Scott Diamond Institute for Medicine and Engineering University of Pennsylvania Biography Publications Institution JoVE Articles Scott Diamond has not added a biography. If you are Scott Diamond and would like to personalize this page please email our Author Liaison for assistance. Publications Drug Discovery for Duchenne Muscular Dystrophy Via Utrophin Promoter Activation Screening PloS One. 2011 | Pubmed ID: 22028826 Small Molecule Inhibition of RISC Loading ACS Chemical Biology. Nov, 2011 | Pubmed ID: 22026461 Relipidated Tissue Factor Linked to Collagen Surfaces Potentiates Platelet Adhesion and Fibrin Formation in a Microfluidic Model of Vessel Injury Bioconjugate Chemistry. Oct, 2011 | Pubmed ID: 21902184 Identification of Specific Inhibitors of Human RAD51 Recombinase Using High-throughput Screening ACS Chemical Biology. Jun, 2011 | Pubmed ID: 21428443 Novel High-throughput Screen Against Candida Albicans Identifies Antifungal Potentiators and Agents Effective Against Biofilms The Journal of Antimicrobial Chemotherapy. Apr, 2011 | Pubmed ID: 21393183 Enhancers of Adeno-associated Virus AAV2 Transduction Via High Throughput SiRNA Screening Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2011 | Pubmed ID: 21304495 Simulation of Aggregating Particles in Complex Flows by the Lattice Kinetic Monte Carlo Method The Journal of Chemical Physics. Jan, 2011 | Pubmed ID: 21261389 A High-throughput Multiplexed Screening Assay for Optimizing Serum-free Differentiation Protocols of Human Embryonic Stem Cells Stem Cell Research. Mar, 2011 | Pubmed ID: 21169079 The Kinetics of αIIbβ3 Activation Determines the Size and Stability of Thrombi in Mice: Implications for Antiplatelet Therapy Blood. Jan, 2011 | Pubmed ID: 20971951 High-throughput Screening of a Small Molecule Library for Promoters and Inhibitors of Mesenchymal Stem Cell Osteogenic Differentiation Biotechnology and Bioengineering. Jan, 2011 | Pubmed ID: 20824673 Systems Biology of Coagulation Initiation: Kinetics of Thrombin Generation in Resting and Activated Human Blood PLoS Computational Biology. 2010 | Pubmed ID: 20941387 Nanodroplet Chemical Microarrays and Label-free Assays Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20857358 Diminished Contact-dependent Reinforcement of Syk Activation Underlies Impaired Thrombus Growth in Mice Lacking Semaphorin 4D Blood. Dec, 2010 | Pubmed ID: 20855865 RGS/Gi2alpha Interactions Modulate Platelet Accumulation and Thrombus Formation at Sites of Vascular Injury Blood. Dec, 2010 | Pubmed ID: 20852125 Identification of Novel Inhibitors of Dietary Lipid Absorption Using Zebrafish PloS One. 2010 | Pubmed ID: 20811635 Novel Cationic Lipids with Enhanced Gene Delivery and Antimicrobial Activity Molecular Pharmacology. Sep, 2010 | Pubmed ID: 20573781 Pairwise Agonist Scanning Predicts Cellular Signaling Responses to Combinatorial Stimuli Nature Biotechnology. Jul, 2010 | Pubmed ID: 20562863 Discovery of Potent Small-molecule Inhibitors of Multidrug-resistant Plasmodium Falciparum Using a Novel Miniaturized High-throughput Luciferase-based Assay Antimicrobial Agents and Chemotherapy. Sep, 2010 | Pubmed ID: 20547797 A Small-molecule Oxocarbazate Inhibitor of Human Cathepsin L Blocks Severe Acute Respiratory Syndrome and Ebola Pseudotype Virus Infection into Human Embryonic Kidney 293T Cells Molecular Pharmacology. Aug, 2010 | Pubmed ID: 20466822 Cathepsin L Occupies a Vacuolar Compartment and is a Protein Maturase Within the Endo/exocytic System of Toxoplasma Gondii Molecular Microbiology. Jun, 2010 | Pubmed ID: 20444089 Design, Synthesis and Biological Evaluation of a Library of Thiocarbazates and Their Activity As Cysteine Protease Inhibitors Combinatorial Chemistry & High Throughput Screening. May, 2010 | Pubmed ID: 20438448 Combined Antibacterial and Anti-inflammatory Activity of a Cationic Disubstituted Dexamethasone-spermine Conjugate Antimicrobial Agents and Chemotherapy. Jun, 2010 | Pubmed ID: 20308375 Tissue Factor Activity Under Flow Thrombosis Research. Apr, 2010 | Pubmed ID: 20149924 Identification of Triazinoindol-benzimidazolones As Nanomolar Inhibitors of the Mycobacterium Tuberculosis Enzyme TDP-6-deoxy-d-xylo-4-hexopyranosid-4-ulose 3,5-epimerase (RmlC) Bioorganic & Medicinal Chemistry. Jan, 2010 | Pubmed ID: 19969466 Molecular Priming of Lyn by GPVI Enables an Immune Receptor to Adopt a Hemostatic Role Proceedings of the National Academy of Sciences of the United States of America. Dec, 2009 | Pubmed ID: 19940238 From Imide to Lactam Metallo-pyridocarbazoles: Distinct Scaffolds for the Design of Selective Protein Kinase Inhibitors The Journal of Organic Chemistry. Dec, 2009 | Pubmed ID: 19886617 Bactericidal Activities of the Cationic Steroid CSA-13 and the Cathelicidin Peptide LL-37 Against Helicobacter Pylori in Simulated Gastric Juice BMC Microbiology. 2009 | Pubmed ID: 19728885 Discovery of Chemical Modulators of a Conserved Translational Control Pathway by Parallel Screening in Yeast Assay and Drug Development Technologies. Oct, 2009 | Pubmed ID: 19715453 Membrane Cholesterol is a Biomechanical Regulator of Neutrophil Adhesion Arteriosclerosis, Thrombosis, and Vascular Biology. Sep, 2009 | Pubmed ID: 19667108 Cationic Lipid Formulations Alter the in Vivo Tropism of AAV2/9 Vector in Lung Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2009 | Pubmed ID: 19638960 Disruption of SEMA4D Ameliorates Platelet Hypersensitivity in Dyslipidemia and Confers Protection Against the Development of Atherosclerosis Arteriosclerosis, Thrombosis, and Vascular Biology. Jul, 2009 | Pubmed ID: 19390055 Lattice Kinetic Monte Carlo Simulations of Convective-diffusive Systems The Journal of Chemical Physics. Mar, 2009 | Pubmed ID: 19275421 Steady-state Kinetic Modeling Constrains Cellular Resting States and Dynamic Behavior PLoS Computational Biology. Mar, 2009 | Pubmed ID: 19266013 Toward the Development of a Potent and Selective Organoruthenium Mammalian Sterile 20 Kinase Inhibitor Journal of Medicinal Chemistry. Mar, 2009 | Pubmed ID: 19226137 High-throughput Screening for Modulators of Mesenchymal Stem Cell Chondrogenesis Annals of Biomedical Engineering. Nov, 2008 | Pubmed ID: 18791827 Ethanol Enhances Neutrophil Membrane Tether Growth and Slows Rolling on P-selectin but Reduces Capture from Flow and Firm Arrest on IL-1-treated Endothelium Journal of Immunology (Baltimore, Md. : 1950). Aug, 2008 | Pubmed ID: 18684938 RNA Interference Screen to Identify Pathways That Enhance or Reduce Nonviral Gene Transfer During Lipofection Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2008 | Pubmed ID: 18628755 Molecular Docking of Cathepsin L Inhibitors in the Binding Site of Papain Journal of Chemical Information and Modeling. Jul, 2008 | Pubmed ID: 18598021 A Molecular Signaling Model of Platelet Phosphoinositide and Calcium Regulation During Homeostasis and P2Y1 Activation Blood. Nov, 2008 | Pubmed ID: 18596227 Evaluation of an Orthogonal Pooling Strategy for Rapid High-throughput Screening of Proteases Assay and Drug Development Technologies. Jun, 2008 | Pubmed ID: 18593377 Proteases' Prime Targets Revealed Nature Biotechnology. Jun, 2008 | Pubmed ID: 18536687 Design, Synthesis, and Evaluation of Inhibitors of Cathepsin L: Exploiting a Unique Thiocarbazate Chemotype Bioorganic & Medicinal Chemistry Letters. Jun, 2008 | Pubmed ID: 18499453 A Membrane-based Microfluidic Device for Controlling the Flux of Platelet Agonists into Flowing Blood Lab on a Chip. May, 2008 | Pubmed ID: 18432339 Kinetic Characterization and Molecular Docking of a Novel, Potent, and Selective Slow-binding Inhibitor of Human Cathepsin L Molecular Pharmacology. Jul, 2008 | Pubmed ID: 18403718 Harry L. Goldsmith, Ph.d Annals of Biomedical Engineering. Apr, 2008 | Pubmed ID: 18330702 Hemodynamic Regulation of Inflammation at the Endothelial-neutrophil Interface Annals of Biomedical Engineering. Apr, 2008 | Pubmed ID: 18299991 Determination of Surface Tissue Factor Thresholds That Trigger Coagulation at Venous and Arterial Shear Rates: Amplification of 100 FM Circulating Tissue Factor Requires Flow Blood. Apr, 2008 | Pubmed ID: 18203955 Identification and Synthesis of a Unique Thiocarbazate Cathepsin L Inhibitor Bioorganic & Medicinal Chemistry Letters. Jan, 2008 | Pubmed ID: 18060772 A Saccharomyces Cerevisiae Cell-based Quantitative Beta-galactosidase Assay Compatible with Robotic Handling and High-throughput Screening Yeast (Chichester, England). Jan, 2008 | Pubmed ID: 17957822 Identification and Characterization of 3-substituted Pyrazolyl Esters As Alternate Substrates for Cathepsin B: the Confounding Effects of DTT and Cysteine in Biological Assays Bioorganic & Medicinal Chemistry Letters. Sep, 2007 | Pubmed ID: 17656088 Biotinylated Photocleavable Polyethylenimine: Capture and Triggered Release of Nucleic Acids from Solid Supports Bioconjugate Chemistry. May-Jun, 2007 | Pubmed ID: 17432825 Synthesis and Structure-activity Relationships of a Series of Increasingly Hydrophobic Cationic Steroid Lipofection Reagents The Journal of Gene Medicine. May, 2007 | Pubmed ID: 17366520 Methods for Mapping Protease Specificity Current Opinion in Chemical Biology. Feb, 2007 | Pubmed ID: 17157549 Differential Utilization of Transcription Activation Subdomains by Distinct Coactivators Regulates Pit-1 Basal and Ras Responsiveness Molecular Endocrinology (Baltimore, Md.). Jan, 2007 | Pubmed ID: 17021049 Controlled Release of DNA/polyamine Complex by Photoirradiation of a Solid Phase Presenting O-nitrobenzyl Ether Tethered Spermine or Polyethyleneimine Bioorganic & Medicinal Chemistry Letters. Nov, 2006 | Pubmed ID: 16931009 Matrix Protein Microarrays for Spatially and Compositionally Controlled Microspot Thrombosis Under Laminar Flow Biophysical Journal. Nov, 2006 | Pubmed ID: 16905604 Photocleavage of O-nitrobenzyl Ether Derivatives for Rapid Biomedical Release Applications Bioorganic & Medicinal Chemistry Letters. Aug, 2006 | Pubmed ID: 16713258 Functional Phenotyping of Human Plasma Using a 361-fluorogenic Substrate Biosensing Microarray Biotechnology and Bioengineering. Aug, 2006 | Pubmed ID: 16575920 Microarrays for the Functional Analysis of the Chemical-kinase Interactome Journal of Biomolecular Screening. Feb, 2006 | Pubmed ID: 16314406 Fibrin Affinity of Erythrocyte-coupled Tissue-type Plasminogen Activators Endures Hemodynamic Forces and Enhances Fibrinolysis in Vivo The Journal of Pharmacology and Experimental Therapeutics. Mar, 2006 | Pubmed ID: 16284278 Stochastic Modeling of Blood Coagulation Initiation Pathophysiology of Haemostasis and Thrombosis. 2005 | Pubmed ID: 16432310 Targeting Viral-mediated Transduction to the Lung Airway Epithelium with the Anti-inflammatory Cationic Lipid Dexamethasone-spermine Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2005 | Pubmed ID: 16099413 Inhibitors of Cathepsin L Prevent Severe Acute Respiratory Syndrome Coronavirus Entry Proceedings of the National Academy of Sciences of the United States of America. Aug, 2005 | Pubmed ID: 16081529 Nanoliter Homogenous Ultra-high Throughput Screening Microarray for Lead Discoveries and IC50 Profiling Assay and Drug Development Technologies. Apr, 2005 | Pubmed ID: 15871692 Profiling Serine Protease Substrate Specificity with Solution Phase Fluorogenic Peptide Microarrays Proteomics. Apr, 2005 | Pubmed ID: 15742319 High Throughput Substrate Specificity Profiling of Serine and Cysteine Proteases Using Solution-phase Fluorogenic Peptide Microarrays Molecular & Cellular Proteomics : MCP. May, 2005 | Pubmed ID: 15705970 Use of D-dimer to Aid in Excluding Deep Venous Thrombosis in Ambulatory Patients American Journal of Surgery. Jan, 2005 | Pubmed ID: 15701485 Blood Coagulation Kinetics: High Throughput Method for Real-time Reaction Monitoring Thrombosis and Haemostasis. Oct, 2004 | Pubmed ID: 15467920 Mouse Embryonic Stem Cells Efficiently Lipofected with Nuclear Localization Peptide Result in a High Yield of Chimeric Mice and Retain Germline Transmission Potency Methods (San Diego, Calif.). Jun, 2004 | Pubmed ID: 15121165 Exogenous Nitric Oxide Activates the Endothelial Glucocorticoid Receptor Biochemical and Biophysical Research Communications. May, 2004 | Pubmed ID: 15110772 Surfactants Attenuate Gas Embolism-induced Thrombin Production Anesthesiology. Jan, 2004 | Pubmed ID: 14695727 Vascular Injuries to the Extremities in a Suburban Trauma Center The American Surgeon. Oct, 2003 | Pubmed ID: 14570361 Printing Chemical Libraries on Microarrays for Fluid Phase Nanoliter Reactions Proceedings of the National Academy of Sciences of the United States of America. Jul, 2003 | Pubmed ID: 12851459 The Epithelial-specific ETS Transcription Factor ESX/ESE-1/Elf-3 Modulates Breast Cancer-associated Gene Expression DNA and Cell Biology. Feb, 2003 | Pubmed ID: 12713734 Alterations in the Intrinsic Properties of the GPIbalpha-VWF Tether Bond Define the Kinetics of the Platelet-type Von Willebrand Disease Mutation, Gly233Val Blood. Jul, 2003 | Pubmed ID: 12637314 Shear Stress Causes Nuclear Localization of Endothelial Glucocorticoid Receptor and Expression from the GRE Promoter Circulation Research. Feb, 2003 | Pubmed ID: 12595339 Neutrophil Cathepsin G Promotes Prothrombinase and Fibrin Formation Under Flow Conditions by Activating Fibrinogen-adherent Platelets The Journal of Biological Chemistry. Mar, 2003 | Pubmed ID: 12524437 Adhesion of Normal Erythrocytes at Depressed Venous Shear Rates to Activated Neutrophils, Activated Platelets, and Fibrin Polymerized from Plasma Blood. Nov, 2002 | Pubmed ID: 12393714 Selectin-like Kinetics and Biomechanics Promote Rapid Platelet Adhesion in Flow: the GPIb(alpha)-vWF Tether Bond Biophysical Journal. Jul, 2002 | Pubmed ID: 12080112 Endovascular Microcoil Gene Delivery Using Immobilized Anti-adenovirus Antibody for Vector Tethering Stroke; a Journal of Cerebral Circulation. May, 2002 | Pubmed ID: 11988618 Comparison of PSGL-1 Microbead and Neutrophil Rolling: Microvillus Elongation Stabilizes P-selectin Bond Clusters Biophysical Journal. Apr, 2002 | Pubmed ID: 11916843 Adenovirus or HA-2 Fusogenic Peptide-assisted Lipofection Increases Cytoplasmic Levels of Plasmid in Nondividing Endothelium with Little Enhancement of Transgene Expression The Journal of Gene Medicine. Jan-Feb, 2002 | Pubmed ID: 11828390 Neutrophil Isolation Protocol Hana Oh1, Brian Siano1, Scott Diamond1 1Institute for Medicine and Engineering, University of Pennsylvania JoVE 745 Biology
Neutrophil Isolation Protocol Hana Oh1, Brian Siano1, Scott Diamond1 1Institute for Medicine and Engineering, University of Pennsylvania JoVE 745 Biology