Name: nuclear spin and nmr-active nuclei
Uploaded: 2024-04-04T10:51:39.000Z
Duration: 1 min 8 s
Channel: JoVE

すべての原子粒子は、固有の角運動量、つまり「スピン」を持っています。電子、陽子、中性子のスピン値はそれぞれ半分です。
電子とは異なり、原子核内の陽子と中性子はスピンが大きくなる可能性がありますが、値は常に半整数です。
原子核内のすべての粒子は、全体的な核スピンIに寄与します。 
原子核内では、陽子は陽子と対になり、中性子は中性子と対になります。ペアになった粒子は、原子核への正味のスピン寄与がゼロです。したがって、スピンがゼロでない原子核には、少なくとも1つの不対粒子があります。
陽子または中性子の数が奇数の場合、不対の陽子または中性子のために核スピンは半整数です。
同様に、中性子と陽子の両方の数が奇数の場合、核スピンはゼロ以外の整数になります。 
ノンゼロスピンを持つすべての原子核はNMR活性ですが、NMR研究には球状の電荷分布と対称磁場を持つスピン半原子核が好まれます。

原子核: 核スピン

Atomic Nuclei: Nuclear Spin

すべての原子粒子は固有の角運動量、つまり「スピン」を持っています。電子、陽子、中性子はそれぞれ 1/2 のスピン値を持っていますが、原子核内の陽子と中性子は、エネルギー的要因により、より高い半整数スピンを持つ場合があります。

原子核には、整数または半整数値を持つことができる正味核スピン CoreOrgo italic i があります。原子核では、陽子のスピンは互いに対になっていますが、中性子とは対になっておりません。逆も同様です。したがって、偶数の陽子は核スピンの値に寄与せず、中性子についても同様です。

炭素 12 と酸素 16 の原子核には、偶数の陽子と中性子の両方が含まれており、正味の核スピンはゼロです ( CoreOrgo italic i = 0)。原子核に奇数の陽子（プロチウムなど）または中性子（炭素 13 など）が含まれている場合、不対核子のため核スピンは半整数になります。奇数の中性子と陽子を含む原子核は、ゼロ以外の整数のスピンを持ちます。非ゼロスピンを持つすべての原子核は NMR 活性です。

スピン値が 1/2 より大きい原子核は四極子原子核と呼ばれます。天然に存在する NMR 活性核の 3 分の 2 以上は四極子です (例には窒素 14、酸素 17、硫黄 33、ホウ素 11、塩素 35 が含まれます)。四極子原子核は非球形の電荷分布を持ち、非対称な電場と磁場を引き起こし、その結果幅広い信号と複雑な NMR 挙動が生じます。したがって、球状の電荷分布と対称的な磁場を備えたスピンハーフ原子核は、NMR 研究に適しています。

すべての原子粒子は、固有の角運動量、つまり「スピン」を持っています。電子、陽子、中性子のスピン値はそれぞれ1/2ですが...

Education

JoVE Core

Analytical Chemistry

分析化学

Unit 1

ユニット1

Principles of Nuclear Magnetic Resonance

核磁気共鳴の原理

KEY TERMS AND CONCEPTS

主要な用語と概念

nuclear spin and nmr-active nuclei

Atomic nuclei have nuclear spin, which comes from the spins of their protons and neutrons. These particle spins are intrinsic angular momentum, and each electron, proton, and neutron has a spin value of 1/2. In nuclei, proton spins pair with other protons, and neutron spins pair with other neutrons. They do not pair with each other, so the final nuclear spin depends on which nucleons are left unpaired.

Even numbers of protons do not add to the nuclear spin, and even numbers of neutrons do not either. That is why carbon-12 and oxygen-16 have zero nuclear spin, or I = 0, because both nuclei contain even numbers of protons and neutrons. When a nucleus has an odd number of protons, such as protium, or an odd number of neutrons, such as carbon-13, the nuclear spin is a half-integer because of the unpaired nucleon. If a nucleus has odd numbers of both protons and neutrons, its spin is an integer and not zero.

Any nucleus with nonzero spin is NMR-active. Nuclei with spin values greater than 1/2 are called quadrupolar nuclei. More than two-thirds of naturally occurring NMR-active nuclei are quadrupolar, including nitrogen-14, oxygen-17, sulfur-33, boron-11, and chlorine-35. These nuclei have non-spherical charge distributions, which create asymmetric electric and magnetic fields and lead to broad signals and more complex NMR behavior. Spin-1/2 nuclei are often preferred for NMR studies because their charge distribution is more spherical and their fields are more symmetric.

Nuclear Spin and NMR-Active Nuclei

nuclear magnetic resonance (nmr): overview

NMR Spectra and MRI Imaging

Nuclear magnetic resonance, or NMR, is a phenomenon that certain nuclei can show when they absorb radio frequency energy under the right conditions. Scientists use it in molecular spectroscopy and in medical imaging. In both cases, the sample or the person being studied is placed in a magnetic field and exposed to radio frequency energy. In NMR spectroscopy, the result is a spectrum. This spectrum plots the absorption frequencies of the sample against peak intensity. The pattern gives detailed...

atomic nuclei: nuclear spin

Atomic nuclei have nuclear spin, which comes from the spins of their protons and neutrons. These particle spins are intrinsic angular momentum, and each electron, proton, and neutron has a spin value of 1/2. In nuclei, proton spins pair with other protons, and neutron spins pair with other neutrons. They do not pair with each other, so the final nuclear spin depends on which nucleons are left unpaired. Even numbers of protons do not add to the nuclear spin, and even numbers of neutrons do not...

atomic nuclei: nuclear magnetic moment

Nuclear Spin States and Magnetic Alignment

Atomic nuclei can act like tiny magnets when they have a nonzero spin. Because they are positively charged and rotating, they generate a magnetic field and a magnetic moment. In the absence of an external magnetic field, this magnetic moment points in random directions. When an external magnetic field, B0, is applied, the nuclear magnetic moments can line up with the field or against it. These two directions create 2I + 1 orientations. A hydrogen nucleus is a proton, and it has spin 1/2, so it...

atomic nuclei: nuclear spin state overview

atomic-nuclei-nuclear-spin-state-overview

Zeeman Splitting in Nuclear Spin States

NMR-active nuclei have spin states that describe the orientation of their nuclear magnetic moments. Without a magnetic field, these moments point in random directions, and the spin states are degenerate, meaning they have the same energy. When an external magnetic field is applied, the nucleus can only take on 2I + 1 orientations, where I is the nuclear spin. A proton with spin 1/2 has two possible orientations. A quadrupolar nucleus with spin 1 has three possible orientations. The...

atomic nuclei: nuclear spin state population distribution

atomic-nuclei-nuclear-spin-state-population-distribution

Nuclear Spin Populations and NMR Signal

Nuclear spin populations help explain why NMR signals appear. In a magnetic field, nuclei can occupy a lower energy spin-up state or a higher energy spin-down state. Near absolute zero, most nuclei stay in the lower energy state. As temperature rises, thermal collisions spread the spins more evenly between the two states. The balance between the spin −1/2 and spin +1/2 populations is described by the Boltzmann distribution equation. In this equation, ΔE is the energy difference, k is the...

atomic nuclei: larmor precession frequency

atomic-nuclei-larmor-precession-frequency

Magnetic Field and Nuclear Precession

Magnetic field strength controls nuclear precession in NMR. A spinning nucleus has a magnetic moment, and that moment turns around an external magnetic field directed along the z-axis. This motion is called Larmor precession, and its angular frequency is the Larmor frequency. The Larmor frequency is directly proportional to the applied magnetic field, B0. The proportionality constant is the gyromagnetic ratio, gamma. This value is fixed for each nucleus because every nucleus has its own ratio...

atomic nuclei: magnetic resonance

Nuclear Spins and Resonance in a Magnetic Field

Nuclear spins can line up in a magnetic field and create nuclear magnetic resonance. In the lower energy state, slightly more spins are aligned than in the higher energy state. That small difference gives the nuclei a net magnetization along the z axis.

atomic nuclei: nuclear relaxation processes

atomic-nuclei-nuclear-relaxation-processes

Nuclear Spin Alignment and Relaxation

Nuclear spin alignment and relaxation describe how nuclear spins respond to a magnetic field and then return to equilibrium. Without an external magnetic field, nuclear spin states are degenerate, meaning they have the same energy, and the spins are randomly oriented. When a magnetic field is applied, the spins begin to precess, or wobble, and orient themselves either along the field in a lower energy state or against it in a higher energy state. At equilibrium, a slight excess of spins...

atomic nuclei: types of nuclear relaxation

atomic-nuclei-types-of-nuclear-relaxation

NMR Relaxation Paths in Atomic Nuclei

Nuclear relaxation in atomic nuclei helps restore the balance between energy levels in NMR systems. It occurs through two main paths: spin-lattice relaxation and spin-spin relaxation. Both are first-order exponential decay processes. Spin-lattice relaxation is also called longitudinal relaxation. In this process, excited spins give energy to the surrounding lattice as they move back to the lower energy level. Magnetic dipolar interactions are an important part of this mechanism. A common...

nmr spectrometers: overview

How NMR Spectrometers Record Signals

NMR spectrometers record signals from samples that contain NMR-active nuclei. The system uses a strong magnet, a radiofrequency transmitter, and a detector connected to a computer console. These parts work together to measure and display the spectrum of the sample. Early NMR instruments were continuous-wave spectrometers. In a frequency-sweep method, the magnetic field stays fixed while the rf signal is swept. In a field-sweep method, the radiofrequency signal stays fixed while the magnetic...

nmr spectrometers: radiofrequency pulses and pulse sequences

nmr-spectrometers-radiofrequency-pulses-and-pulse-sequences

NMR Pulse Angles and Signal Collection

NMR pulse angles and signal collection explain how radiofrequency energy starts a measurement. A pulse is a short burst of radio waves spread across a range of frequencies. It excites the nuclei in the sample at the same time. When a radiofrequency pulse is applied along the x-axis, nuclei absorb energy that matches their Larmor frequencies and reach resonance. The net magnetization vector moves away from the z-axis and toward the transverse plane. This rotation angle is called the flip angle.

nmr spectrometers: resolution and error correction

nmr-spectrometers-resolution-and-error-correction

NMR Peak Shape and Magnetic Field Shimming

NMR peak shape depends on the signal created after magnetic nuclei resonate and relax. The detected free induction decay is approximately exponential. When that decay is Fourier transformed, it becomes a Lorentzian peak in the frequency domain. A Lorentzian peak in an NMR spectrum is described by its amplitude, full width at half maximum, and position. Its width is governed by the spin-spin relaxation time alone. In real experiments, the sample and probe can make the magnetic field...

diamagnetic shielding of nuclei: local diamagnetic current

diamagnetic-shielding-of-nuclei-local-diamagnetic-current

How Electron Density Shields Nuclei in NMR

Electron density around a nucleus affects how strongly it is shielded in NMR spectroscopy. When an applied magnetic field acts on a molecule, the electrons begin to circulate. This creates a local diamagnetic current within the molecule. The circulating sigma-bonding electrons produce a local magnetic field, B local, that opposes the applied field, B0. The nucleus then feels an effective magnetic field, which is the difference between the applied field and the local field. This effect is...

key terms and concepts

Learn how proton and neutron pairing affects nuclear spin, why some nuclei are NMR-active, and why spin-1/2 nuclei give cleaner NMR signals.

Nuclear Spin and NMR-Active Nuclei | JoVE K12

JoVE Core 分析化学 は、複雑な化学原理をアニメーションで視覚化することで、SI 単位から NMR 分光法を含むトピックをよりわかりやすくします。実験を撮影した実写動画では、これらの概念が世界中の研究所でどのように応用されているかを取り上げています。

analytical chemistry

Nuclear Spin and NMR-Active Nuclei

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