Name: ion channels in cells and membranes
Uploaded: 2019-03-11T09:21:08.000Z
Duration: 1 min 19 s
Channel: JoVE

Ion channels are transmembrane proteins that allow the passive movement of a specific ion across the membrane, down its electrochemical gradient.
These channels contain pores for the ions to pass through. The channels&#160; can be gated or non-gated. Gated ion channels require a stimulus, such as ligand binding, voltage change, or mechanical stress, to open. Non-gated ion channels need no such stimulus, they can open and close at random.&#160;
Ion channels have wide roles in living organisms. For example, in neurons, the opening and closing of sodium and potassium voltage-gated channels helps transmit nerve impulses.
Likewise, the non-gated sodium and potassium channels play an essential role in maintaining the resting membrane potential of a cell, negative 70 millivolts.
In plant leaves, the opening and closing of the stomata are triggered by the inward and outward flow of potassium ions through the specialized potassium channels.
Ion channels are also widespread in bacteria, playing important roles in the influx of salts and nutrients and maintaining osmotic balance.

ion channels

Ion Channels

The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels&#8212;a class of membrane transport proteins&#8212;help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow specific ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential critical for cell viability. Two types of channels traverse the plasma membrane, the gated and non-gated channels, that can transport more than a thousand ions within milliseconds.
For most cells, especially excitable ones, there is a more negative charge in the interior of the cell than the exterior due to a greater number of negative ions than positive ions. For excitable cells, like firing neurons, contracting muscle cells, or sensory touch cells, the membrane potential must be able to change rapidly, moving from a negative membrane potential to one that is more positive. To achieve this, cells rely on two types of gated ion channels: ligand-gated and voltage-gated ion channels.
Ion channels may play a role in migraine headaches. The dura mater is a protective covering for the brain. It is innervated by several cranial nerves. It is hypothesized that migraines originate in these nerves. Both ligand- and voltage-gated ion channels in the dura mater may potentiate pain signals by altering membrane potentials.
Ion channels are found in plants. For instance, in plant leaves, the opening of the stomata by the surrounding guard cells requires potassium ion (K+) gradients. The active transport of hydrogen ions (H+) out of the guard cell creates a membrane potential that drives the inward movement of&#160; K+. This uptake of K+ by guard cells through the potassium channels triggers water movement into the cells. This osmotic influx causes the guard cells to expand, opening the stomata. When the potassium leaves the guard cells, water follows via osmosis. The now flaccid guard cells close the stoma.
Bacteria require ion gradients for several cellular functions maintained by different ion channels. Porins in prokaryotes allow the passive diffusion of nutrients, salts, and waste across the membrane and down the concentration gradient without the expenditure of ATP. Also, gated mechanosensitive channels play an important role during osmotic shock. When the bacteria move from a region of high osmolarity to a region of low osmolarity, these channels, acting as emergency release valves, open to release the solutes out into the cytoplasm to maintain the imbalance between the external and internal environments.

The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. ...

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ion channels in cells and membranes

Ion channels are membrane proteins that help cells move ions across the plasma membrane. Ions such as sodium, potassium, and calcium move into and out of cells to maintain the electrochemical gradient. This gradient supports cell size and volume, nerve signaling, and gas and nutrient exchange.

Ion channels are specialized integral membrane proteins that let specific ions pass down their electrochemical gradient. Their main job is to help keep the membrane potential, which is needed for cell survival. Some channels are non-gated, and others are gated. These channels can move more than a thousand ions in milliseconds.

Most cells have a more negative charge inside than outside because they contain more negative ions than positive ions. Excitable cells need that membrane potential to change quickly. Neurons, muscle cells, and sensory touch cells can shift from a negative membrane potential to a more positive one. They use ligand-gated ion channels, which open when a molecule binds, and voltage-gated ion channels, which open when the membrane voltage changes.

Ion channels may also be involved in migraine headaches. The dura mater is the protective covering around the brain, and several cranial nerves innervate it. Researchers think migraines may begin in these nerves. Ligand-gated and voltage-gated ion channels in the dura mater may strengthen pain signals by changing membrane potentials.

Ion channels are also important in plants. In leaves, guard cells use potassium ion gradients to open and close stomata. Hydrogen ions are actively pumped out of the guard cell, creating a membrane potential that drives potassium ions into the cell through potassium channels. Water then moves in by osmosis, the guard cells swell, and the stoma opens. When potassium leaves, water follows, the cells become flaccid, and the stoma closes.

Bacteria also depend on ion gradients for key cell functions. Porins in prokaryotes allow passive diffusion of nutrients, salts, and waste across the membrane without ATP. Gated mechanosensitive channels help during osmotic shock. When bacteria move from a high-osmolarity region to a low-osmolarity region, these channels act like emergency release valves and let solutes out to help restore balance between the inside and outside of the cell.

Ion Channels in Cells and Membranes

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Ion channels are membrane proteins that help cells move ions across the plasma membrane. Ions such as sodium, potassium, and calcium move into and out of cells to maintain the electrochemical gradient. This gradient supports cell size and volume, nerve signaling, and gas and nutrient exchange. Ion channels are specialized integral membrane proteins that let specific ions pass down their electrochemical gradient. Their main job is to help keep the membrane potential, which is needed for cell...

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intracellular signaling cascades

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key terms and concepts

Learn how ion channels move sodium, potassium, and calcium to maintain membrane potential, support nerve signals, open stomata, and help bacteria handle osmotic shock.

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Ion Channels in Cells and Membranes

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