Retinoblastoma Gene and Cell Cycle Control

The retinoblastoma gene helps control the cell cycle. It is a tumor suppressor gene, which means it helps prevent cells from dividing when they should not. Its role is closely tied to normal cell growth and the checks that keep division under control.

The gene is often discussed in relation to ca...

Rb gene was the first-ever tumor suppressor gene discovered. Loss of function mutations in the Rb gene leads to retinoblastoma - cancer of the retinal cells of the eye.

A healthy individual possesses two functional copies of the Rb gene, which encode a retinoblastoma protein that regulates cell cycle progression...