Cell Cycle Stop Signals: p53, p21, and Rb

Cell cycle stop signals help control when a cell can move forward through division. Negative regulators pause or end the cell cycle until the cell meets the right conditions. Three well-studied negative regulators are p53, p21, and retinoblastoma protein, or Rb. Their roles became clear after faulty versions were found in ca...

Mehrere Proteine regulieren den Zellzyklus negativ, um die Replikation zu verhindern, bevor die Zellen bereit sind. Wenn während G1 die DNA einer Zelle beschädigt ist, rekrutiert das Protein p53 Enzyme, um die DNA zu reparieren, bevor die Zelle in die S-Phase übergeht. p53 stimuliert auch die Produktion des CVK-Inhibitors p21, der an CDK-Cyc...