Blood Stem Cell Fate Decisions

Blood stem cell fate decisions guide how hematopoietic stem cells become specific blood and immune cells. During commitment, stem cells lose the ability to form all cell types and change irreversibly into a more limited fate.

Multipotent hematopoietic stem cells, or HSCs, first differentiate into...

Lineage commitment is an irreversible process where hematopoietic stem cells or HSCs lose their multipotency and differentiate into precursors of a particular cell type.

The stepwise process is primarily determined by growth factors called cytokines, which help the progenitors give rise to specific blood and immune cells.

First, th...