Name: how sunlight triggers vitamin d in skin
Uploaded: 2023-06-23T15:38:44.000Z
Duration: 1 min 23 s
Channel: JoVE

K12 Standards

ohios-learning-standards-and-model-curriculum

Ohio’s Learning Standards and Model Curriculum

9-12

Human Anatomy and Physiology

Support And Motion

Integumentary System

Role of Skin in Vitamin D Synthesis

Dietary intake and sunlight-driven synthesis are the two main sources of vitamin D for the human body.
Under optimal sunlight exposure skin cells can synthesize vitamin D3, a vitamin D precursor. Briefly, the UVB component of the sunlight reacts with provitamin D3, a cholesterol-based steroid in the cells of the stratum basale and stratum spinosum converting it to previtamin D3, which later transforms into cholecalciferol or vitamin D3.
It then enters the circulation, attaches to vitamin D-binding protein in the serum, and reaches the liver, where it is converted into calcidiol.
It is a biologically inactive primary circulating form of the vitamin, which ultimately reaches the kidneys and undergoes conversion to calcitriol, the active form of vitamin D.
Calcitriol stimulates calcium and phosphorus absorption from the gastrointestinal tract to raise their serum levels aiding skeletal health. Severe vitamin D deficiency can cause rickets in children, osteomalacia, and osteoporosis in adults.
Seasons, location, and sunscreen use can also influence sun-induced vitamin D3 production.

role of skin in vitamin d synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol). Once vitamin D3 is formed in the skin, it diffuses into the blood vessels of the dermis, the layer of skin beneath the epidermis. From there, it enters the bloodstream and is transported to various tissues and organs in the body.
Vitamin D3 is lipid soluble, so adipocytes can store it during excessive production. The vitamin has both inhibitory and stimulatory effects on the differentiation of adipocytes. The result depends on the differentiation stage of the cell and cell type.
It is important to note that while sunlight is a significant source of vitamin D, other factors can influence the skin&#39;s ability to produce it. These factors include the latitude, the season, the time of day, skin pigmentation, clothing, sunscreen use, and age. For example, people with darker skin have higher levels of melanin, which can reduce the skin&#39;s ability to synthesize vitamin D compared to individuals with lighter skin.
Vitamin D is vital in energy metabolism modulating fatty acid oxidation, insulin resistance, and even adipokine production. It aids absorption of calcium and phosphates in the intestine to improve bone health.
This text is adapted from <a href="https://openstax.org/books/anatomy-and-physiology-2e/pages/17-10-organs-with-secondary-endocrine-functions">https://openstax.org/books/anatomy-and-physiology-2e/pages/17-10-organs-with-secondary-endocrine-functions</a>

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because ...

Education

JoVE Core

Anatomy and Physiology

Unit 1

The Integumentary System

KEY TERMS AND CONCEPTS

how sunlight triggers vitamin d in skin

The skin helps make vitamin D when it is exposed to sunlight. UVB radiation from the sun, with wavelengths of 290 to 315 nm, starts a chemical reaction in the skin. This makes vitamin D unique because it can be synthesized in the body through the skin.

In this process, UVB rays are absorbed by the skin and convert 7-dehydrocholesterol, also called provitamin D3, into previtamin D3. Previtamin D3 then changes quickly into vitamin D3, also known as cholecalciferol. Once vitamin D3 forms, it diffuses into the blood vessels of the dermis, which is the skin layer below the epidermis.

How Sunlight Triggers Vitamin D in Skin

introduction to the integumentary system

Layers and Functions of Skin

The integumentary system includes the skin and its associated structures. It is the largest organ system in the human body. It helps protect the body and maintain homeostasis, which means keeping internal conditions stable. Skin has three main layers: the epidermis, dermis, and hypodermis, also called subcutaneous tissue. The epidermis is the outermost layer. It forms a protective barrier against bacteria, UV radiation, and chemicals. It also contains melanocytes, the cells that make melanin,...

cells of the epidermis

Epidermis Layers and Cell Turnover

The epidermis is the outer skin layer and is built from four or five layers of epithelial cells, depending on where it is found in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum. Most of the cells in these layers are keratinocytes, which make and store keratin, a protective protein. The stratum basale is a single cell layer made mostly of basal cells. A basal cell is a cuboidal stem cell that...

layers of the epidermis

Epidermis Cell Renewal and Skin Protection

The epidermis is the outermost layer of skin, and it is built to protect the body. It contains several distinct layers that change as cells move upward. From the deepest layer to the surface, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum. The stratum basale, also called the stratum germinativum, is the deepest layer of the epidermis. It has a single layer of actively dividing basal cells, or basal keratinocytes. These cells keep...

papillary dermis

Papillary Layer of the Dermis

The papillary layer is the outer part of the dermis. It is made of loose, areolar connective tissue, so its collagen and elastin fibers form a loose mesh. This layer sits next to the epidermis and helps show how the skin is organized into distinct layers. The papillary layer projects into the stratum basale of the epidermis. These finger-like extensions are called dermal papillae. Inside this layer are fibroblasts, a small number of adipocytes, and many small blood vessels. It also contains...

reticular dermis

Reticular Dermis and Skin Support

The reticular dermis is the thicker inner layer of the dermis. It lies beneath the papillary layer, and both layers are made of connective tissue. Collagen fibers extend from one layer to the other, so the border between them is not very clear. The papillary layer includes the dermal papillae that extend into the epidermis. Below that, the reticular layer is made of dense, irregular connective tissue. It has a tight meshwork of fibers, which gives it a net-like, or reticulated, appearance. <br...

hypodermis

Hypodermis and Body Fat Storage

The hypodermis is the layer beneath the dermis. It is also called the subcutaneous layer or superficial fascia. It links the skin to the fascia, which is fibrous tissue over the bones and muscles. The border between the hypodermis and dermis can be hard to see, and the hypodermis is not strictly part of the skin. The hypodermis contains loose areolar connective tissue and adipose tissue. Adipose tissue is fat tissue, and its cells are called adipocytes. This layer stores much of the body fat...

pigmentation

How Skin Gets Its Color

Skin color comes from melanin, carotene, and hemoglobin. Melanin is made by melanocytes, which are scattered through the stratum basale of the epidermis. The pigment moves to keratinocytes through melanosomes, which help carry the color into the skin cells. Melanin appears in two main forms. Eumelanin gives black and brown color, while pheomelanin gives red color. People with darker skin make more melanin than people with pale skin. Sun exposure changes melanin production. UV rays from the...

changes in skin color: clinical perspectives

changes-in-skin-color-clinical-perspectives

Skin Color Changes as Health Clues

Skin color changes can be an important clue about health. A careful skin exam is part of a full physical examination. Most skin disorders are harmless, but some, including melanoma, can be fatal if they are not treated. Two visible disorders, albinism and vitiligo, change the color of the skin and its accessory organs. Albinism is a genetic disorder that affects the color of the skin, hair, and eyes. It happens when melanocytes, the cells that make melanin, cannot produce enough or any melanin.

accessory structures of the skin: hair and hair follicles

accessory-structures-of-the-skin-hair-and-hair-follicles

Hair Follicles and Their Skin Functions

Hair and hair follicles are accessory structures of the skin. Hair is a keratin-filled filament that grows from the epidermis. It is mainly made of dead, keratinized cells. Hair is found on most body surfaces, but not on areas such as the palms of the hands and the soles of the feet. Each hair strand begins in a hair follicle, which is an epidermal opening that extends into the skin. The part above the skin surface is the hair shaft. The part below the surface is the hair root. Deep in the...

accessory structures of the skin: hair growth and types

accessory-structures-of-the-skin-hair-growth-and-types

Hair Growth Cycle and Pigment Basics

Hair is an accessory structure of the skin that grows from a hair bulb inside a follicle. Basal cells in the hair bulb make keratinocytes, and new cells are added there as the hair shaft is pushed upward toward the surface. As the cells move up, keratinization finishes, and the visible part of the hair becomes a dead structure made mostly of keratin. Because only the surface of the hair is cut or shaved, these methods do not damage the hair structure. Most chemical hair removers also work only...

accessory structures of the skin: nails

Nail Structure and Function in the Skin

Nails are hard accessory structures of the skin on the tips of fingers and toes. They cover the dorsal surface of the distal phalanges. Nails are made of specialized keratinized cells. They help protect the fingertips and toes, support sensation, and aid manual dexterity. The nail plate is the visible part of the nail that extends beyond the fingertips or toes. It is hard and translucent, but it often looks pink because blood vessels underneath show through. The nail plate is made of layers of...

accessory structures of the skin: sweat glands

accessory-structures-of-the-skin-sweat-glands

How Sweat Glands Help Cool the Body

Sweat glands help the body control temperature and remove waste. These sudoriferous glands are small, coiled tubes in the dermis, which is the middle layer of the skin. They release sweat, a watery fluid that supports homeostasis, the body’s stable internal balance. Sweat glands are classified as merocrine glands. In merocrine secretion, the gland releases its product by exocytosis through a duct, and the gland cells stay intact. This process allows sweat to move out of the gland without...

accessory structures of the skin: sebaceous glands

accessory-structures-of-the-skin-sebaceous-glands

Sebum, Acne, and Sebaceous Glands

Sebaceous glands are oil glands in the skin that release sebum. They are found almost everywhere on the body, except on the palms and soles. Most of them are linked to hair follicles, where they help keep the skin and hair lubricated and waterproofed. These glands make a lipid-rich mixture called sebum and release it onto the skin surface. Sebum softens the dry, dead cells of the stratum corneum, the outer keratinized layer of the skin, and helps keep that layer pliable. Sebaceous glands are...

sensory functions of the skin

Skin Receptors and the Sense of Touch

The skin is the largest organ of the human body, and it helps us sense touch, temperature, and pain. It contains many sensory receptors that detect physical, biological, and environmental cues. These signals help protect the body and guide fast responses. Skin receptors are grouped into two main categories: capsulated and non-capsulated. The non-capsulated receptors are mainly pain receptors. The capsulated receptors respond to specific kinds of stimuli, such as pressure, vibration, and...

The skin helps make vitamin D when it is exposed to sunlight. UVB radiation from the sun, with wavelengths of 290 to 315 nm, starts a chemical reaction in the skin. This makes vitamin D unique because it can be synthesized in the body through the skin. In this process, UVB rays are absorbed by the skin and convert 7-dehydrocholesterol, also called provitamin D3, into previtamin D3. Previtamin D3 then changes quickly into vitamin D3, also known as cholecalciferol. Once vitamin D3 forms, it...

skin diseases and disorders

Common Skin Infections and Their Causes

Skin infections often start when microbes affect the body’s first line of defense. Many skin conditions can affect people of all ages. They may come from genetic factors, infections, autoimmune reactions, environmental factors, or lifestyle choices. Many of the most common skin infections are caused by gram-positive Staphylococcus spp. and Streptococcus spp. However, many skin problems are not linked to just one pathogen. Opportunistic pathogens can infect skin wounds, and similar symptoms may...

skin cancer

Skin Cancer Signs and Treatments

Skin cancer develops when skin cells grow in an abnormal way because their DNA has been damaged. Ultraviolet, or UV, radiation from the sun and from tanning beds is the main cause. The number of skin cancer cases continues to rise, and it is the most common type of cancer worldwide. Basal cell carcinoma, or BCC, is the most common form and makes up about 80% of cases. It usually appears on skin that gets a lot of sun, such as the face, scalp, neck, and hands. A BCC may look like a small raised...

burn injuries

Burn Severity, Healing, and Care

Burn injuries damage the skin and the tissues below it. They can result from heat, electricity, chemicals, radiation, or friction. These injuries range from minor superficial burns to deep burns that can be life-threatening. Severe burns can kill skin cells and cause a major loss of fluid. That fluid loss can lead to dehydration, electrolyte imbalance, and failure of the kidneys and circulatory system. Burn patients often receive intravenous fluids to replace water loss and intravenous...

key terms and concepts

Learn how UVB light helps the skin make vitamin D3, how it enters the bloodstream, and why factors like skin tone, season, and sunscreen can affect production.

How Sunlight Triggers Vitamin D in Skin | JoVE K12

anatomy and physiology

JoVE Core Anatomy and Physiology showcases the anatomical and physiological details of the human body in comprehensive, clear, and engaging video animations. This collection of lessons focuses on the structures, components, functions, and requirements of the human body. It is complemented by scientist-in-action videos that demonstrate the application of this knowledge in real-world medical and research settings.

Florida Department of Education

High School

Life Science

SC.912.L.14

SC.912.L.14.51

Introduction to the Integumentary System

The integumentary system is the organ system that comprises the skin and its associated structures. It is the largest system in the human body and plays a ...

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the ...

Layers of the Epidermis

The epidermis, the outermost layer of the skin, is composed of several distinct layers. From deep to superficial, the layers of the epidermis are as ...

Papillary Dermis

Dermis
The dermis might be considered the &#34;core&#34; of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and ...

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the ...

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous ...

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called ...

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are ...

Accessory Structures of the Skin: Hair and Hair Follicles

Hair and hair follicles are integral components of the integumentary system. Hair is a filamentous structure composed mainly of a protein called keratin. ...

Accessory Structures of the Skin: Hair Growth and Types

Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft ...

Accessory Structures of the Skin: Nails

Nails are one of the important accessory structures of the skin. They are hard, protective structures that cover the dorsal surface of the distal ...

Accessory Structures of the Skin: Sweat Glands

Sweat glands or sudoriferous glands are one of the important accessory structures of the skin. They are small, coiled tubular structures located in the ...

Accessory Structures of the Skin: Sebaceous Glands

A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. ...

Sensory Functions of the Skin

The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that ...

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the ...

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. ...

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can ...

Integumentary System

Content elaboration: The integumentary system consists of skin and accessory structures. The skin is composed of three layers: the epidermis, the dermis and the hypodermis (subcutaneous layer). The accessory structures can include sweat glands, sebaceous glands, arrector pili muscles, hair follicles and nails. Skin functions include protection, temperature regulation, excretion and sensory perception. These occur through the processes of perspiration, skin production and shedding, vitamin D synthesis and repair. Homeostatic imbalances are explored. These include, but are not limited to, burns, skin cancer, anhidrosis, acne, eczema or scleroderma. Investigations are used to understand and explain the integumentary system in a variety of inquiry and design scenarios that can incorporate evolutionary concepts, scientific reasoning, comparative analysis, communication skills and real-world applications.

Introduction to the Skeletal System

The skeletal system is the central framework of the body, consisting of different connective tissues: bones, cartilage, tendons, and ligaments.
Components ...

The Functions of the Skeletal System

The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical ...

Classification of Bones

The bones of the human skeletal system are of varied shapes, sizes, and functions. They can be classified based on their shape and function into four ...

Gross Anatomy of Bone

The two main features of a long bone are the diaphysis and the epiphysis.
The diaphysis is the tubular shaft that runs between the proximal and distal ...

Compact Bone

Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone&#39;s overall function.
Compact ...

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long ...

Bone Markings

Bones have various surface features that help form joints and attach to other soft tissues. Depending on the function, bone markings are categorized into ...

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small ...

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt ...

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical ...

bone-formation-by-intramembranous-ossification

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the ...

bone-formation-by-endochondral-ossification

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template ...

Bone Remodeling and Repair

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient&#39;s age.
Minor fractures with no bone displacement are ...

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at ...

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, ...

role-of-vitamins-in-maintaining-bone-health

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin ...

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is ...

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone ...

Overview of the Axial Skeleton

The skeleton is subdivided into two major divisions&#8212;the axial skeleton and the appendicular skeleton. The axial skeleton forms the vertical, central ...

Overview of the Skull

The cranium (skull) is the skeletal structure of the head that supports the face and protects the brain. It is subdivided into the facial bones and the ...

cranial-bones-superior-and-posterior-view

Cranial Bones: Superior and Posterior View

The superior view of the cranium shows the frontal and paired parietal bones.
The frontal bone is the single bone that forms the forehead. At its anterior ...

Cranial Bones: Lateral View

The lateral view of the cranium is dominated by temporal, sphenoid, and ethmoid bones.
The temporal bone forms the lower lateral side of the skull. The ...

Sutures of the Skull

The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these ...

The Hyoid Bone

The hyoid bone is a small U-shaped bone located in the upper neck at the level of the inferior mandible, with its tips pointing posteriorly. It does not ...

The Auditory Ossicles

The auditory ossicles of the middle ear transmit sounds from the air as vibrations to the fluid-filled cochlea. The auditory ossicles consist of two ...

Vertebral Column: Regions and Curvature

The vertebral column or spine is a flexible column that supports the head, neck, and body and&#160; allows for their movements. It also protects the ...

General Structure of a Vertebra

A typical vertebra, with the exception of the sacrum and coccyx, consists of a body, a vertebral arch, and seven different projections termed processes. ...

The Thoracic Cage: Sternum

The thoracic or rib cage forms the body&#39;s thorax (chest) portion. Its primary function in the body is to protect vital organs in the thoracic cavity, ...

The Thoracic Cage: Ribs

Ribs are curved, flattened bones forming the thoracic cavity wall with the thoracic muscles. There are 12 pairs of thoracic ribs. The posterior ends of ...

Structural Joints: Fibrous Joints

Fibrous joints are a type of joint where the bones are connected by fibrous connective tissue. These joints provide stability and minimal to no movement ...

Bones of the Upper Limb: Humerus

The upper limb consists of the arm, forearm, wrist, and hand bones. The humerus is the single bone of the upper arm region. Proximally, it has a large, ...

Structural Joints: Cartilaginous Joints

As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike ...

Bones of the Upper Limb: Ulna

The ulna and radius are parallel bones of the antebrachium or the forearm. The ulna lies medially and consists of a bony tip called the olecranon process ...

Structural Joints: Synovial Joints

Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. ...

Bones of the Upper Limb: Radius

The radius is longer of the two bones that make up the human antebrachium or forearm. At the proximal end, the radius articulates with the capitulum of ...

Articulations of the Vertebral Column

In addition to being held together by the intervertebral discs, adjacent vertebrae also articulate with each other at synovial joints formed between the ...

bones-of-the-lower-limb-femur-and-patella

Bones of the Lower Limb: Femur and Patella

The femur is the body&#39;s longest and strongest bone spanning the thigh region. Its head articulates with the acetabulum of the hip bone to form the hip ...

Skeletal System

Content elaboration: The skeletal system is composed of bones, cartilage, joints and ligaments. Bones make up most of the skeleton. There are four main cell types that compose bone tissue, each with a specific function: osteogenic cells, osteocytes, osteoblasts and osteoclasts. The microscopic anatomy of compact bone includes osteons. Bones are classified by their shape. The structure of a typical long bone can be explored. Specific bones of the skeleton can be studied by their subdivisions: the axial skeleton and the appendicular skeleton. Cartilage is found in areas of the nose, ears, ribs and joints. Joints can be classified by structure or by function. The general structure of synovial joints may be explored. Ligaments connect bone to bone, stabilizing joints. The skeletal system provides support for the human body, protects soft organs, allows for movement due to attachment of muscles, stores minerals and fat and forms blood cells. Processes of the skeletal system include hematopoiesis, ossification and bone growth and remodeling. A comparison of male to female, juvenile to adult or human to other vertebrate skeletons may be explored. Homeostatic imbalances are explored. These include, but are not limited to, osteoporosis, malnutrition, fractures, anterior cruciate ligament (ACL) injuries and arthritis. Investigations are used to understand and explain the skeletal system in a variety of inquiry and design scenarios that can incorporate evolutionary concepts, scientific reasoning, comparative analysis, communication skills and real-world applications.

Skeletal System

How Sunlight Triggers Vitamin D in Skin

Description

Transcript

Tags

More videos by Standards