Name: gene delivery for serious diseases
Uploaded: 2026-08-26T08:21:16.396Z
Duration: 1 min 22 s
Channel: JoVE

K12 Standards

Tennessee Academic Standards

High School

Biology

links-among-engineering-technology-science-and-society

Links Among Engineering, Technology, Science, and Society

BIO1.ETS2.3

Gene Therapy

- [Istruttore] La terapia genica
&#xE8; l&#x27;inserimento di un gene

nelle cellule di un individuo

per prevenire o curare malattie gravi.

Il gene inserito pu&#xF2; essere una
copia sana di un gene mutato

o pu&#xF2; essere un gene diverso

che contrasta gli effetti
di un gene difettoso.

I geni possono essere trasmessi in vivo,

direttamente in una persona,

o ex vivo, in cellule rimosse dal corpo,

che vengono poi trapiantate di nuovo.

Il nuovo gene viene inserito
utilizzando un vettore,

di solito un virus modificato
che pu&#xF2; entrare in una cellula

e consegnare il DNA al nucleo.

Alcuni vettori integrano
il DNA nel genoma,

mentre altri rimangono
fuori dal cromosoma.

I vettori contengono
una regione promotrice

in modo che il gene
possa essere trascritto.

Il gene introdotto viene
poi tradotto in proteina

fornendo un trattamento per la malattia.

Dunbar, Cynthia E., Katherine A. High, J. Keith Joung, Donald B. Kohn, Keiya Ozawa e Michel Sadelain. "La terapia genica diventa maggiorenne". Science 359, n. 6372 (12 gennaio 2018): eaan4672. [<a href="https://doi.org/10.1126/science.aan4672" target="__blank">Sorgente</a>]

Anguela, Xavier M. e Katherine A. High. "Entrare nell'era moderna della terapia genica". Rassegna annuale di medicina 70, n. 1 (2019): 273–88. [<a href="https://doi.org/10.1146/annurev-med-012017-043332" target="__blank">Sorgente</a>]

terapia genica

La terapia genica &#xE8; una tecnica in cui un gene viene inserito nelle cellule di una persona per prevenire o trattare una malattia grave. Il gene aggiunto pu&#xF2; essere una versione sana del gene che &#xE8; mutato nel paziente, o potrebbe essere un gene diverso che inattiva o compensa il gene che causa la malattia del paziente. Ad esempio, nei pazienti con immunodeficienza combinata grave (SCID) a causa di una mutazione nel gene per la deaminasi enzimatica adenosina, pu&#xF2; essere inserita una versione funzionante del gene. Le cellule del paziente possono quindi rendere l&#x27;enzima, curando questa malattia potenzialmente mortale in alcuni casi.

<h4>Inserimento genico</h4>

I geni possono essere introdotti nelle cellule di un paziente in due modi principali: in vivo, direttamente in una persona attraverso l&#x27;iniezione in tessuti specifici o nel flusso sanguigno; ed ex vivo, nelle cellule che sono state rimosse dal paziente, che vengono trapiantate dopo l&#x27;inserimento del gene.

Il gene viene solitamente inserito in un vettore, spesso un virus che &#xE8; stato modificato per non causare la malattia, per ottenere il gene nelle cellule del paziente e consegnato al nucleo. In alcuni casi, ad esempio quando si utilizzano vettori retrovirali, il gene viene inserito casualmente nel genoma della persona, portando all&#x27;espressione stabile del gene inserito. In altri, come quando si utilizzano vettori adenovirali, il gene non si integra nel genoma dell&#x27;ospite ed &#xE8; espresso solo in modo transitorio. Il vettore &#xE8; anche progettato per contenere una regione promotrice in modo che il nuovo gene possa essere trascritto in RNA messaggero (mRNA). Quindi, usando il meccanismo della cellula, l&#x27;mRNA viene tradotto in proteina. Il prodotto proteico, come l&#x27;adenosina deaminasi, fornisce il trattamento per la malattia.

<h4>Clinici</h4>

La terapia genica &#xE8; ancora nelle prime fasi e comporta rischi significativi, in parte perch&#xE9; l&#x27;integrazione e l&#x27;attivit&#xE0; dei geni inseriti non possono essere completamente controllate. Ad esempio, in alcuni studi precoci di terapia genica per un&#x27;altra forma di SCID, alcuni pazienti hanno sviluppato il cancro e gli studi sono stati interrotti. Tuttavia, la tecnologia &#xE8; in continuo miglioramento, e per le malattie gravi senza altri trattamenti efficaci, i benefici possono superare i rischi. Oltre a SCID, altre malattie in cui la terapia genica ha avuto successo includono un tipo di cecit&#xE0; ereditaria e leucemia delle cellule B resistenti al trattamento.

Terapia genica

Gene therapy is a technique where a gene is inserted into a person&#x2019;s cells to prevent or treat a serious disease. The added gene may be a healthy ...

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Education

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Biologia

Genetics

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Biotecnologia

KEY TERMS AND CONCEPTS

TERMINI E CONCETTI CHIAVE

gene delivery for serious diseases

Gene therapy is a technique used to treat serious disease by adding a gene to a person’s cells. The added gene may be a healthy copy of a mutated gene. It may also be a different gene that inactivates or compensates for the disease-causing gene.

One example is severe combined immunodeficiency, or SCID, caused by a mutation in the gene for adenosine deaminase. In that case, a working copy of the gene can be inserted so the patient’s cells make the enzyme again. This can cure the disease in some cases.

Genes can be delivered in two main ways. In vivo gene delivery means the gene is placed directly into the body, often by injection into a specific tissue or into the bloodstream. Ex vivo gene delivery means cells are removed from the patient, given the gene, and then transplanted back.

The gene is usually carried in a vector, which is often a virus that has been changed so it does not cause disease. The vector helps move the gene into the cell and deliver it to the nucleus. Retroviral vectors can insert the gene randomly into the genome, which can lead to stable expression. Adenoviral vectors do not integrate into the host genome, so their gene expression is temporary.

The vector is also engineered with a promoter region. A promoter helps start transcription, so the new gene is copied into messenger RNA, or mRNA. The cell then uses its own machinery to translate the mRNA into protein. That protein, such as adenosine deaminase, is what helps treat the disease.

Gene therapy is still in an early stage and can carry serious risks because inserted genes are hard to control fully. In some early trials for another form of SCID, some patients developed cancer, and the trials were stopped. Even so, the technology continues to improve, and for serious diseases with no other effective treatment, the benefits can outweigh the risks. Successful uses have included inherited blindness and treatment-resistant B-cell leukemia.

Gene Delivery for Serious Diseases

what is genetic engineering?

How Scientists Edit DNA for New Traits

Genetic engineering changes an organism’s DNA to add useful traits. Scientists use it in bacteria, plants, animals, and even viruses for research, medicine, agriculture, and industry. It can bring major benefits, but it also raises ethical concerns about humans and the food supply. This work is possible because DNA has the same basic structure and genetic code across life. That shared code lets scientists modify DNA in several ways. One method is CRISPR/Cas9, often called molecular scissors,...

dna isolation

Steps in DNA Extraction

DNA extraction is the process of removing and purifying DNA from cells. It is used in many biotechnology and research applications, including molecular cloning. The main goal is to free DNA from the cell and prepare it for later study or use. The first step is cell lysis, which means breaking cells open. Researchers may use a homogenizer, sonicator, or bead beater to physically lyse the cells. They also often add detergent to chemically disrupt the lipid-based cell membranes. This helps...

recombinant dna technology

Recombinant DNA in Cloning and GMOs

Recombinant DNA is made by joining DNA from different sources in the lab. Scientists often use it to clone genes and study them in cells that are easy to handle, such as bacteria. Organisms that carry recombinant DNA are called genetically modified organisms, or GMOs. This technology gives scientists new tools for research, medicine, and agriculture. To build recombinant DNA, researchers place a gene of interest into a vector, which is a DNA carrier that moves foreign DNA into a host cell. The...

PCR Cycle for DNA Amplification

PCR is a laboratory method for making many copies of a DNA segment. It can turn a small amount of DNA into millions or even billions of copies in just a few hours. The process uses a heat-resistant DNA polymerase inside a machine called a thermocycler. PCR was developed by Kary Mullis in 1983, and he received the 1993 Nobel Prize in Chemistry for it. The method is fast, relatively inexpensive, and precise. It has become useful for molecular cloning, gene mutagenesis, pathogen detection, gene...

complementary dna

From mRNA to cDNA for Gene Studies

Complementary DNA, or cDNA, is made from messenger RNA (mRNA) so scientists can study which genes are active in cells and tissues. Only genes that are transcribed into mRNA are expressed. By extracting mRNA from cells, researchers can compare gene expression across samples. cDNA is produced by reverse transcription. This process copies mRNA into DNA, which is useful because mRNA does not contain introns, or non-coding regions, and other regulatory sequences. As a result, cDNA can help...

antibiotic selection

Antibiotic Resistance in Cloning

Antibiotic resistance genes help scientists find bacteria that took up a plasmid with a gene of interest. In genetic engineering, this resistance is used as a marker, not just as a medical concern. The same process also connects to the growing problem of resistant bacteria in the real world. Antibiotics, such as penicillin, stop bacterial growth or kill bacteria. When bacteria naturally have, or are engineered to carry, an antibiotic resistance gene, the antibiotic no longer works on them.

transgenic organisms

Creating Transgenic Plants and Animals

Transgenic organisms are genetically engineered to carry a transgene, which is a gene from a different species, in their genome. The inserted gene may be a new gene for that organism or a different version of one it already has. Scientists usually make transgenes with recombinant DNA and DNA cloning methods. Researchers use transgenic bacteria, plants, and animals to answer biological questions and to build useful tools. To make a transgenic organism, they first choose a transgenesis method,...

in-vitro mutagenesis (gene knockouts)

Knockout Mice and Gene Replacement

Knockout mice help researchers study gene function by showing what happens when a gene is turned off. These engineered animals are also useful for modeling human diseases such as cancer, Parkinson’s disease, and diabetes. A specific gene can be targeted by using a targeting vector, which is a piece of engineered DNA that replaces the normal gene and inactivates it. The vector has matching DNA sequences on both ends. These homologous sequences let the vector swap in for the target gene through...

crispr

CRISPR-Cas9 Gene Editing in Action

CRISPR-Cas9 is a genome editing tool that lets scientists change DNA at a specific location. It can add, remove, or rearrange genetic material. Researchers study it because it may help treat genetic disorders such as hemophilia and sickle cell anemia. CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats, and Cas9 is a CRISPR-associated protein 9. The basic system includes a Cas9 endonuclease, which is an enzyme that cuts DNA, and a small RNA that guides Cas9 to the...

gene therapy

Gene therapy is a technique used to treat serious disease by adding a gene to a person’s cells. The added gene may be a healthy copy of a mutated gene. It may also be a different gene that inactivates or compensates for the disease-causing gene. One example is severe combined immunodeficiency, or SCID, caused by a mutation in the gene for adenosine deaminase. In that case, a working copy of the gene can be inserted so the patient’s cells make the enzyme again. This can cure the disease in some...

embryonic stem cells

How Embryonic Stem Cells Become Specialized

Embryonic stem cells are pluripotent cells that have not yet specialized. Pluripotent means they can give rise to many different cell types in the body. Because of this, they are useful in science and medicine for making cells needed in research or for replacing cells lost to damage or disease. These cells come from the inner cell mass of a blastocyst, which is an early embryo about 3 to 5 days after fertilization in humans. At this stage, the embryo has not yet implanted in the uterus. Human...

adult stem cells

Adult Stem Cells in the Small Intestine

Adult stem cells help maintain tissues by replacing old or damaged cells. These undifferentiated cells divide to make more stem cells or progenitor cells, which then become mature, specialized cells. Small groups of adult stem cells are found in many tissues, including the bone marrow, brain, skin, and gut. The small intestine shows this process clearly. Its lining, called the epithelium, is renewed continuously by adult stem cells. It is also the fastest replaced tissue in the human body,...

induced pluripotent stem cells

Reprogramming Mature Cells into Stem Cells

Reprogramming mature cells into stem cells lets scientists turn specialized cells back into an unspecialized state. These cells are called induced pluripotent stem cells, or iPSCs. Like embryonic stem cells, iPSCs are pluripotent, which means they can form all cell types. To make iPSCs, researchers start with mature cells such as skin fibroblasts or blood cells. The cells are grown in culture, and genes for several transcription factors are delivered with a viral vector. The cells then make...

reproductive cloning

Cloning Animals with SCNT

Reproductive cloning can produce a genetically identical copy of an entire organism. In adult animals, this is usually done with somatic cell nuclear transfer, or SCNT. Another way clones can form is by splitting an early embryo, which is similar to how identical twins arise naturally. In SCNT, an egg cell is taken from an animal and its nucleus is removed. This creates an enucleated egg. A somatic cell, which is any body cell that is not a sex cell, is then taken from the animal to be cloned.

genomics

Genomics and DNA Sequencing

Genomics studies the full set of genetic material in an organism. In humans, that genome includes the DNA carried in 23 pairs of chromosomes in the nucleus, along with mitochondrial DNA. Genomics looks at both coding DNA and non-coding DNA, which helps scientists study how living things are built and how they differ. This field is useful in many areas of biology and medicine. Scientists use genomics to build phylogenetic trees, improve crop productivity and sustainability, help with criminal...

key terms and concepts

See how gene therapy delivers working genes with viral vectors, in vivo or ex vivo methods, and why the approach can help treat SCID and other diseases.

Gene Delivery for Serious Diseases | JoVE K12

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JoVE Core Biologia illustra i concetti chiave della biologia grazie a oltre 300 video-lezioni animate, concise e di facile comprensione. Inoltre, negli oltre 150 video di "scienziati in azione", i concetti scientifici vengono applicati e dimostrati da ricercatori attraverso esperimenti in laboratorio.

Florida Department of Education

Life Science

SC.912.L.16

SC.912.L.16.10

Molecular Cloning

Molecular cloning is a set of methods, which are used to insert recombinant DNA into a vector - a carrier of DNA molecules that will replicate recombinant ...

An Overview of Genetic Engineering

Genetic engineering &#8211; the process of purposefully altering an organism&#8217;s DNA &#8211; has been used to create powerful research tools and model ...

Recombineering and Gene Targeting

One of the most widely used tools in modern biology is molecular cloning with restriction enzymes, which create compatible ends between DNA fragments that ...

Genome Editing

A well-established technique for modifying specific sequences in the genome is gene targeting by homologous recombination, but this method can be ...

Recombinant DNA

DNA Ligation Reactions

In molecular biology, ligation refers to the joining of two DNA fragments through the formation of a phosphodiester bond.  An enzyme known as a ligase ...

Restriction Enzyme Digests

Restriction enzymes or endonucleases recognize and cut DNA at a specific sequence.  These enzymes occur naturally in bacteria as a defense against ...

DNA Isolation

DNA isolation protocols can be fast and straightforward or complex and time-consuming depending on the type and quality of DNA required for further ...

Restriction Enzymes

Restriction enzymes are bacterial enzymes used to cut DNA in a sequence-specific manner. To cleave DNA, they bind to specific palindromic sequences called ...

DNA Agarose Gel Electrophoresis

Agarose gel electrophoresis is a laboratory technique commonly used to separate DNA fragments by size. However, it can also be used to isolate and purify ...

DNA Gel Electrophoresis

DNA gel electrophoresis is a technique used for the detection and separation of DNA molecules. An electric field is applied to a gel matrix comprised of ...

Separating Protein with SDS-PAGE

Sodium Dodecyl Sulfate Poly-Acrylamide Gel Electrophoresis, or SDS-PAGE, is a widely-used technique for separating mixtures of proteins based on their ...

Plasmid Purification

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Gel Purification

Gel purification is used to recover DNA fragments after electrophoretic separation. DNA recovery from an agarose gel includes three basic steps: binding, ...

PCR - Polymerase Chain Reaction

Real Time RT-PCR

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RACE - Rapid Amplification of cDNA Ends

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PCR: The Polymerase Chain Reaction

The polymerase chain reaction, or PCR, is a technique used to amplify DNA through thermocycling &#8211; cyles of temperature changes at fixed time ...

bacterial-transformation-the-heat-shock-method

Bacterial Transformation: The Heat Shock Method

Transformation is the process that occurs when a cell ingests foreign DNA from its surroundings. Transformation can occur in nature in certain types of ...

Bacterial Transformation: Electroporation

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An Introduction to Transfection

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Labeling DNA Probes

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Southern Blot

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DNA Microarrays

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An Overview of Gene Expression

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Expression Profiling with Microarrays

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Complementary DNA

FISH - Fluorescent In-situ Hybridization

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Sanger Sequencing

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Maxam-Gilbert Sequencing

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Next-generation Sequencing

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Chromatin Immunoprecipitation- ChIP

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RNA-seq

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Synthetic Biology

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Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base ...

Ribosome Profiling

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The ELISA Method

An enzyme-linked immunosorbent assay (ELISA) is typically performed to detect the presence and/or amount of a target protein of interest within an ...

Transgenic Plants

Recombinant DNA technology called transgenesis is often used to add a foreign gene or remove a detrimental gene from an organism. Such genetically ...

Transgenic Organisms

Reproductive Cloning

CRISPR

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. ...

Reporter Genes

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In-situ Hybridization

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Obtain, evaluate, and communicate information on how molecular biotechnology may be used in a variety of fields.
EXPLANATION: The goal is to help students appreciate that the basic science knowledge being studied can be manipulated and used to design useful tools for further scientific investigations, medical treatments, agricultural yields, etc. A detailed understanding of any technical procedures is not expected, but rather a "big picture" view of concepts the technology utilizes and the applications the technology is being used for. These technologies may be best investigated along with the standards from LS1 From Molecules to Organisms: Structure and Functions, as the students are learning about DNA and protein. Comparative DNA and protein sequence analysis is also a large part of current phylogenic research and could accompany LS4 Biological Change: Unity and Diversity. Students may also consider the pros and cons of biotechnical applications. Investigation of techniques utilized could come from field trips to witness the use of these techniques in practice, lab exercises, virtual labs, simulation activities, interviews with professionals, etc. Molecular techniques could include: PCR, electrophoresis, restriction enzyme digestion of DNA, DNA sequencing, plasmid-based transformation, transfection, etc. These techniques are used in fields of medicine, agriculture, biomedical engineering, forensic science, etc.

BIO1.ETS2.1

Karyotyping

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Polytene Chromosomes

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Euchromatin

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Heterochromatin

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The Y Chromosome Determines Maleness

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The Ratio of X Chromosome to Autosomes

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Investigate means by which karyotypes are utilized in diagnostic medicine.
EXPLANATION: Engineers incorporate growing scientific knowledge in order to increase benefits to humans and decrease cost and risks. Karyotyping technology and its use in medical diagnosis can complement the standards from LS3: Hereditary: Inheritance, and Variation of Traits, as the students are learning about chromosomal organization of genomic information that determines one's phenotype. Analyze a large set of karyotypes to identify common patterns. Identify variations from the most commonly observed patterns and correlate them with patient phenotypes to propose a cause and effect relationship, discussing limitations of correlative data interpretation.

BIO1.ETS2.2

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Stem Cell Therapy for Tissue Regeneration

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Methods of Nuclear Reprogramming

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Cloning of Dolly the Sheep

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embryonic-stem-cell-culture-and-differentiation

Embryonic Stem Cell Culture and Differentiation

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Induced Pluripotency

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Analyze scientific and ethical arguments to support the pros and cons of applications of a specific biotechnology technique such as stem cell usage, in vitro fertilization, or genetically modified organisms.
EXPLANATION: The utilization of new technologies in any field of science is dependent on both economic and social factors. In addition to evaluating these factors, scientists must also consider long-term consequences that may not be initially apparent. The emphasis should be on the construction of a rationale argument that supports a position on the use of an application with ethical and social impact. Students should begin to appreciate the differences in ethical values that exist, and recognize that discussion of these values is imperative as knowledge and technology continue to advance, even when resolutions of differences can be rare. After investigation of a specific biotechnology application, students can write a position paper and/or participate in a classroom debate.

Gene Delivery for Serious Diseases

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