Histological Staining of Spinal Cord for Assessing EAE Disease Severity

February 23rd, 2024

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Carmen C. Ucciferri¹, Annette Gower², Nuria Alvarez-Sanchez^1,2, Heather Whetstone³, Valeria Ramaglia¹, Jennifer L. Gommerman¹, Koroboshka Brand-Arzamendi², Raphael Schneider^2,4, Shannon E Dunn^1,2,5

¹Department of Immunology, University of Toronto, ²Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, ³Sickkids Research Institute, The Hospital for Sick Children, ⁴BARLO MS Centre, St. Michael’s Hospital, ⁵Women’s College Research Institute, Women’s College Hospital

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Экспериментальный аутоиммунный энцефаломиелит (ЭАЭ) служит животной моделью рассеянного склероза. В данной статье описан подход к оценке воспаления, демиелинизации и повреждения аксонов спинного мозга при ЭАЭ. Кроме того, представлен метод количественной оценки растворимых уровней света нейрофиламентов в сыворотке крови мышей, облегчающий оценку повреждения аксонов у живых мышей.

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Histological Staining of Spinal Cord for Assessing EAE Disease Severity

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