Ephrin-Eph Signalling in Gut Cell Positioning

Ephrin-Eph signalling helps intestinal cells stay in the right place as the gut lining renews itself. Eph receptors and their Ephrin ligands were first found in a human carcinoma cell line, which is how they got their names. This signalling system is also important in the immune system because it supports immune cell migrati...

Ephrin-Eph signaling mediates the correct sorting of intestinal cells. Ephrins are a family of membrane-bound ligands that bind to the Eph family of tyrosine kinase receptors on adjacent cells.

In the intestinal crypt, Wnt signaling induces the expression of the EphB receptor in intestinal stem cells, ISCs, and Paneth cells and suppresses...