Name: radical cyclization in one molecule
Uploaded: 2023-04-30T11:21:28.000Z
Duration: 1 min 33 s
Channel: JoVE

Dans les réactions radicalaires intermoléculaires, le radical et le piège à radicaux sont deux molécules différentes.
Le piège à radicaux doit être activé et présent à des concentrations élevées, et la source radicalaire doit avoir une faible liaison carbone-hétéroatome.
Considérons maintenant une réaction radicalaire intramoléculaire, dans laquelle un radical nucléophile s’ajoute à une double liaison nucléophile, produisant un produit cyclisé.
Ici, le piège radical n’est ni activé ni présent en excès. Le lien C-S est également relativement fort.
Pourtant, une telle réaction est réalisable, donnant un rendement de produit élevé. Pourquoi ?
En effet, pour les réactions intramoléculaires, le radical et le piège à radicaux font partie de la même molécule et sont toujours tenus serrés, favorisant une cyclisation rapide.
Par conséquent, la possibilité d’une réduction radicale par un donneur d’hydrure diminue.
De plus, le piège à radicaux n'est ni très réactif ni en excès, ce qui réduit ses chances de réagir avec le radical hydrure d'étain, quelle que soit la concentration de ce dernier.
Par conséquent, les réactions radicalaires intramoléculaires sont très efficaces et trouvent des applications dans la synthèse de cycles à cinq chaînons. Les plus petites tailles d’anneau présentent une tension annulaire. Les bagues de plus grande taille ne sont pas préférées.

réactivité radicalaire : intramoléculaire vs intermoléculaire

Radical Reactivity: Intramolecular vs Intermolecular

Les réactions radicales peuvent se produire de manière intermoléculaire ou intramoléculaire. Dans une réaction radicalaire intermoléculaire, un radical nucléophile s’ajoute à un alcène électrophile ou vice versa. Dans de telles réactions, le radical et généralement l'alcène, également appelé piège à radicaux, sont deux molécules différentes. De plus, pour que de telles réactions intermoléculaires se produisent, le piège à radicaux doit être actif, présent en concentration excessive, et le matériau de départ radical doit avoir une faible liaison carbone-halogène.

En revanche, une réaction radicalaire intramoléculaire implique un radical et un piège à radicaux, qui font partie de la même molécule. Dans de telles réactions, le piège à radicaux n’est pas activé et n’est pas non plus présent en excès. De plus, les liaisons dans le matériau radicalaire de départ sont relativement fortes. Mais la cyclisation intramoléculaire est néanmoins extrêmement favorisée, le produit étant formé avec des rendements élevés. En effet, le radical et le piège à radicaux font partie de la même molécule, ce qui fait qu'ils sont tous deux proches l'un de l'autre. En conséquence, la cyclisation se produit rapidement. Cette cyclisation rapide exclut la possibilité d'une réduction radicale par un donneur d'hydrure.

Enfin, les réactions intramoléculaires sont très puissantes et efficaces. Ces réactions sont souvent utilisées pour synthétiser des cycles à cinq chaînons sur toutes les autres tailles de cycles.

Réactivité radicalaire : intramoléculaire vs intermoléculaire

Les réactions radicalaires peuvent se produire soit intermoléculairement, soit intramoléculairement. Dans une réaction radicalaire intermoléculaire, un radical nucléophile s’ajoute à un ...

radical-reactivity-intramolecular-vs-intermolecular

Education

Enseignement

JoVE Core

Organic Chemistry

Chimie organique

Unit 1

Unité 1

Radical Chemistry

Chimie radicalaire

KEY TERMS AND CONCEPTS

TERMES ET CONCEPTS CLÉS

radical cyclization in one molecule

Radical reactions can happen either between two separate molecules or within one molecule. In an intermolecular radical reaction, a nucleophilic radical adds to an electrophilic alkene, or an electrophilic radical adds to a nucleophilic alkene. The alkene is the radical trap, and it is a different molecule from the radical.

Intermolecular reactions need the radical trap to be active and present in excess. They also usually require the radical starting material to contain a weak carbon-halogen bond. These conditions help the two separate reactants meet and react efficiently.

Intramolecular radical reactions follow a different path. Here, the radical and the radical trap are parts of the same molecule. The trap does not need activation, and it is not present in excess. Even when the starting bonds are relatively strong, intramolecular cyclization is still strongly favored and often gives high yields.

This happens because the radical and the radical trap stay close together in the same molecule. The reaction can cyclize very quickly, which leaves less chance for reduction by a hydride donor. Intramolecular radical reactions are powerful and efficient, and they are often used to make five-membered rings over other ring sizes.

Radical Cyclization in One Molecule

radicals: electronic structure and geometry

radicals-electronic-structure-and-geometry

Radical Geometry: Planarity and Inversion

Radical geometry depends on the electronic structure around the radical center. An unpaired electron, like a lone pair, affects the shape of the molecule. For a trivalent radical, the structure falls between the geometries of carbocations and carbanions. A carbocation with sp2 hybridization is trigonal planar. A carbanion with sp3 hybridization is trigonal pyramidal. The difference comes from the number of nonbonding electrons. The carbocation has none, while the carbanion has two. A carbon...

electron paramagnetic resonance (epr) spectroscopy: organic radicals

electron-paramagnetic-resonance-epr-spectroscopy-organic-radicals

EPR Hyperfine Splitting in Organic Radicals

Electron paramagnetic resonance (EPR) spectroscopy can show how an unpaired electron behaves in an organic radical. A simple radical may give a single peak because the electron moves between two spin energy states. In many radicals, the unpaired electron also interacts with nearby spin-active nuclei. This interaction is called hyperfine coupling. It causes hyperfine splitting, which divides the EPR signal into multiplets, or groups of peaks. The number of peaks follows the pattern 2nI + 1,...

radical formation: overview

How Radicals Are Generated

Radicals are generated when bonds break in specific ways or when one radical leads to another. In homolytic bond cleavage, a bond splits evenly and forms radicals. In heterolytic bond cleavage, the bond breaks to form ions instead. A fishhook arrow shows the movement of a single electron during homolytic cleavage. Radicals can come from spin-paired molecules by homolysis or by electron transfer. Homolysis forms two radicals. Electron transfer adds an electron to the molecule, and this process...

radical formation: homolysis

Homolysis and Radical Bonds

Homolysis is a bond-breaking process that splits a shared electron pair evenly. When a bond is broken with enough energy, the two electrons can also move to one atom in heterolysis, which forms ions. Homolysis gives one electron to each atom and creates radicals, which are highly reactive particles with an unpaired electron. HCl shows the difference between these bond cleavages. In solution, HCl can break into H+ and Cl− ions, and chlorine takes both bonding electrons, leaving a naked proton.

radical formation: abstraction

Radical Abstraction in Chain Reactions

Radical abstraction helps drive radical chain reactions. In this process, a relatively unstable radical removes an atom from a compound and forms a new radical that is more stable. The atom taken in this step can be hydrogen or a halogen. A radical initiator can first form radicals by homolysis, which is the breaking of a spin-paired molecule into two radicals. That is different from abstraction. In abstraction, a radical reacts with a spin-paired molecule and produces one new radical plus one...

radical formation: addition

Radical Addition and Spin Conservation

Radical addition can form a new radical when an unpaired electron adds to a spin-paired molecule. This is often seen with unsaturated species. In these reactions, the radical adds across a pi bond and breaks that bond to make a new radical. A bromine radical adding to an alkene is a clear example. The product is a carbon-centered radical. Radical reactions also follow spin conservation, much like chemical reactions follow charge conservation. If the starting material has an unpaired electron,...

radical formation: elimination

Radicals from Elimination Reactions

Radicals can form through elimination reactions. This route is the opposite of the addition route. It is driven by the instability of the radical. Dibenzoyl peroxide is one example of this process. It first undergoes homolysis, which is an even split of a bond, to give a pair of unstable radicals. Because the radical is unstable, it then undergoes elimination on its own. During elimination, a C-C bond breaks. The cleavage occurs between the alpha and beta positions relative to the radical...

radical reactivity: overview

Radical Reaction Pathways and Stability

Radical reactions follow a small set of pathways that help highly reactive species become more stable. A radical can react with another radical, with a spin-paired molecule, or through unimolecular decomposition, which means one radical species breaks down on its own. In radical-radical coupling, two radicals join to form a spin-paired molecule. In a radical reaction with a spin-paired molecule, a new radical and a new spin-paired molecule are formed. In radical decomposition, one radical...

radical reactivity: steric effects

Steric Shielding in Stable Radicals

Steric shielding helps make some radicals more stable and less reactive. A radical is a species with an unpaired electron at its center. In many cases, nearby groups can also give electronic stabilization, including electron-donating, electron-withdrawing, or conjugating groups. Several radicals are known as persistent radicals because they are remarkably stable. Examples include triphenylmethyl, tetramethylpiperidine-N-oxide, and 2,2-diphenyl-1-picrylhydrazyl. Some of these persistent...

radical reactivity: concentration effects

How Concentration Steers Radical Additions

Radical reaction selectivity can change when the concentrations of the reactants change. In this chemistry example, an alkyl halide reacts with an alkene in the presence of tin hydride and AIBN, an initiator that helps start the radical process. The reaction begins when a tin radical is formed. The tin radical removes the halogen from the alkyl halide. This step creates an alkyl radical. That radical then has two possible paths. It can react with tin hydride to form an alkane, or it can add to...

radical reactivity: electrophilic radicals

radical-reactivity-electrophilic-radicals

Electrophilic Radicals and Alkene Reactions

Electrophilic radicals are radicals next to electron-withdrawing groups. These radicals react readily with nucleophilic alkenes. A key example is the malonate radical, where the radical center is flanked by two electron-withdrawing groups. It reacts easily with butyl vinyl ether, which has an electron-donating oxygen substituent. This reaction is favored because the malonate radical has a low-energy SOMO, or singly occupied molecular orbital. That low-energy orbital matches best with the...

radical reactivity: nucleophilic radicals

Nucleophilic Radicals and Alkene Traps

Nucleophilic radicals are electron-rich radicals that form next to electron-donating groups. They react readily with electrophilic alkenes, which are electron-poor double bonds. The key driving force is a SOMO–LUMO interaction. The high-energy SOMO, or singly occupied molecular orbital, of the radical overlaps with the low-energy LUMO of the alkene. These SOMO–LUMO interactions also explain radical traps and their effect on reaction selectivity. In radical chemistry, a trap is a molecule that...

radical reactivity: intramolecular vs intermolecular

Radical reactions can happen either between two separate molecules or within one molecule. In an intermolecular radical reaction, a nucleophilic radical adds to an electrophilic alkene, or an electrophilic radical adds to a nucleophilic alkene. The alkene is the radical trap, and it is a different molecule from the radical. Intermolecular reactions need the radical trap to be active and present in excess. They also usually require the radical starting material to contain a weak carbon-halogen...

radical autoxidation

Autoxidation in Oils and Ethers

Autoxidation is the oxidation of an organic compound in the presence of air or oxygen. In this process, compounds such as cumene can react with oxygen to form hydroperoxide. The reaction follows three main stages: initiation, propagation, and termination. Many organic compounds can undergo autoxidation. Ethers are especially vulnerable when oxygen is present, and they can form hydroperoxides. Even though this reaction is slow, old ether bottles may contain small amounts of peroxide. That is...

radical oxidation of allylic and benzylic alcohols

radical-oxidation-of-allylic-and-benzylic-alcohols

Selective MnO2 Oxidation of Alcohols

Activated manganese(IV) oxide, or MnO2, is a selective oxidizing agent for allylic and benzylic alcohols. It changes primary allylic alcohols into aldehydes and secondary allylic alcohols into ketones. The reaction happens by a radical pathway, so the carbon next to the alcohol group plays a key role. The oxidizing agent is made from the redox reaction of potassium permanganate with an Mn(II) salt such as manganese sulfate. This can be done under alkaline or acidic conditions. After that, the...

radical substitution: halogenation of alkanes and alkyl substituents

radical-substitution-halogenation-of-alkanes-and-alkyl-substituents

How Alkanes Form Alkyl Halides by Halogenation

Alkanes can react with halogens to form alkyl halides when heat or light is present. This reaction is called radical halogenation. It is a substitution reaction, which means a hydrogen atom on the alkane is replaced by a halogen atom. Radical chlorination of methane shows the process clearly. The reaction begins with initiation, when a chlorine molecule splits evenly under light or heat. This homolytic cleavage forms two very reactive chlorine radicals. The next stage is propagation. In the...

radical halogenation: thermodynamics

Alkane Halogenation: Stability and Reaction Rates

Alkane halogenation is shaped by thermodynamic stability and reaction rate. In radical halogenation, the key question is whether the reaction is favorable and how fast it happens. Gibbs free energy, or ΔG, helps answer the first question. ΔG has two parts: enthalpy, or ΔH, and entropy, or ΔS. For alkane halogenation, the entropy term is negligible because the number of reactant and product molecules is the same. That means ΔG is controlled mainly by enthalpy. Bond strength is the most...

radical halogenation: stereochemistry

Radical Halogenation: Chiral Products

Radical halogenation can change the chirality of a molecule, which is the three-dimensional arrangement of its atoms. The products depend on whether the reaction creates a new chiral center, reacts at an existing chiral center, or adds a second chiral center. When radical halogenation forms a new chiral center, the product can be a racemic mixture. For example, halogenation of butane gives 2-chlorobutane and 1-chlorobutane. The 2-chlorobutane product has a chiral center, but it is formed as a...

radical substitution: allylic chlorination

radical-substitution-allylic-chlorination

Allylic Chlorination by Radical Chain Reaction

Allylic chlorination is a radical chain reaction in alkenes. It happens when halogen reactions move away from simple addition and toward substitution at the allylic position, which is the carbon next to a double bond. At low temperatures, alkenes usually react with halogens by addition. When the temperature increases, or when the reaction conditions create radicals, allylic substitution becomes favored. This works because allylic hydrogens are very reactive and the intermediate formed is...

radical substitution: allylic bromination

Allylic Bromination with NBS

Allylic bromination with NBS changes propene into allyl bromide under radical conditions. In this reaction, the goal is to favor substitution at the allylic position instead of bromine addition across the double bond. Using N-bromosuccinimide, or NBS, helps keep the bromine concentration low so the addition product is less likely to form. The reaction conditions matter. Propene gives a dibromo addition product with bromine at room temperature. In non-polar solvents at high temperature, propene...

radical substitution: hydrogenolysis of alkyl halides with tributyltin hydride

radical-substitution-hydrogenolysis-alkyl-halides-with-tributyltin

Alkyl Halide Reduction with Tributyltin Hydride

Alkyl halide reduction with tributyltin hydride removes a halogen and replaces it with hydrogen. This reaction turns alkyl halides into alkanes. The reagent Bu3SnH has a weak Sn–H bond, and the reaction forms tributyltin halide as a byproduct. Because the new bonds are stronger than the bonds that are broken, the reaction is energetically favorable. The reaction proceeds by a radical chain mechanism, which is similar to radical halogenation. Light causes Bu3SnH to split homolytically, meaning...

radical anti-markovnikov addition to alkenes: overview

radical-anti-markovnikov-addition-to-alkenes-overview

Peroxide Effect in HBr Addition to Alkenes

Hydrogen bromide can add to alkenes through a peroxide-driven radical pathway. In this reaction, hydroperoxides or peroxides change the usual addition pattern and lead to alkyl bromides with anti-Markovnikov regiochemistry, which means bromine ends up on the less substituted carbon. This regioselectivity can be explained by radical stability. When the bromine radical adds to the alkene at the less substituted carbon, the reaction forms a more stable tertiary radical intermediate. The same...

radical anti-markovnikov addition to alkenes: mechanism

radical-anti-markovnikov-addition-to-alkenes-mechanism

Hydrogen Bromide Addition to Alkenes by Radicals

Hydrogen bromide can add to alkenes through a radical chain reaction when hydroperoxides or peroxides are present. This pathway gives anti-Markovnikov addition, which means the bromine ends up on the less substituted side of the double bond. The reaction begins with chain initiation. First, mild heating breaks the weak peroxide bond by homolytic cleavage, which means each atom keeps one electron and two alkoxy radicals form. Next, an alkoxy radical abstracts a hydrogen atom and forms a bromine...

radical anti-markovnikov addition to alkenes: thermodynamics

radical-anti-markovnikov-addition-to-alkenes-thermodynamics

HBr Selectivity in Alkene Addition Thermodynamics

Anti-Markovnikov addition of hydrogen halides to alkenes depends on thermodynamics. In this radical reaction, only HBr makes the overall process feasible. With HCl and HI, the same addition is thermodynamically unfavorable. Temperature affects whether the reaction is spontaneous. Spontaneity is measured with Gibbs free energy, or ΔG. When ΔG is negative, the reaction can occur on its own. ΔG is determined by two terms: ΔH, which is the enthalpy change, and −TΔS, which is the entropy term. The...

vicinal diols via reductive coupling of aldehydes or ketones: pinacol coupling overview

vicinal-diols-via-reductive-coupling-aldehydes-or-ketones-pinacol

Pinacol Coupling and Solvent Effects

Pinacol coupling is a radical dimerization reaction that joins aldehydes or ketones to form vicinal diols. Wilhelm Rudolph Fittig first discovered this reaction in 1859. It is a reductive coupling, which means the molecules are joined after they gain electrons. The reaction begins with a single electron transfer from metals such as sodium or magnesium to an aldehyde or ketone. This forms a ketyl, a radical anion. In a ketyl, the carbon atom can carry radical character while the oxygen atom...

alkenes via reductive coupling of aldehydes or ketones: mcmurry reaction

alkenes-via-reductive-coupling-aldehydes-or-ketones-mcmurry

Titanium-Coupled Alkenes from Carbonyls

The McMurry reaction turns aldehydes or ketones into alkenes with titanium metal. It first forms a diol-like intermediate through a coupling step, and then removes oxygen to make the double bond. In some cases, this process can be compared to pinacol coupling, which also joins carbonyl compounds. Titanium acts as a source of electrons in the first step. It transfers a single electron to the carbonyl group and forms a ketyl intermediate. That intermediate can lead to a vicinal diol, which is a...

&alpha;-hydroxy ketones via reductive coupling of esters: acyloin condensation overview

hydroxy-ketones-via-reductive-coupling-esters-acyloin-condensation

Acyloin Condensation: Ester Coupling Pathway

Acyloin condensation is a reaction that joins two ester molecules to form an alpha-hydroxy ketone. The product is also called an acyloin. In this reaction, sodium metal is used in an aprotic solvent, which supports the reductive coupling step. The reaction is related to the pinacol and McMurry reactions, which also involve reductive coupling of ketones or aldehydes. Here, the ester first becomes a ketyl. These ketyl species undergo radical dimerization and form an unstable tetrahedral...

key terms and concepts

Compare intermolecular and intramolecular radical reactions, including radical traps, reaction conditions, fast cyclization, and why five-membered rings are favored.

Radical Cyclization in One Molecule | JoVE K12

organic chemistry

JoVE Core Chimie Organique explique les concepts de base de la stéréochimie, des réactions et des mécanismes à l'aide de leçons vidéo animées concises et faciles à comprendre. De plus, les vidéos de scientifiques à l'action présentent l'application de ces concepts grâce à des expériences de recherche classiques et originales réalisées dans des laboratoires modernes.

Radical Cyclization in One Molecule

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