Porin Assembly in Mitochondria

Porin assembly in mitochondria depends on beta-barrel proteins that move across the outer membrane and fold into their final form. Mitochondria, chloroplasts, and gram-negative bacteria use these transmembrane proteins to let ions and metabolites diffuse freely across membranes.

Mitochondrial por...

Porins are barrel-shaped proteins of the outer mitochondrial membrane that allow the free diffusion of ions and metabolites through a central channel.

Porins are formed of beta-sheets arranged into a circular hollow structure with hydrophobic amino acid residues facing the lipid bilayer and the hydrophilic amino acid residues lining the i...