of 10 Human Glioma Cell Lines BMC Genomics. 2008 | Pubmed ID: 18230158 Prospective Study Demonstrating the Efficacy of Combined Preoperative Three-day Application of Antibiotics and Povidone-iodine Irrigation Annals of Ophthalmology (Skokie, Ill.). 2007 | Pubmed ID: 18025652 Genome-level Longitudinal Expression of Signaling Pathways and Gene Networks in Pediatric Septic Shock Molecular Medicine (Cambridge, Mass.). Sep-Oct, 2007 | Pubmed ID: 17932561 Observational Trial of Antibiotic-coated Central Venous Catheters in Critically Ill Pediatric Patients The Pediatric Infectious Disease Journal. Sep, 2007 | Pubmed ID: 17721377 Angiogenesis is Induced by Airway Smooth Muscle Strain American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2007 | Pubmed ID: 17693481 Decreased L-type Ca2+ Current in Cardiac Myocytes of Type 1 Diabetic Akita Mice Due to Reduced Phosphatidylinositol 3-kinase Signaling Diabetes. Nov, 2007 | Pubmed ID: 17666471 Inhibition of Mammalian Target of Rapamycin Signaling by 2-(morpholin-1-yl)pyrimido[2,1-alpha]isoquinolin-4-one The Journal of Biological Chemistry. Aug, 2007 | Pubmed ID: 17562705 Genome-level Expression Profiles in Pediatric Septic Shock Indicate a Role for Altered Zinc Homeostasis in Poor Outcome Physiological Genomics. Jul, 2007 | Pubmed ID: 17374846 Natural Mutations in the Receptor Binding Domain of Spike Glycoprotein Determine the Reactivity of Cross-neutralization Between Palm Civet Coronavirus and Severe Acute Respiratory Syndrome Coronavirus Journal of Virology. May, 2007 | Pubmed ID: 17314167 Moderate Pulmonary Arterial Hypertension in Male Mice Lacking the Vasoactive Intestinal Peptide Gene Circulation. Mar, 2007 | Pubmed ID: 17309917 Retrospective Analysis of the Prognostic Value of Electroencephalography Patterns Obtained in Pediatric In-hospital Cardiac Arrest Survivors During Three Years Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. Jan, 2007 | Pubmed ID: 17251876 Antiangiogenic Therapy in Neovascular Age-related Macular Degeneration International Ophthalmology Clinics. 2007 | Pubmed ID: 17237677 Reversible Heart Failure in G Alpha(q) Transgenic Mice The Journal of Biological Chemistry. Oct, 2006 | Pubmed ID: 16893886 A Child with Anterior Mediastinal Mass Supported with Veno-arterial Extracorporeal Membrane Oxygenation Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. Sep, 2006 | Pubmed ID: 16885791 Short-term Safety and Efficacy of Intravitreal Bevacizumab (Avastin) for Neovascular Age-related Macular Degeneration Retina (Philadelphia, Pa.). May-Jun, 2006 | Pubmed ID: 16770255 Galphaq Binds to P110alpha/p85alpha Phosphoinositide 3-kinase and Displaces Ras The Biochemical Journal. Mar, 2006 | Pubmed ID: 16268778 A Transgenic Mouse Model of Heart Failure Using Inducible Galpha Q The Journal of Biological Chemistry. Dec, 2005 | Pubmed ID: 16210321 Galpha Q Inhibits Cardiac L-type Ca2+ Channels Through Phosphatidylinositol 3-kinase The Journal of Biological Chemistry. Dec, 2005 | Pubmed ID: 16186103 Granulysin-derived Peptides Demonstrate Antimicrobial and Anti-inflammatory Effects Against Propionibacterium Acnes The Journal of Investigative Dermatology. Aug, 2005 | Pubmed ID: 16098035 Kinetic Therapy Improves Oxygenation in Critically Ill Pediatric Patients Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. Jul, 2005 | Pubmed ID: 15982429 A Toddler with Obtundation and Miosis Pediatric Emergency Care. Mar, 2005 | Pubmed ID: 15744203 Preoperative Tibiofemoral Angle Predicts Survival of Proximal Tibia Osteotomy Clinical Orthopaedics and Related Research. Mar, 2005 | Pubmed ID: 15738821 An Integrated Data Analysis Approach to Characterize Genes Highly Expressed in Hepatocellular Carcinoma Oncogene. May, 2005 | Pubmed ID: 15735714 Age Alterations in Extent and Severity of Experimental Intranasal Infection with Chlamydophila Pneumoniae in BALB/c Mice Infection and Immunity. Mar, 2005 | Pubmed ID: 15731073 Time Out! Is Timepiece Variability a Factor in Critical Care? American Journal of Critical Care : an Official Publication, American Association of Critical-Care Nurses. Mar, 2005 | Pubmed ID: 15728953 An Evaluation of a Noninvasive Cardiac Output Measurement Using Partial Carbon Dioxide Rebreathing in Children Anesthesia and Analgesia. Dec, 2004 | Pubmed ID: 15562047 Phospholipase C-independent Activation of Glycogen Synthase Kinase-3beta and C-terminal Src Kinase by Galphaq The Journal of Biological Chemistry. Dec, 2003 | Pubmed ID: 14561750 Ca(2+)- and Phospholipase D-dependent and -independent Pathways Activate MTOR Signaling FEBS Letters. Aug, 2003 | Pubmed ID: 12935885 Self-expandable Metal Stents in Palliation of Malignant Gastrointestinal Obstruction: Review of the Current Literature Data and 5-year Experience at Harbor-UCLA Medical Center MedGenMed : Medscape General Medicine. Jan, 2003 | Pubmed ID: 12827077 Activated G Alpha Q Inhibits P110 Alpha Phosphatidylinositol 3-kinase and Akt The Journal of Biological Chemistry. Jun, 2003 | Pubmed ID: 12704201 Stimulation of the Alpha1A Adrenergic Receptor Inhibits PDGF-induced PDGF Beta Receptor Tyr751 Phosphorylation and PI 3-kinase Activation FEBS Letters. Apr, 2003 | Pubmed ID: 12681492 Selective Decreases in Amphetamine Self-administration and Regulation of Dopamine Transporter Function in Diabetic Rats Neuroendocrinology. Feb, 2003 | Pubmed ID: 12624535 Withdrawing Life-sustaining Medical Treatment--a Physician's Personal Reflection Mental Retardation and Developmental Disabilities Research Reviews. 2003 | Pubmed ID: 12587132 The Sensitivity of Fixed-bed Biological Perchlorate Removal to Changes in Operating Conditions and Water Quality Characteristics Water Research. Jan, 2003 | Pubmed ID: 12465802 Junctional Ectopic Tachycardia in Association with Blunt Abdominal Trauma Annals of Emergency Medicine. Sep, 2002 | Pubmed ID: 12192355 PI 3-kinase Regulation of Dopamine Uptake Journal of Neurochemistry. May, 2002 | Pubmed ID: 12065645 Sutureless Securement Device Reduces Complications of Peripherally Inserted Central Venous Catheters Journal of Vascular and Interventional Radiology : JVIR. Jan, 2002 | Pubmed ID: 11788698 CD4+ T-Lymphocyte Capture Using a Disposable Microfluidic Chip for HIV Sang Jun Moon1, Richard Lin2, Utkan Demirci1 1Bio-Acoustic-MEMS Laboratory in Medicine (BAMM), HST-Center for Bioengineering, Brigham and Women's Hospital, 2Massachusetts Institute of Technology Biology
CD4+ T-Lymphocyte Capture Using a Disposable Microfluidic Chip for HIV Sang Jun Moon1, Richard Lin2, Utkan Demirci1 1Bio-Acoustic-MEMS Laboratory in Medicine (BAMM), HST-Center for Bioengineering, Brigham and Women's Hospital, 2Massachusetts Institute of Technology Biology