How Stem Cell Niches Control Cell Fate

Stem cell niches control how stem cells stay active, rest, or begin to specialize. A niche is the local microenvironment where stem cells live. In this setting, stem cells can remain undifferentiated, renew themselves, or become lineage-specific progenitor cells.

Stem cells do not work alone in a...

The stem cell niche is a tissue microenvironment where the stem cells remain in a quiescent state until stimulated to differentiate and replace dead or damaged cells.

Stromal cells in the bone marrow, Paneth cells in the intestine, and keratinocytes of skin epithelium alongside the adult stem cells constitute specific niches in mammalian ...